Ian J Davis

Ian J Davis

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Ian J Davis

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Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction.

Cell Rep 2018 12;25(12):3476-3489.e5

Department of Biochemistry & Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.11.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347388PMC
December 2018

PBRM1 bromodomains variably influence nucleosome interactions and cellular function.

J Biol Chem 2018 08 9;293(35):13592-13603. Epub 2018 Jul 9.

From the Department of Genetics, Curriculum in Genetics and Molecular Biology,

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http://dx.doi.org/10.1074/jbc.RA118.003381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120218PMC
August 2018

CHD4 and the NuRD complex directly control cardiac sarcomere formation.

Proc Natl Acad Sci U S A 2018 06 11;115(26):6727-6732. Epub 2018 Jun 11.

University of North Carolina McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://dx.doi.org/10.1073/pnas.1722219115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042121PMC
June 2018

Spt6 Association with RNA Polymerase II Directs mRNA Turnover During Transcription.

Mol Cell 2018 06;70(6):1054-1066.e4

Department of Biochemistry & Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://www.cell.com/article/S1097276518303940/pdf
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https://linkinghub.elsevier.com/retrieve/pii/S10972765183039
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http://dx.doi.org/10.1016/j.molcel.2018.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323640PMC
June 2018

Cavitation Enhancement Increases the Efficiency and Consistency of Chromatin Fragmentation from Fixed Cells for Downstream Quantitative Applications.

Biochemistry 2018 05 25;57(19):2756-2761. Epub 2018 Apr 25.

Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy , The University of North Carolina , Chapel Hill , North Carolina 27599 , United States.

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http://dx.doi.org/10.1021/acs.biochem.8b00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962036PMC
May 2018

H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity.

Cell Rep 2017 06;19(11):2371-2382

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528882PMC
June 2017

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.

Cold Spring Harb Perspect Med 2017 May 1;7(5). Epub 2017 May 1.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295.

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http://dx.doi.org/10.1101/cshperspect.a026468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411680PMC
May 2017

Assessment of dental plaque coverage by Quantitative Light-induced Fluorescence (QLF) in domestic short-haired cats.

Res Vet Sci 2017 Apr 10;111:99-107. Epub 2017 Feb 10.

The WALTHAM Centre for Pet Nutrition, Melton Mowbray, Leicestershire LE14 4RT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00345288163018
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http://dx.doi.org/10.1016/j.rvsc.2017.02.005DOI Listing
April 2017

Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer.

Cell Rep 2016 11;17(6):1607-1620

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pediatrics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267842PMC
November 2016

Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.

J Biol Chem 2016 Sep 15;291(40):21283-21295. Epub 2016 Aug 15.

From the Department of Genetics, Curriculum in Genetics and Molecular Biology, the Lineberger Comprehensive Cancer Center, and the Division of Hematology and Oncology, Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232

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http://dx.doi.org/10.1074/jbc.M116.739375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076534PMC
September 2016

Dual Chromatin and Cytoskeletal Remodeling by SETD2.

Cell 2016 Aug;166(4):950-962

Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101839PMC
August 2016

Longitudinal quantification of the gingival crevicular fluid proteome during progression from gingivitis to periodontitis in a canine model.

J Clin Periodontol 2016 07 23;43(7):584-94. Epub 2016 May 23.

Periodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/jcpe.12548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089638PMC
July 2016

Post-transplant lymphoproliferative disorder of the pediatric airway: Presentation and management.

Int J Pediatr Otorhinolaryngol 2016 Jul 30;86:218-23. Epub 2016 Apr 30.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Otolaryngology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ijporl.2016.04.035DOI Listing
July 2016

Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties.

Nanomedicine 2016 May 7;12(4):1053-1062. Epub 2016 Jan 7.

Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA; Departments of Genetics and Pediatrics, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2015.12.382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836989PMC
May 2016

High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility.

Proc Natl Acad Sci U S A 2016 Mar 29;113(11):3018-23. Epub 2016 Feb 29.

Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Carolina Center for Genome Sciences, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.1073/pnas.1521827113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801272PMC
March 2016

The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.

Dev Cell 2016 Feb;36(3):262-75

University of North Carolina McAllister Heart Institute, UNC-Chapel Hill, Chapel Hill, NC 27599, USA; Integrative Program for Biological & Genome Sciences, UNC-Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biology, UNC-Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://www.cell.com/developmental-cell/pdf/S1534-5807(16)000
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http://linkinghub.elsevier.com/retrieve/pii/S153458071600043
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http://dx.doi.org/10.1016/j.devcel.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920128PMC
February 2016

A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.

J Biol Chem 2015 Oct 3;290(43):26088-102. Epub 2015 Sep 3.

the Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599,

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http://dx.doi.org/10.1074/jbc.M115.654459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646261PMC
October 2015

Linking germline and somatic variation in Ewing sarcoma.

Nat Genet 2015 Sep;47(9):964-5

Department of Genetics and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/ng.3387DOI Listing
September 2015

FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma.

Sci Signal 2015 Feb 3;8(362):ra12. Epub 2015 Feb 3.

Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. Division of Microbiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27516-7361, USA.

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http://dx.doi.org/10.1126/scisignal.2005654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356208PMC
February 2015

PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition.

Mol Cancer Res 2014 Nov 3;12(11):1610-20. Epub 2014 Jul 3.

Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233155PMC
November 2014

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.

J Cell Biol 2014 Oct;207(2):299-315

University of North Carolina Lineberger Comprehensive Cancer Center, Department of Cell Biology and Physiology, Department of Genetics, Department of Biomedical Engineering, Carolina Center for Genome Science, Department of Pediatrics, and Howard Hughes Medical Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599 University of North Carolina Lineberger Comprehensive Cancer Center, Department of Cell Biology and Physiology, Department of Genetics, Department of Biomedical Engineering, Carolina Center for Genome Science, Department of Pediatrics, and Howard Hughes Medical Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599 University of North Carolina Lineberger Comprehensive Cancer Center, Department of Cell Biology and Physiology, Department of Genetics, Department of Biomedical Engineering, Carolina Center for Genome Science, Department of Pediatrics, and Howard Hughes Medical Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.1083/jcb.201404067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210439PMC
October 2014

A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a.

ChemMedChem 2014 Mar 17;9(3):549-53. Epub 2014 Jan 17.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/cmdc.201300450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005005PMC
March 2014

The open chromatin landscape of Kaposi's sarcoma-associated herpesvirus.

J Virol 2013 Nov 28;87(21):11831-42. Epub 2013 Aug 28.

Lineberger Comprehensive Cancer Center.

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http://dx.doi.org/10.1128/JVI.01685-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807352PMC
November 2013

A detailed protocol for formaldehyde-assisted isolation of regulatory elements (FAIRE).

Curr Protoc Mol Biol 2013 ;Chapter 21:Unit21.26

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1002/0471142727.mb2126s102DOI Listing
June 2013

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription.

Genome Res 2012 Feb 15;22(2):259-70. Epub 2011 Nov 15.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1101/gr.125666.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266033PMC
February 2012

Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA.

Nat Protoc 2012 Jan 19;7(2):256-67. Epub 2012 Jan 19.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nprot.2011.444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784247PMC
January 2012

Validation of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinomas.

Diagn Mol Pathol 2011 Sep;20(3):129-37

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1097/PDM.0b013e31820e9c67DOI Listing
September 2011

Unintentional weight loss as the sole indication for colonoscopy is rarely associated with colorectal cancer.

J Am Board Fam Med 2011 Mar-Apr;24(2):218-9

Department of Internal Medicine, Medical College of Georgia-Georgia Health Sciences University, Augusta.

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http://dx.doi.org/10.3122/jabfm.2011.02.100166DOI Listing
July 2011

Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.

J Biol Chem 2011 Jan 8;286(2):1649-58. Epub 2010 Nov 8.

Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M110.106922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020773PMC
January 2011

Regulation of neurotoxin production and sporulation by a Putative agrBD signaling system in proteolytic Clostridium botulinum.

Appl Environ Microbiol 2010 Jul 7;76(13):4448-60. Epub 2010 May 7.

Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.

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http://dx.doi.org/10.1128/AEM.03038-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897414PMC
July 2010

Array comparative hybridisation reveals a high degree of similarity between UK and European clinical isolates of hypervirulent Clostridium difficile.

BMC Genomics 2010 Jun 21;11:389. Epub 2010 Jun 21.

Centre for Biomolecular Sciences, School of Molecular Medical Sciences, Nottingham Digestive Diseases Centre NIHR Biomedical Research, University of Nottingham, Nottingham NG7 2RD, UK.

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http://dx.doi.org/10.1186/1471-2164-11-389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224701PMC
June 2010

Improved ChIP-chip analysis by a mixture model approach.

BMC Bioinformatics 2009 Jun 7;10:173. Epub 2009 Jun 7.

Department of Biostatistics, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1186/1471-2105-10-173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700807PMC
June 2009

MiT transcription factor associated malignancies in man.

Cell Cycle 2007 Jul 24;6(14):1724-9. Epub 2007 May 24.

Division of Hematology/Oncology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.4161/cc.6.14.4484DOI Listing
July 2007

Characterization of the ends and target site of a novel tetracycline resistance-encoding conjugative transposon from Enterococcus faecium 664.1H1.

J Bacteriol 2006 Jun;188(12):4356-61

Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, University of London, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom.

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http://dx.doi.org/10.1128/JB.00129-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482970PMC
June 2006

Inhibition of the met receptor in mesothelioma.

Clin Cancer Res 2005 Nov;11(22):8122-30

Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-05-1191DOI Listing
November 2005

Linkage of a novel mercury resistance operon with streptomycin resistance on a conjugative plasmid in Enterococcus faecium.

Plasmid 2005 Jul 2;54(1):26-38. Epub 2004 Dec 2.

Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London, WC1X 8LD, UK.

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http://dx.doi.org/10.1016/j.plasmid.2004.10.004DOI Listing
July 2005

Sumoylation of MITF and its related family members TFE3 and TFEB.

J Biol Chem 2005 Jan 25;280(1):146-55. Epub 2004 Oct 25.

Dana-Farber Cancer Institute and Children's Hospital, Department of Pediatric Hematology/Oncology, Melanoma Program in Medical Oncology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M411757200DOI Listing
January 2005

A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes.

J Biol Chem 2003 Nov 27;278(46):45224-30. Epub 2003 Aug 27.

Division of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M309036200
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http://dx.doi.org/10.1074/jbc.M309036200DOI Listing
November 2003