Ian H Gilbert

Ian H Gilbert

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Ian H Gilbert

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A platform for target prediction of phenotypic screening hit molecules.

J Mol Graph Model 2020 Mar 24;95:107485. Epub 2019 Oct 24.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2019.107485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983931PMC
March 2020

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

PLoS One 2019 31;14(5):e0217828. Epub 2019 May 31.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544269PMC
January 2020

The Q Site of Cytochrome is a Promiscuous Drug Target in and .

ACS Infect Dis 2020 Jan 30. Epub 2020 Jan 30.

Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences , University of Dundee , Dow Street , Dundee DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.9b00426DOI Listing
January 2020

Small Polar Hits against : Screening, Initial Hit Optimization, and Metabolomic Studies.

ACS Omega 2019 Nov 4;4(21):19199-19215. Epub 2019 Nov 4.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1021/acsomega.9b02507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869403PMC
November 2019

Characterising covalent warhead reactivity.

Bioorg Med Chem 2019 05 3;27(10):2066-2074. Epub 2019 Apr 3.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538824PMC
May 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2018 Nov;16(11):714

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1038/s41579-018-0085-1DOI Listing
November 2018

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas' disease.

Bioorg Med Chem Lett 2018 10 3;28(18):3025-3030. Epub 2018 Aug 3.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970618PMC
October 2018

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.

ACS Infect Dis 2018 10 28;4(10):1475-1486. Epub 2018 Sep 28.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.8b00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199744PMC
October 2018

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Proc Natl Acad Sci U S A 2018 09 5;115(38):9616-9621. Epub 2018 Sep 5.

The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1807915115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156652PMC
September 2018

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

J Med Chem 2018 09 12;61(18):8374-8389. Epub 2018 Sep 12.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167002PMC
September 2018

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.

Antimicrob Agents Chemother 2018 08 27;62(8). Epub 2018 Jul 27.

Wellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.00235-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105827PMC
August 2018

Challenges and recent progress in drug discovery for tropical diseases.

Nature 2018 07 25;559(7715):498-506. Epub 2018 Jul 25.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/s41586-018-0327-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129172PMC
July 2018

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments.

Chem Biol Drug Des 2018 03 12;91(3):655-667. Epub 2017 Dec 12.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1111/cbdd.13129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836963PMC
March 2018

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Malar J 2017 11 7;16(1):446. Epub 2017 Nov 7.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/s12936-017-2085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678585PMC
November 2017

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

ACS Infect Dis 2017 10 2;3(10):718-727. Epub 2017 Oct 2.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.7b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663395PMC
October 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2017 Feb 27;15(4):217-231. Epub 2017 Feb 27.

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/nrmicro.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582623PMC
February 2017

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.

Drug Discov Today 2017 01 26;22(1):43-56. Epub 2016 Oct 26.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.10.005DOI Listing
January 2017

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi.

PLoS Negl Trop Dis 2016 Apr 29;10(4):e0004540. Epub 2016 Apr 29.

The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0004540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851402PMC
April 2016

Discovery and optimisation studies of antimalarial phenotypic hits.

Eur J Med Chem 2015 Oct 9;103:530-8. Epub 2015 Sep 9.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.08.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607724PMC
October 2015

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.

J Med Chem 2015 Oct 29;58(19):7695-706. Epub 2015 Sep 29.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Sir James Black Centre, Dundee, DD1 5EH, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601051PMC
October 2015

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.

ACS Chem Biol 2015 Jun 27;10(6):1425-34. Epub 2015 Feb 27.

†Division of Molecular Microbiology, ‡Division of Biological Chemistry and Drug Discovery, §MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/cb5008647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477619PMC
June 2015

Application of RNAi to Genomic Drug Target Validation in Schistosomes.

PLoS Negl Trop Dis 2015 May 20;9(5):e0003801. Epub 2015 May 20.

Department of Infection and Immunity, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0003801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438872PMC
May 2015

Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis.

Antimicrob Agents Chemother 2014 Oct 14;58(10):5747-57. Epub 2014 Jul 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, United Kingdom

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http://aac.asm.org/content/58/10/5747.full.pdf
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http://aac.asm.org/cgi/doi/10.1128/AAC.01449-13
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http://dx.doi.org/10.1128/AAC.01449-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187918PMC
October 2014

Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei.

PLoS Comput Biol 2013 5;9(12):e1003371. Epub 2013 Dec 5.

Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation and Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom ; Systems and Synthetic Biology Group, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.

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http://dx.doi.org/10.1371/journal.pcbi.1003371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854711PMC
August 2014

Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.

PLoS Negl Trop Dis 2013 17;7(10):e2492. Epub 2013 Oct 17.

The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada ; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America.

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http://www.drugdiscovery.dundee.ac.uk/sites/www.drugdiscover
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http://dx.plos.org/10.1371/journal.pntd.0002492
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http://dx.doi.org/10.1371/journal.pntd.0002492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798429PMC
May 2014

Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues.

Org Biomol Chem 2014 Mar 12;12(12):1919-34. Epub 2014 Feb 12.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1039/c3ob42164cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326964PMC
March 2014

Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase.

Carbohydr Res 2014 Mar 30;387:54-8. Epub 2013 Dec 30.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.carres.2013.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991331PMC
March 2014

Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter.

Authors:
Ian H Gilbert

Parasitology 2014 Jan 9;141(1):28-36. Epub 2013 Aug 9.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1017/S0031182013001017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884840PMC
January 2014

Fragment-based hit identification: thinking in 3D.

Drug Discov Today 2013 Dec 30;18(23-24):1221-7. Epub 2013 Jul 30.

College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2013.07.011DOI Listing
December 2013

Drug discovery for neglected diseases: molecular target-based and phenotypic approaches.

Authors:
Ian H Gilbert

J Med Chem 2013 Oct 9;56(20):7719-26. Epub 2013 Sep 9.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1021/jm400362bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954685PMC
October 2013

Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.

Bioorg Med Chem 2013 Sep 12;21(18):5876-85. Epub 2013 Jul 12.

Division of Biological Chemistry and Drug Discovery, College of Life Science, University of Dundee, Sir James Black Centre, UK.

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http://dx.doi.org/10.1016/j.bmc.2013.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776224PMC
September 2013

Structure-activity relationship studies of pyrrolone antimalarial agents.

ChemMedChem 2013 Sep 5;8(9):1537-44. Epub 2013 Aug 5.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow St, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201300177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963473PMC
September 2013

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

Antimicrob Agents Chemother 2013 Jul 9;57(7):2913-22. Epub 2013 Apr 9.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1128/AAC.02398-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697379PMC
July 2013

From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules.

ChemMedChem 2013 Jul 14;8(7):1127-37. Epub 2013 Jun 14.

Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201300072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728731PMC
July 2013

Discovery and structure-activity relationships of pyrrolone antimalarials.

J Med Chem 2013 Apr 21;56(7):2975-90. Epub 2013 Mar 21.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1021/jm400009cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624797PMC
April 2013

Synthesis and evaluation of α-thymidine analogues as novel antimalarials.

J Med Chem 2012 Dec 14;55(24):10948-57. Epub 2012 Dec 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1021/jm301328hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530961PMC
December 2012

Quinol derivatives as potential trypanocidal agents.

Bioorg Med Chem 2012 Feb 27;20(4):1607-15. Epub 2011 Dec 27.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2011.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281193PMC
February 2012

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.

ChemMedChem 2012 Jan 8;7(1):95-106. Epub 2011 Dec 8.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/cmdc.201100420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320663PMC
January 2012

Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.

ChemMedChem 2011 Dec 13;6(12):2214-24. Epub 2011 Sep 13.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201100344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272345PMC
December 2011

Investigation of copper(II) tetrafluoroborate catalysed epoxide opening.

Tetrahedron Lett 2011 Dec;52(52):7091-7094

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.tetlet.2011.10.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314918PMC
December 2011

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

ChemMedChem 2011 Oct 10;6(10):1832-40. Epub 2011 Aug 10.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229842PMC
October 2011

Finding new hits in neglected disease projects: target or phenotypic based screening?

Curr Top Med Chem 2011 ;11(10):1284-91

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, Sir James Black Centre, University of Dundee, UK.

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http://dx.doi.org/10.2174/156802611795429176DOI Listing
August 2011

Target validation: linking target and chemical properties to desired product profile.

Curr Top Med Chem 2011 ;11(10):1275-83

Drug Discovery Unit, College of Life Sciences, University of Dundee, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182078PMC
http://dx.doi.org/10.2174/156802611795429185DOI Listing
August 2011

Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase.

Eur J Med Chem 2011 Aug 27;46(8):3309-14. Epub 2011 Apr 27.

Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento, s/n, 18100 Armilla, Granada, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S022352341100350
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http://dx.doi.org/10.1016/j.ejmech.2011.04.052DOI Listing
August 2011

Evaluation of three novel azasterols against Toxoplasma gondii.

Vet Parasitol 2011 Apr 1;177(1-2):157-61. Epub 2010 Dec 1.

Laboratório de Ultraestrutura Celular Herth, Meyer, Instituto de Biofísica Carlos Chagas Filho, UFRJ, CCS, Bloco G, Av. Carlo, Chagas Filho, Cidade Universitária, Ilha do Fundão, 21941-902, Rio de Janeiro, RJ, Brazil.

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http://dx.doi.org/10.1016/j.vetpar.2010.11.034DOI Listing
April 2011

β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.

Bioorg Med Chem 2011 Apr 17;19(7):2378-91. Epub 2011 Feb 17.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2011.02.012DOI Listing
April 2011

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

ChemMedChem 2011 Feb 29;6(2):302-8. Epub 2010 Dec 29.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, Scotland, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047710PMC
February 2011

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

Eur J Med Chem 2010 Nov 14;45(11):5140-9. Epub 2010 Aug 14.

Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Avda. del Conocimiento s/n, 18100-Armilla, Granada, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2010.08.026DOI Listing
November 2010

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

Bioorg Med Chem 2010 Oct 6;18(20):7302-9. Epub 2010 Aug 6.

College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2010.07.006DOI Listing
October 2010

Design and preparation of sterol mimetics as potential antiparasitics.

Bioorg Med Chem 2010 Oct 9;18(20):7291-301. Epub 2010 Aug 9.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2010.08.007DOI Listing
October 2010

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.

Bioorg Med Chem Lett 2010 Aug 17;20(15):4364-6. Epub 2010 Jun 17.

Division of Biological Chemistry and Drug Discovery, College of Life Science, University of Dundee, Sir James Black Centre, Dundee, UK.

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http://dx.doi.org/10.1016/j.bmcl.2010.06.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935964PMC
August 2010

Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.

J Med Chem 2010 Aug;53(16):6071-8

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1021/jm1004754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923871PMC
August 2010

Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.

Bioorg Med Chem 2010 Jul 9;18(14):5056-62. Epub 2010 Jun 9.

Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2010.05.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939770PMC
July 2010

Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis.

Bioorg Med Chem 2010 Apr 2;18(7):2559-65. Epub 2010 Mar 2.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2010.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862900PMC
April 2010

Thiolactomycin analogues as potential anti-Toxoplasma gondii agents.

Parasitol Int 2009 Dec 19;58(4):411-5. Epub 2009 Aug 19.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

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http://dx.doi.org/10.1016/j.parint.2009.08.004DOI Listing
December 2009

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

J Biol Chem 2009 Dec 14;284(52):36137-45. Epub 2009 Oct 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.045336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794729PMC
December 2009

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

ChemMedChem 2009 Dec;4(12):2060-9

Drug Discovery Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855869PMC
December 2009

Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.

ChemMedChem 2009 Aug;4(8):1333-40

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.200900097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929371PMC
August 2009

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

ChemMedChem 2009 Aug;4(8):1341-53

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929374PMC
August 2009

SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents.

Bioorg Med Chem 2009 Aug 3;17(16):5950-61. Epub 2009 Jul 3.

University of Dundee, Sir James Black Centre, UK.

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http://dx.doi.org/10.1016/j.bmc.2009.06.062DOI Listing
August 2009

N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents.

Int J Antimicrob Agents 2009 May 20;33(5):441-8. Epub 2008 Dec 20.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.ijantimicag.2008.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669511PMC
May 2009

Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.

Bioorg Med Chem 2009 Mar 31;17(6):2512-23. Epub 2009 Jan 31.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bmc.2009.01.058DOI Listing
March 2009

Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites.

Org Biomol Chem 2009 Mar 28;7(6):1154-66. Epub 2009 Jan 28.

School of Life Sciences, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1039/b813394hDOI Listing
March 2009

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni.

J Enzyme Inhib Med Chem 2009 Feb;24(1):111-6

Instituto de Parastiologia y Biomedicina "Lopez-Neyra". Consejo Superior de Investigaciones Cientificas, Armilla, Granada, Spain.

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http://dx.doi.org/10.1080/14756360801915476DOI Listing
February 2009

Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.

Eur J Med Chem 2009 Feb 10;44(2):678-88. Epub 2008 Jul 10.

Welsh School of Pharmacy, University of Wales Cardiff, King Edward VII Avenue, Cardiff CF103XF, UK.

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http://dx.doi.org/10.1016/j.ejmech.2008.05.018DOI Listing
February 2009

Synthesis and testing of peptides for anti-prion activity.

Eur J Med Chem 2008 Nov 8;43(11):2418-27. Epub 2008 Feb 8.

Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.

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http://dx.doi.org/10.1016/j.ejmech.2008.01.041DOI Listing
November 2008

Target assessment for antiparasitic drug discovery.

Trends Parasitol 2007 Dec 24;23(12):589-95. Epub 2007 Oct 24.

Drug Discovery Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.pt.2007.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979298PMC
December 2007

Mechanistic insights into the cure of prion disease by novel antiprion compounds.

J Virol 2007 Oct 25;81(19):10729-41. Epub 2007 Jul 25.

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

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http://dx.doi.org/10.1128/JVI.01075-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045489PMC
October 2007

Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.

ChemMedChem 2007 Aug;2(8):1169-80

Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://doi.wiley.com/10.1002/cmdc.200700040
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http://dx.doi.org/10.1002/cmdc.200700040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248282PMC
August 2007