Ian D Clarke

Ian D Clarke

UNVERIFIED PROFILE

Are you Ian D Clarke?   Register this Author

Register author
Ian D Clarke

Ian D Clarke

Publications by authors named "Ian D Clarke"

Are you Ian D Clarke?   Register this Author

18Publications

914Reads

30Profile Views

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Cell Stem Cell 2017 08 14;21(2):209-224.e7. Epub 2017 Jul 14.

Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2017.06.004DOI Listing
August 2017

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.

Cancer Cell 2016 06;29(6):859-873

Arthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children (SickKids), Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, SickKids, Toronto, ON M5G 1X8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/cancer-cell/pdf/S1535-6108(16)30207-0.pd
Web Search
http://dx.doi.org/10.1016/j.ccell.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968455PMC
June 2016

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

Cancer Cell 2015 Dec 25;28(6):715-729. Epub 2015 Nov 25.

Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00382-7.pd
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S153561081500382
Publisher Site
http://dx.doi.org/10.1016/j.ccell.2015.10.005DOI Listing
December 2015

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.

Proc Natl Acad Sci U S A 2015 Jan 5;112(3):851-6. Epub 2015 Jan 5.

Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1320611111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311802PMC
January 2015

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Cancer Discov 2014 Oct 6;4(10):1198-213. Epub 2014 Aug 6.

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada. Division of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-14-0157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184920PMC
October 2014

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.

Cancer Cell 2014 Jul 19;26(1):33-47. Epub 2014 Jun 19.

Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, Hospital for Sick Children (HSC), Toronto, ON M5G 1L7, Canada; Program in Developmental and Stem Cell Biology, HSC, Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441014PMC
July 2014

A tumorigenic MLL-homeobox network in human glioblastoma stem cells.

Cancer Res 2013 Jan 29;73(1):417-27. Epub 2012 Oct 29.

Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/content/73/1/417.full.pdf
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-12-1881DOI Listing
January 2013

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.

J Exp Med 2011 Apr 4;208(4):689-702. Epub 2011 Apr 4.

The Arthur and Sonia Labatt's Brain Tumor Research Centre, The Hospital for Sick Children's Research Institute, Toronto Western Hospital, University of Toronto, Toronto M5A 2N4, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20102099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135351PMC
April 2011

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat Chem Biol 2007 May 8;3(5):268-73. Epub 2007 Apr 8.

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto M5G 1X8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio873DOI Listing
May 2007

IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme.

Cancer Res 2006 Sep;66(18):9074-82

Institut National de la Santé et de la Recherche Médicale EMI 0104, Département de Réponse et Dynamique Cellulaires, CEA Grenoble, Grenoble, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-06-0761DOI Listing
September 2006

Identification of human brain tumour initiating cells.

Nature 2004 Nov;432(7015):396-401

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature03128DOI Listing
November 2004

Cancer stem cells in nervous system tumors.

Oncogene 2004 Sep;23(43):7267-73

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Canada.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/1207946
Publisher Site
http://dx.doi.org/10.1038/sj.onc.1207946DOI Listing
September 2004

Identification of a cancer stem cell in human brain tumors.

Cancer Res 2003 Sep;63(18):5821-8

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

View Article

Download full-text PDF

Source
September 2003