Publications by authors named "Ian G Young"

20Publications

Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation.

Authors:
Paul D Carr Cameron L Ewens Jin Dai David L Ollis James M Murphy Colin J Jackson Ian G Young

Biochem J 2014 Nov;463(3):393-403

†John Curtin School of Medical Research, Australian National University, Acton 0200, Australia.

View Article and Find Full Text PDF
November 2014

Identification of microRNAs regulating the developmental pathways of bone marrow derived mast cells.

Authors:
Yang Xiang Fiona Eyers Ian G Young Helene F Rosenberg Paul S Foster Ming Yang

PLoS One 2014 21;9(5):e98139. Epub 2014 May 21.

Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia.

View Article and Find Full Text PDF
January 2015

Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between microRNAs and their target mRNAs.

Authors:
Ming Yang Fiona Eyers Yang Xiang Man Guo Ian G Young Helene F Rosenberg Paul S Foster

PLoS One 2014 13;9(5):e97537. Epub 2014 May 13.

Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia.

View Article and Find Full Text PDF
June 2015

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties.

Authors:
Timothy R Hercus Emma F Barry Mara Dottore Barbara J McClure Andrew I Webb Angel F Lopez Ian G Young James M Murphy

PLoS One 2013 26;8(8):e74376. Epub 2013 Aug 26.

Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia.

View Article and Find Full Text PDF
June 2014

Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution.

Authors:
Shenggen Yao Ian G Young Raymond S Norton James M Murphy

Biochemistry 2011 Apr 2;50(13):2464-77. Epub 2011 Mar 2.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

View Article and Find Full Text PDF
April 2011

The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.

Authors:
Shamaruh Mirza Jinglong Chen James M Murphy Ian G Young

J Biol Chem 2010 Aug 1;285(32):24759-68. Epub 2010 Jun 1.

Department of Structural Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

View Article and Find Full Text PDF
August 2010

Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.

Authors:
Shamaruh Mirza Jinglong Chen Bin Wen Cameron L Ewens Jin Dai James M Murphy Ian G Young

J Biol Chem 2010 Jul 14;285(29):22370-81. Epub 2010 May 14.

Department of Structural Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

View Article and Find Full Text PDF
July 2010

The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation.

Authors:
Shamaruh Mirza Andrew Walker Jinglong Chen James M Murphy Ian G Young

Biochem J 2010 Feb 24;426(3):307-17. Epub 2010 Feb 24.

Structural Biology Program, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.

View Article and Find Full Text PDF
February 2010

A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity.

Authors:
James M Murphy Donald Metcalf Ian G Young Douglas J Hilton

Growth Factors 2010 Apr;28(2):104-10

Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

View Article and Find Full Text PDF
April 2010

A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode.

Authors:
Jinglong Chen Jane Olsen Sally Ford Shamaruh Mirza Andrew Walker James M Murphy Ian G Young

J Biol Chem 2009 Feb 24;284(9):5763-73. Epub 2008 Dec 24.

Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia

View Article and Find Full Text PDF
February 2009

Clarification of the role of N-glycans on the common beta-subunit of the human IL-3, IL-5 and GM-CSF receptors and the murine IL-3 beta-receptor in ligand-binding and receptor activation.

Authors:
James M Murphy Tatiana A Soboleva Shamaruh Mirza Sally C Ford Jane E Olsen Jinglong Chen Ian G Young

Cytokine 2008 May 18;42(2):234-242. Epub 2008 Apr 18.

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia. Electronic address:

View Article and Find Full Text PDF
May 2008

Expression and evolution of the mammalian brain gene Ttyh1.

Authors:
Clayton A Matthews John E Shaw Jane A Hooper Ian G Young Michael F Crouch Hugh D Campbell

J Neurochem 2007 Feb 20;100(3):693-707. Epub 2006 Nov 20.

Molecular Genetics and Evolution Group and Centre for the Molecular Genetics of Development, Research School of Biological Sciences, Australian National University, Canberra, Australian Capital Territory, Australia.

View Article and Find Full Text PDF
February 2007

IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor.

Authors:
James M Murphy Ian G Young

Vitam Horm 2006 ;74:1-30

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia 0200.

View Article and Find Full Text PDF
December 2006

A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes.

Authors:
Jun Wang M Frances Shannon Ian G Young

Int Immunol 2006 Feb 22;18(2):313-23. Epub 2005 Dec 22.

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Mills Road, Acton, ACT 0200 Australia.

View Article and Find Full Text PDF
February 2006

Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.

Authors:
James M Murphy Sally C Ford Jane E Olsen Sonja E Gustin Peter D Jeffrey David L Ollis Ian G Young

J Biol Chem 2004 Jun 1;279(25):26500-8. Epub 2004 Apr 1.

Division of Molecular Bioscience, John Curtin School of Medical Research and Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.

View Article and Find Full Text PDF
June 2004

Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity.

Authors:
Ming Yang Simon P Hogan Surendran Mahalingam Sam M Pope Nives Zimmermann Patricia Fulkerson Lindsay A Dent Ian G Young Klaus I Matthaei Marc E Rothenberg Paul S Foster

J Allergy Clin Immunol 2003 Nov;112(5):935-43

Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT.

View Article and Find Full Text PDF
November 2003

A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5.

Authors:
James M Murphy Sally C Ford Ursula M Wiedemann Paul D Carr David L Ollis Ian G Young

J Biol Chem 2003 Mar 12;278(12):10572-7. Epub 2003 Jan 12.

Division of Molecular Bioscience, John Curtin School of Medical Research and the Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.

View Article and Find Full Text PDF
March 2003

Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma.

Authors:
Joerg Mattes Ming Yang Surendran Mahalingam Joachim Kuehr Dianne C Webb Ljubov Simson Simon P Hogan Aulikki Koskinen Andrew N J McKenzie Lindsay A Dent Marc E Rothenberg Klaus I Matthaei Ian G Young Paul S Foster

J Exp Med 2002 Jun;195(11):1433-44

Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.

View Article and Find Full Text PDF
June 2002

Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development.

Authors:
Hugh D Campbell Shelley Fountain Ian S McLennan Leise A Berven Michael F Crouch Deborah A Davy Jane A Hooper Kynan Waterford Ken-Shiung Chen James R Lupski Birgit Ledermann Ian G Young Klaus I Matthaei

Mol Cell Biol 2002 May;22(10):3518-26

Molecular Genetics and Evolution Group, Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia.

View Article and Find Full Text PDF
May 2002

Interleukin-5 and eosinophils as therapeutic targets for asthma.

Authors:
Paul S Foster Simon P Hogan Ming Yang Joerg Mattes Ian G Young Klaus I Matthaei Rakesh K Kumar Surendran Mahalingam Dianne C Webb

Trends Mol Med 2002 Apr;8(4):162-7

Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia.

View Article and Find Full Text PDF
April 2002