Ian P Hall

Ian P Hall

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Ian P Hall

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Abnormalities of mucosal serotonin metabolism and 5-HT receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron.

Aliment Pharmacol Ther 2019 Sep 24;50(5):538-546. Epub 2019 Jul 24.

NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1111/apt.15420DOI Listing
September 2019

Defining a role for lung function associated gene GSTCD in cell homeostasis.

Respir Res 2019 Aug 1;20(1):172. Epub 2019 Aug 1.

Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1186/s12931-019-1146-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676530PMC
August 2019

Challenges of chronic obstructive pulmonary disease in rural Nepal.

Lancet Respir Med 2019 Jun 14;7(6):476-478. Epub 2019 Mar 14.

Department of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, University of Nottingham, Nottingham NG5 1PB, UK.

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http://dx.doi.org/10.1016/S2213-2600(19)30079-7DOI Listing
June 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Genetic risk factors for the development of pulmonary disease identified by genome-wide association.

Respirology 2019 Mar 13;24(3):204-214. Epub 2018 Nov 13.

Division of Respiratory Medicine, NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.

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http://doi.wiley.com/10.1111/resp.13436
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http://dx.doi.org/10.1111/resp.13436DOI Listing
March 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

Authors:
A Mesut Erzurumluoglu Mengzhen Liu Victoria E Jackson Daniel R Barnes Gargi Datta Carl A Melbourne Robin Young Chiara Batini Praveen Surendran Tao Jiang Sheikh Daud Adnan Saima Afaq Arpana Agrawal Elisabeth Altmaier Antonis C Antoniou Folkert W Asselbergs Clemens Baumbach Laura Bierut Sarah Bertelsen Michael Boehnke Michiel L Bots David M Brazel John C Chambers Jenny Chang-Claude Chu Chen Janie Corley Yi-Ling Chou Sean P David Rudolf A de Boer Christiaan A de Leeuw Joe G Dennis Anna F Dominiczak Alison M Dunning Douglas F Easton Charles Eaton Paul Elliott Evangelos Evangelou Jessica D Faul Tatiana Foroud Alison Goate Jian Gong Hans J Grabe Jeff Haessler Christopher Haiman Göran Hallmans Anke R Hammerschlag Sarah E Harris Andrew Hattersley Andrew Heath Chris Hsu William G Iacono Stavroula Kanoni Manav Kapoor Jaakko Kaprio Sharon L Kardia Fredrik Karpe Jukka Kontto Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Markku Laakso Dongbing Lai Claudia Langenberg Nhung Le Guillaume Lettre Anu Loukola Jian'an Luan Pamela A F Madden Massimo Mangino Riccardo E Marioni Eirini Marouli Jonathan Marten Nicholas G Martin Matt McGue Kyriaki Michailidou Evelin Mihailov Alireza Moayyeri Marie Moitry Martina Müller-Nurasyid Aliya Naheed Matthias Nauck Matthew J Neville Sune Fallgaard Nielsen Kari North Markus Perola Paul D P Pharoah Giorgio Pistis Tinca J Polderman Danielle Posthuma Neil Poulter Beenish Qaiser Asif Rasheed Alex Reiner Frida Renström John Rice Rebecca Rohde Olov Rolandsson Nilesh J Samani Maria Samuel David Schlessinger Steven H Scholte Robert A Scott Peter Sever Yaming Shao Nick Shrine Jennifer A Smith John M Starr Kathleen Stirrups Danielle Stram Heather M Stringham Ioanna Tachmazidou Jean-Claude Tardif Deborah J Thompson Hilary A Tindle Vinicius Tragante Stella Trompet Valerie Turcot Jessica Tyrrell Ilonca Vaartjes Andries R van der Leij Peter van der Meer Tibor V Varga Niek Verweij Henry Völzke Nicholas J Wareham Helen R Warren David R Weir Stefan Weiss Leah Wetherill Hanieh Yaghootkar Ersin Yavas Yu Jiang Fang Chen Xiaowei Zhan Weihua Zhang Wei Zhao Wei Zhao Kaixin Zhou Philippe Amouyel Stefan Blankenberg Mark J Caulfield Rajiv Chowdhury Francesco Cucca Ian J Deary Panos Deloukas Emanuele Di Angelantonio Marco Ferrario Jean Ferrières Paul W Franks Tim M Frayling Philippe Frossard Ian P Hall Caroline Hayward Jan-Håkan Jansson J Wouter Jukema Frank Kee Satu Männistö Andres Metspalu Patricia B Munroe Børge Grønne Nordestgaard Colin N A Palmer Veikko Salomaa Naveed Sattar Timothy Spector David Peter Strachan Pim van der Harst Eleftheria Zeggini Danish Saleheen Adam S Butterworth Louise V Wain Goncalo R Abecasis John Danesh Martin D Tobin Scott Vrieze Dajiang J Liu Joanna M M Howson

Mol Psychiatry 2019 Jan 7. Epub 2019 Jan 7.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

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http://www.nature.com/articles/s41380-018-0313-0
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http://dx.doi.org/10.1038/s41380-018-0313-0DOI Listing
January 2019

Clinical and Molecular Features of Thiazide-Induced Hyponatremia.

Curr Hypertens Rep 2018 04 10;20(4):31. Epub 2018 Apr 10.

Division of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1007/s11906-018-0826-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893690PMC
April 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Authors:
Victoria E Jackson Jeanne C Latourelle Louise V Wain Albert V Smith Megan L Grove Traci M Bartz Ma'en Obeidat Michael A Province Wei Gao Beenish Qaiser David J Porteous Patricia A Cassano Tarunveer S Ahluwalia Niels Grarup Jin Li Elisabeth Altmaier Jonathan Marten Sarah E Harris Ani Manichaikul Tess D Pottinger Ruifang Li-Gao Allan Lind-Thomsen Anubha Mahajan Lies Lahousse Medea Imboden Alexander Teumer Bram Prins Leo-Pekka Lyytikäinen Gudny Eiriksdottir Nora Franceschini Colleen M Sitlani Jennifer A Brody Yohan Bossé Wim Timens Aldi Kraja Anu Loukola Wenbo Tang Yongmei Liu Jette Bork-Jensen Johanne M Justesen Allan Linneberg Leslie A Lange Rajesh Rawal Stefan Karrasch Jennifer E Huffman Blair H Smith Gail Davies Kristin M Burkart Josyf C Mychaleckyj Tobias N Bonten Stefan Enroth Lars Lind Guy G Brusselle Ashish Kumar Beate Stubbe Mika Kähönen Annah B Wyss Bruce M Psaty Susan R Heckbert Ke Hao Taina Rantanen Stephen B Kritchevsky Kurt Lohman Tea Skaaby Charlotta Pisinger Torben Hansen Holger Schulz Ozren Polasek Archie Campbell John M Starr Stephen S Rich Dennis O Mook-Kanamori Åsa Johansson Erik Ingelsson André G Uitterlinden Stefan Weiss Olli T Raitakari Vilmundur Gudnason Kari E North Sina A Gharib Don D Sin Kent D Taylor George T O'Connor Jaakko Kaprio Tamara B Harris Oluf Pederson Henrik Vestergaard James G Wilson Konstantin Strauch Caroline Hayward Shona Kerr Ian J Deary R Graham Barr Renée de Mutsert Ulf Gyllensten Andrew P Morris M Arfan Ikram Nicole Probst-Hensch Sven Gläser Eleftheria Zeggini Terho Lehtimäki David P Strachan Josée Dupuis Alanna C Morrison Ian P Hall Martin D Tobin Stephanie J London

Wellcome Open Res 2018 12;3. Epub 2018 Jan 12.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.12688/wellcomeopenres.12583.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081985PMC
January 2018

β Agonists.

Handb Exp Pharmacol 2017 ;237:23-40

Division of Respiratory Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.

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http://dx.doi.org/10.1007/164_2016_64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480238PMC
September 2017

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls.

PLoS One 2017 23;12(1):e0170222. Epub 2017 Jan 23.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170222PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256917PMC
August 2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Authors:
Louise V Wain Nick Shrine María Soler Artigas A Mesut Erzurumluoglu Boris Noyvert Lara Bossini-Castillo Ma'en Obeidat Amanda P Henry Michael A Portelli Robert J Hall Charlotte K Billington Tracy L Rimington Anthony G Fenech Catherine John Tineka Blake Victoria E Jackson Richard J Allen Bram P Prins Archie Campbell David J Porteous Marjo-Riitta Jarvelin Matthias Wielscher Alan L James Jennie Hui Nicholas J Wareham Jing Hua Zhao James F Wilson Peter K Joshi Beate Stubbe Rajesh Rawal Holger Schulz Medea Imboden Nicole M Probst-Hensch Stefan Karrasch Christian Gieger Ian J Deary Sarah E Harris Jonathan Marten Igor Rudan Stefan Enroth Ulf Gyllensten Shona M Kerr Ozren Polasek Mika Kähönen Ida Surakka Veronique Vitart Caroline Hayward Terho Lehtimäki Olli T Raitakari David M Evans A John Henderson Craig E Pennell Carol A Wang Peter D Sly Emily S Wan Robert Busch Brian D Hobbs Augusto A Litonjua David W Sparrow Amund Gulsvik Per S Bakke James D Crapo Terri H Beaty Nadia N Hansel Rasika A Mathias Ingo Ruczinski Kathleen C Barnes Yohan Bossé Philippe Joubert Maarten van den Berge Corry-Anke Brandsma Peter D Paré Don D Sin David C Nickle Ke Hao Omri Gottesman Frederick E Dewey Shannon E Bruse David J Carey H Lester Kirchner Stefan Jonsson Gudmar Thorleifsson Ingileif Jonsdottir Thorarinn Gislason Kari Stefansson Claudia Schurmann Girish Nadkarni Erwin P Bottinger Ruth J F Loos Robin G Walters Zhengming Chen Iona Y Millwood Julien Vaucher Om P Kurmi Liming Li Anna L Hansell Chris Brightling Eleftheria Zeggini Michael H Cho Edwin K Silverman Ian Sayers Gosia Trynka Andrew P Morris David P Strachan Ian P Hall Martin D Tobin

Nat Genet 2017 Mar 6;49(3):416-425. Epub 2017 Feb 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326681PMC
March 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways.

BMC Genomics 2017 03 23;18(1):248. Epub 2017 Mar 23.

Division of Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1186/s12864-017-3628-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364626PMC
March 2017

NMR Hyperpolarization Techniques of Gases.

Chemistry 2017 Jan 5;23(4):725-751. Epub 2016 Dec 5.

Department of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1002/chem.201603884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462469PMC
January 2017

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease.

Chron Respir Dis 2016 Aug 10;13(3):247-55. Epub 2016 Mar 10.

Nottingham Respiratory Research Unit and Division of Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, UK

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http://dx.doi.org/10.1177/1479972316636995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720186PMC
August 2016

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Nat Commun 2015 Dec 4;6:8658. Epub 2015 Dec 4.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ncomms9658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825PMC
December 2015

Use of FEV1 as a measure of lung health in the UK BiLEVE study - Authors' reply.

Lancet Respir Med 2015 Dec;3(12):e42-3

Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(15)00460-9DOI Listing
December 2015

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

PLoS One 2014 1;9(7):e100776. Epub 2014 Jul 1.

Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America; Department of Health Care Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York, United States of America.

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http://repub.eur.nl/pub/55346/journal.pone.0100776.pdf
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http://dx.plos.org/10.1371/journal.pone.0100776
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077649PMC
November 2015

Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype.

Am J Respir Cell Mol Biol 2015 Aug;53(2):174-83

1 Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom; and.

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http://dx.doi.org/10.1165/rcmb.2014-0296OCDOI Listing
August 2015

Complications and mortality in hereditary hemorrhagic telangiectasia: A population-based study.

Neurology 2015 May 10;84(18):1886-93. Epub 2015 Apr 10.

From the Divisions of Epidemiology and Public Health (J.W.D., T.M.M., R.B.H., A.W.F.) and Therapeutics and Molecular Medicine (I.P.H.), University of Nottingham, UK.

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http://dx.doi.org/10.1212/WNL.0000000000001538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433463PMC
May 2015

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Authors:
Daan W Loth María Soler Artigas Sina A Gharib Louise V Wain Nora Franceschini Beate Koch Tess D Pottinger Albert Vernon Smith Qing Duan Chris Oldmeadow Mi Kyeong Lee David P Strachan Alan L James Jennifer E Huffman Veronique Vitart Adaikalavan Ramasamy Nicholas J Wareham Jaakko Kaprio Xin-Qun Wang Holly Trochet Mika Kähönen Claudia Flexeder Eva Albrecht Lorna M Lopez Kim de Jong Bharat Thyagarajan Alexessander Couto Alves Stefan Enroth Ernst Omenaas Peter K Joshi Tove Fall Ana Viñuela Lenore J Launer Laura R Loehr Myriam Fornage Guo Li Jemma B Wilk Wenbo Tang Ani Manichaikul Lies Lahousse Tamara B Harris Kari E North Alicja R Rudnicka Jennie Hui Xiangjun Gu Thomas Lumley Alan F Wright Nicholas D Hastie Susan Campbell Rajesh Kumar Isabelle Pin Robert A Scott Kirsi H Pietiläinen Ida Surakka Yongmei Liu Elizabeth G Holliday Holger Schulz Joachim Heinrich Gail Davies Judith M Vonk Mary Wojczynski Anneli Pouta Asa Johansson Sarah H Wild Erik Ingelsson Fernando Rivadeneira Henry Völzke Pirro G Hysi Gudny Eiriksdottir Alanna C Morrison Jerome I Rotter Wei Gao Dirkje S Postma Wendy B White Stephen S Rich Albert Hofman Thor Aspelund David Couper Lewis J Smith Bruce M Psaty Kurt Lohman Esteban G Burchard André G Uitterlinden Melissa Garcia Bonnie R Joubert Wendy L McArdle A Bill Musk Nadia Hansel Susan R Heckbert Lina Zgaga Joyce B J van Meurs Pau Navarro Igor Rudan Yeon-Mok Oh Susan Redline Deborah L Jarvis Jing Hua Zhao Taina Rantanen George T O'Connor Samuli Ripatti Rodney J Scott Stefan Karrasch Harald Grallert Nathan C Gaddis John M Starr Cisca Wijmenga Ryan L Minster David J Lederer Juha Pekkanen Ulf Gyllensten Harry Campbell Andrew P Morris Sven Gläser Christopher J Hammond Kristin M Burkart John Beilby Stephen B Kritchevsky Vilmundur Gudnason Dana B Hancock O Dale Williams Ozren Polasek Tatijana Zemunik Ivana Kolcic Marcy F Petrini Matthias Wjst Woo Jin Kim David J Porteous Generation Scotland Blair H Smith Anne Viljanen Markku Heliövaara John R Attia Ian Sayers Regina Hampel Christian Gieger Ian J Deary H Marike Boezen Anne Newman Marjo-Riitta Jarvelin James F Wilson Lars Lind Bruno H Stricker Alexander Teumer Timothy D Spector Erik Melén Marjolein J Peters Leslie A Lange R Graham Barr Ken R Bracke Fien M Verhamme Joohon Sung Pieter S Hiemstra Patricia A Cassano Akshay Sood Caroline Hayward Josée Dupuis Ian P Hall Guy G Brusselle Martin D Tobin Stephanie J London

Nat Genet 2014 Jul 15;46(7):669-77. Epub 2014 Jun 15.

1] Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA. [2].

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http://dx.doi.org/10.1038/ng.3011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140093PMC
July 2014

GSTCD and INTS12 regulation and expression in the human lung.

PLoS One 2013 18;8(9):e74630. Epub 2013 Sep 18.

Division of Respiratory Medicine, University of Nottingham, Queen's Medical Center, Nottingham, United Kingdom ; James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074630PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776747PMC
June 2014

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity.

Respir Res 2014 May 3;15:57. Epub 2014 May 3.

Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, NG7 2UH Nottingham, United Kingdom.

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http://respiratory-research.com/content/15/1/57
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http://dx.doi.org/10.1186/1465-9921-15-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014754PMC
May 2014

Should we use ADRB2 variation to stratify asthma treatment?

Authors:
Ian P Hall

Lancet Respir Med 2014 Mar 11;2(3):169-71. Epub 2014 Feb 11.

University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK. Electronic address:

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http://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(
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http://linkinghub.elsevier.com/retrieve/pii/S221326001470025
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http://dx.doi.org/10.1016/S2213-2600(14)70025-6DOI Listing
March 2014

Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr.

Magn Reson Imaging 2014 Jan 18;32(1):48-53. Epub 2013 Oct 18.

Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham NG7 2RD, UK; School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S0730725X130028
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http://dx.doi.org/10.1016/j.mri.2013.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898897PMC
January 2014

IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.

J Allergy Clin Immunol 2013 Oct 27;132(4):933-41. Epub 2013 Jun 27.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.05.012DOI Listing
October 2013

Effects of atopy and grass pollen season on histamine H₄ receptor expression in human leukocytes.

Ann Allergy Asthma Immunol 2013 Jul 31;111(1):38-44. Epub 2013 May 31.

Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.

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http://dx.doi.org/10.1016/j.anai.2013.04.017DOI Listing
July 2013

HTR4 gene structure and altered expression in the developing lung.

Respir Res 2013 Jul 26;14:77. Epub 2013 Jul 26.

Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1186/1465-9921-14-77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750317PMC
July 2013

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

PLoS Genet 2012 20;8(12):e1003098. Epub 2012 Dec 20.

Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1371/journal.pgen.1003098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527213PMC
May 2013

Stratified medicine: drugs meet genetics.

Authors:
Ian P Hall

Eur Respir Rev 2013 Mar;22(127):53-7

Division of Therapeutics and Molecular Medicine, Queen's Medical Centre, Nottingham, UK.

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http://dx.doi.org/10.1183/09059180.00008312DOI Listing
March 2013

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

Am J Respir Crit Care Med 2012 Oct 26;186(7):622-32. Epub 2012 Jul 26.

Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA.

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http://dx.doi.org/10.1164/rccm.201202-0366OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480517PMC
October 2012

Novel cAMP signalling paradigms: therapeutic implications for airway disease.

Br J Pharmacol 2012 May;166(2):401-10

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, The University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01719.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417475PMC
May 2012

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Authors:
María Soler Artigas Daan W Loth Louise V Wain Sina A Gharib Ma'en Obeidat Wenbo Tang Guangju Zhai Jing Hua Zhao Albert Vernon Smith Jennifer E Huffman Eva Albrecht Catherine M Jackson David M Evans Gemma Cadby Myriam Fornage Ani Manichaikul Lorna M Lopez Toby Johnson Melinda C Aldrich Thor Aspelund Inês Barroso Harry Campbell Patricia A Cassano David J Couper Gudny Eiriksdottir Nora Franceschini Melissa Garcia Christian Gieger Gauti Kjartan Gislason Ivica Grkovic Christopher J Hammond Dana B Hancock Tamara B Harris Adaikalavan Ramasamy Susan R Heckbert Markku Heliövaara Georg Homuth Pirro G Hysi Alan L James Stipan Jankovic Bonnie R Joubert Stefan Karrasch Norman Klopp Beate Koch Stephen B Kritchevsky Lenore J Launer Yongmei Liu Laura R Loehr Kurt Lohman Ruth J F Loos Thomas Lumley Khalid A Al Balushi Wei Q Ang R Graham Barr John Beilby John D Blakey Mladen Boban Vesna Boraska Jonas Brisman John R Britton Guy G Brusselle Cyrus Cooper Ivan Curjuric Santosh Dahgam Ian J Deary Shah Ebrahim Mark Eijgelsheim Clyde Francks Darya Gaysina Raquel Granell Xiangjun Gu John L Hankinson Rebecca Hardy Sarah E Harris John Henderson Amanda Henry Aroon D Hingorani Albert Hofman Patrick G Holt Jennie Hui Michael L Hunter Medea Imboden Karen A Jameson Shona M Kerr Ivana Kolcic Florian Kronenberg Jason Z Liu Jonathan Marchini Tricia McKeever Andrew D Morris Anna-Carin Olin David J Porteous Dirkje S Postma Stephen S Rich Susan M Ring Fernando Rivadeneira Thierry Rochat Avan Aihie Sayer Ian Sayers Peter D Sly George Davey Smith Akshay Sood John M Starr André G Uitterlinden Judith M Vonk S Goya Wannamethee Peter H Whincup Cisca Wijmenga O Dale Williams Andrew Wong Massimo Mangino Kristin D Marciante Wendy L McArdle Bernd Meibohm Alanna C Morrison Kari E North Ernst Omenaas Lyle J Palmer Kirsi H Pietiläinen Isabelle Pin Ozren Pola Sbreve Ek Anneli Pouta Bruce M Psaty Anna-Liisa Hartikainen Taina Rantanen Samuli Ripatti Jerome I Rotter Igor Rudan Alicja R Rudnicka Holger Schulz So-Youn Shin Tim D Spector Ida Surakka Veronique Vitart Henry Völzke Nicholas J Wareham Nicole M Warrington H-Erich Wichmann Sarah H Wild Jemma B Wilk Matthias Wjst Alan F Wright Lina Zgaga Tatijana Zemunik Craig E Pennell Fredrik Nyberg Diana Kuh John W Holloway H Marike Boezen Debbie A Lawlor Richard W Morris Nicole Probst-Hensch Jaakko Kaprio James F Wilson Caroline Hayward Mika Kähönen Joachim Heinrich Arthur W Musk Deborah L Jarvis Sven Gläser Marjo-Riitta Järvelin Bruno H Ch Stricker Paul Elliott George T O'Connor David P Strachan Stephanie J London Ian P Hall Vilmundur Gudnason Martin D Tobin

Nat Genet 2011 Sep 25;43(11):1082-90. Epub 2011 Sep 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267376PMC
September 2011

Real time analysis of β(2)-adrenoceptor-mediated signaling kinetics in human primary airway smooth muscle cells reveals both ligand and dose dependent differences.

Respir Res 2011 Jul 2;12:89. Epub 2011 Jul 2.

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, Floor D, South Block, University Hospital of Nottingham, The University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1186/1465-9921-12-89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143098PMC
July 2011

Current progress in pharmacogenetics.

Br J Clin Pharmacol 2011 Jun;71(6):824-31

Respiratory Biomedical Research Unit, City Hospital Campus, Nottingham, UK.

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http://dx.doi.org/10.1111/j.1365-2125.2011.03912.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099369PMC
June 2011

Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies.

Br J Pharmacol 2011 May;163(1):96-105

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, UK.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01222.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085871PMC
May 2011

Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation.

Gastroenterology 2011 May 23;140(5):1434-43.e1. Epub 2011 Mar 23.

National Institute for Health Research Biomedical Research Unit, Nottingham Digestive Diseases Centre, School of Clinical Sciences, Nottingham, England.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085110013
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http://dx.doi.org/10.1053/j.gastro.2011.01.052DOI Listing
May 2011

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom.

J Allergy Clin Immunol 2011 Jan 20;127(1):223-31, 231.e1-3. Epub 2010 Nov 20.

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S009167491001565
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http://dx.doi.org/10.1016/j.jaci.2010.10.006DOI Listing
January 2011

Reverse mode Na+/Ca2+ exchange mediated by STIM1 contributes to Ca2+ influx in airway smooth muscle following agonist stimulation.

Respir Res 2010 Dec 2;11:168. Epub 2010 Dec 2.

Division of Therapeutics and Molecular Medicine, Respiratory Biomedical Research Unit, Queens Medical Centre, Nottingham, UK.

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http://dx.doi.org/10.1186/1465-9921-11-168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012663PMC
December 2010

The genetics of obstructive lung disease: big is beautiful.

Thorax 2010 Sep;65(9):760-1

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http://dx.doi.org/10.1136/thx.2010.147173DOI Listing
September 2010

Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

Am J Physiol Lung Cell Mol Physiol 2010 Aug 30;299(2):L169-83. Epub 2010 Apr 30.

Univ. of Nottingham, Queen's Medical Centre, UK.

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http://dx.doi.org/10.1152/ajplung.00311.2009DOI Listing
August 2010

Genome-wide association study identifies five loci associated with lung function.

Nat Genet 2010 Jan 13;42(1):36-44. Epub 2009 Dec 13.

Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862965PMC
January 2010

PLAUR polymorphisms and lung function in UK smokers.

BMC Med Genet 2009 Oct 31;10:112. Epub 2009 Oct 31.

Division of Therapeutics & Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1186/1471-2350-10-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784766PMC
October 2009

Association of the cysteinyl leukotriene receptor 1 gene with atopy in the British 1958 birth cohort.

J Allergy Clin Immunol 2009 Sep;124(3):566-72, 572.e1-3

Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2009.06.004DOI Listing
September 2009

How will genetic approaches assist in the management of respiratory diseases?

Authors:
Ian P Hall

Curr Opin Pharmacol 2009 Jun 4;9(3):256-61. Epub 2009 May 4.

Division of Therapeutics & Molecular Medicine, D Floor, South Block, QMC Campus, Nottingham University Hospitals, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1016/j.coph.2009.03.003DOI Listing
June 2009

PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.

J Allergy Clin Immunol 2009 Jun 13;123(6):1391-400.e17. Epub 2009 May 13.

Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2009.03.014DOI Listing
June 2009

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.

Nat Genet 2009 Mar 8;41(3):342-7. Epub 2009 Feb 8.

deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.323DOI Listing
March 2009

ORAI and store-operated calcium influx in human airway smooth muscle cells.

Am J Respir Cell Mol Biol 2008 Jun 31;38(6):744-9. Epub 2008 Jan 31.

Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK.

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http://dx.doi.org/10.1165/rcmb.2007-0395OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643203PMC
June 2008

Meta-analysis of genome-wide linkage studies of asthma and related traits.

Respir Res 2008 Apr 28;9:38. Epub 2008 Apr 28.

Division of Therapeutics & Molecular Medicine, University Hospital of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1186/1465-9921-9-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391165PMC
April 2008

Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance.

Am J Respir Crit Care Med 2008 Feb 15;177(3):248-52. Epub 2007 Nov 15.

Airway Biology and Disease Program, Division of Lung Diseases, National Heart, Lung, and Blood Institute, Two Rockledge Center, Suite 10042, 6701 Rockledge Drive, MSC 7952, Bethesda, MD 20892-7952, USA.

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http://dx.doi.org/10.1164/rccm.200708-1217PPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2218850PMC
February 2008

Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes.

Cell Biochem Biophys 2007 ;47(1):119-30

Division of Therapeutics and Molecular Medicine, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

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January 2008

A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells.

Am J Respir Cell Mol Biol 2008 Jan 2;38(1):1-7. Epub 2007 Aug 2.

Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK.

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http://dx.doi.org/10.1165/rcmb.2007-0171OCDOI Listing
January 2008

Airway myofibroblasts and their relationship with airway myocytes and fibroblasts.

Proc Am Thorac Soc 2008 Jan;5(1):127-32

Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1513/pats.200706-070VSDOI Listing
January 2008

ADRB2 polymorphisms and beta2 agonists.

Lancet 2007 Dec;370(9605):2075-6

Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1016/S0140-6736(07)61876-5DOI Listing
December 2007

Bradykinin activates calcium-dependent potassium channels in cultured human airway smooth muscle cells.

Am J Physiol Lung Cell Mol Physiol 2007 Apr 8;292(4):L898-907. Epub 2006 Dec 8.

Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1152/ajplung.00461.2005DOI Listing
April 2007

Pharmacogenetics of asthma.

Authors:
Ian P Hall

Chest 2006 Dec;130(6):1873-8

Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1378/chest.130.6.1873DOI Listing
December 2006

A key role for STIM1 in store operated calcium channel activation in airway smooth muscle.

Respir Res 2006 Sep 20;7:119. Epub 2006 Sep 20.

Division of Therapeutics and Molecular Medicine, University Hospital, Queens Medical Centre, Nottingham, UK.

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http://dx.doi.org/10.1186/1465-9921-7-119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1584236PMC
September 2006

Alternative promoter use and splice variation in the human histamine H1 receptor gene.

Am J Respir Cell Mol Biol 2006 Jul 16;35(1):118-26. Epub 2006 Feb 16.

Division of Therapeutics and Molecular Medicine, D Floor, South Block, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom.

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http://dx.doi.org/10.1165/rcmb.2005-0408OCDOI Listing
July 2006

Glucocorticoids increase repair potential in a novel in vitro human airway epithelial wounding model.

J Clin Immunol 2006 Jul 20;26(4):376-87. Epub 2006 Jun 20.

Division of Therapeutics and Molecular Medicine, D floor, South Block, Queens Medical Centre, University Hospital, Nottingham, NG7 2UH, United Kingdom.

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http://dx.doi.org/10.1007/s10875-006-9029-zDOI Listing
July 2006

Eosinophil-mediated cholinergic nerve remodeling.

Am J Respir Cell Mol Biol 2006 Jun 2;34(6):775-86. Epub 2006 Feb 2.

Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1165/rcmb.2005-0196OCDOI Listing
June 2006

The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells.

Eur J Pharmacol 2006 Feb 17;531(1-3):9-12. Epub 2006 Jan 17.

Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S001429990501186
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http://dx.doi.org/10.1016/j.ejphar.2005.11.026DOI Listing
February 2006

Molecular and phenotypic analyses of human embryonic stem cell-derived cardiomyocytes: opportunities and challenges for clinical translation.

Thromb Haemost 2005 Oct;94(4):728-37

Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, UK.

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http://dx.doi.org/10.1160/TH05-04-0268DOI Listing
October 2005

Pharmacogenetic approaches in the treatment of asthma.

Curr Allergy Asthma Rep 2005 Mar;5(2):101-8

Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, D Floor, South Block, Nottingham, NG7 2UH, UK.

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March 2005

Pharmacogenetics and ethnicity: more complexities of personalized prescribing.

Authors:
Ian P Hall

Am J Respir Crit Care Med 2005 Mar;171(6):535-6

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http://dx.doi.org/10.1164/rccm.2412003DOI Listing
March 2005

Are beta2-adrenoceptor polymorphisms important in asthma--an unravelling story.

Lancet 2004 Oct 23-29;364(9444):1464-6

Respiratory Division, Nottingham City Hospital NHS Trust, Nottingham, NG5 1PB, UK.

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http://dx.doi.org/10.1016/S0140-6736(04)17286-3DOI Listing
November 2004