Ian D Pavord

Ian D Pavord

UNVERIFIED PROFILE

Are you Ian D Pavord?   Register this Author

Register author
Ian D Pavord

Ian D Pavord

Publications by authors named "Ian D Pavord"

Are you Ian D Pavord?   Register this Author

100Publications

2552Reads

21Profile Views

Point-of-care biomarkers in asthma management: Time to move forward.

Allergy 2019 Sep 10. Epub 2019 Sep 10.

Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.14045DOI Listing
September 2019

Defining severe obstructive lung disease in the biologic era: an endotype-based approach.

Eur Respir J 2019 Sep 12. Epub 2019 Sep 12.

Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00108-2019DOI Listing
September 2019

Sputum microbiomic clustering in asthma and COPD reveals a Haemophilus-predominant subgroup.

Allergy 2019 Sep 25. Epub 2019 Sep 25.

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Respiratory Sciences, College of Life Sciences, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.14058DOI Listing
September 2019

Resistance to apoptosis underpins the corticosteroid insensitivity of group 2 innate lymphoid cells.

J Allergy Clin Immunol 2019 Aug 22. Epub 2019 Aug 22.

Respiratory Medicine Unit, Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.08.008DOI Listing
August 2019

COPD exacerbation phenotypes: The next frontier.

Respirology 2019 Aug 29. Epub 2019 Aug 29.

Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/resp.13693DOI Listing
August 2019

Asthma progression and mortality: the role of inhaled corticosteroids.

Eur Respir J 2019 Jul 18;54(1). Epub 2019 Jul 18.

Section of Epidemiology, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00491-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637285PMC
July 2019

Prognostic and predictive value of blood eosinophil count, fractional exhaled nitric oxide and their combination in severe asthma: a post-hoc analysis.

Am J Respir Crit Care Med 2019 Jul 12. Epub 2019 Jul 12.

Oxford University, Nuffield department of Medicine, Respiratory Medicine, Oxford, Oxfordshire, United Kingdom of Great Britain and Northern Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201903-0599LEDOI Listing
July 2019

Reply to: Inhaled Corticosteroids and Adult Asthma.

Am J Respir Crit Care Med 2019 Jul 24. Epub 2019 Jul 24.

Oxford University, Nuffield department of Medicine, Respiratory Medicine, Oxford, Oxfordshire, United Kingdom of Great Britain and Northern Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201907-1408LEDOI Listing
July 2019

Inhaled Corticosteroid Therapy in Adult Asthma. Time for a New Therapeutic Dose Terminology.

Am J Respir Crit Care Med 2019 Jun;199(12):1471-1477

5 Oxford Respiratory, National Institute for Health Research Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201810-1868CIDOI Listing
June 2019

Fevipiprant, a selective prostaglandin D receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function.

J Allergy Clin Immunol 2019 Jun 28;143(6):2329-2333. Epub 2019 Feb 28.

MRC Human Immunology Unit and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.02.015DOI Listing
June 2019

Usability of mepolizumab single-use prefilled autoinjector for patient self-administration.

J Asthma 2019 Jun 28:1-12. Epub 2019 Jun 28.

g Respiratory Therapeutic Area, GSK , Research Triangle Park , NC , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02770903.2019.1630641DOI Listing
June 2019

Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report.

Eur Respir J 2019 May 9;53(5). Epub 2019 May 9.

Priority Research Centre for Healthy Lungs and Centre of Excellence in Severe Asthma, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.

View Article

Download full-text PDF

Source
http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02058
Publisher Site
http://dx.doi.org/10.1183/13993003.02058-2018DOI Listing
May 2019

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019.

Eur Respir J 2019 May 18;53(5). Epub 2019 May 18.

Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00164-2019DOI Listing
May 2019

Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma.

N Engl J Med 2019 05 19;380(21):2020-2030. Epub 2019 May 19.

From the Medical Research Institute of New Zealand (R.B., M.H., I.B., S.E., C.H., K.O., M. Williams), the Capital and Coast District Health Board (R.B.), and the University of Otago Wellington (M. Weatherall), Wellington, the Department of Respiratory Medicine, Waikato Hospital, Hamilton (R.J.H.), and the Department of Preventive and Social Medicine, University of Otago, Dunedin (R.J.H.) - all in New Zealand; Woolcock Institute of Medical Research, University of Sydney, Sydney (H.K.R.); the Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham (T.H.), and the Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford (I.D.P.) - both in the United Kingdom; and the Respiratory Medicine Unit, Department of Medical Sciences, Università di Ferrara, Ferrara, Italy (A.P.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1901963DOI Listing
May 2019

Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials. Bridging Clinical and Patient Perspectives.

Am J Respir Crit Care Med 2019 Apr;199(7):823-829

2 Allergy, Pulmonary, and Critical Care Division, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201809-1817PPDOI Listing
April 2019

Controversies in Allergy: Should Severe Asthma with Eosinophilic Phenotype Always Be Treated with Anti-IL-5 Therapies.

J Allergy Clin Immunol Pract 2019 May - Jun;7(5):1430-1436. Epub 2019 Apr 5.

Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.03.010DOI Listing
April 2019

Oral corticosteroid-dependent asthma: current knowledge and future needs.

Authors:
Ian D Pavord

Curr Opin Pulm Med 2019 Jan;25(1):51-58

Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCP.0000000000000541DOI Listing
January 2019

Do we really need a new classification of airway diseases?

Lancet Respir Med 2018 12 9;6(12):891-893. Epub 2018 Nov 9.

Respiratory Medicine Unit and Oxford NIHR Respiratory Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(18)30386-2DOI Listing
December 2018

Exacerbations of severe asthma in patients treated with mepolizumab.

Eur Respir J 2018 12 13;52(6). Epub 2018 Dec 13.

Dept of Respiratory Medicine, Allergy and Thoracic Surgery and NIHR BRC Respiratory Theme, Glenfield Hospital, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01127
Publisher Site
http://dx.doi.org/10.1183/13993003.01127-2018DOI Listing
December 2018

GLUCOLD, eosinophils and chronic obstructive pulmonary disease.

Authors:
Ian D Pavord

Respirology 2018 11 26;23(11):966-967. Epub 2018 Jun 26.

Oxford NIHR Respiratory BRC, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/resp.13361DOI Listing
November 2018

Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis.

Lancet Oncol 2018 07 13;19(7):930-939. Epub 2018 Jun 13.

Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Laboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(18)30294-8DOI Listing
July 2018

Will precision medicine become an effective tool for airway disease?

Per Med 2018 07 21;15(4):243-245. Epub 2018 Jun 21.

Respiratory Medicine Unit, NIHR Oxford Biomedical Research Centre, Nuffield Department of Medicine, NDM Research Building, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pme-2018-0027DOI Listing
July 2018

Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles.

J Allergy Clin Immunol 2018 06 28;141(6):2027-2036.e12. Epub 2018 Apr 28.

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986707PMC
June 2018

Biologics and chronic obstructive pulmonary disease.

Authors:
Ian D Pavord

J Allergy Clin Immunol 2018 06 4;141(6):1983-1991. Epub 2018 May 4.

Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, Oxford, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2018.04.020DOI Listing
June 2018

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.

N Engl J Med 2018 06 21;378(26):2486-2496. Epub 2018 May 21.

From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) - both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundación CIDEA (Centro de Investigación de Enfermedades Alérgicas y Respiratorias), Buenos Aires (J.M.); the University of Pittsburgh Asthma Institute, University of Pittsburgh, Pittsburgh (S.W.); LungenClinic Grosshansdorf, Grosshansdorf, and Christian Albrechts University Kiel, Kiel - both in Germany (K.F.R.); the Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison (W.W.B.); the Asthma and Allergy Center, Bellevue, NE (L.F.); the University of British Columbia, Vancouver, Canada (J.M.F.); Campbelltown Hospital and Western Sydney University, Sydney (C.K.); the Faculty of Medicine, Kindai University, Osakasayama, Japan (Y.T.); Sanofi, Bridgewater, NJ (B.Z., H.S., G.P., B.N.S., A.T.); Regeneron Pharmaceuticals, Tarrytown, NY (N.A., M.R., B.A., J. Chao, N.M.H.G., J.D.H., N.S., G.D.Y.); Sanofi, Chilly-Mazarin, France (A.K.); and Sanofi, Prague, Czech Republic (R.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1804092DOI Listing
June 2018

Blood eosinophil levels as a biomarker in COPD.

Respir Med 2018 05 15;138:21-31. Epub 2018 Mar 15.

Respiratory Medical Franchise, GSK, Brentford, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmed.2018.03.016DOI Listing
May 2018

The Significance of Eosinophilic Inflammation in Chronic Obstructive Pulmonary Disease.

Am J Respir Crit Care Med 2018 04;197(7):967-968

5 University of Oxford Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://www.atsjournals.org/doi/10.1164/rccm.201709-1797LE
Publisher Site
http://dx.doi.org/10.1164/rccm.201709-1797LEDOI Listing
April 2018

Rebuttal From Dr Pavord.

Authors:
Ian D Pavord

Chest 2018 04 2;153(4):786-787. Epub 2018 Feb 2.

Respiratory Medicine Unit and Oxford Respiratory National Institute for Health Research Biomedical Research Centre, Nuffield Department of Medicine, Oxford, England. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2018.01.026DOI Listing
April 2018

COUNTERPOINT: Should an Attempt Be Made to Withdraw Inhaled Corticosteroids in All Patients With Stable GOLD 3 (30% ≤ FEV < 50% Predicted) COPD? No.

Authors:
Ian D Pavord

Chest 2018 04 2;153(4):782-784. Epub 2018 Feb 2.

Respiratory Medicine Unit and Oxford Respiratory National Institute for Health Research Biomedical Research Centre, Nuffield Department of Medicine, Oxford, England. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2018.01.030DOI Listing
April 2018

Associations between blood eosinophils and decline in lung function among adults with and without asthma.

Eur Respir J 2018 04 19;51(4). Epub 2018 Apr 19.

Firestone Institute for Respiratory Health, Michael de Groote School of Medicine, McMaster University and St Joseph's Healthcare, Hamilton, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.02536-2017DOI Listing
April 2018

Mepolizumab for Eosinophilic COPD.

N Engl J Med 2018 02;378(7):681-683

Oxford Respiratory NIHR Biomedical Research Centre, Oxford, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1715454DOI Listing
February 2018

After asthma: redefining airways diseases.

Lancet 2018 01 11;391(10118):350-400. Epub 2017 Sep 11.

Department of Paediatrics, Imperial College, London, UK; Department of Paediatric Respiratory Medicine, Imperial College, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(17)30879-6DOI Listing
January 2018

Treating asthma exacerbations in athletes: TUE or not TUE?

Lancet Respir Med 2018 01 30;6(1):8-10. Epub 2017 Oct 30.

Respiratory Medicine Unit and NIHR Oxford Respiratory BRC, Nuffield Department of Medicine, NDM Research Building, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(17)30428-9DOI Listing
January 2018

Physiotherapy breathing retraining for asthma: a randomised controlled trial.

Lancet Respir Med 2018 01 14;6(1):19-28. Epub 2017 Dec 14.

NIHR Southampton Biomedical Research Centre, Southampton, UK; Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; Asthma UK Centre for Applied Research, University of Edinburgh, Edinburgh, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(17)30474-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757422PMC
January 2018

Cytometric Gating Stringency Impacts Studies of Type 2 Innate Lymphoid Cells in Asthma.

Am J Respir Cell Mol Biol 2017 12;57(6):745-747

1 University of Oxford Oxford, United Kingdom and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2017-0201LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765422PMC
December 2017

Evaluation of Potential Continuation Rules for Mepolizumab Treatment of Severe Eosinophilic Asthma.

J Allergy Clin Immunol Pract 2018 May - Jun;6(3):874-882.e4. Epub 2017 Dec 16.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2017.11.026DOI Listing
December 2017

The Objective Assessment of Cough Frequency in Bronchiectasis.

Lung 2017 10 13;195(5):575-585. Epub 2017 Jul 13.

Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London, SE5 9RS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00408-017-0038-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599483PMC
October 2017

Multidimensional assessment of severe asthma: A systematic review and meta-analysis.

Respirology 2017 10 3;22(7):1262-1275. Epub 2017 Aug 3.

National Health and Medical Research Council Centre for Research Excellence in Severe Asthma and The Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/resp.13134DOI Listing
October 2017

Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease.

N Engl J Med 2017 10 11;377(17):1613-1629. Epub 2017 Sep 11.

From the Respiratory Medicine Unit and Oxford Respiratory Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford (I.D.P.), and Clinical Statistics, GlaxoSmithKline, Uxbridge (B.M.) - both in the United Kingdom; the Department of Respiratory Medicine and CIC Nord, Aix-Marseille University, Marseille, France (P.C.); the Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia (G.J.C.); the Department of Pulmonary Medicine and Tuberculosis, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands (H.A.M.K.); the Pulmonary Department, Mainz University Hospital, Mainz, Germany (S.K.); the Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Durham (N.L.), and the Respiratory Medical Franchise (F.C.A.) and the Respiratory Therapeutic Area (E.S.B., S.S.H., D.B.R., S.W.Y.), GlaxoSmithKline, Research Triangle Park - all in North Carolina; the Department of Pneumology, Centre Hospitalier Universitaire-Université Catholique de Louvain, Namur, Namur, Belgium (J.-B.M.); the Division of Allergology and Respiratory Medicine, Showa University School of Medicine, Tokyo (H.S.); and the Department of Medicine, University of Pittsburgh, Pittsburgh (F.C.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1708208DOI Listing
October 2017

Precision medicine in airway diseases: moving to clinical practice.

Eur Respir J 2017 10 19;50(4). Epub 2017 Oct 19.

Dept of Respiratory Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01655-2017DOI Listing
October 2017

Eosinophils in COPD: just another biomarker?

Lancet Respir Med 2017 09 7;5(9):747-759. Epub 2017 Jun 7.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(17)30217-5DOI Listing
September 2017

After the asthmas: Star Wars and Star Trek.

Eur Respir J 2017 09 12;50(3). Epub 2017 Sep 12.

Respiratory Medicine Unit and Oxford NIHR Biomedical Research Centre, Nuffield Department of Medicine, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01362-2017DOI Listing
September 2017

Mepolizumab, quality of life, and severe eosinophilic asthma.

Authors:
Ian D Pavord

Lancet Respir Med 2017 05 5;5(5):362-363. Epub 2017 Apr 5.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(17)30132-7DOI Listing
May 2017

A new approach to the classification and management of airways diseases: identification of treatable traits.

Clin Sci (Lond) 2017 May;131(10):1027-1043

Nuffield Department of Medicine, NDM Research Building, University of Oxford, Oxford OX3 7FZ, U.K.

View Article

Download full-text PDF

Source
http://clinsci.org/lookup/doi/10.1042/CS20160028
Publisher Site
http://dx.doi.org/10.1042/CS20160028DOI Listing
May 2017

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma.

J Allergy Clin Immunol 2017 Apr 7;139(4):1167-1175.e2. Epub 2016 Oct 7.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.08.008DOI Listing
April 2017

Interleukin-5 Inhibitors for Severe Asthma: Rationale and Future Outlook.

BioDrugs 2017 Apr;31(2):93-103

Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Oxford, OX3 7FZ, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40259-017-0215-8
Publisher Site
http://dx.doi.org/10.1007/s40259-017-0215-8DOI Listing
April 2017

Exacerbations of COPD.

Int J Chron Obstruct Pulmon Dis 2016 19;11 Spec Iss:21-30. Epub 2016 Feb 19.

Department of Medicine, Christian Albrecht University, Kiel, Germany; LungenClinic, Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S85978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764047PMC
December 2016

Asthma-like Features and Chronic Obstructive Pulmonary Disease.

Am J Respir Crit Care Med 2016 12;194(11):1308-1309

1 Nuffield Department of Medicine University of Oxford Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201606-1157EDDOI Listing
December 2016

What can we learn from blood granulocyte patterns in patients with asthma?

Eur Respir J 2016 10;48(4):976-978

Respiratory Medicine Unit, Nuffield Dept of Medicine, University of Oxford, Oxford, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01567-2016DOI Listing
October 2016

Lessons from LAVOLTA.

Authors:
Ian D Pavord

Lancet Respir Med 2016 10;4(10):764-765

Respiratory Medicine Unit, Nuffield Department of Medicine, NDM Research Building, Old Road Campus, University of Oxford, OX3 7FZ, Oxford, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(16)30274-0DOI Listing
October 2016

Blood eosinophil count and pneumonia risk in patients with chronic obstructive pulmonary disease: a patient-level meta-analysis.

Lancet Respir Med 2016 09 23;4(9):731-741. Epub 2016 Jul 23.

Respiratory Medical Franchise, GSK, Brentford, UK; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(16)30148-5DOI Listing
September 2016

Step 4: stick or twist? A review of asthma therapy.

BMJ Open Respir Res 2016 5;3(1):e000143. Epub 2016 Sep 5.

Division of Respiratory Medicine , University of Nottingham, Nottingham City Hospital , Nottingham , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjresp-2016-000143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020663PMC
September 2016

Blood Eosinophils and Outcomes in Severe Hospitalized Exacerbations of COPD.

Chest 2016 08 3;150(2):320-8. Epub 2016 Feb 3.

Centre for Exercise and Rehabilitation Science, University of Leicester NHS Hospitals Trust, Glenfield Hospital, Leicester, UK; NIHR Respiratory Biomedical Research Unit, University of Leicester, Leicester, UK; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2016.01.026DOI Listing
August 2016

Emerging Biologics in Severe Asthma.

Immunol Allergy Clin North Am 2016 08;36(3):609-23

Department of Respiratory Medicine, University of Oxford, Old Road, Oxford, OX3 7LE, UK; Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, OX3 7FZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.iac.2016.04.001DOI Listing
August 2016

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies.

Lancet Respir Med 2016 07 10;4(7):549-556. Epub 2016 May 10.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(16)30031-5DOI Listing
July 2016

Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma.

Lancet Respir Med 2016 07 24;4(7):585-592. Epub 2016 May 24.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(16)30018-2DOI Listing
July 2016

Predictors of objective cough frequency in pulmonary sarcoidosis.

Eur Respir J 2016 05 4;47(5):1461-71. Epub 2016 Feb 4.

Division of Asthma, Allergy and Lung Biology, King's College London, King's Health Partners, London, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01369-2015DOI Listing
May 2016

Blood eosinophil count: a biomarker of an important treatable trait in patients with airway disease.

Eur Respir J 2016 05;47(5):1299-303

Respiratory Institute, Hospital Clinic, IDIBAPS, Univ. Barcelona and CIBER Enfermedades Respiratorias (CIBERES), Spain

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00055-2016DOI Listing
May 2016

Morbidity associated with oral corticosteroids in patients with severe asthma.

Thorax 2016 Apr 22;71(4):302-4. Epub 2016 Feb 22.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2015-208242DOI Listing
April 2016

Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function.

Int J Chron Obstruct Pulmon Dis 2015 9;10:1075-83. Epub 2015 Jun 9.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK ; Institute for Lung Health, National Institute for Health Research Respiratory Biomedical Research Unit, Glenfield Hospital, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S80091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468933PMC
March 2016

Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial.

Pediatr Pulmonol 2016 Mar 27;51(3):253-7. Epub 2015 Dec 27.

Division of Public Health and Epidemiology, University of Nottingham, Nottingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.23370DOI Listing
March 2016

Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD.

Thorax 2016 Feb 19;71(2):118-25. Epub 2015 Nov 19.

Respiratory Medical Franchise, GSK, Uxbridge, UK William Harvey Institute, Barts and The London School of Medicine and Dentistry, London, UK.

View Article

Download full-text PDF

Source
http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2015-2070
Publisher Site
http://dx.doi.org/10.1136/thoraxjnl-2015-207021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752631PMC
February 2016

Treatable traits: toward precision medicine of chronic airway diseases.

Eur Respir J 2016 Feb;47(2):410-9

Respiratory Medicine Unit, NDM Research Building, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01359-2015DOI Listing
February 2016

Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma.

Ther Adv Respir Dis 2015 Aug 21;9(4):135-45. Epub 2015 Apr 21.

Professor of Respiratory Medicine, NDM Research Building, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753465815581279DOI Listing
August 2015

Asthma diagnosis: addressing the challenges.

Lancet Respir Med 2015 May 6;3(5):339-41. Epub 2015 Mar 6.

Immunopharmacology, Faculty of Medicine Clinical and Experimental Sciences, Southampton General Hospital, Southampton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(15)00056-9DOI Listing
May 2015

Biomarkers and inhaled corticosteroid responsiveness in asthmatic patients.

J Allergy Clin Immunol 2015 Apr;135(4):884-5

Respiratory Medicine Unit, Nuffield Department of Medicine, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2015.01.031DOI Listing
April 2015

The asthmas in 2015 and beyond: a Lancet Commission.

Lancet 2015 Apr;385(9975):1273-5

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(15)60654-7DOI Listing
April 2015

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease.

Int J Chron Obstruct Pulmon Dis 2014 15;9:975-81. Epub 2014 Sep 15.

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S63568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168852PMC
February 2015

Association between pathogens detected using quantitative polymerase chain reaction with airway inflammation in COPD at stable state and exacerbations.

Chest 2015 Jan;147(1):46-55

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, England. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1378/chest.14-0764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285081PMC
January 2015

Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease.

J Allergy Clin Immunol 2015 Jan 13;135(1):63-72. Epub 2014 Aug 13.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom; NIHR Respiratory Biomedical Research Unit, University Hospitals of Leicester, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2014.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282726PMC
January 2015

Inhaled glucocorticoids and COPD exacerbations.

N Engl J Med 2015 01;372(1):93

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1413308DOI Listing
January 2015

IL-33-dependent Th2 response after rhinovirus infection in asthma: more information needed.

Am J Respir Crit Care Med 2015 Jan;191(2):237

1 University of Oxford Oxford, United Kingdom and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201411-2067LEDOI Listing
January 2015

Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: a cohort study.

Eur Respir J 2014 Dec 19;44(6):1705-7. Epub 2014 Aug 19.

Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/09031936.00093614DOI Listing
December 2014

Glucocorticoids and mepolizumab in eosinophilic asthma.

N Engl J Med 2014 12;371(25):2434

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1412892DOI Listing
December 2014

Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis.

Eur Respir J 2014 Sep 12;44(3):789-91. Epub 2014 Jun 12.

Dept of Respiratory Medicine, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/09031936.00062614DOI Listing
September 2014

Mepolizumab treatment in patients with severe eosinophilic asthma.

N Engl J Med 2014 Sep 8;371(13):1198-207. Epub 2014 Sep 8.

From the Respiratory Therapeutic Area Unit, GlaxoSmithKline, Research Triangle Park, NC (H.G.O., L.E.K., S.W.Y.); Johns Hopkins Asthma and Allergy Center, Baltimore (M.C.L.); Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford (I.D.P.), and Clinical Statistics, GlaxoSmithKline, Stockley Park, Middlesex (O.N.K.) - both in the United Kingdom; the Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium (G.G.B.); the Lung Centre, Institute for Heart and Lung Health, Vancouver, BC, Canada (J.M.F.); the Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy (A.C.); and Assistance Publique-Hôpitaux de Paris, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie, Hôpital Bicêtre, Université Paris-Sud, and INSERM Unité Mixte de Recherche 999, Le Kremlin-Bicêtre (M.H.), and Unités Mixtes de Recherche INSERM Unité 1067 Centre Nationale de la Recherche Scientifique 7733, Aix-Marseille Université, Department of Respiratory Diseases and Clinical Investigation Center, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Marseille (P.C.) - both in France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1403290DOI Listing
September 2014

Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma.

N Engl J Med 2014 Sep 8;371(13):1189-97. Epub 2014 Sep 8.

From the Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (E.H.B.); the Department of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Asthma Institute at the University of Pittsburgh Medical Center-University of Pittsburgh School of Medicine, Pittsburgh (S.E.W.); the Lung Institute of Western Australia, Nedlands, and the Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Crawley - both in Australia (P.J.T.); Respiratory Therapeutic Area, GlaxoSmithKline, Research Triangle Park, NC (C.M.P., S.W.Y., H.G.O.); and Clinical Statistics, GlaxoSmithKline, Stockley Park (O.N.K.), and the Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford (I.D.P.) - both in the United Kingdom.

View Article

Download full-text PDF

Source
http://www.usahealthsystem.com/workfiles/com_docs%2Facademic
Web Search
http://www.nejm.org/doi/abs/10.1056/NEJMoa1403291
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1403291DOI Listing
September 2014

Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial.

Int J Chron Obstruct Pulmon Dis 2014 7;9:179-86. Epub 2014 Feb 7.

Department of Respiratory Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S55419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923615PMC
August 2014