Ian H Frazer

Ian H Frazer

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Ian H Frazer

Publications by authors named "Ian H Frazer"

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Single-cell RNA sequencing reveals cell type-specific HPV expression in hyperplastic skin lesions.

Virology 2019 Aug 13;537:14-19. Epub 2019 Aug 13.

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.

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http://dx.doi.org/10.1016/j.virol.2019.08.007DOI Listing
August 2019

Immunotherapy for HPV associated cancer.

Papillomavirus Res 2019 Jul 13;8:100176. Epub 2019 Jul 13.

The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Queensland, 4102, Australia.

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http://dx.doi.org/10.1016/j.pvr.2019.100176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639647PMC
July 2019

Acute exercise does not improve immune response to HPV vaccination series in adolescents.

Papillomavirus Res 2019 Jul 15;8:100178. Epub 2019 Jul 15.

The University of Sydney, Faculty of Health Sciences & Charles Perkins Centre, Sydney, Australia.

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http://dx.doi.org/10.1016/j.pvr.2019.100178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658927PMC
July 2019

HPV16 E7-Driven Epithelial Hyperplasia Promotes Impaired Antigen Presentation and Regulatory T-Cell Development.

J Invest Dermatol 2019 Jun 15. Epub 2019 Jun 15.

The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.

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http://dx.doi.org/10.1016/j.jid.2019.03.1162DOI Listing
June 2019

High-risk human papillomavirus detection in oropharyngeal cancers: Comparison of saliva sampling methods.

Head Neck 2019 May 23;41(5):1484-1489. Epub 2018 Dec 23.

The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

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http://doi.wiley.com/10.1002/hed.25578
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http://dx.doi.org/10.1002/hed.25578DOI Listing
May 2019

Unlocking the Potential of Saliva-Based Test to Detect HPV-16-Driven Oropharyngeal Cancer.

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology and the Translational Research Institute, Queensland 4059, Australia.

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https://www.mdpi.com/2072-6694/11/4/473
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http://dx.doi.org/10.3390/cancers11040473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521163PMC
April 2019

An Ex Vivo Human Tumor Assay Shows Distinct Patterns of EGFR Trafficking in Squamous Cell Carcinoma Correlating to Therapeutic Outcomes.

J Invest Dermatol 2019 Jan 2;139(1):213-223. Epub 2018 Aug 2.

The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183245
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http://dx.doi.org/10.1016/j.jid.2018.06.190DOI Listing
January 2019

The projected timeframe until cervical cancer elimination in Australia: a modelling study.

Lancet Public Health 2019 Jan 2;4(1):e19-e27. Epub 2018 Oct 2.

Cancer Research Division, Cancer Council NSW, Sydney, NSW, Australia; School of Public Health, University of Sydney, Sydney, NSW, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S24682667183018
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http://dx.doi.org/10.1016/S2468-2667(18)30183-XDOI Listing
January 2019

Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis.

J Invest Dermatol 2018 12 30;138(12):2558-2567. Epub 2018 Jun 30.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.jid.2018.06.169DOI Listing
December 2018

Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction.

Front Immunol 2018 18;9:2896. Epub 2018 Dec 18.

Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02896
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http://dx.doi.org/10.3389/fimmu.2018.02896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305623PMC
December 2018

A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes.

MBio 2018 10 9;9(5). Epub 2018 Oct 9.

Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01432-18
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http://dx.doi.org/10.1128/mBio.01432-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178618PMC
October 2018

HPV16E7-Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3 T-Cell Migration to Skin.

J Invest Dermatol 2018 06 23;138(6):1348-1359. Epub 2017 Dec 23.

The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.

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http://dx.doi.org/10.1016/j.jid.2017.12.021DOI Listing
June 2018

Eradicating HPV-Associated Cancer Through Immunization: A Glass Half Full….

Authors:
Ian H Frazer

Viral Immunol 2018 03 3;31(2):80-85. Epub 2018 Jan 3.

The University of Queensland Diamantina Institute , Woolloongabba, Australia .

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http://dx.doi.org/10.1089/vim.2017.0119DOI Listing
March 2018

No Vacillation on HPV Vaccination.

Cell 2018 03;172(6):1163-1167

Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney, Camperdown 2050, Australia; Sydney Medical School, University of Sydney, NSW 2006, Australia; Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown 2050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.045DOI Listing
March 2018

CD8 lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury.

Exp Dermatol 2018 01 6;27(1):71-79. Epub 2017 Dec 6.

Diamantina Institute, University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1111/exd.13436DOI Listing
January 2018

Modulation of antigen presenting cell functions during chronic HPV infection.

Papillomavirus Res 2017 12 18;4:58-65. Epub 2017 Aug 18.

The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, 37 Kent Street, Woolloongabba, Queensland 4102, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pvr.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883240PMC
December 2017

CD4CD8β double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin.

J Leukoc Biol 2017 09 21;102(3):837-844. Epub 2017 Jun 21.

The University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia;

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http://doi.wiley.com/10.1189/jlb.1AB0217-065R
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http://dx.doi.org/10.1189/jlb.1AB0217-065RDOI Listing
September 2017

RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers.

PeerJ 2017 21;5:e3631. Epub 2017 Aug 21.

Dermatology Research Centre, Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.7717/peerj.3631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572537PMC
August 2017

Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity.

Cell Death Dis 2017 06 1;8(6):e2836. Epub 2017 Jun 1.

The University of Queensland Diamantina Institute, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD 4102, Australia.

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http://dx.doi.org/10.1038/cddis.2017.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520949PMC
June 2017

HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts.

Front Immunol 2017 4;8:524. Epub 2017 May 4.

Diamantina Institute, University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.3389/fimmu.2017.00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415560PMC
May 2017

Batf3 selectively determines acquisition of CD8 dendritic cell phenotype and function.

Immunol Cell Biol 2017 02 29;95(2):215-223. Epub 2016 Nov 29.

The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.

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http://dx.doi.org/10.1038/icb.2016.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309136PMC
February 2017

An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1.

Hum Vaccin Immunother 2016 12;12(12):3079-3088

a Admedus Vaccines Pty Ltd (formerly Coridon Pty Ltd) , Translational Research Institute , Woolloongabba , QLD , Australia.

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http://dx.doi.org/10.1080/21645515.2016.1221872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215501PMC
December 2016

Epithelium Expressing the E7 Oncoprotein of HPV16 Attracts Immune-Modulatory Dendritic Cells to the Skin and Suppresses Their Antigen-Processing Capacity.

PLoS One 2016 31;11(3):e0152886. Epub 2016 Mar 31.

University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Queensland 4102, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152886PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816461PMC
August 2016

A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury.

EBioMedicine 2016 Jul 7;9:314-323. Epub 2016 Jun 7.

The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/j.ebiom.2016.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972546PMC
July 2016

Role of Ultraviolet Radiation in Papillomavirus-Induced Disease.

PLoS Pathog 2016 05 31;12(5):e1005664. Epub 2016 May 31.

McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887022PMC
May 2016

Interleukin-17A Promotes Arginase-1 Production and 2,4-Dinitrochlorobenzene-Induced Acute Hyperinflammation in Human Papillomavirus E7 Oncoprotein-Expressing Skin.

J Innate Immun 2015 14;7(4):392-404. Epub 2015 Feb 14.

The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Qld., Australia.

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http://dx.doi.org/10.1159/000374115DOI Listing
March 2016

A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16(INK4a) expression in head and neck squamous cell carcinoma patients.

BMC Cancer 2016 Mar 3;16:178. Epub 2016 Mar 3.

The School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD, Australia.

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http://dx.doi.org/10.1186/s12885-016-2217-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778285PMC
March 2016

Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?

Int J Cancer 2016 Jan 5;138(2):281-92. Epub 2015 Feb 5.

The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD.

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http://dx.doi.org/10.1002/ijc.29450DOI Listing
January 2016

The kinematics of cytotoxic lymphocytes influence their ability to kill target cells.

PLoS One 2014 6;9(5):e95248. Epub 2014 May 6.

The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095248PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011687PMC
October 2015

The actinic keratosis virome: can we prevent squamous cell carcinoma with a vaccine?

Authors:
Ian H Frazer

Curr Probl Dermatol 2015 18;46:28-35. Epub 2014 Dec 18.

The University of Queensland Diamantina Institute, Brisbane, Qld., Australia.

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http://dx.doi.org/10.1159/000366532DOI Listing
September 2015

HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions.

Immunol Cell Biol 2015 Jul 20;93(6):540-7. Epub 2015 Jan 20.

The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/icb.2014.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496302PMC
July 2015

Microprojection arrays to immunise at mucosal surfaces.

J Control Release 2014 Dec 5;196:252-60. Epub 2014 Oct 5.

The University of Queensland, Delivery of Drugs and Genes Group (D(2)G(2)), The Australian Institute for Bioengineering and Nanotechnology, St Lucia, QLD 4072, Australia; Vaxxas Pty Ltd, Australian Institute for Bioengineering and Nanotechnology, Brisbane, Queensland, Australia; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.09.028DOI Listing
December 2014

CXCL1 gene silencing in skin using liposome-encapsulated siRNA delivered by microprojection array.

J Control Release 2014 Nov 1;194:148-56. Epub 2014 Sep 1.

Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, QLD 4072, Australia; University of Queensland Diamantina Institute, Woolloongabba, QLD 4102, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.08.021DOI Listing
November 2014

IL-18, but not IL-12, induces production of IFN-γ in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin.

J Invest Dermatol 2014 Oct 22;134(10):2562-2569. Epub 2014 Apr 22.

The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/jid.2014.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165718PMC
October 2014

HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells.

PLoS Pathog 2014 Oct 23;10(10):e1004466. Epub 2014 Oct 23.

Division of Human Immunology, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1004466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207828PMC
October 2014

Colocalization of cell death with antigen deposition in skin enhances vaccine immunogenicity.

J Invest Dermatol 2014 Sep 8;134(9):2361-2370. Epub 2014 Apr 8.

D2G2, The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia; The University of Queensland, Diamantina Institute for Cancer, Brisbane, Queensland, Australia; Faculty of Medicine and Biomedical Sciences, The University of Queensland, Centre for Clinical Research, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153698
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http://dx.doi.org/10.1038/jid.2014.174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216316PMC
September 2014

IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia.

J Immunol 2014 Sep 25;193(5):2248-57. Epub 2014 Jul 25.

University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia; and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4102, Australia.

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http://dx.doi.org/10.4049/jimmunol.1400216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135400PMC
September 2014

Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4.

Eur J Immunol 2014 May 7;44(5):1480-90. Epub 2014 Mar 7.

The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1002/eji.201343959DOI Listing
May 2014

Development and implementation of papillomavirus prophylactic vaccines.

Authors:
Ian H Frazer

J Immunol 2014 May;192(9):4007-11

University of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland 4102, Australia.

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http://dx.doi.org/10.4049/jimmunol.1490012DOI Listing
May 2014

The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals.

Eur J Immunol 2014 Feb 16;44(2):409-19. Epub 2013 Dec 16.

Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia; Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1002/eji.201243109DOI Listing
February 2014

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein e7.

J Invest Dermatol 2013 Dec 7;133(12):2686-2694. Epub 2013 May 7.

The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779505PMC
December 2013

Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes.

PLoS One 2013 26;8(2):e57798. Epub 2013 Feb 26.

The University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057798PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582605PMC
August 2013

A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin.

J Immunol 2012 Dec 9;189(12):5622-31. Epub 2012 Nov 9.

University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.

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http://dx.doi.org/10.4049/jimmunol.1200709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518562PMC
December 2012

γδ T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen.

J Invest Dermatol 2012 Jun 23;132(6):1656-64. Epub 2012 Feb 23.

The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1535782
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http://dx.doi.org/10.1038/jid.2012.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352982PMC
June 2012

Prevalence of cervical human papillomavirus (HPV) infection in Vanuatu.

Cancer Prev Res (Phila) 2012 May 16;5(5):746-53. Epub 2012 Mar 16.

Department of Public Health, Ministry of Health, Port Vila, Efate, Vanuatu.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0515DOI Listing
May 2012

A randomized trial of immunotherapy for persistent genital warts.

Hum Vaccin Immunother 2012 May 1;8(5):623-9. Epub 2012 May 1.

Princess Alexandra Sexual Health, Princess Alexandra Hospital, Brisbane, QLD, Australia.

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http://dx.doi.org/10.4161/hv.19319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495719PMC
May 2012

Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses.

J Control Release 2012 Apr 28;159(2):215-21. Epub 2012 Jan 28.

The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.jconrel.2012.01.030DOI Listing
April 2012

Diamantina Health Partners: integrating leadership in research, research translation, education and clinical care.

Med J Aust 2012 Mar;196(4):237-9

Southside Clinical School, School of Medicine, University of Queensland, Brisbane, QLD.

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http://dx.doi.org/10.5694/mja11.11251DOI Listing
March 2012

Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin.

J Control Release 2012 Feb 29;158(1):78-84. Epub 2011 Oct 29.

The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.jconrel.2011.10.026DOI Listing
February 2012

New gene functions in megakaryopoiesis and platelet formation.

Authors:
Christian Gieger Aparna Radhakrishnan Ana Cvejic Weihong Tang Eleonora Porcu Giorgio Pistis Jovana Serbanovic-Canic Ulrich Elling Alison H Goodall Yann Labrune Lorna M Lopez Reedik Mägi Stuart Meacham Yukinori Okada Nicola Pirastu Rossella Sorice Alexander Teumer Katrin Voss Weihua Zhang Ramiro Ramirez-Solis Joshua C Bis David Ellinghaus Martin Gögele Jouke-Jan Hottenga Claudia Langenberg Peter Kovacs Paul F O'Reilly So-Youn Shin Tõnu Esko Jaana Hartiala Stavroula Kanoni Federico Murgia Afshin Parsa Jonathan Stephens Pim van der Harst C Ellen van der Schoot Hooman Allayee Antony Attwood Beverley Balkau François Bastardot Saonli Basu Sebastian E Baumeister Ginevra Biino Lorenzo Bomba Amélie Bonnefond François Cambien John C Chambers Francesco Cucca Pio D'Adamo Gail Davies Rudolf A de Boer Eco J C de Geus Angela Döring Paul Elliott Jeanette Erdmann David M Evans Mario Falchi Wei Feng Aaron R Folsom Ian H Frazer Quince D Gibson Nicole L Glazer Chris Hammond Anna-Liisa Hartikainen Susan R Heckbert Christian Hengstenberg Micha Hersch Thomas Illig Ruth J F Loos Jennifer Jolley Kay Tee Khaw Brigitte Kühnel Marie-Christine Kyrtsonis Vasiliki Lagou Heather Lloyd-Jones Thomas Lumley Massimo Mangino Andrea Maschio Irene Mateo Leach Barbara McKnight Yasin Memari Braxton D Mitchell Grant W Montgomery Yusuke Nakamura Matthias Nauck Gerjan Navis Ute Nöthlings Ilja M Nolte David J Porteous Anneli Pouta Peter P Pramstaller Janne Pullat Susan M Ring Jerome I Rotter Daniela Ruggiero Aimo Ruokonen Cinzia Sala Nilesh J Samani Jennifer Sambrook David Schlessinger Stefan Schreiber Heribert Schunkert James Scott Nicholas L Smith Harold Snieder John M Starr Michael Stumvoll Atsushi Takahashi W H Wilson Tang Kent Taylor Albert Tenesa Swee Lay Thein Anke Tönjes Manuela Uda Sheila Ulivi Dirk J van Veldhuisen Peter M Visscher Uwe Völker H-Erich Wichmann Kerri L Wiggins Gonneke Willemsen Tsun-Po Yang Jing Hua Zhao Paavo Zitting John R Bradley George V Dedoussis Paolo Gasparini Stanley L Hazen Andres Metspalu Mario Pirastu Alan R Shuldiner L Joost van Pelt Jaap-Jan Zwaginga Dorret I Boomsma Ian J Deary Andre Franke Philippe Froguel Santhi K Ganesh Marjo-Riitta Jarvelin Nicholas G Martin Christa Meisinger Bruce M Psaty Timothy D Spector Nicholas J Wareham Jan-Willem N Akkerman Marina Ciullo Panos Deloukas Andreas Greinacher Steve Jupe Naoyuki Kamatani Jyoti Khadake Jaspal S Kooner Josef Penninger Inga Prokopenko Derek Stemple Daniela Toniolo Lorenz Wernisch Serena Sanna Andrew A Hicks Augusto Rendon Manuel A Ferreira Willem H Ouwehand Nicole Soranzo

Nature 2011 Nov 30;480(7376):201-8. Epub 2011 Nov 30.

Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nature10659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335296PMC
November 2011

Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancer.

Curr Opin Virol 2011 Oct;1(4):268-79

Translational Research Institute, The University of Queensland Diamantina Institute, PO Box 6116, Buranda Queensland 4102, Australia.

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http://dx.doi.org/10.1016/j.coviro.2011.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185382PMC
October 2011

New Approaches to Immunotherapy for HPV Associated Cancers.

Cancers (Basel) 2011 Sep 2;3(3):3461-95. Epub 2011 Sep 2.

The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Qld 4102, Australia.

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http://dx.doi.org/10.3390/cancers3033461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759206PMC
September 2011

NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins.

J Immunol 2011 Aug 8;187(4):1601-8. Epub 2011 Jul 8.

University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.

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http://dx.doi.org/10.4049/jimmunol.1100756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150369PMC
August 2011

Prevention and treatment of papillomavirus-related cancers through immunization.

Annu Rev Immunol 2011 ;29:111-38

The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia.

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http://dx.doi.org/10.1146/annurev-immunol-031210-101308DOI Listing
June 2011

Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization.

J Control Release 2011 Jun 1;152(3):349-55. Epub 2011 Mar 1.

The University of Queensland, Delivery of Drugs and Genes Group (D(2)G(2)), Australian Institute for Bioengineering and Nanotechnology, Brisbane.

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http://dx.doi.org/10.1016/j.jconrel.2011.02.026DOI Listing
June 2011

Human papillomavirus 16 E7 protein inhibits interferon-γ-mediated enhancement of keratinocyte antigen processing and T-cell lysis.

FEBS J 2011 Apr 5;278(6):955-63. Epub 2011 Feb 5.

The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1111/j.1742-4658.2011.08011.xDOI Listing
April 2011

Regulation of immune responses to HPV infection and during HPV-directed immunotherapy.

Immunol Rev 2011 Jan;239(1):85-98

The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia.

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http://dx.doi.org/10.1111/j.1600-065X.2010.00966.xDOI Listing
January 2011

Evaluation of a cervical cancer screening program based on HPV testing and LLETZ excision in a low resource setting.

PLoS One 2010 Oct 7;5(10):e13266. Epub 2010 Oct 7.

The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951361PMC
October 2010

Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model.

PLoS One 2010 Oct 18;5(10):e13460. Epub 2010 Oct 18.

Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013460PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956639PMC
October 2010

Cervical cancer vaccine development.

Authors:
Ian H Frazer

Sex Health 2010 Sep;7(3):230-4

The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Qld 4102, Australia.

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http://dx.doi.org/10.1071/SH09132DOI Listing
September 2010

IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes.

Exp Dermatol 2010 Aug;19(8):723-9

The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Qld, Australia.

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http://dx.doi.org/10.1111/j.1600-0625.2010.01092.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921627PMC
August 2010

Antigen-specific CD8 T cells can eliminate antigen-bearing keratinocytes with clonogenic potential via an IFN-gamma-dependent mechanism.

J Invest Dermatol 2010 Jul 18;130(7):1841-8. Epub 2010 Mar 18.

The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/jid.2010.49DOI Listing
July 2010

Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes.

J Invest Dermatol 2010 Jun 11;130(6):1581-9. Epub 2010 Feb 11.

Immunology and Metabolic Medicine, The University of Queensland Diamantina Institute for Cancer, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/jid.2010.17DOI Listing
June 2010

Measuring serum antibody to human papillomavirus following infection or vaccination.

Authors:
Ian H Frazer

Gynecol Oncol 2010 Jun;118(1 Suppl):S8-11

The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1016/j.ygyno.2010.04.003DOI Listing
June 2010

The two faces of human papillomavirus.

Authors:
Ian H Frazer

Gynecol Oncol 2010 May 27;117(2 Suppl):S4. Epub 2010 Jan 27.

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http://dx.doi.org/10.1016/j.ygyno.2010.01.023DOI Listing
May 2010

Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen.

J Immunol 2010 May 21;184(10):5663-9. Epub 2010 Apr 21.

The University of Queensland Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0903730
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http://dx.doi.org/10.4049/jimmunol.0903730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921625PMC
May 2010

Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model.

PLoS One 2010 Apr 21;5(4):e10266. Epub 2010 Apr 21.

Delivery of Drugs and Genes Group, Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858085PMC
April 2010

Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes.

Virology 2010 Mar 20;399(1):46-58. Epub 2010 Jan 20.

Diamantina Institute for Cancer Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia; University of Queensland Centre for Clinical Research, The University of Queensland, Royal Brisbane & Women's Hospital Campus, Herston, Queensland 4029, Australia; Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland 4029, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2009.12.021DOI Listing
March 2010

Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production.

J Immunol 2010 Feb 18;184(3):1242-50. Epub 2009 Dec 18.

The University of Queensland Diamantina Institute, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

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http://dx.doi.org/10.4049/jimmunol.0902191DOI Listing
February 2010

Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis.

Exp Dermatol 2009 Dec;18(12):1053-9

The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1111/j.1600-0625.2009.00907.xDOI Listing
December 2009

Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin.

J Control Release 2009 Nov 3;139(3):212-20. Epub 2009 Jul 3.

Delivery of Drugs and Genes Group (D(2)G(2)), Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.jconrel.2009.06.029DOI Listing
November 2009

Development of therapeutic HPV vaccines.

Lancet Oncol 2009 Oct;10(10):975-80

Johns Hopkins University Hospital, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/S1470-2045(09)70227-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090037PMC
October 2009

IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host.

J Immunol 2009 Jul 17;183(1):51-8. Epub 2009 Jun 17.

University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia.

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http://dx.doi.org/10.4049/jimmunol.0802047DOI Listing
July 2009

Interaction of human papillomaviruses with the host immune system: a well evolved relationship.

Authors:
Ian H Frazer

Virology 2009 Feb 4;384(2):410-4. Epub 2008 Nov 4.

The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.virol.2008.10.004DOI Listing
February 2009

Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4+CD25+ T cells.

Eur J Immunol 2009 Feb;39(2):481-90

Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1002/eji.200838527DOI Listing
February 2009

Up-regulated expression of Sp1 protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation marker.

Differentiation 2008 Dec 30;76(10):1068-80. Epub 2008 Jul 30.

Diamantina Institute for Cancer Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.

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http://dx.doi.org/10.1111/j.1432-0436.2008.00300.xDOI Listing
December 2008

Autoimmunity and persistent viral infection: two sides of the same coin?

Authors:
Ian H Frazer

J Autoimmun 2008 Nov 27;31(3):216-8. Epub 2008 May 27.

Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Queensland 4102, Australia.

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http://dx.doi.org/10.1016/j.jaut.2008.04.014DOI Listing
November 2008

TLR7 stimulation augments T effector-mediated rejection of skin expressing neo-self antigen in keratinocytes.

Eur J Immunol 2008 Jan;38(1):73-81

Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.

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http://doi.wiley.com/10.1002/eji.200737599
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http://dx.doi.org/10.1002/eji.200737599DOI Listing
January 2008

Prevention of cancer through immunization: Prospects and challenges for the 21st century.

Eur J Immunol 2007 Nov;37 Suppl 1:S148-55

Diamantina Institute for Cancer Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

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http://dx.doi.org/10.1002/eji.200737820DOI Listing
November 2007

HPV immunisation: a significant advance in cancer control.

Authors:
Ian H Frazer

Gynecol Oncol 2007 Nov;107(2 Suppl 1):S1

Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S009082580700568
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http://dx.doi.org/10.1016/j.ygyno.2007.07.071DOI Listing
November 2007

Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation.

Nucleic Acids Res 2007 9;35(14):4820-32. Epub 2007 Jul 9.

Diamantina Institute for Cancer, Immunology & Metabolic Medicine, The University of Queensland, Research Extension, Building 1, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia.

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http://dx.doi.org/10.1093/nar/gkm496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950544PMC
September 2007