Ian E Alexander

Ian E Alexander

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Ian E Alexander

Ian E Alexander

Publications by authors named "Ian E Alexander"

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Efficient editing of OTC-deficient patient-derived primary human hepatocytes.

JHEP Rep 2020 Feb 27;2(1):100065. Epub 2019 Dec 27.

Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia.

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http://dx.doi.org/10.1016/j.jhepr.2019.100065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005564PMC
February 2020

Prevention of Cholestatic Liver Disease and Reduced Tumorigenicity in a Murine Model of PFIC Type 3 Using Hybrid AAV-piggyBac Gene Therapy.

Hepatology 2019 Dec 26;70(6):2047-2061. Epub 2019 Jun 26.

Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia.

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http://dx.doi.org/10.1002/hep.30773DOI Listing
December 2019

A User's Guide to the Inverted Terminal Repeats of Adeno-Associated Virus.

Hum Gene Ther Methods 2019 Dec;30(6):206-213

Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, University of Sydney, Westmead, Australia.

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http://dx.doi.org/10.1089/hgtb.2019.276DOI Listing
December 2019

Insights into Gene Therapy for Urea Cycle Defects by Mathematical Modeling.

Hum Gene Ther 2019 11 17;30(11):1385-1394. Epub 2019 Jul 17.

Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health and Sydney Children's Hospitals Network, The University of Sydney, Westmead, Australia.

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http://dx.doi.org/10.1089/hum.2019.053DOI Listing
November 2019

The implementation of newborn screening for spinal muscular atrophy: the Australian experience.

Genet Med 2019 Oct 14. Epub 2019 Oct 14.

Department of Neurology, Sydney Children's Hospital, Randwick, Sydney, NSW, Australia.

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http://dx.doi.org/10.1038/s41436-019-0673-0DOI Listing
October 2019

AAV-Mediated Gene Delivery to the Mouse Liver.

Methods Mol Biol 2019 ;1937:213-219

Gene Therapy Research Unit, Children's Medical Research Institute, The University of Sydney, Faculty of Medicine and Health and Sydney Children's Hospitals Network, Westmead, NSW, Australia.

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http://dx.doi.org/10.1007/978-1-4939-9065-8_12DOI Listing
July 2019

Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort.

Hum Gene Ther 2019 01 19;30(1):79-87. Epub 2018 Oct 19.

1 Genetics and Genomic Medicine Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

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http://www.liebertpub.com/doi/10.1089/hum.2018.098
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http://dx.doi.org/10.1089/hum.2018.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343184PMC
January 2019

Thymocyte self-renewal and oncogenic risk in immunodeficient mouse models: relevance for human gene therapy clinical trials targeting haematopoietic stem cell populations?

Mamm Genome 2018 12 4;29(11-12):771-776. Epub 2018 Sep 4.

Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Locked Bag 2023, Wentworthville, NSW, 2145, Australia.

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http://dx.doi.org/10.1007/s00335-018-9780-5DOI Listing
December 2018

Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain Tumors.

Hum Gene Ther 2018 08 23;29(8):874-885. Epub 2018 Mar 23.

4 Children's Cancer Centre, The Children's Hospital at Westmead, Westmead, Australia.

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http://dx.doi.org/10.1089/hum.2017.235DOI Listing
August 2018

Gene therapy clinical trials worldwide to 2017: An update.

J Gene Med 2018 05 19;20(5):e3015. Epub 2018 Apr 19.

Department of Laboratory Medicine, Uppsala University Hospital, Uppsala, Sweden.

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http://doi.wiley.com/10.1002/jgm.3015
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http://dx.doi.org/10.1002/jgm.3015DOI Listing
May 2018

Partial pancreatic transdifferentiation of primary human hepatocytes in the livers of a humanised mouse model.

J Gene Med 2018 05 16;20(5):e3017. Epub 2018 Apr 16.

School of Life Sciences, University of Technology Sydney, Sydney, Australia.

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http://dx.doi.org/10.1002/jgm.3017DOI Listing
May 2018

Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.

Heart Lung Circ 2018 Jan 21;27(1):114-121. Epub 2017 Mar 21.

Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; Westmead Institute for Medical Research, Sydney, NSW, Australia; The University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/j.hlc.2017.02.010DOI Listing
January 2018

Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Nat Genet 2017 Aug 19;49(8):1267-1273. Epub 2017 Jun 19.

Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/ng.3893DOI Listing
August 2017

Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.

J Inherit Metab Dis 2017 07 31;40(4):497-517. Epub 2017 May 31.

Genetics and Genomic Medicine Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1007/s10545-017-0053-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500673PMC
July 2017

Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data.

BMC Bioinformatics 2017 Jun 17;18(1):305. Epub 2017 Jun 17.

Children's Cancer Research Unit, Kids' Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.

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http://dx.doi.org/10.1186/s12859-017-1719-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474025PMC
June 2017

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency.

Mol Ther Nucleic Acids 2017 Mar 10;6:1-14. Epub 2016 Dec 10.

Gene Therapy Research Unit, Children's Medical Research Institute, The University of Sydney and The Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia; Discipline of Child and Adolescent Health, The University of Sydney, Westmead, NSW 2145, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2016.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363493PMC
March 2017

Methyl-Guanine-Methyl-Transferase Transgenic Bone Marrow Transplantation Allows N,N-bis(2-chloroethyl)-Nitrosourea Driven Donor Mixed-Chimerism Without Graft-Versus-Host Disease, and With Donor-Specific Allograft Tolerance.

Transplantation 2015 Dec;99(12):2476-84

1 Centre for Kidney Research, The Children's Hospital at Westmead, University of Sydney, NSW, Australia. 2 Centre for Transplant and Renal Research, Westmead Millennium Institute for Medical Research, University of Sydney, NSW, Australia. 3 Children's Cancer Research Unit, The Children's Hospital at Westmead, University of Sydney, NSW, Australia. 4 Centre for Medical and Molecular Bioscience, University of Wollongong, NSW, Australia. 5 Australia Microsurgical Consultants, Melbourne, VIC, Australia. 6 Gene Therapy Research Unit, The Children's Hospital at Westmead and Children's Medical Research Institute, University of Sydney, NSW, Australia. 7 Oncology Research Unit, School of Medical Science, University of New South Wales, NSW Australia.

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http://dx.doi.org/10.1097/TP.0000000000000825DOI Listing
December 2015

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice.

Mol Ther 2015 Sep 25;23(9):1434-43. Epub 2015 May 25.

Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1038/mt.2015.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817885PMC
September 2015

Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system.

Hepatology 2015 Aug 23;62(2):417-28. Epub 2015 May 23.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1002/hep.27842DOI Listing
August 2015

Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions.

Mol Ther Methods Clin Dev 2015 29;2:15015. Epub 2015 Apr 29.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead , Westmead, Australia ; The University of Sydney, Discipline of Paediatrics and Child Health , Westmead, Australia.

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http://dx.doi.org/10.1038/mtm.2015.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445430PMC
June 2015

Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs.

Cell Stem Cell 2015 Apr 12;16(4):367-72. Epub 2015 Mar 12.

The Salk Institute of Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545662PMC
April 2015

Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence.

Nucleic Acids Res 2014 10;42(16):e129. Epub 2014 Jul 10.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1093/nar/gku607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176369PMC
January 2015

A genome-wide map of adeno-associated virus-mediated human gene targeting.

Nat Struct Mol Biol 2014 Nov 5;21(11):969-75. Epub 2014 Oct 5.

1] Department of Medicine, University of Washington, Seattle, Washington, USA. [2] Department of Biochemistry, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nsmb.2895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405182PMC
November 2014

Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease.

Int J Biochem Cell Biol 2014 Nov 27;56:141-52. Epub 2014 Oct 27.

The Centre for Medical Research, Harry Perkins Institute of Medical Research, Crawley, WA 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.10.023DOI Listing
November 2014

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

J Immunol 2014 Sep 28;193(5):2087-95. Epub 2014 Jul 28.

Centenary Institute and University of Sydney, Newtown, New South Wales 2042, Australia; AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital/University of Sydney, Camperdown, New South Wales 2050, Australia; Collaborative Transplantation Research Group, Bosch Institute, Royal Prince Alfred Hospital/University of Sydney, Camperdown, New South Wales 2006, Australia

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http://dx.doi.org/10.4049/jimmunol.1400037DOI Listing
September 2014

Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses.

Proc Natl Acad Sci U S A 2014 Jun 10;111(25):E2540-9. Epub 2014 Jun 10.

Liver Immunology Group and AW Morrow Gastroenterology and Liver Centre, Centenary Institute, Royal Prince Alfred Hospital and University of Sydney, Newtown, NSW 2042, Australia;Collaborative Transplantation Research Group, Bosch Institute, Royal Prince Alfred Hospital and University of Sydney, Newtown, NSW 2042, Australia;

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http://dx.doi.org/10.1073/pnas.1406674111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078818PMC
June 2014

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model.

Nature 2014 Feb 25;506(7488):382-6. Epub 2013 Dec 25.

Stanford University, School of Medicine, Departments of Pediatrics and Genetics, 269 Campus Drive, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature12875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939040PMC
February 2014

The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.

Cell Stem Cell 2014 Jan 17;14(1):107-20. Epub 2013 Oct 17.

Embryology Unit, Children's Medical Research Institute, Westmead NSW 2145, Australia; Sydney Medical School, University of Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2013.09.014DOI Listing
January 2014

Adeno-associated virus-mediated rescue of neonatal lethality in argininosuccinate synthetase-deficient mice.

Mol Ther 2013 Oct 2;21(10):1823-31. Epub 2013 Jul 2.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Sydney, Australia.

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http://dx.doi.org/10.1038/mt.2013.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808136PMC
October 2013

Gene therapy researchers' assessments of risks and perceptions of risk acceptability in clinical trials.

Mol Ther 2013 Apr 22;21(4):806-15. Epub 2013 Jan 22.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1038/mt.2012.230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616541PMC
April 2013

Gene therapy clinical trials worldwide to 2012 - an update.

J Gene Med 2013 Feb;15(2):65-77

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, NSW, Australia.

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http://dx.doi.org/10.1002/jgm.2698DOI Listing
February 2013

Mitochondrial respiratory chain hepatopathies: role of liver transplantation. A case series of five patients.

JIMD Rep 2012 4;4:5-11. Epub 2011 Nov 4.

Department of Gastroenterology, The Children's Hospital at Westmead (CHW), Hawkesbury Road, Locked Bag 4001, Westmead, 2145, NSW, Australia.

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http://dx.doi.org/10.1007/8904_2011_29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509872PMC
February 2013

Adeno-associated virus vectors: immunobiology and potential use for immune modulation.

Curr Gene Ther 2012 Aug;12(4):333-43

Gene Therapy Research Unit, Children's Medical Research Institute, Wentworthville, NSW, Sydney, Australia.

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http://dx.doi.org/10.2174/156652312802083639DOI Listing
August 2012

Gene therapy for metabolic disorders: an overview with a focus on urea cycle disorders.

J Inherit Metab Dis 2012 Jul 9;35(4):641-5. Epub 2012 Mar 9.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.

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http://dx.doi.org/10.1007/s10545-012-9467-0DOI Listing
July 2012

Gene therapy: progress in childhood disease.

J Paediatr Child Health 2012 Jun 21;48(6):466-71. Epub 2011 Oct 21.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Australia.

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http://doi.wiley.com/10.1111/j.1440-1754.2011.02204.x
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http://dx.doi.org/10.1111/j.1440-1754.2011.02204.xDOI Listing
June 2012

Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery.

Mol Ther 2011 May 8;19(5):854-9. Epub 2011 Mar 8.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, New South Wales, Australia.

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http://dx.doi.org/10.1038/mt.2011.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098641PMC
May 2011

The ethics of gene therapy: balancing the risks.

Curr Opin Mol Ther 2010 Oct;12(5):578-85

Children's Medical Research Institute, Gene Therapy Research Unit, 214 Hawkesbury Road, Australia.

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October 2010

Liver-directed gene expression using recombinant AAV 2/8 vectors--a tolerogenic strategy for gene delivery?

Discov Med 2010 Jun;9(49):519-27

Transplantation Research Group, Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia.

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June 2010

Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression.

Mol Ther 2010 May 30;18(5):965-76. Epub 2010 Mar 30.

Gene Therapy Research Unit of the Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1038/mt.2010.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890120PMC
May 2010

Antigen fusion with C3d3 augments or inhibits humoral immunity to AAV genetic vaccines in a transgene-dependent manner.

Immunol Cell Biol 2010 Feb 24;88(2):228-32. Epub 2009 Nov 24.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital, Westmead, Australia.

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http://dx.doi.org/10.1038/icb.2009.92DOI Listing
February 2010

Accepting risk in clinical research: is the gene therapy field becoming too risk-averse?

Mol Ther 2009 Nov 22;17(11):1842-8. Epub 2009 Sep 22.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S152500161630795
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http://dx.doi.org/10.1038/mt.2009.223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835028PMC
November 2009

Sexually dimorphic patterns of episomal rAAV genome persistence in the adult mouse liver and correlation with hepatocellular proliferation.

Mol Ther 2009 Sep 30;17(9):1548-54. Epub 2009 Jun 30.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1038/mt.2009.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835267PMC
September 2009

AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice.

Mol Ther 2009 Aug 21;17(8):1340-6. Epub 2009 Apr 21.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, New South Wales, Australia.

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http://search.proquest.com/openview/5b0c9b2174ddd97076d4e18f
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http://www.nature.com/doifinder/10.1038/mt.2009.88
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http://dx.doi.org/10.1038/mt.2009.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835243PMC
August 2009

Gene therapy in transplantation.

Transplant Rev (Orlando) 2009 Jul 9;23(3):159-70. Epub 2009 May 9.

Collaborative Transplantation Research Group, Bosch Insitute, Royal Prince Alfred Hospital and University of Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1016/j.trre.2009.04.001DOI Listing
July 2009

Gene delivery to the juvenile mouse liver using AAV2/8 vectors.

Mol Ther 2008 Jun 15;16(6):1081-8. Epub 2008 Apr 15.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, Westmead, Australia.

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http://dx.doi.org/10.1038/mt.2008.72DOI Listing
June 2008

Gene Delivery to the Juvenile Mouse Liver Using AAV2/8 Vectors.

Mol Ther 2008 Jun 8;16(6):1081-1088. Epub 2016 Dec 8.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, Westmead, Australia; Discipline of Paediatrics and Child Health, University of Sydney, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1038/mt.2008.72DOI Listing
June 2008

Developing strategies for detection of gene doping.

J Gene Med 2008 Jan;10(1):3-20

National Measurement Institute, 1 Suakin St, Pymble, NSW 2073, Australia.

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http://dx.doi.org/10.1002/jgm.1114DOI Listing
January 2008

Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression.

Cancer Immunol Immunother 2007 Dec 5;56(12):1955-65. Epub 2007 Jun 5.

Gene Therapy Research Unit, The Children's Hospital at Westmead and Children's Medical Research Institute, Westmead, NSW, Australia.

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http://link.springer.com/10.1007/s00262-007-0339-7
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http://dx.doi.org/10.1007/s00262-007-0339-7DOI Listing
December 2007

Potential use of gene transfer in athletic performance enhancement.

Mol Ther 2007 Oct 7;15(10):1751-66. Epub 2007 Aug 7.

National Measurement Institute, Pymble, New South Wales, Australia.

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http://dx.doi.org/10.1038/sj.mt.6300278DOI Listing
October 2007

Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors.

Blood 2007 Jul 15;110(1):91-8. Epub 2007 Mar 15.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Australia.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-11-05
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http://dx.doi.org/10.1182/blood-2006-11-055442DOI Listing
July 2007

Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy.

Circ Res 2007 Jun 10;100(11):1597-604. Epub 2007 May 10.

Gene Therapy Research Unit, The Children's Hospital at Westmead and Children's Medical Research Institute, Westmead, Australia.

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http://dx.doi.org/10.1161/CIRCRESAHA.106.144956DOI Listing
June 2007

Dystrophinopathy carrier determination and detection of protein deficiencies in muscular dystrophy using lentiviral MyoD-forced myogenesis.

Neuromuscul Disord 2007 Apr 15;17(4):276-84. Epub 2007 Feb 15.

Neurogenetics Research Unit and Institute for Neuromuscular Research, The Children's Hospital at Westmead, Locked Bag 4001, Sydney, NSW 2145, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S096089660600635
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http://dx.doi.org/10.1016/j.nmd.2006.12.010DOI Listing
April 2007

AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection.

Vaccine 2007 Jan 9;25(6):1014-22. Epub 2006 Oct 9.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, Australia.

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http://dx.doi.org/10.1016/j.vaccine.2006.09.072DOI Listing
January 2007

Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow.

J Gene Med 2006 Sep;8(9):1071-85

Oncology Research Unit, The Children's Hospital at Westmead, and Discipline of Paediatric and Child Health, University of Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/jgm.937DOI Listing
September 2006

Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin.

J Am Soc Nephrol 2006 Mar 8;17(3):697-706. Epub 2006 Feb 8.

Centre for Kidney Research, Children's Hospital at Westmead, and Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, New South Wales 2145, Sydney, Australia.

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http://dx.doi.org/10.1681/ASN.2005090978DOI Listing
March 2006

Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors.

Hum Gene Ther 2005 Aug;16(8):947-56

Gene Therapy Research Unit, The Children's Hospital at Westmead and Children's Medical Research Institute, Sydney, NSW, Australia.

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http://dx.doi.org/10.1089/hum.2005.16.947DOI Listing
August 2005

Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy.

Int Immunol 2005 Feb 27;17(2):123-32. Epub 2004 Dec 27.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Locked Bag 23, Wentworthville, NSW, 2145.

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https://academic.oup.com/intimm/article-lookup/doi/10.1093/i
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http://dx.doi.org/10.1093/intimm/dxh193DOI Listing
February 2005

A novel splice-site mutation in the common gamma chain (gammac) gene IL2RG results in X-linked severe combined immunodeficiency with an atypical NK+ phenotype.

Hum Mutat 2004 May;23(5):522-3

Gene Therapy Research Unit of the Children's Medical Research Institute and The Children's Hospital at Westmead, NSW, Australia.

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http://dx.doi.org/10.1002/humu.9235DOI Listing
May 2004

CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection.

Immunol Cell Biol 2004 Apr;82(2):132-5

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, NSW, Australia.

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http://dx.doi.org/10.1046/j.0818-9641.2004.01228.xDOI Listing
April 2004

Dorsal root ganglia sensory neurons.

Methods Mol Biol 2003 ;229:155-67

Gene Therapy Unit of The Children's Hospital at Westmead and Children's Medical Research Institute, Sydney, Australia.

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http://dx.doi.org/10.1385/1-59259-393-3:155DOI Listing
October 2003

Promoter interference mediated by the U3 region in early-generation HIV-1-derived lentivirus vectors can influence detection of transgene expression in a cell-type and species-specific manner.

Hum Gene Ther 2003 Aug;14(12):1127-37

Gene Therapy Research Unit, The Children's Hospital at Westmead and Children's Medical Research Institute, Westmead, NSW, Australia 2145.

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http://www.liebertpub.com/doi/10.1089/104303403322167975
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http://dx.doi.org/10.1089/104303403322167975DOI Listing
August 2003

HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity.

Immunology 2002 Apr;105(4):478-87

Gene Therapy Research Unit of The Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville NSW 2145, Westmead, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782674PMC
http://dx.doi.org/10.1046/j.1365-2567.2002.01390.xDOI Listing
April 2002

The adenovirus E4 ORF6 and E1b 55 kDa proteins cooperate in a p53-independent manner to enhance transduction by recombinant adeno-associated virus vectors.

J Gen Virol 2000 Dec;81(Pt 12):2983-2991

Gene Therapy Research Unit of the Children's Medical Research Institute and The New Children's Hospital1, and The University of Sydney Department of Paediatrics and Child Health2, PO Box 3515, Parramatta, NSW 2124, Australia.

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http://dx.doi.org/10.1099/0022-1317-81-12-2983DOI Listing
December 2000