Ian P M Tomlinson

Ian P M Tomlinson

UNVERIFIED PROFILE

Are you Ian P M Tomlinson?   Register this Author

Register author
Ian P M Tomlinson

Ian P M Tomlinson

Publications by authors named "Ian P M Tomlinson"

Are you Ian P M Tomlinson?   Register this Author

87Publications

2559Reads

29Profile Views

Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer.

Mol Aspects Med 2019 Oct 4;69:41-47. Epub 2019 Feb 4.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; Division of Molecular Pathology, The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mam.2019.01.002DOI Listing
October 2019

The effects of mutational processes and selection on driver mutations across cancer types.

Nat Commun 2018 05 10;9(1):1857. Epub 2018 May 10.

Evolution and Cancer laboratory, Barts Cancer Institute, QMUL, Charterhouse Sq, London, EC1M 6BQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-04208-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945620PMC
May 2018

Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk.

Authors:
Xingyi Guo Jirong Long Chenjie Zeng Kyriaki Michailidou Maya Ghoussaini Manjeet K Bolla Qin Wang Roger L Milne Xiao-Ou Shu Qiuyin Cai Jonathan Beesley Siddhartha P Kar Irene L Andrulis Hoda Anton-Culver Volker Arndt Matthias W Beckmann Alicia Beeghly-Fadiel Javier Benitez William Blot Natalia Bogdanova Stig E Bojesen Hiltrud Brauch Hermann Brenner Louise Brinton Annegien Broeks Thomas Brüning Barbara Burwinkel Hui Cai Sander Canisius Jenny Chang-Claude Ji-Yeob Choi Fergus J Couch Angela Cox Simon S Cross Kamila Czene Hatef Darabi Peter Devilee Arnaud Droit Thilo Dörk Peter A Fasching Olivia Fletcher Henrik Flyger Florentia Fostira Valerie Gaborieau Montserrat García-Closas Graham G Giles Mervi Grip Pascal Guénel Christopher A Haiman Ute Hamann Mikael Hartman Antoinette Hollestelle John L Hopper Chia-Ni Hsiung Hidemi Ito Anna Jakubowska Nichola Johnson Maria Kabisch Daehee Kang Sofia Khan Julia A Knight Veli-Matti Kosma Diether Lambrechts Loic Le Marchand Jingmei Li Annika Lindblom Artitaya Lophatananon Jan Lubinski Arto Mannermaa Siranoush Manoukian Sara Margolin Frederik Marme Keitaro Matsuo Catriona A McLean Alfons Meindl Kenneth Muir Susan L Neuhausen Heli Nevanlinna Silje Nord Janet E Olson Nick Orr Paolo Peterlongo Thomas Choudary Putti Anja Rudolph Suleeporn Sangrajrang Elinor J Sawyer Marjanka K Schmidt Rita K Schmutzler Chen-Yang Shen Jiajun Shi Martha J Shrubsole Melissa C Southey Anthony Swerdlow Soo Hwang Teo Bernard Thienpont Amanda Ewart Toland Robert A E M Tollenaar Ian P M Tomlinson Thérèse Truong Chiu-Chen Tseng Ans van den Ouweland Wanqing Wen Robert Winqvist Anna Wu Cheng Har Yip M Pilar Zamora Ying Zheng Per Hall Paul D P Pharoah Jacques Simard Georgia Chenevix-Trench Alison M Dunning Douglas F Easton Wei Zheng

Cancer Epidemiol Biomarkers Prev 2015 Nov 9;24(11):1680-91. Epub 2015 Sep 9.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-15-0363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633342PMC
November 2015

Prognostic significance of POLE proofreading mutations in endometrial cancer.

J Natl Cancer Inst 2015 Jan 12;107(1):402. Epub 2014 Dec 12.

Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK (DNC, IPMT); Oxford Cancer Centre, Churchill Hospital, Oxford, UK (DNC); Department of Pathology (ES, NtH, VTHBMS, TB) and Department of Clinical Oncology (RAN, CLC), Leiden University Medical Center, Leiden, the Netherlands; Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland (NV, AN, PJW); Vesalius Research Center (VRC), VIB, Leuven, Belgium (JD, DL); Laboratory of Translational Genetics, Department of Oncology, KU Leuven, Belgium (FA, DL); Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, University Hospitals Gasthuisberg, Leuven, Belgium (FA); Genomic Medicine Theme, Oxford Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK (IPMT); Department of Radiation Oncology, University Medical Centrum Utrecht, the Netherlands (IMJS); Department of Radiation Oncology, Medisch Spectrum Twente, Enschede, the Netherlands (JJJ).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/dju402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301706PMC
January 2015

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.

Hum Mutat 2014 Sep 21;35(9):1136-41. Epub 2014 Jul 21.

Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.22612DOI Listing
September 2014

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Cancer Res 2014 Jun 22;74(12):3238-47. Epub 2014 Apr 22.

Authors' Affiliations: Ludwig Institute for Cancer Research; Systems Biology and Personalised Medicine Division; Structural Biology Division; Walter and Eliza Hall Institute of Medical Research; Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville; VLSCI Life Sciences Computation Centre, a collaboration between Melbourne, Monash and LaTrobe Universities, c/o The University of Melbourne, Carlton; Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research, Austin, VIC, Australia; Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD, Australia; Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, 08035 Barcelona; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN); Spain; Ludwig Collaborative Laboratory for Cancer Biology and Therapy, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Ludwig Institute for Cancer Research Ltd., New York, New York; Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford; and Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Oxford, United KingdomAuthors' Affiliations: Ludwig Institute for Cancer Research; Systems Biology and Personalised Medicine Division; Structural Biology Division; Walter and Eliza Hall Institute of Medical Research; Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville; VLSCI Life Sciences Computation Centre, a collaboration between Melbourne, Monash and LaTrobe Universities, c/o The University of Melbourne, Carlton; Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research, Austin, VIC, Australia; Cancer and Population Studies

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-0013DOI Listing
June 2014

What can be learnt about disease progression in breast cancer dormancy from relapse data?

PLoS One 2013 6;8(5):e62320. Epub 2013 May 6.

Centre for Mathematics and Physics in the Life Sciences and EXperimental Biology, University College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062320PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646031PMC
December 2013

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer.

J Clin Oncol 2013 Dec 23;31(34):4297-305. Epub 2013 Sep 23.

Enric Domingo, David N. Church, Rajarajan Ramamoorthy, and Ian P.M. Tomlinson, The Wellcome Trust Centre for Human Genetics, University of Oxford; David N. Church, David J. Kerr, and Rachel Midgley, Oxford Cancer Centre, Churchill Hospital; Yoko Yanagisawa, Elaine Johnstone, David J. Kerr, and Rachel Midgley, University of Oxford, Oxford; Rajarajan Ramamoorthy and Brian Davidson, University College London, Royal Free Hospital, London, United Kingdom; and Oliver Sieber, Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

Source
http://jco.ascopubs.org/content/early/2013/09/18/JCO.2013.50
Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.50.0322
Publisher Site
http://dx.doi.org/10.1200/JCO.2013.50.0322DOI Listing
December 2013

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.

Am J Gastroenterol 2013 Nov 17;108(11):1785-93. Epub 2013 Sep 17.

1] Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Parkville, Victoria, Australia [2] Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ajg.2013.292DOI Listing
November 2013

Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation.

PLoS Genet 2013 May 9;9(5):e1003488. Epub 2013 May 9.

Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649993PMC
May 2013

Whole-genome methylation analysis of benign and malignant colorectal tumours.

J Pathol 2013 Apr 24;229(5):697-704. Epub 2013 Jan 24.

Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619233PMC
April 2013

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer.

Mutagenesis 2012 Mar;27(2):219-23

Molecular and Population Genetics Laboratory and Oxford NIHR Comprehensive Biomedical Research Centre, Nuffield Department of Clinical Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mutage/ger070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610049PMC
March 2012

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients.

Oncotarget 2011 Dec;2(12):966-9

Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282101PMC
http://dx.doi.org/10.18632/oncotarget.370DOI Listing
December 2011

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

BMC Med Genet 2011 Feb 14;12:23. Epub 2011 Feb 14.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2350-12-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045878PMC
February 2011

Are we there yet?: journeying along the cancer genetic information superhighway.

Curr Opin Genet Dev 2010 Jun 3;20(3):197-200. Epub 2010 May 3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gde.2010.04.004DOI Listing
June 2010

Low-penetrance susceptibility variants in familial colorectal cancer.

Cancer Epidemiol Biomarkers Prev 2010 Jun 25;19(6):1478-83. Epub 2010 May 25.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-09-1320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883738PMC
June 2010

Breast cancer dormancy can be maintained by small numbers of micrometastases.

Cancer Res 2010 Jun 25;70(11):4310-7. Epub 2010 May 25.

CoMPLEX, University College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-3144DOI Listing
June 2010

CD24 is upregulated in inflammatory bowel disease and stimulates cell motility and colony formation.

Inflamm Bowel Dis 2010 May;16(5):795-803

Division of Pathology, School of Molecular Medical Sciences, Queen's Medical Centre Campus, University of Nottingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ibd.21134DOI Listing
May 2010

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

Exp Mol Pathol 2008 Dec 11;85(3):201-6. Epub 2008 Oct 11.

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2008.09.006DOI Listing
December 2008

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Nat Genet 2008 May 30;40(5):623-30. Epub 2008 Mar 30.

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.111DOI Listing
May 2008

Unregulated smooth-muscle myosin in human intestinal neoplasia.

Proc Natl Acad Sci U S A 2008 Apr 7;105(14):5513-8. Epub 2008 Apr 7.

Department of Medical Genetics and Division of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and Genome Scale Biology Program, Biomedicum Helsinki, University of Helsinki, 00014, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0801213105
Publisher Site
http://dx.doi.org/10.1073/pnas.0801213105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291082PMC
April 2008

The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency.

BMC Med Genet 2008 Mar 25;9:20. Epub 2008 Mar 25.

Department of Human Genetics, Leiden University Medical Center, P,O, Box 9503, 2300 RA, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2350-9-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322961PMC
March 2008

What can we learn from the population incidence of cancer? Armitage and Doll revisited.

Lancet Oncol 2007 Nov;8(11):1030-8

Department of Computer Science, University College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(07)70343-1DOI Listing
November 2007

A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt.

J Theor Biol 2007 Feb 8;244(3):367-74. Epub 2006 Sep 8.

Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, Milano, Italy I-20141.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtbi.2006.08.022DOI Listing
February 2007

Molecular genetic evidence that endometriosis is a precursor of ovarian cancer.

Int J Cancer 2006 Aug;119(3):556-62

Nuffield Department of Obstetrics and Gynaecology, The Women's Centre, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.21845DOI Listing
August 2006

Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations.

J Clin Endocrinol Metab 2006 Aug 6;91(8):3071-5. Epub 2006 Jun 6.

Laboratory of Molecular and Population Genetics, London Research Institute, Cancer Research UK, London WC2A 3PX, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2006-0183DOI Listing
August 2006

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.

BMC Cancer 2006 Jun 1;6:145. Epub 2006 Jun 1.

Department of Medical Genetics, Molecular and Cancer Biology Research Program, P,O, BOX 63, 00014 University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-6-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513590PMC
June 2006

Deletion at chromosome band 20p12.1 in colorectal cancer revealed by high resolution array comparative genomic hybridization.

Genes Chromosomes Cancer 2005 Dec;44(4):384-91

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/gcc.20252
Publisher Site
http://dx.doi.org/10.1002/gcc.20252DOI Listing
December 2005

Mitochondrial tumour suppressors: a genetic and biochemical update.

Nat Rev Cancer 2005 Nov;5(11):857-66

Apoptosis and Tumour Physiology Laboratory, Cancer Research UK, the Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc1737DOI Listing
November 2005

Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer.

J Mol Diagn 2005 Oct;7(4):437-43

Molecular and Population Genetics Laboratory, Cancer Research UK, Lincoln's Inn Fields, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888487PMC
http://dx.doi.org/10.1016/S1525-1578(10)60574-0DOI Listing
October 2005

A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history.

Fam Cancer 2005 ;4(2):127-33

Department of Medicine, Division of Gastroenterology and the Comprehensive Cancer Center, University of California-San Francisco, 2330 Post Street, San Francisco, CA 94115-1623, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10689-004-5814-0DOI Listing
September 2005

Tissue, cell and stage specificity of (epi)mutations in cancers.

Nat Rev Cancer 2005 08;5(8):649-55

Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc1674DOI Listing
August 2005

Allelic loss studies do not provide evidence for the "endometriosis-as-tumor" theory.

Fertil Steril 2005 Apr;83 Suppl 1:1134-43

Nuffield Department of Obstetrics and Gynaecology and Women's Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2004.07.982DOI Listing
April 2005

Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma.

Oncogene 2005 Jan;24(1):118-29

Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1208194DOI Listing
January 2005

Analysis of ovarian cancer cell lines using array-based comparative genomic hybridization.

J Pathol 2005 Jan;205(1):29-40

Molecular and Population Genetics Laboratory, Cancer Research UK, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.1681DOI Listing
January 2005

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

Cancer Res 2004 Dec;64(24):8876-81

Molecular and Population Genetics Laboratory, Histopathology Unit, and Experimental Pathology Laboratory, London Research Institute, Cancer Research United Kingdom, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-04-2958DOI Listing
December 2004

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.

Proc Natl Acad Sci U S A 2004 Nov 1;101(45):15992-7. Epub 2004 Nov 1.

Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0407187101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC528777PMC
November 2004

Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas.

Cancer Res 2004 Jul;64(14):4817-25

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-04-0328DOI Listing
July 2004

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

Ann Med 2003 ;35(8):632-9

Molecular and Population Genetics Laboratory, Cancer Research UK, Lincoln's Inn Fields, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07853890310018458DOI Listing
April 2004

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.

Cancer Res 2003 Nov;63(22):7595-9

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research United Kingdom, London WC2A 3PX, United Kingdom.

View Article

Download full-text PDF

Source
November 2003

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.

Cancer Lett 2003 Oct;200(2):149-52

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0304-3835(03)00391-4DOI Listing
October 2003

Genomic instability--the engine of tumorigenesis?

Nat Rev Cancer 2003 09;3(9):701-8

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc1170DOI Listing
September 2003

Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit.

J Pathol 2003 May;200(1):59-64

Molecular and Population Genetics Laboratory, Cancer Research UK, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.1318DOI Listing
May 2003

DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones.

Genes Chromosomes Cancer 2003 Apr;36(4):361-74

Wellcome Trust Sanger Institute/Cancer Research UK Genomic Microarray Group, Hinxton, Cambridge, CB10 1SA, United Kingdom.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/gcc.10155
Publisher Site
http://dx.doi.org/10.1002/gcc.10155DOI Listing
April 2003

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.

N Engl J Med 2003 Feb;348(9):791-9

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa025283DOI Listing
February 2003

Loss of heterozygosity analysis: practically and conceptually flawed?

Genes Chromosomes Cancer 2002 Aug;34(4):349-53

Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.10085DOI Listing
August 2002

The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours.

J Pathol 2002 Apr;196(4):437-44

Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.1067DOI Listing
April 2002

Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.

Virchows Arch 2002 Apr 25;440(4):362-6. Epub 2002 Jan 25.

Academic Department of Pathology and Imperial Cancer Research Fund Colorectal Cancer Unit, St. Mark's Hospital, Harrow, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-001-0570-0DOI Listing
April 2002

MAJOR-GENE MODELS OF SEXUAL SELECTION UNDER CYCLICAL NATURAL SELECTION.

Evolution 1988 Jul;42(4):814-816

Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1558-5646.1988.tb02499.xDOI Listing
July 1988