Ian R A Mackenzie

Ian R A Mackenzie

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Ian R A Mackenzie

Ian R A Mackenzie

Publications by authors named "Ian R A Mackenzie"

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Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers.

Authors:
Qin Chen Bradley F Boeve Christopher G Schwarz Robert Reid Nirubol Tosakulwong Timothy G Lesnick Jessica Bove Patrick Brannelly Danielle Brushaber Giovanni Coppola Christina Dheel Bradford C Dickerson Susan Dickinson Kelley Faber Julie Fields Jamie Fong Tatiana Foroud Leah Forsberg Ralitza H Gavrilova Debra Gearhart Nupur Ghoshal Jill Goldman Jonathan Graff-Radford Neill R Graff-Radford Murray Grossman Dana Haley Hilary W Heuer Ging-Yuek R Hsiung Edward Huey David J Irwin Clifford R Jack David T Jones Lynne Jones Anna M Karydas David S Knopman John Kornak Joel Kramer Walter Kremers Walter A Kukull Maria Lapid Diane Lucente Codrin Lungu Ian R A Mackenzie Masood Manoochehri Scott McGinnis Bruce L Miller Rodney Pearlman Leonard Petrucelli Madeline Potter Rosa Rademakers Eliana M Ramos Katherine P Rankin Katya Rascovsky Pheth Sengdy Leslie Shaw Jeremy Syrjanen Nadine Tatton Joanne Taylor Arthur W Toga John Trojanowski Sandra Weintraub Bonnie Wong Adam L Boxer Howie Rosen Zbigniew Wszolek Kejal Kantarci

Neurobiol Aging 2019 Nov 15;83:54-62. Epub 2019 Aug 15.

Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858933PMC
November 2019

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://link.springer.com/10.1007/s00401-019-01962-9
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http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers.

Authors:
Petra Frick Chantal Sellier Ian R A Mackenzie Chieh-Yu Cheng Julie Tahraoui-Bories Cecile Martinat R Jeroen Pasterkamp Johannes Prudlo Dieter Edbauer Mustapha Oulad-Abdelghani Regina Feederle Nicolas Charlet-Berguerand Manuela Neumann

Acta Neuropathol Commun 2018 08 3;6(1):72. Epub 2018 Aug 3.

German Center for Neurodegenerative Diseases (DZNE), Otfried-Müllerstr. 23, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1186/s40478-018-0579-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091050PMC
August 2018

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Authors:
Cyril Pottier Xiaolai Zhou Ralph B Perkerson Matt Baker Gregory D Jenkins Daniel J Serie Roberta Ghidoni Luisa Benussi Giuliano Binetti Adolfo López de Munain Miren Zulaica Fermin Moreno Isabelle Le Ber Florence Pasquier Didier Hannequin Raquel Sánchez-Valle Anna Antonell Albert Lladó Tammee M Parsons NiCole A Finch Elizabeth C Finger Carol F Lippa Edward D Huey Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Robert A Rissman Jaroslaw Slawek Emilia Sitek Peter Johannsen Jørgen E Nielsen Yingxue Ren Marka van Blitterswijk Mariely DeJesus-Hernandez Elizabeth Christopher Melissa E Murray Kevin F Bieniek Bret M Evers Camilla Ferrari Sara Rollinson Anna Richardson Elio Scarpini Giorgio G Fumagalli Alessandro Padovani John Hardy Parastoo Momeni Raffaele Ferrari Francesca Frangipane Raffaele Maletta Maria Anfossi Maura Gallo Leonard Petrucelli EunRan Suh Oscar L Lopez Tsz H Wong Jeroen G J van Rooij Harro Seelaar Simon Mead Richard J Caselli Eric M Reiman Marwan Noel Sabbagh Mads Kjolby Anders Nykjaer Anna M Karydas Adam L Boxer Lea T Grinberg Jordan Grafman Salvatore Spina Adrian Oblak M-Marsel Mesulam Sandra Weintraub Changiz Geula John R Hodges Olivier Piguet William S Brooks David J Irwin John Q Trojanowski Edward B Lee Keith A Josephs Joseph E Parisi Nilüfer Ertekin-Taner David S Knopman Benedetta Nacmias Irene Piaceri Silvia Bagnoli Sandro Sorbi Marla Gearing Jonathan Glass Thomas G Beach Sandra E Black Mario Masellis Ekaterina Rogaeva Jean-Paul Vonsattel Lawrence S Honig Julia Kofler Amalia C Bruni Julie Snowden David Mann Stuart Pickering-Brown Janine Diehl-Schmid Juliane Winkelmann Daniela Galimberti Caroline Graff Linn Öijerstedt Claire Troakes Safa Al-Sarraj Carlos Cruchaga Nigel J Cairns Jonathan D Rohrer Glenda M Halliday John B Kwok John C van Swieten Charles L White Bernardino Ghetti Jill R Murell Ian R A Mackenzie Ging-Yuek R Hsiung Barbara Borroni Giacomina Rossi Fabrizio Tagliavini Zbigniew K Wszolek Ronald C Petersen Eileen H Bigio Murray Grossman Vivianna M Van Deerlin William W Seeley Bruce L Miller Neill R Graff-Radford Bradley F Boeve Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Lancet Neurol 2018 06 30;17(6):548-558. Epub 2018 Apr 30.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30126-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237181PMC
June 2018

Fused in Sarcoma Neuropathology in Neurodegenerative Disease.

Authors:
Ian R A Mackenzie Manuela Neumann

Cold Spring Harb Perspect Med 2017 Dec 1;7(12). Epub 2017 Dec 1.

Department of Neuropathology, University of Tübingen and German Center for Neurodegenerative Diseases (DZNE), Tübingen 72076, Germany.

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http://dx.doi.org/10.1101/cshperspect.a024299DOI Listing
December 2017

Clinical and neuropathological features of ALS/FTD with TIA1 mutations.

Authors:
Veronica Hirsch-Reinshagen Cyril Pottier Alexandra M Nicholson Matt Baker Ging-Yuek R Hsiung Charles Krieger Pheth Sengdy Kevin B Boylan Dennis W Dickson Marsel Mesulam Sandra Weintraub Eileen Bigio Lorne Zinman Julia Keith Ekaterina Rogaeva Sasha A Zivkovic David Lacomis J Paul Taylor Rosa Rademakers Ian R A Mackenzie

Acta Neuropathol Commun 2017 Dec 7;5(1):96. Epub 2017 Dec 7.

Department of Pathology and Laboratory Medicine, University of British Colombia, British Columbia, Canada.

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http://dx.doi.org/10.1186/s40478-017-0493-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719900PMC
December 2017

An Unusual Case of Rabies Encephalitis.

Authors:
Greg Walker Brian Thiessen Doug Graeb G R Wayne Moore Ian R A Mackenzie

Can J Neurol Sci 2016 Nov 31;43(6):852-855. Epub 2016 Aug 31.

3Department of Pathology and Laboratory Medicine,Vancouver Coastal Health and the University of British Columbia,Vancouver,Canada.

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http://dx.doi.org/10.1017/cjn.2016.287DOI Listing
November 2016

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies.

Authors:
Ian R A Mackenzie Manuela Neumann

J Neurochem 2016 08 15;138 Suppl 1:54-70. Epub 2016 Jun 15.

Department of Neuropathology, University of Tübingen and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.

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http://dx.doi.org/10.1111/jnc.13588DOI Listing
August 2016

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.

Authors:
Marc Suárez-Calvet Manuela Neumann Thomas Arzberger Claudia Abou-Ajram Eva Funk Hannelore Hartmann Dieter Edbauer Elisabeth Kremmer Christoph Göbl Moritz Resch Benjamin Bourgeois Tobias Madl Stefan Reber Daniel Jutzi Marc-David Ruepp Ian R A Mackenzie Olaf Ansorge Dorothee Dormann Christian Haass

Acta Neuropathol 2016 Apr 19;131(4):587-604. Epub 2016 Feb 19.

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen Strasse 17, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-016-1544-2DOI Listing
April 2016

Two cases of rheumatoid meningitis.

Authors:
Shino Magaki Edward Chang Robert R Hammond Isaac Yang Ian R A Mackenzie Benedict T Chou Soo I Choi Joanna C Jen Whitney B Pope David A Bell Harry V Vinters

Neuropathology 2016 Feb 8;36(1):93-102. Epub 2015 Sep 8.

Section of Neuropathology, Department of Pathology and Laboratory Medicine.

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http://dx.doi.org/10.1111/neup.12238DOI Listing
February 2016

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.

Authors:
Ian R A Mackenzie Petra Frick Friedrich A Grässer Tania F Gendron Leonard Petrucelli Neil R Cashman Dieter Edbauer Elisabeth Kremmer Johannes Prudlo Dirk Troost Manuela Neumann

Acta Neuropathol 2015 Dec 15;130(6):845-61. Epub 2015 Sep 15.

German Center for Neurodegenerative Diseases (DZNE), Otfried-Müllerstr. 23, 72076, Tübingen, Germany.

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http://link.springer.com/content/pdf/10.1007%2Fs00401-015-14
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http://link.springer.com/10.1007/s00401-015-1476-2
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http://dx.doi.org/10.1007/s00401-015-1476-2DOI Listing
December 2015

Frontotemporal dementia and its subtypes: a genome-wide association study.

Authors:
Raffaele Ferrari Dena G Hernandez Michael A Nalls Jonathan D Rohrer Adaikalavan Ramasamy John B J Kwok Carol Dobson-Stone William S Brooks Peter R Schofield Glenda M Halliday John R Hodges Olivier Piguet Lauren Bartley Elizabeth Thompson Eric Haan Isabel Hernández Agustín Ruiz Mercè Boada Barbara Borroni Alessandro Padovani Carlos Cruchaga Nigel J Cairns Luisa Benussi Giuliano Binetti Roberta Ghidoni Gianluigi Forloni Daniela Galimberti Chiara Fenoglio Maria Serpente Elio Scarpini Jordi Clarimón Alberto Lleó Rafael Blesa Maria Landqvist Waldö Karin Nilsson Christer Nilsson Ian R A Mackenzie Ging-Yuek R Hsiung David M A Mann Jordan Grafman Christopher M Morris Johannes Attems Timothy D Griffiths Ian G McKeith Alan J Thomas P Pietrini Edward D Huey Eric M Wassermann Atik Baborie Evelyn Jaros Michael C Tierney Pau Pastor Cristina Razquin Sara Ortega-Cubero Elena Alonso Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Alexander Kurz Innocenzo Rainero Elisa Rubino Lorenzo Pinessi Ekaterina Rogaeva Peter St George-Hyslop Giacomina Rossi Fabrizio Tagliavini Giorgio Giaccone James B Rowe Johannes C M Schlachetzki James Uphill John Collinge Simon Mead Adrian Danek Vivianna M Van Deerlin Murray Grossman John Q Trojanowski Julie van der Zee William Deschamps Tim Van Langenhove Marc Cruts Christine Van Broeckhoven Stefano F Cappa Isabelle Le Ber Didier Hannequin Véronique Golfier Martine Vercelletto Alexis Brice Benedetta Nacmias Sandro Sorbi Silvia Bagnoli Irene Piaceri Jørgen E Nielsen Lena E Hjermind Matthias Riemenschneider Manuel Mayhaus Bernd Ibach Gilles Gasparoni Sabrina Pichler Wei Gu Martin N Rossor Nick C Fox Jason D Warren Maria Grazia Spillantini Huw R Morris Patrizia Rizzu Peter Heutink Julie S Snowden Sara Rollinson Anna Richardson Alexander Gerhard Amalia C Bruni Raffaele Maletta Francesca Frangipane Chiara Cupidi Livia Bernardi Maria Anfossi Maura Gallo Maria Elena Conidi Nicoletta Smirne Rosa Rademakers Matt Baker Dennis W Dickson Neill R Graff-Radford Ronald C Petersen David Knopman Keith A Josephs Bradley F Boeve Joseph E Parisi William W Seeley Bruce L Miller Anna M Karydas Howard Rosen John C van Swieten Elise G P Dopper Harro Seelaar Yolande A L Pijnenburg Philip Scheltens Giancarlo Logroscino Rosa Capozzo Valeria Novelli Annibale A Puca Massimo Franceschi Alfredo Postiglione Graziella Milan Paolo Sorrentino Mark Kristiansen Huei-Hsin Chiang Caroline Graff Florence Pasquier Adeline Rollin Vincent Deramecourt Florence Lebert Dimitrios Kapogiannis Luigi Ferrucci Stuart Pickering-Brown Andrew B Singleton John Hardy Parastoo Momeni

Lancet Neurol 2014 Jul;13(7):686-99

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70065-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112126PMC
July 2014

The neuropathology associated with repeat expansions in the C9ORF72 gene.

Authors:
Ian R A Mackenzie Petra Frick Manuela Neumann

Acta Neuropathol 2014 Mar 20;127(3):347-57. Epub 2013 Dec 20.

Department of Pathology, University of British Columbia and Vancouver General Hospital, Vancouver, Canada.

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http://dx.doi.org/10.1007/s00401-013-1232-4DOI Listing
March 2014

Early dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability.

Authors:
Malcolm Proudfoot Nick J Gutowski Dieter Edbauer David A Hilton Mark Stephens Julia Rankin Ian R A Mackenzie

Acta Neuropathol 2014 Mar 21;127(3):451-8. Epub 2014 Jan 21.

Department of Neurology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK,

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http://dx.doi.org/10.1007/s00401-014-1245-7DOI Listing
March 2014

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.

Authors:
Wen-Yuan Wang Ling Pan Susan C Su Emma J Quinn Megumi Sasaki Jessica C Jimenez Ian R A Mackenzie Eric J Huang Li-Huei Tsai

Nat Neurosci 2013 Oct 15;16(10):1383-91. Epub 2013 Sep 15.

1] Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA. [3].

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http://dx.doi.org/10.1038/nn.3514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564396PMC
October 2013

Angiotropism in primary cutaneous melanoma with brain metastasis: a study of 20 cases.

Authors:
Tawny Hung Jason Morin William R Munday Ian R A Mackenzie Claire Lugassy Raymond L Barnhill

Am J Dermatopathol 2013 Aug;35(6):650-4

Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1097/DAD.0b013e31827e8315ADDOI Listing
August 2013

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.

Authors:
Kohji Mori Sven Lammich Ian R A Mackenzie Ignasi Forné Sonja Zilow Hans Kretzschmar Dieter Edbauer Jonathan Janssens Gernot Kleinberger Marc Cruts Jochen Herms Manuela Neumann Christine Van Broeckhoven Thomas Arzberger Christian Haass

Acta Neuropathol 2013 Mar 5;125(3):413-23. Epub 2013 Feb 5.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Schillerstr. 44, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-013-1088-7DOI Listing
March 2013

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Authors:
Manuela Neumann Chiara F Valori Olaf Ansorge Hans A Kretzschmar David G Munoz Hirofumi Kusaka Osamu Yokota Kenji Ishihara Lee-Cyn Ang Juan M Bilbao Ian R A Mackenzie

Acta Neuropathol 2012 Nov 28;124(5):705-16. Epub 2012 Jul 28.

Institute of Neuropathology, University Hospital Zurich, Switzerland.

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http://link.springer.com/content/pdf/10.1007/s00401-012-1020
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http://link.springer.com/10.1007/s00401-012-1020-6
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http://dx.doi.org/10.1007/s00401-012-1020-6DOI Listing
November 2012

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.

Authors:
Dorothee Dormann Tobias Madl Chiara F Valori Eva Bentmann Sabina Tahirovic Claudia Abou-Ajram Elisabeth Kremmer Olaf Ansorge Ian R A Mackenzie Manuela Neumann Christian Haass

EMBO J 2012 Nov 11;31(22):4258-75. Epub 2012 Sep 11.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1038/emboj.2012.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501225PMC
November 2012

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects.

Authors:
Glenda Halliday Eileen H Bigio Nigel J Cairns Manuela Neumann Ian R A Mackenzie David M A Mann

Acta Neuropathol 2012 Sep 10;124(3):373-82. Epub 2012 Aug 10.

Neuroscience Research Australia, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1007/s00401-012-1030-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445027PMC
September 2012

Rapidly progressive dementia in a Chinese patient due to C90RF72 mutation.

Authors:
Nagaendran Kandiah Pheth Sengdy Ian R A Mackenzie Ging-Yuek Hsiung Mariely de Jesus-Hernandez Rosa Rademakers

Can J Neurol Sci 2012 Sep;39(5):676-7

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617408PMC
http://dx.doi.org/10.1017/s0317167100015481DOI Listing
September 2012

FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis.

Authors:
Ian R A Mackenzie Manuela Neumann

Brain Res 2012 Jun 13;1462:40-3. Epub 2011 Dec 13.

Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, Canada V5Z 1M9.

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http://dx.doi.org/10.1016/j.brainres.2011.12.010DOI Listing
June 2012

Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p.

Authors:
Heather Stewart Nicola J Rutherford Hannah Briemberg Charles Krieger Neil Cashman Marife Fabros Matt Baker Alice Fok Mariely DeJesus-Hernandez Andrew Eisen Rosa Rademakers Ian R A Mackenzie

Acta Neuropathol 2012 Mar 7;123(3):409-17. Epub 2012 Jan 7.

Division of Neurology, University of British Columbia, Vancouver, BC, Canada.

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http://link.springer.com/10.1007/s00401-011-0937-5
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http://dx.doi.org/10.1007/s00401-011-0937-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322555PMC
March 2012

Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p.

Authors:
Ging-Yuek R Hsiung Mariely DeJesus-Hernandez Howard H Feldman Pheth Sengdy Phoenix Bouchard-Kerr Emily Dwosh Rachel Butler Bonnie Leung Alice Fok Nicola J Rutherford Matt Baker Rosa Rademakers Ian R A Mackenzie

Brain 2012 Mar 17;135(Pt 3):709-22. Epub 2012 Feb 17.

Division of Neurology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

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http://dx.doi.org/10.1093/brain/awr354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286328PMC
March 2012

Synaptic dysfunction in progranulin-deficient mice.

Authors:
Terri L Petkau Scott J Neal Austen Milnerwood Ada Mew Austin M Hill Paul Orban Jenny Gregg Ge Lu Howard H Feldman Ian R A Mackenzie Lynn A Raymond Blair R Leavitt

Neurobiol Dis 2012 Feb 25;45(2):711-22. Epub 2011 Oct 25.

Centre for Molecular Medicine & Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/j.nbd.2011.10.016DOI Listing
February 2012

Baylisascaris procyonis infection in elderly person, British Columbia, Canada.

Authors:
Tawny Hung Ronald C Neafie Ian R A Mackenzie

Emerg Infect Dis 2012 Feb;18(2):341-2

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http://dx.doi.org/10.3201/eid1802.111046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310454PMC
February 2012

Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43.

Authors:
Ian R A Mackenzie Manuela Neumann Nigel J Cairns David G Munoz Adrian M Isaacs

J Mol Neurosci 2011 Nov 21;45(3):402-8. Epub 2011 May 21.

Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada.

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http://dx.doi.org/10.1007/s12031-011-9551-1DOI Listing
November 2011

Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID).

Authors:
Richard A Armstrong Marla Gearing Eileen H Bigio Felix F Cruz-Sanchez Charles Duyckaerts Ian R A Mackenzie Robert H Perry Kari Skullerud Hideaki Yokoo Nigel J Cairns

J Neural Transm (Vienna) 2011 Nov 27;118(11):1651-7. Epub 2011 Jul 27.

Vision Sciences, Aston University, Birmingham, UK.

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http://link.springer.com/10.1007/s00702-011-0690-x
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http://dx.doi.org/10.1007/s00702-011-0690-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199334PMC
November 2011

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.

Authors:
Manuela Neumann Eva Bentmann Dorothee Dormann Ali Jawaid Mariely DeJesus-Hernandez Olaf Ansorge Sigrun Roeber Hans A Kretzschmar David G Munoz Hirofumi Kusaka Osamu Yokota Lee-Cyn Ang Juan Bilbao Rosa Rademakers Christian Haass Ian R A Mackenzie

Brain 2011 Sep 19;134(Pt 9):2595-609. Epub 2011 Aug 19.

Institute of Neuropathology, Schmelzbergstr. 12, 8091 Zurich, Switzerland.

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https://academic.oup.com/brain/article-lookup/doi/10.1093/br
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http://dx.doi.org/10.1093/brain/awr201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170539PMC
September 2011

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation.

Authors:
Ian R A Mackenzie Olaf Ansorge Michael Strong Juan Bilbao Lorne Zinman Lee-Cyn Ang Matt Baker Heather Stewart Andrew Eisen Rosa Rademakers Manuela Neumann

Acta Neuropathol 2011 Jul 21;122(1):87-98. Epub 2011 May 21.

Department of Pathology, University of British Columbia and Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada.

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http://dx.doi.org/10.1007/s00401-011-0838-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319073PMC
July 2011

A harmonized classification system for FTLD-TDP pathology.

Authors:
Ian R A Mackenzie Manuela Neumann Atik Baborie Deepak M Sampathu Daniel Du Plessis Evelyn Jaros Robert H Perry John Q Trojanowski David M A Mann Virginia M Y Lee

Acta Neuropathol 2011 Jul 5;122(1):111-3. Epub 2011 Jun 5.

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http://dx.doi.org/10.1007/s00401-011-0845-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285143PMC
July 2011

Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.

Authors:
Alice S Chen-Plotkin Maria Martinez-Lage Patrick M A Sleiman William Hu Robert Greene Elisabeth McCarty Wood Shaoxu Bing Murray Grossman Gerard D Schellenberg Kimmo J Hatanpaa Myron F Weiner Charles L White William S Brooks Glenda M Halliday Jillian J Kril Marla Gearing Thomas G Beach Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Stuart M Pickering-Brown Julie Snowden John C van Swieten Peter Heutink Harro Seelaar Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman Jeffrey A Kaye Randall L Woltjer Marsel Mesulam Eileen Bigio Albert Lladó Bruce L Miller Ainhoa Alzualde Fermin Moreno Jonathan D Rohrer Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Marc Cruts Sebastiaan Engelborghs Peter P De Deyn Christine Van Broeckhoven Thomas D Bird Nigel J Cairns Allison Goate Matthew P Frosch Peter F Riederer Nenad Bogdanovic Virginia M Y Lee John Q Trojanowski Vivianna M Van Deerlin

Arch Neurol 2011 Apr;68(4):488-97

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1001/archneurol.2011.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160280PMC
April 2011

The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease.

Authors:
Richard A Armstrong Marla Gearing Eileen H Bigio Felix F Cruz-Sanchez Charles Duyckaerts Ian R A Mackenzie Robert H Perry Kari Skullerud Hedeaki Yokoo Nigel J Cairns

Acta Neuropathol 2011 Feb 1;121(2):219-28. Epub 2010 Oct 1.

Aston University, Birmingham, UK.

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http://dx.doi.org/10.1007/s00401-010-0753-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035044PMC
February 2011

Distinct pathological subtypes of FTLD-FUS.

Authors:
Ian R A Mackenzie David G Munoz Hirofumi Kusaka Osamu Yokota Kenji Ishihara Sigrun Roeber Hans A Kretzschmar Nigel J Cairns Manuela Neumann

Acta Neuropathol 2011 Feb 30;121(2):207-18. Epub 2010 Oct 30.

Department of Pathology, Vancouver General Hospital, University of British Columbia, BC, Canada.

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http://link.springer.com/10.1007/s00401-010-0764-0
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February 2011

rs5848 polymorphism and serum progranulin level.

Authors:
Ging-Yuek R Hsiung Alice Fok Howard H Feldman Rosa Rademakers Ian R A Mackenzie

J Neurol Sci 2011 Jan 2;300(1-2):28-32. Epub 2010 Nov 2.

Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.jns.2010.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085023PMC
January 2011

Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis.

Authors:
Rosa Rademakers Heather Stewart Mariely Dejesus-Hernandez Charles Krieger Neill Graff-Radford Marife Fabros Hannah Briemberg Neil Cashman Andrew Eisen Ian R A Mackenzie

Muscle Nerve 2010 Aug;42(2):170-6

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1002/mus.21665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2969843PMC
August 2010

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.

Authors:
Dorothee Dormann Ramona Rodde Dieter Edbauer Eva Bentmann Ingeborg Fischer Alexander Hruscha Manuel E Than Ian R A Mackenzie Anja Capell Bettina Schmid Manuela Neumann Christian Haass

EMBO J 2010 Aug 6;29(16):2841-57. Epub 2010 Jul 6.

DZNE-German Center for Neurodegenerative Diseases, Munich, Germany.

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http://dx.doi.org/10.1038/emboj.2010.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924641PMC
August 2010

FUS-immunoreactive intranuclear inclusions in neurodegenerative disease.

Authors:
John Woulfe Douglas A Gray Ian R A Mackenzie

Brain Pathol 2010 May 21;20(3):589-97. Epub 2009 Sep 21.

Cancer Therapeutics Group, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1750-3639.2009.00337.xDOI Listing
May 2010

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

Authors:
Vivianna M Van Deerlin Patrick M A Sleiman Maria Martinez-Lage Alice Chen-Plotkin Li-San Wang Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Murray Grossman Steven E Arnold David M A Mann Stuart M Pickering-Brown Harro Seelaar Peter Heutink John C van Swieten Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman John Hodges Maria Grazia Spillantini Sid Gilman Andrew P Lieberman Jeffrey A Kaye Randall L Woltjer Eileen H Bigio Marsel Mesulam Safa Al-Sarraj Claire Troakes Roger N Rosenberg Charles L White Isidro Ferrer Albert Lladó Manuela Neumann Hans A Kretzschmar Christine Marie Hulette Kathleen A Welsh-Bohmer Bruce L Miller Ainhoa Alzualde Adolfo Lopez de Munain Ann C McKee Marla Gearing Allan I Levey James J Lah John Hardy Jonathan D Rohrer Tammaryn Lashley Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Steven T Dekosky Julie van der Zee Samir Kumar-Singh Christine Van Broeckhoven Richard Mayeux Jean Paul G Vonsattel Juan C Troncoso Jillian J Kril John B J Kwok Glenda M Halliday Thomas D Bird Paul G Ince Pamela J Shaw Nigel J Cairns John C Morris Catriona Ann McLean Charles DeCarli William G Ellis Stefanie H Freeman Matthew P Frosch John H Growdon Daniel P Perl Mary Sano David A Bennett Julie A Schneider Thomas G Beach Eric M Reiman Bryan K Woodruff Jeffrey Cummings Harry V Vinters Carol A Miller Helena C Chui Irina Alafuzoff Päivi Hartikainen Danielle Seilhean Douglas Galasko Eliezer Masliah Carl W Cotman M Teresa Tuñón M Cristina Caballero Martínez David G Munoz Steven L Carroll Daniel Marson Peter F Riederer Nenad Bogdanovic Gerard D Schellenberg Hakon Hakonarson John Q Trojanowski Virginia M-Y Lee

Nat Genet 2010 Mar 14;42(3):234-9. Epub 2010 Feb 14.

[1] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [2] These authors contributed equally to this work.

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http://dx.doi.org/10.1038/ng.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828525PMC
March 2010

Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis.

Authors:
Richard A Armstrong William Ellis Ronald L Hamilton Ian R A Mackenzie John Hedreen Marla Gearing Thomas Montine Jean-Paul Vonsattel Elizabeth Head Andrew P Lieberman Nigel J Cairns

J Neural Transm (Vienna) 2010 Feb 10;117(2):227-39. Epub 2009 Dec 10.

Vision Sciences, Aston University, Birmingham B4 7ET, UK.

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http://dx.doi.org/10.1007/s00702-009-0350-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830004PMC
February 2010

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update.

Authors:
Ian R A Mackenzie Manuela Neumann Eileen H Bigio Nigel J Cairns Irina Alafuzoff Jillian Kril Gabor G Kovacs Bernardino Ghetti Glenda Halliday Ida E Holm Paul G Ince Wouter Kamphorst Tamas Revesz Annemieke J M Rozemuller Samir Kumar-Singh Haruhiko Akiyama Atik Baborie Salvatore Spina Dennis W Dickson John Q Trojanowski David M A Mann

Acta Neuropathol 2010 Jan 19;119(1):1-4. Epub 2009 Nov 19.

Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada.

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http://link.springer.com/10.1007/s00401-009-0612-2
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http://dx.doi.org/10.1007/s00401-009-0612-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799633PMC
January 2010

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.

Authors:
Manuela Neumann Sigrun Roeber Hans A Kretzschmar Rosa Rademakers Matt Baker Ian R A Mackenzie

Acta Neuropathol 2009 Nov 9;118(5):605-16. Epub 2009 Aug 9.

Institute of Neuropathology, University Hospital of Zürich, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00401-009-0581-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864784PMC
November 2009

A new subtype of frontotemporal lobar degeneration with FUS pathology.

Authors:
Manuela Neumann Rosa Rademakers Sigrun Roeber Matt Baker Hans A Kretzschmar Ian R A Mackenzie

Brain 2009 Nov 11;132(Pt 11):2922-31. Epub 2009 Aug 11.

Institute of Neuropathology, University Hospital of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1093/brain/awp214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768659PMC
November 2009

Absence of FUS-immunoreactive pathology in frontotemporal dementia linked to chromosome 3 (FTD-3) caused by mutation in the CHMP2B gene.

Authors:
Ida Elisabeth Holm Adrian M Isaacs Ian R A Mackenzie

Acta Neuropathol 2009 Nov 21;118(5):719-20. Epub 2009 Oct 21.

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http://dx.doi.org/10.1007/s00401-009-0593-1DOI Listing
November 2009

The molecular basis of frontotemporal dementia.

Authors:
Manuela Neumann Markus Tolnay Ian R A Mackenzie

Expert Rev Mol Med 2009 Jul 29;11:e23. Epub 2009 Jul 29.

Institute of Neuropathology, University Hospital of Zürich, Switzerland.

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http://dx.doi.org/10.1017/S1462399409001136DOI Listing
July 2009

Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.

Authors:
Tetsuaki Arai Ian R A Mackenzie Masato Hasegawa Takashi Nonoka Kazhuhiro Niizato Kuniaki Tsuchiya Shuji Iritani Mitsumoto Onaya Haruhiko Akiyama

Acta Neuropathol 2009 Feb 13;117(2):125-36. Epub 2009 Jan 13.

Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.

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http://dx.doi.org/10.1007/s00401-008-0480-1DOI Listing
February 2009

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations.

Authors:
Ian R A Mackenzie Manuela Neumann Eileen H Bigio Nigel J Cairns Irina Alafuzoff Jillian Kril Gabor G Kovacs Bernardino Ghetti Glenda Halliday Ida E Holm Paul G Ince Wouter Kamphorst Tamas Revesz Annemieke J M Rozemuller Samir Kumar-Singh Haruhiko Akiyama Atik Baborie Salvatore Spina Dennis W Dickson John Q Trojanowski David M A Mann

Acta Neuropathol 2009 Jan 18;117(1):15-8. Epub 2008 Nov 18.

Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00401-008-0460-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710877PMC
January 2009

The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia.

Authors:
Ian R A Mackenzie Rosa Rademakers

Curr Opin Neurol 2008 Dec;21(6):693-700

Department of Pathology, Vancouver General Hospital, British Columbia, Canada.

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http://dx.doi.org/10.1097/WCO.0b013e3283168d1dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869081PMC
December 2008

Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease.

Authors:
Howard H Feldman Luis F Maia Ian R A Mackenzie Bruce B Forster Jeff Martzke Andrew Woolfenden

Stroke 2008 Oct 17;39(10):2894-7. Epub 2008 Jul 17.

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http://dx.doi.org/10.1161/STROKEAHA.107.510826DOI Listing
October 2008

TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD.

Authors:
Sigrun Roeber Ian R A Mackenzie Hans A Kretzschmar Manuela Neumann

Acta Neuropathol 2008 Aug 7;116(2):147-57. Epub 2008 Jun 7.

Center for Neuropathology and Prion Research, Ludwig-Maximilians University Munich, Feodor-Lynen-Str. 23, 81377, Munich, Germany.

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August 2008

Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions.

Authors:
Ian R A Mackenzie Dean Foti John Woulfe Trevor A Hurwitz

Brain 2008 May 24;131(Pt 5):1282-93. Epub 2008 Mar 24.

Department of Pathology, University of British Columbia, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, British Columbia, V5Z 1M9 Canada.

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http://dx.doi.org/10.1093/brain/awn061DOI Listing
May 2008

Clinical presentation of prodromal frontotemporal dementia.

Authors:
Bradley J Hallam Noah D Silverberg Amanda K Lamarre Ian R A Mackenzie Howard H Feldman

Am J Alzheimers Dis Other Demen 2007 Dec-2008 Jan;22(6):456-67

Division of Neurology, Geriatric Psychiatry Outreach Team, Vancouver Hospital, Vancouver, British Columbia.

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http://dx.doi.org/10.1177/1533317507308781DOI Listing
March 2008

The neuropathology of FTD associated With ALS.

Authors:
Ian R A Mackenzie

Alzheimer Dis Assoc Disord 2007 Oct-Dec;21(4):S44-9

Department of Pathology, University of British Columbia and Vancouver General Hospital, British Columbia, Canada.

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http://dx.doi.org/10.1097/WAD.0b013e31815c3486DOI Listing
February 2008

Progranulin: normal function and role in neurodegeneration.

Authors:
Jason L Eriksen Ian R A Mackenzie

J Neurochem 2008 Jan 22;104(2):287-97. Epub 2007 Oct 22.

Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04968.xDOI Listing
January 2008

The molecular genetics and neuropathology of frontotemporal lobar degeneration: recent developments.

Authors:
Ian R A Mackenzie Rosa Rademakers

Neurogenetics 2007 Nov 6;8(4):237-48. Epub 2007 Sep 6.

Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada.

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http://dx.doi.org/10.1007/s10048-007-0102-4DOI Listing
November 2007

A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3.

Authors:
Ida Elisabeth Holm Elisabet Englund Ian R A Mackenzie Peter Johannsen Adrian M Isaacs

J Neuropathol Exp Neurol 2007 Oct;66(10):884-91

Department of Pathology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.

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http://dx.doi.org/10.1097/nen.0b013e3181567f02DOI Listing
October 2007

Progressive anomia revisited: focal degeneration associated with progranulin gene mutation.

Authors:
Julie S Snowden Stuart M Pickering-Brown Daniel Du Plessis Ian R A Mackenzie Anoop Varma David M A Mann David Neary

Neurocase 2007 Oct;13(5):366-77

School of Translational Medicine, University of Manchester, Hope Hospital, Salford, UK.

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http://dx.doi.org/10.1080/13554790701851510DOI Listing
October 2007

The neuropathology and clinical phenotype of FTD with progranulin mutations.

Authors:
Ian R A Mackenzie

Acta Neuropathol 2007 Jul 26;114(1):49-54. Epub 2007 Apr 26.

Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00401-007-0223-8DOI Listing
July 2007

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration.

Authors:
Nigel J Cairns Eileen H Bigio Ian R A Mackenzie Manuela Neumann Virginia M-Y Lee Kimmo J Hatanpaa Charles L White Julie A Schneider Lea Tenenholz Grinberg Glenda Halliday Charles Duyckaerts James S Lowe Ida E Holm Markus Tolnay Koichi Okamoto Hideaki Yokoo Shigeo Murayama John Woulfe David G Munoz Dennis W Dickson Paul G Ince John Q Trojanowski David M A Mann

Acta Neuropathol 2007 Jul 20;114(1):5-22. Epub 2007 Jun 20.

Department of Neurology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO, 63110, USA.

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http://link.springer.com/10.1007/s00401-007-0237-2
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http://dx.doi.org/10.1007/s00401-007-0237-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827877PMC
July 2007

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.

Authors:
Nigel J Cairns Manuela Neumann Eileen H Bigio Ida E Holm Dirk Troost Kimmo J Hatanpaa Chan Foong Charles L White Julie A Schneider Hans A Kretzschmar Deborah Carter Lisa Taylor-Reinwald Katherine Paulsmeyer Jeffrey Strider Michael Gitcho Alison M Goate John C Morris Manjari Mishra Linda K Kwong Anna Stieber Yan Xu Mark S Forman John Q Trojanowski Virginia M-Y Lee Ian R A Mackenzie

Am J Pathol 2007 Jul;171(1):227-40

MRCPath, Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, St Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941578PMC
http://dx.doi.org/10.2353/ajpath.2007.070182DOI Listing
July 2007

Clinical phenotypes of Cerebral Amyloid Angiopathy.

Authors:
Luís F Maia Ian R A Mackenzie Howard H Feldman

J Neurol Sci 2007 Jun 6;257(1-2):23-30. Epub 2007 Mar 6.

Department of Neurology, Hospital Geral Santo António, Porto, Portugal.

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http://dx.doi.org/10.1016/j.jns.2007.01.054DOI Listing
June 2007

Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.

Authors:
Yvonne Davidson Thomas Kelley Ian R A Mackenzie Stuart Pickering-Brown Daniel Du Plessis David Neary Julie S Snowden David M A Mann

Acta Neuropathol 2007 May 12;113(5):521-33. Epub 2007 Jan 12.

Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, M6 8HD, UK,

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http://dx.doi.org/10.1007/s00401-006-0189-yDOI Listing
May 2007

Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.

Authors:
Ian R A Mackenzie Eileen H Bigio Paul G Ince Felix Geser Manuela Neumann Nigel J Cairns Linda K Kwong Mark S Forman John Ravits Heather Stewart Andrew Eisen Leo McClusky Hans A Kretzschmar Camelia M Monoranu J Robin Highley Janine Kirby Teepu Siddique Pamela J Shaw Virginia M-Y Lee John Q Trojanowski

Ann Neurol 2007 May;61(5):427-34

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/ana.21147DOI Listing
May 2007

Progranulin in frontotemporal lobar degeneration and neuroinflammation.

Authors:
Zeshan Ahmed Ian R A Mackenzie Michael L Hutton Dennis W Dickson

J Neuroinflammation 2007 Feb 11;4. Epub 2007 Feb 11.

Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA.

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http://dx.doi.org/10.1186/1742-2094-4-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805428PMC
February 2007

Dementia lacking distinctive histology (DLDH) revisited.

Authors:
Ian R A Mackenzie Jing Shi Catherine L Shaw Daniel Duplessis David Neary Julie S Snowden David M A Mann

Acta Neuropathol 2006 Nov 10;112(5):551-9. Epub 2006 Aug 10.

Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00401-006-0123-3DOI Listing
November 2006

Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype.

Authors:
Ian R A Mackenzie Atik Baborie Stuart Pickering-Brown Daniel Du Plessis Evelyn Jaros Robert H Perry David Neary Julie S Snowden David M A Mann

Acta Neuropathol 2006 Nov 26;112(5):539-49. Epub 2006 Sep 26.

Department of Pathology, Vancouver General Hospital, V5Z 1M9, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00401-006-0138-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668618PMC
November 2006

The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene.

Authors:
Ian R A Mackenzie Matt Baker Stuart Pickering-Brown Ging-Yuek R Hsiung Caroline Lindholm Emily Dwosh Jennifer Gass Ashley Cannon Rosa Rademakers Mike Hutton Howard H Feldman

Brain 2006 Nov;129(Pt 11):3081-90

Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver Coastal Health Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/brain/awl271DOI Listing
November 2006

Mutations in progranulin explain atypical phenotypes with variants in MAPT.

Authors:
Stuart M Pickering-Brown Matt Baker Jenny Gass Bradley F Boeve Clement T Loy William S Brooks Ian R A Mackenzie Ralph N Martins John B J Kwok Glenda M Halliday Jillian Kril Peter R Schofield David M A Mann Mike Hutton

Brain 2006 Nov;129(Pt 11):3124-6

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http://dx.doi.org/10.1093/brain/awl289DOI Listing
November 2006

Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum.

Authors:
Ian R A Mackenzie Howard H Feldman

J Neuropathol Exp Neurol 2005 Aug;64(8):730-9

Division of Neuropathology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1097/01.jnen.0000174335.27708.0aDOI Listing
August 2005

alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases.

Authors:
Nigel J Cairns Kunihiro Uryu Eileen H Bigio Ian R A Mackenzie Marla Gearing Charles Duyckaerts Hideaki Yokoo Yoichi Nakazato Evelyn Jaros Robert H Perry Steven E Arnold Virginia M-Y Lee John Q Trojanowski

Acta Neuropathol 2004 Sep 28;108(3):213-23. Epub 2004 May 28.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104-4283, USA.

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http://dx.doi.org/10.1007/s00401-004-0882-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516855PMC
September 2004

Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases.

Authors:
Ian R A Mackenzie Howard Feldman

Dement Geriatr Cogn Disord 2004 ;17(4):333-6

Department of Pathology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1159/000077166DOI Listing
September 2004

alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease.

Authors:
Nigel J Cairns Victoria Zhukareva Kunihiro Uryu Bin Zhang Eileen Bigio Ian R A Mackenzie Marla Gearing Charles Duyckaerts Hideaki Yokoo Yoichi Nakazato Evelyn Jaros Robert H Perry Virginia M-Y Lee John Q Trojanowski

Am J Pathol 2004 Jun;164(6):2153-61

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615782PMC
http://dx.doi.org/10.1016/s0002-9440(10)63773-xDOI Listing
June 2004

The neuropathology and biochemistry of frontotemporal dementia.

Authors:
David G Munoz Dennis W Dickson Catherine Bergeron Ian R A Mackenzie Andre Delacourte Victoria Zhukareva

Ann Neurol 2003 ;54 Suppl 5:S24-8

Department of Pathology, University of Western Ontario, London, Ontario, Canada.

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http://doi.wiley.com/10.1002/ana.10571
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December 2003

Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases.

Authors:
Ian R A Mackenzie Howard Feldman

Acta Neuropathol 2003 Jun 15;105(6):543-8. Epub 2003 Feb 15.

Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, V5Z 1M9, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1007/s00401-003-0678-1DOI Listing
June 2003

The relationship between extramotor ubiquitin-immunoreactive neuronal inclusions and dementia in motor neuron disease.

Authors:
Ian R A Mackenzie Howard Feldman

Acta Neuropathol 2003 Feb 17;105(2):98-102. Epub 2002 Oct 17.

Department of Pathology, University of British Columbia, Vancouver General Hospital, 855 West 12th Avenue, Canada V5Z 1M9.

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http://dx.doi.org/10.1007/s00401-002-0620-yDOI Listing
February 2003