Publications by authors named "Ian D Hickson"

100Publications

The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells.

Cell Rep 2020 Jul;32(1):107849

Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473174PMC
July 2020

Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.

Proc Natl Acad Sci U S A 2020 07 29;117(28):16527-16536. Epub 2020 Jun 29.

Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark;

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http://dx.doi.org/10.1073/pnas.1921219117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368274PMC
July 2020

High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing.

Cell Res 2020 Nov 19;30(11):997-1008. Epub 2020 Jun 19.

Department of Molecular Biology, University of Geneva, 1205, Geneva, Switzerland.

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http://dx.doi.org/10.1038/s41422-020-0358-xDOI Listing
November 2020

RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome.

Nat Struct Mol Biol 2020 05 11;27(5):424-437. Epub 2020 May 11.

Center for Chromosome Stability, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41594-020-0408-6DOI Listing
May 2020

Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes.

Mol Cell 2020 05 29;78(4):714-724.e5. Epub 2020 Apr 29.

Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.04.005DOI Listing
May 2020

Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase.

Cell Rep 2020 04;31(3):107533

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107533DOI Listing
April 2020

The many lives of type IA topoisomerases.

J Biol Chem 2020 May 10;295(20):7138-7153. Epub 2020 Apr 10.

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark

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http://dx.doi.org/10.1074/jbc.REV120.008286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242696PMC
May 2020

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability.

J Cell Biol 2019 12 15;218(12):3943-3953. Epub 2019 Oct 15.

Protein Signaling Program, Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark

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http://dx.doi.org/10.1083/jcb.201905064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891097PMC
December 2019

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication.

Elife 2019 09 23;8. Epub 2019 Sep 23.

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.7554/eLife.48686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773462PMC
September 2019

Chromosome instability syndromes.

Nat Rev Dis Primers 2019 09 19;5(1):64. Epub 2019 Sep 19.

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1038/s41572-019-0113-0DOI Listing
September 2019

PICH and TOP3A cooperate to induce positive DNA supercoiling.

Nat Struct Mol Biol 2019 04 1;26(4):267-274. Epub 2019 Apr 1.

Center for Chromosome Stability & Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41594-019-0201-6DOI Listing
April 2019

The RIF1-PP1 Axis Controls Abscission Timing in Human Cells.

Curr Biol 2019 04 21;29(7):1232-1242.e5. Epub 2019 Mar 21.

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.02.037DOI Listing
April 2019

Esc2 promotes telomere stability in response to DNA replication stress.

Nucleic Acids Res 2019 05;47(9):4597-4611

Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1093/nar/gkz158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511870PMC
May 2019

Folate deficiency drives mitotic missegregation of the human locus.

Proc Natl Acad Sci U S A 2018 12 3;115(51):13003-13008. Epub 2018 Dec 3.

Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1808377115
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http://dx.doi.org/10.1073/pnas.1808377115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304931PMC
December 2018

Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality.

Cell Rep 2018 09;24(12):3274-3284

Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167640PMC
September 2018

Reconstitution of anaphase DNA bridge recognition and disjunction.

Nat Struct Mol Biol 2018 09 3;25(9):868-876. Epub 2018 Sep 3.

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41594-018-0123-8DOI Listing
September 2018

Pathways for maintenance of telomeres and common fragile sites during DNA replication stress.

Open Biol 2018 04;8(4)

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark

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http://dx.doi.org/10.1098/rsob.180018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936717PMC
April 2018

DNA replication stress and its impact on chromosome segregation and tumorigenesis.

Semin Cancer Biol 2019 04 23;55:61-69. Epub 2018 Apr 23.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2018.04.005DOI Listing
April 2019

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism.

Oncotarget 2018 Mar 23;9(22):15836-15846. Epub 2018 Mar 23.

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.18632/oncotarget.24745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882301PMC
March 2018

Anaphase: a fortune-teller of genomic instability.

Curr Opin Cell Biol 2018 06 9;52:112-119. Epub 2018 Mar 9.

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2018.02.012DOI Listing
June 2018

Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci.

Methods Enzymol 2018 3;601:45-58. Epub 2018 Feb 3.

Center for Chromosome Stability, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2017.11.025DOI Listing
March 2019

Erratum to: Detection of Ultrafine Anaphase Bridges.

Methods Mol Biol 2018 ;1672:E1

Department of Cellular and Molecular Medicine, Center for Chromosome Stability, University of Copenhagen, Panum Institute, 2200, Copenhagen, N, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_43DOI Listing
January 2018

Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase.

Cold Spring Harb Symp Quant Biol 2017 22;82:187-195. Epub 2017 Nov 22.

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1101/sqb.2017.82.033647DOI Listing
November 2017

Detection of Ultrafine Anaphase Bridges.

Methods Mol Biol 2018 ;1672:495-508

Department of Cellular and Molecular Medicine, Center for Chromosome Stability, University of Copenhagen, Panum Institute, 2200, Copenhagen, N, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_33DOI Listing
June 2018

The Detection and Analysis of Chromosome Fragile Sites.

Methods Mol Biol 2018 ;1672:471-482

Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_31DOI Listing
June 2018

A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation.

Methods Mol Biol 2018 ;1672:295-309

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_20DOI Listing
June 2018

A novel TPR-BEN domain interaction mediates PICH-BEND3 association.

Nucleic Acids Res 2017 Nov;45(19):11413-11424

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

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http://academic.oup.com/nar/article/45/19/11413/4103598
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http://dx.doi.org/10.1093/nar/gkx792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737856PMC
November 2017

Stalled replication forks generate a distinct mutational signature in yeast.

Proc Natl Acad Sci U S A 2017 09 21;114(36):9665-9670. Epub 2017 Aug 21.

Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark;

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http://dx.doi.org/10.1073/pnas.1706640114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594675PMC
September 2017

The "enemies within": regions of the genome that are inherently difficult to replicate.

F1000Res 2017 12;6:666. Epub 2017 May 12.

Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.12688/f1000research.11024.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461909PMC
May 2017

Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.

Genes Dev 2017 04 9;31(8):816-829. Epub 2017 May 9.

Division of Molecular Cell Engineering, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima, Shizuoka 411-8540, Japan.

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http://dx.doi.org/10.1101/gad.297663.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435893PMC
April 2017

Potential biomarkers of DNA replication stress in cancer.

Oncotarget 2017 Jun;8(23):36996-37008

Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.18632/oncotarget.16940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514887PMC
June 2017

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.

Mol Cell 2016 12;64(6):1117-1126

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.10.037DOI Listing
December 2016

Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells.

Methods Mol Biol 2017 ;1491:131-144

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, Astra Zeneca, Godsmottagningen MA1, Pepparedsleden, 43183, Mölndal, Sweden.

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http://dx.doi.org/10.1007/978-1-4939-6439-0_10DOI Listing
January 2018

PICH promotes mitotic chromosome segregation: Identification of a novel role in rDNA disjunction.

Cell Cycle 2016 Oct 26;15(20):2704-11. Epub 2016 Aug 26.

a Center for Chromosome Stability , Department of Cellular and Molecular Medicine , University of Copenhagen , Copenhagen , Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053587PMC
http://dx.doi.org/10.1080/15384101.2016.1222336DOI Listing
October 2016

Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex.

Acta Crystallogr F Struct Biol Commun 2016 08 27;72(Pt 8):646-51. Epub 2016 Jul 27.

Protein Structure and Function Programme, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1107/S2053230X16010724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973307PMC
August 2016

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis.

Nat Commun 2015 Dec 8;6:8962. Epub 2015 Dec 8.

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ncomms9962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686863PMC
December 2015

Replication stress activates DNA repair synthesis in mitosis.

Nature 2015 Dec 2;528(7581):286-90. Epub 2015 Dec 2.

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1038/nature16139DOI Listing
December 2015

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.

Oncotarget 2015 Dec;6(38):40464-79

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen N, Denmark.

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http://dx.doi.org/10.18632/oncotarget.6342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747346PMC
December 2015

Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.

Oncotarget 2015 Nov;6(35):37638-46

Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.5497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741954PMC
November 2015

FBH1 Catalyzes Regression of Stalled Replication Forks.

Cell Rep 2015 Mar 12;10(10):1749-1757. Epub 2015 Mar 12.

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.028DOI Listing
March 2015

Regulation of SUMO2 target proteins by the proteasome in human cells exposed to replication stress.

J Proteome Res 2015 Apr 19;14(4):1687-99. Epub 2015 Mar 19.

†Center for Chromosome Stability, and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/pr500997pDOI Listing
April 2015

FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.

Nat Commun 2015 Jan 14;6:5931. Epub 2015 Jan 14.

1] Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK [2] Center for Healthy Aging, Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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http://www.nature.com/articles/ncomms6931
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http://dx.doi.org/10.1038/ncomms6931DOI Listing
January 2015

Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells.

DNA Repair (Amst) 2015 Jan 25;25:84-96. Epub 2014 Nov 25.

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, DK-2200 Copenhagen, Denmark; Molecular Oncology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.10.011DOI Listing
January 2015

Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes.

Cell Cycle 2014 ;13(19):2994-8

a Center for Healthy Aging; Department of Cellular and Molecular Medicine ; University of Copenhagen ; Copenhagen , Denmark.

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http://dx.doi.org/10.4161/15384101.2014.958912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614373PMC
August 2015

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.

Nat Commun 2014 Nov 24;5:5556. Epub 2014 Nov 24.

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, MSB 394, 550 First Avenue, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/ncomms6556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243535PMC
November 2014

The dissolution of double Holliday junctions.

Cold Spring Harb Perspect Biol 2014 Jul 1;6(7):a016477. Epub 2014 Jul 1.

Nordea Center for Healthy Aging, Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1101/cshperspect.a016477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067992PMC
July 2014

The origins and processing of ultra fine anaphase DNA bridges.

Curr Opin Genet Dev 2014 Jun 8;26:1-5. Epub 2014 May 8.

Centre for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2014.03.003DOI Listing
June 2014

The Escherichia coli Tus-Ter replication fork barrier causes site-specific DNA replication perturbation in yeast.

Nat Commun 2014 Apr 7;5:3574. Epub 2014 Apr 7.

1] Nordea Center for Healthy Aging, Department of Cellular and Molecular Medicine, Panum Institute 18.1, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark [2] Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1038/ncomms4574DOI Listing
April 2014

Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.

DNA Repair (Amst) 2014 Apr 27;16:44-53. Epub 2014 Feb 27.

Laboratory of Molecular Gerontology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, USA; Center for Healthy Aging, SUND, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156482PMC
April 2014

Structure-specific endonucleases: guardians of fragile site stability.

Trends Cell Biol 2014 May 19;24(5):321-7. Epub 2013 Dec 19.

Nordea Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2013.11.007DOI Listing
May 2014

FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.

J Biol Chem 2013 Nov 9;288(47):34168-80. Epub 2013 Oct 9.

From the Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 14300 Prague, Czech Republic.

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http://dx.doi.org/10.1074/jbc.M113.484493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837158PMC
November 2013

A role for BLM in double-strand break repair pathway choice: prevention of CtIP/Mre11-mediated alternative nonhomologous end-joining.

Cell Rep 2013 Oct 3;5(1):21-8. Epub 2013 Oct 3.

CNRS UMR217, CEA, DSV, Institut de Radiobiologie Cellulaire et Moléculaire, 18 Route du Panorama, Fontenay aux Roses F-92265, France.

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http://dx.doi.org/10.1016/j.celrep.2013.08.034DOI Listing
October 2013

How unfinished business from S-phase affects mitosis and beyond.

EMBO J 2013 Oct 24;32(20):2661-71. Epub 2013 Sep 24.

Department of Cellular and Molecular Medicine, Nordea Center for Healthy Aging, Copenhagen N, Denmark.

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http://dx.doi.org/10.1038/emboj.2013.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801442PMC
October 2013

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

Bioorg Med Chem Lett 2013 Oct 13;23(20):5660-6. Epub 2013 Aug 13.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20892.

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http://dx.doi.org/10.1016/j.bmcl.2013.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824626PMC
October 2013

PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.

Mol Cell 2013 Sep 22;51(5):691-701. Epub 2013 Aug 22.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, U. K.

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http://dx.doi.org/10.1016/j.molcel.2013.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161920PMC
September 2013

MUS81 promotes common fragile site expression.

Nat Cell Biol 2013 Aug 30;15(8):1001-7. Epub 2013 Jun 30.

Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK.

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http://search.proquest.com/openview/8db366cd5c644ee7ee30e2b8
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http://www.nature.com/doifinder/10.1038/ncb2773
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http://dx.doi.org/10.1038/ncb2773DOI Listing
August 2013

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.

Nat Commun 2013 ;4:1423

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N DK-2200, Denmark.

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http://dx.doi.org/10.1038/ncomms2395DOI Listing
June 2013

RecQ Helicases: Conserved Guardians of Genomic Integrity.

Adv Exp Med Biol 2013 ;767:161-84

Nordea Center for Healthy Ageing, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200N, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4614-5037-5_8DOI Listing
April 2016

BLM and RMI1 alleviate RPA inhibition of TopoIIIα decatenase activity.

PLoS One 2012 20;7(7):e41208. Epub 2012 Jul 20.

Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041208PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401101PMC
April 2013

A novel antirecombinase gains PARIty.

Mol Cell 2012 Jan;45(1):6-7

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Panum Institute, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1016/j.molcel.2011.12.015DOI Listing
January 2012

The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination.

DNA Repair (Amst) 2011 Nov 31;10(11):1095-105. Epub 2011 Aug 31.

Department of Cell Biology & Genetics, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2011.08.006DOI Listing
November 2011

Processing of homologous recombination repair intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexes.

Cell Cycle 2011 Sep 15;10(18):3078-85. Epub 2011 Sep 15.

Nordea Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.4161/cc.10.18.16919DOI Listing
September 2011

New insights into the formation and resolution of ultra-fine anaphase bridges.

Semin Cell Dev Biol 2011 Oct 18;22(8):906-12. Epub 2011 Jul 18.

Department of Biochemistry, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.semcdb.2011.07.001DOI Listing
October 2011

Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis.

Int J Hematol 2011 Apr 8;93(4):440-445. Epub 2011 Apr 8.

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX39DS, UK.

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April 2011

Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage.

Proc Natl Acad Sci U S A 2011 Mar 7;108(12):4944-9. Epub 2011 Mar 7.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1014240108
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064375PMC
March 2011

Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.

Mol Cell Biol 2011 May 22;31(9):1921-33. Epub 2011 Feb 22.

Center for Healthy Aging, Department of Cellular and Molecular Medicine, Panum Institute 18.1, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133222PMC
May 2011

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.

EMBO J 2011 Feb 14;30(4):692-705. Epub 2011 Jan 14.

Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1038/emboj.2010.362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041957PMC
February 2011

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.

Nat Struct Mol Biol 2010 Nov 10;17(11):1377-82. Epub 2010 Oct 10.

Department of Microbiology, University of California, Davis, Davis, California, USA.

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http://dx.doi.org/10.1038/nsmb.1919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988882PMC
November 2010

Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha.

Eur J Immunol 2010 Sep;40(9):2379-84

Department of Developmental Immunology, Max-Planck Institute of Immunobiology, Freiburg, Germany.

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http://dx.doi.org/10.1002/eji.201040634DOI Listing
September 2010

Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.

J Biol Chem 2010 Jul 5;285(28):21426-36. Epub 2010 May 5.

Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada and.

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http://dx.doi.org/10.1074/jbc.M110.123216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898442PMC
July 2010

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

Cancer Res 2010 Apr 16;70(7):2984-93. Epub 2010 Mar 16.

Gray Institute for Radiation Oncology and Biology, Oxford University, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848966PMC
April 2010

Yeast as a model system to study RecQ helicase function.

DNA Repair (Amst) 2010 Mar 13;9(3):303-14. Epub 2010 Jan 13.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1016/j.dnarep.2009.12.007DOI Listing
March 2010

Dissolution of double Holliday junctions by the concerted action of BLM and topoisomerase IIIalpha.

Methods Mol Biol 2009 ;582:91-102

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/978-1-60761-340-4_8DOI Listing
January 2010

On the origins of ultra-fine anaphase bridges.

Cell Cycle 2009 Oct 8;8(19):3065-6. Epub 2009 Oct 8.

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http://dx.doi.org/10.4161/cc.8.19.9513DOI Listing
October 2009

RecQ helicases: multifunctional genome caretakers.

Nat Rev Cancer 2009 Sep 6;9(9):644-54. Epub 2009 Aug 6.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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http://www.nature.com/articles/nrc2682
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September 2009

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

Nat Cell Biol 2009 Jun 24;11(6):753-60. Epub 2009 May 24.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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June 2009

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.

Biochem Soc Trans 2009 Jun;37(Pt 3):553-9

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1042/BST0370553DOI Listing
June 2009

Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.

Mol Biol Cell 2009 Mar 21;20(6):1683-94. Epub 2009 Jan 21.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655263PMC
March 2009

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.

Genes Dev 2008 Oct;22(20):2843-55

Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1101/gad.1708608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569887PMC
October 2008

The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.

Nucleic Acids Res 2008 Sep 5;36(16):5166-79. Epub 2008 Aug 5.

Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1093/nar/gkn498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532730PMC
September 2008

The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

J Biol Chem 2008 Jun 30;283(26):17766-76. Epub 2008 Apr 30.

International Centre for Genetic Engineering and Biotechnology Padriciano 99, Trieste, Italy.

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June 2008

RecQ helicases: guardian angels of the DNA replication fork.

Chromosoma 2008 Jun 11;117(3):219-33. Epub 2008 Jan 11.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1007/s00412-007-0142-4DOI Listing
June 2008

The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'?

Trends Biochem Sci 2007 Dec 5;32(12):538-46. Epub 2007 Nov 5.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.tibs.2007.09.009DOI Listing
December 2007

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.

Nat Struct Mol Biol 2007 Nov 14;14(11):1096-104. Epub 2007 Oct 14.

Department of Cell Biology & Genetics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/nsmb1313DOI Listing
November 2007

Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3.

Mol Biol Cell 2007 Oct 1;18(10):4062-73. Epub 2007 Aug 1.

Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e07-05-0490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995734PMC
October 2007

Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.

Mol Cancer Res 2007 Jul;5(7):713-24

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, U.S. Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0028DOI Listing
July 2007

Role for BLM in replication-fork restart and suppression of origin firing after replicative stress.

Nat Struct Mol Biol 2007 Jul 24;14(7):677-9. Epub 2007 Jun 24.

Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1038/nsmb1267DOI Listing
July 2007

BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.

EMBO J 2007 Jul 28;26(14):3397-409. Epub 2007 Jun 28.

Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933408PMC
July 2007