Ian R Phillips

Ian R Phillips

UNVERIFIED PROFILE

Are you Ian R Phillips?   Register this Author

Register author
Ian R Phillips

Ian R Phillips

Publications by authors named "Ian R Phillips"

Are you Ian R Phillips?   Register this Author

45Publications

1003Reads

18Profile Views

Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease.

Xenobiotica 2020 Jan 1;50(1):19-33. Epub 2019 Aug 1.

Research Department of Structural and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00498254.2019.1643515DOI Listing
January 2020

Flavin-containing monooxygenases: new structures from old proteins.

Nat Struct Mol Biol 2020 Jan;27(1):3-4

Department of Structural and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41594-019-0356-1DOI Listing
January 2020

Biochar amendment and water stress alter rhizosphere carbon and nitrogen budgets in bauxite-processing residue sand under rehabilitation.

J Environ Manage 2019 Jan 6;230:446-455. Epub 2018 Oct 6.

Australian Rivers Institute, School of Environment and Science, Griffith University, Nathan, Qld 4111, Australia. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03014797183110
Publisher Site
http://dx.doi.org/10.1016/j.jenvman.2018.09.093DOI Listing
January 2019

Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine -oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis.

Drug Metab Dispos 2018 01 25;46(1):20-25. Epub 2017 Oct 25.

Institute of Structural and Molecular Biology (S.V., F.S., D.F., I.R.P., E.A.S.) and Mass Spectrometry Facility, Department of Chemistry (K.K.), University College London, London, United Kingdom; and School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom (I.R.P.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.117.077636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733448PMC
January 2018

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.

Drug Metab Dispos 2017 09 23;45(9):982-989. Epub 2017 Jun 23.

Institute of Structural and Molecular Biology, University College London, London, United Kingdom (F.S., S.G.G.M., B.A.O., D.F., S.V., C.R.C., I.R.P., E.A.S.); and School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom (I.R.P.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.117.076612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539585PMC
September 2017

Drug metabolism by flavin-containing monooxygenases of human and mouse.

Expert Opin Drug Metab Toxicol 2017 Feb 29;13(2):167-181. Epub 2016 Sep 29.

a Institute of Structural and Molecular Biology , University College London , London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17425255.2017.1239718DOI Listing
February 2017

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease.

Drug Metab Dispos 2016 11 17;44(11):1839-1850. Epub 2016 May 17.

Institute of Structural and Molecular Biology, University College London (D.F., I.R.P., E.A.S.), and School of Biological and Chemical Sciences, Queen Mary University of London (I.R.P.), London, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.116.070615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074467PMC
November 2016

Isolation and Culture of Mouse Hepatocytes: Gender-Specific Gene Expression Responses to Chemical Treatments.

Methods Mol Biol 2015 ;1250:3-12

Institute of Structural and Molecular Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4939-2074-7_1
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-2074-7_1DOI Listing
May 2016

Shifts in leaf N:P stoichiometry during rehabilitation in highly alkaline bauxite processing residue sand.

Sci Rep 2015 Oct 7;5:14811. Epub 2015 Oct 7.

School of Life Sciences, Arizona State University, Tempe, AZ 85287 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep14811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595801PMC
October 2015

Clinical utility gene card for: Trimethylaminuria - update 2014.

Eur J Hum Genet 2015 Sep 22;23(9). Epub 2014 Oct 22.

1] Institute of Structural and Molecular Biology, University College London, London, UK [2] School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ejhg.2014.226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538216PMC
September 2015

The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.

Biochem Pharmacol 2014 Jul 30;90(1):88-95. Epub 2014 Apr 30.

Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2014.04.007DOI Listing
July 2014

Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.

Br J Clin Pharmacol 2014 May;77(5):839-51

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.12240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004404PMC
May 2014

Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse.

Pharmaceuticals (Basel) 2012 ;5(11):1147-59

Department of Environmental and Molecular Toxicology, Oregon State University, 1007 ALS Corvallis, OR 97331, USA; (A.L.P.); (V.L.L.); (A.L.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ph5111147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621790PMC
November 2013

Isolation of mouse hepatocytes.

Methods Mol Biol 2013 ;987:283-93

Institute of Structural and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-62703-321-3_24DOI Listing
August 2013

Clinical utility gene card for: trimethylaminuria.

Eur J Hum Genet 2012 Mar 30;20(3). Epub 2011 Nov 30.

Institute of Structural and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ejhg.2011.214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283181PMC
March 2012

Predictive hydrogeochemical modelling of bauxite residue sand in field conditions.

J Hazard Mater 2011 Jul 23;191(1-3):306-24. Epub 2011 Apr 23.

Ecole Polytechnique Fédérale de Lausanne (EPFL), Faculté de l'Environnement Naturel, Architectural et Construit (ENAC), Laboratoire de Technologie Ecologique, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2011.04.078DOI Listing
July 2011

Influence of organic waste and residue mud additions on chemical, physical and microbial properties of bauxite residue sand.

Environ Sci Pollut Res Int 2011 Feb 30;18(2):199-211. Epub 2010 Jun 30.

School of Land, Crop and Food Sciences/CRC CARE, The University of Queensland, St Lucia, Brisbane, Queensland, 4072, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-010-0364-5DOI Listing
February 2011

The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism.

Expert Opin Drug Metab Toxicol 2010 Sep;6(9):1083-94

University College London, Institute of Structural and Molecular Biology, Gower Street, London WC1E 6BT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17425255.2010.503705DOI Listing
September 2010

Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.

Pharmacogenet Genomics 2009 Apr;19(4):289-99

Department of Biochemical Engineering, Institute of Structural and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e328328d507DOI Listing
April 2009

Planning the human variome project: the Spain report.

Authors:
Jim Kaput Richard G H Cotton Lauren Hardman Michael Watson Aida I Al Aqeel Jumana Y Al-Aama Fahd Al-Mulla Santos Alonso Stefan Aretz Arleen D Auerbach Bharati Bapat Inge T Bernstein Jong Bhak Stacey L Bleoo Helmut Blöcker Steven E Brenner John Burn Mariona Bustamante Rita Calzone Anne Cambon-Thomsen Michele Cargill Paola Carrera Lawrence Cavedon Yoon Shin Cho Yeun-Jun Chung Mireille Claustres Garry Cutting Raymond Dalgleish Johan T den Dunnen Carlos Díaz Steven Dobrowolski M Rosário N dos Santos Rosemary Ekong Simon B Flanagan Paul Flicek Yoichi Furukawa Maurizio Genuardi Ho Ghang Maria V Golubenko Marc S Greenblatt Ada Hamosh John M Hancock Ross Hardison Terence M Harrison Robert Hoffmann Rania Horaitis Heather J Howard Carol Isaacson Barash Neskuts Izagirre Jongsun Jung Toshio Kojima Sandrine Laradi Yeon-Su Lee Jong-Young Lee Vera L Gil-da-Silva-Lopes Finlay A Macrae Donna Maglott Makia J Marafie Steven G E Marsh Yoichi Matsubara Ludwine M Messiaen Gabriela Möslein Mihai G Netea Melissa L Norton Peter J Oefner William S Oetting James C O'Leary Ana Maria Oller de Ramirez Mark H Paalman Jillian Parboosingh George P Patrinos Giuditta Perozzi Ian R Phillips Sue Povey Suyash Prasad Ming Qi David J Quin Rajkumar S Ramesar C Sue Richards Judith Savige Dagmar G Scheible Rodney J Scott Daniela Seminara Elizabeth A Shephard Rolf H Sijmons Timothy D Smith María-Jesús Sobrido Toshihiro Tanaka Sean V Tavtigian Graham R Taylor Jon Teague Thoralf Töpel Mollie Ullman-Cullere Joji Utsunomiya Henk J van Kranen Mauno Vihinen Elizabeth Webb Thomas K Weber Meredith Yeager Young I Yeom Seon-Hee Yim Hyang-Sook Yoo

Hum Mutat 2009 Apr;30(4):496-510

Division of Personalised Nutrition and Medicine, FDA/National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.

View Article

Download full-text PDF

Source
http://compbio.berkeley.edu/people/brenner/pubs/kaput-2009-h
Web Search
http://doi.wiley.com/10.1002/humu.20972
Publisher Site
http://dx.doi.org/10.1002/humu.20972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879779PMC
April 2009

Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.

Drug Metab Dispos 2009 Jan 23;37(1):178-86. Epub 2008 Oct 23.

Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

View Article

Download full-text PDF

Source
http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.108.024158
Publisher Site
http://dx.doi.org/10.1124/dmd.108.024158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683658PMC
January 2009

Flavin-containing monooxygenases: mutations, disease and drug response.

Trends Pharmacol Sci 2008 Jun 16;29(6):294-301. Epub 2008 Apr 16.

School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tips.2008.03.004DOI Listing
June 2008

Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3).

Pharmacogenet Genomics 2007 Oct;17(10):827-39

Department of Biochemistry and Molecular Biology, University College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e328256b198DOI Listing
October 2007

Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse.

Biochem J 2007 Sep;406(3):491-9

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20070523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2049042PMC
September 2007

Tributyltin partitioning in sediments: effect of aging.

Chemosphere 2006 Mar 16;63(1):73-81. Epub 2005 Sep 16.

School of Environmental Engineering, Faculty of Environmental Sciences, Griffith University, Nathan, QLD 4111, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2005.07.048DOI Listing
March 2006

Transfection of Primary Cultures of Rat Hepatocytes.

Methods Mol Biol 2006;320:273-282

Department of Biochemistry and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1385/1-59259-998-2:273
Publisher Site
http://dx.doi.org/10.1385/1-59259-998-2:273DOI Listing
January 2006

Determination of Cellular Localization of Expression of Flavin-Containing Monooxygenase Genes in Mouse Tissues by In Situ Hybridization.

Methods Mol Biol 2006;320:295-305

Department of Biochemistry and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1385/1-59259-998-2:295
Publisher Site
http://dx.doi.org/10.1385/1-59259-998-2:295DOI Listing
January 2006

Deletion of Genes From the Mouse Genome Using Cre/loxP Technology.

Methods Mol Biol 2006;320:307-319

Department of Biochemistry and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-998-2:307DOI Listing
January 2006

Characterization of Targeted Mouse Embryonic Stem Cell Chromosomes : Karyotyping and Fluorescence In Situ Hybridization of Metaphase Spreads.

Methods Mol Biol 2006;320:321-327

School of Biological Sciences, Queen Mary, University of London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-998-2:321DOI Listing
January 2006

Microinjection of Targeted Embryonic Stem Cells and Establishment of Knockout Mouse Lines for Fmo Genes.

Methods Mol Biol 2006;320:329-341

Department of Biochemistry and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-998-2:329DOI Listing
January 2006

Expression of Recombinant Flavin-Containing Monooxygenases in a Baculovirus/Insect Cell System.

Methods Mol Biol 2006;320:39-59

School of Biological Sciences, Queen Mary, University of London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-998-2:39DOI Listing
January 2006

Trace metal distribution and enrichment in benthic, estuarine sediments: Southport Broadwater, Australia.

Environ Geochem Health 2005 Sep;27(5-6):369-83

School of Environmental Engineering, Faculty of Environmental Sciences, Griffith University, Nathan, QLD 4111, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10653-004-7086-xDOI Listing
September 2005

Reactive sulfide relationships with trace metal extractability in sediments from southern Moreton Bay, Australia.

Mar Pollut Bull 2005 May 16;50(5):589-95. Epub 2005 Mar 16.

School of Environmental Engineering, Faculty of Environmental Sciences, Griffith University, Nathan, QLD 4111, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.marpolbul.2005.01.022DOI Listing
May 2005

Geochemical partitioning of copper, lead, and zinc in benthic, estuarine sediment profiles.

J Environ Qual 2005 Jan-Feb;34(1):263-73

School of Environmental Engineering, Faculty of Environmental Sciences, Griffith University, Nathan, QLD, 4111, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2134/jeq2005.0263DOI Listing
April 2005

In-situ partitioning of butyltin compounds in estuarine sediments.

Chemosphere 2005 Apr 8;59(5):585-92. Epub 2004 Dec 8.

School of Environmental Engineering, Faculty of Environmental Sciences, Griffith University, Nathan 4111, Qld, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2004.10.067DOI Listing
April 2005

Sorption and desorption behavior of tributyltin with natural sediments.

Environ Sci Technol 2004 Dec;38(24):6694-700

Faculty of Environmental Sciences, Griffith University, Nathan, Queensland 4111, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/es049291sDOI Listing
December 2004

Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos).

Biochem Pharmacol 2004 Jul;68(1):73-83

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2004.02.036DOI Listing
July 2004

Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.

Pharmacogenetics 2004 Feb;14(2):117-30

Department of Biochemistry and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00008571-200402000-00006DOI Listing
February 2004

Trimethylaminuria and a human FMO3 mutation database.

Hum Mutat 2003 Sep;22(3):209-13

Department of Biochemistry and Molecular Biology, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.10252DOI Listing
September 2003

Genetic polymorphisms of flavin-containing monooxygenase (FMO).

Drug Metab Rev 2002 Aug;34(3):523-32

Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1081/dmr-120005653DOI Listing
August 2002

Transfection of liver in vivo by biolistic particle delivery: its use in the investigation of cytochrome P450 gene regulation.

Mol Biotechnol 2002 Feb;20(2):145-51

Department of Biochemistry and Molecular Biology, University College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/mb:20:2:145DOI Listing
February 2002