Publications by authors named "Ian G Young"

20Publications

Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation.

Biochem J 2014 Nov;463(3):393-403

†John Curtin School of Medical Research, Australian National University, Acton 0200, Australia.

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November 2014

Identification of microRNAs regulating the developmental pathways of bone marrow derived mast cells.

PLoS One 2014 21;9(5):e98139. Epub 2014 May 21.

Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia.

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January 2015

Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between microRNAs and their target mRNAs.

PLoS One 2014 13;9(5):e97537. Epub 2014 May 13.

Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia.

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June 2015

Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution.

Biochemistry 2011 Apr 2;50(13):2464-77. Epub 2011 Mar 2.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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April 2011

The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.

J Biol Chem 2010 Aug 1;285(32):24759-68. Epub 2010 Jun 1.

Department of Structural Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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August 2010

Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.

J Biol Chem 2010 Jul 14;285(29):22370-81. Epub 2010 May 14.

Department of Structural Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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July 2010

The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation.

Biochem J 2010 Feb 24;426(3):307-17. Epub 2010 Feb 24.

Structural Biology Program, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.

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February 2010

A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity.

Growth Factors 2010 Apr;28(2):104-10

Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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April 2010

A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode.

J Biol Chem 2009 Feb 24;284(9):5763-73. Epub 2008 Dec 24.

Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia

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February 2009

Clarification of the role of N-glycans on the common beta-subunit of the human IL-3, IL-5 and GM-CSF receptors and the murine IL-3 beta-receptor in ligand-binding and receptor activation.

Cytokine 2008 May 18;42(2):234-242. Epub 2008 Apr 18.

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia. Electronic address:

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May 2008

Expression and evolution of the mammalian brain gene Ttyh1.

J Neurochem 2007 Feb 20;100(3):693-707. Epub 2006 Nov 20.

Molecular Genetics and Evolution Group and Centre for the Molecular Genetics of Development, Research School of Biological Sciences, Australian National University, Canberra, Australian Capital Territory, Australia.

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February 2007

IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor.

Vitam Horm 2006 ;74:1-30

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia 0200.

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December 2006

A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes.

Int Immunol 2006 Feb 22;18(2):313-23. Epub 2005 Dec 22.

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Mills Road, Acton, ACT 0200 Australia.

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February 2006

Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.

J Biol Chem 2004 Jun 1;279(25):26500-8. Epub 2004 Apr 1.

Division of Molecular Bioscience, John Curtin School of Medical Research and Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.

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June 2004

Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity.

J Allergy Clin Immunol 2003 Nov;112(5):935-43

Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT.

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November 2003

A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5.

J Biol Chem 2003 Mar 12;278(12):10572-7. Epub 2003 Jan 12.

Division of Molecular Bioscience, John Curtin School of Medical Research and the Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.

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March 2003

Interleukin-5 and eosinophils as therapeutic targets for asthma.

Trends Mol Med 2002 Apr;8(4):162-7

Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia.

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April 2002