Ian Blair

Ian Blair

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Evaluation of antibodies for western blot analysis of frataxin protein isoforms.

J Immunol Methods 2019 Nov 4;474:112629. Epub 2019 Jul 4.

Penn/CHOP Center of Excellence in Friedreich's Ataxia, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn SRP Center and Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2019.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829029PMC
November 2019

In Vitro Biotransformation of the Nrf2 Activator Bardoxolone: Formation of an Epoxide Metabolite That Undergoes Two Novel Glutathione-Mediated Metabolic Pathways: Epoxide Reduction and Oxidative Elimination of Nitrile Moiety.

Chem Res Toxicol 2019 Nov 25;32(11):2268-2280. Epub 2019 Oct 25.

Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics , University of Pennsylvania , Philadelphia , Pennsylvania 19104-6606 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00289DOI Listing
November 2019

Theme 3 In vitro experimental models.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Nov;20(sup1):135-159

Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

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http://dx.doi.org/10.1080/21678421.2019.1646991DOI Listing
November 2019

CMS-01 Genetic testing for familial amyotrophic lateral sclerosis (ALS): insights and challenges.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Nov;20(sup1):327-347

Department of Clinical Medicine.

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http://dx.doi.org/10.1080/21678421.2019.1647002DOI Listing
November 2019

Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth.

Am J Obstet Gynecol 2019 Nov 20. Epub 2019 Nov 20.

Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1016/j.ajog.2019.11.1252DOI Listing
November 2019

Generation and characterization of a human induced pluripotent stem cell line UOWi005-A from dermal fibroblasts derived from a CCNF familial amyotrophic lateral sclerosis patient using mRNA reprogramming.

Stem Cell Res 2019 Oct 14;40:101530. Epub 2019 Aug 14.

Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101530DOI Listing
October 2019

Analytical Methods for Mass Spectrometry-Based Metabolomics Studies.

Adv Exp Med Biol 2019 ;1140:635-647

Penn SRP Center and Center of Excellence in Environmental Toxicology Center, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-3-030-15950-4_38DOI Listing
September 2019

The hexanucleotide repeat expansion presents a challenge for testing laboratories and genetic counseling.

Amyotroph Lateral Scler Frontotemporal Degener 2019 08 23;20(5-6):310-316. Epub 2019 Mar 23.

a Department of Clinical Medicine, Faculty of Medicine and Health Sciences , Macquarie University , Sydney , Australia.

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http://dx.doi.org/10.1080/21678421.2019.1588904DOI Listing
August 2019

The proteome and its dynamics: A missing piece for integrative multi-omics in schizophrenia.

Schizophr Res 2019 Aug 12. Epub 2019 Aug 12.

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09209964193030
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http://dx.doi.org/10.1016/j.schres.2019.07.025DOI Listing
August 2019

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.

Neurosci Lett 2019 06 3;704:89-94. Epub 2019 Apr 3.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1016/j.neulet.2019.04.001DOI Listing
June 2019

The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting.

Future Sci OA 2019 Jun 28;5(6):FSO398. Epub 2019 Jun 28.

Department of Neurology McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

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http://dx.doi.org/10.2144/fsoa-2019-0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609901PMC
June 2019

Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome.

Clin Endocrinol (Oxf) 2019 01 25;90(1):155-161. Epub 2018 Oct 25.

Penn SRP Center and Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/cen.13869DOI Listing
January 2019

Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone.

Chem Res Toxicol 2018 11 8;31(11):1277-1288. Epub 2018 Nov 8.

Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer-Foundation , Grosshansdorf 22927 , Germany.

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http://dx.doi.org/10.1021/acs.chemrestox.8b00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319660PMC
November 2018

Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes.

Sci Rep 2018 11 19;8(1):17043. Epub 2018 Nov 19.

Penn SRP Center and Center of Excellence in Environmental Toxicology Center, Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.

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http://www.nature.com/articles/s41598-018-35346-y
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http://dx.doi.org/10.1038/s41598-018-35346-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242848PMC
November 2018

Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease.

Biol Open 2018 Oct 16;7(10). Epub 2018 Oct 16.

Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia

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http://dx.doi.org/10.1242/bio.036475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215410PMC
October 2018

Effect of a tissue selective estrogen complex on breast cancer: Role of unique properties of conjugated equine estrogen.

Int J Cancer 2018 09 16;143(5):1259-1268. Epub 2018 Apr 16.

Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Systems, Charlottesville, VA.

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http://dx.doi.org/10.1002/ijc.31401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377943PMC
September 2018

Gestational Diabetes Alters the Metabolomic Profile in 2nd Trimester Amniotic Fluid in a Sex-Specific Manner.

Int J Mol Sci 2018 Sep 10;19(9). Epub 2018 Sep 10.

Center for Research in Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.mdpi.com/1422-0067/19/9/2696
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http://dx.doi.org/10.3390/ijms19092696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165183PMC
September 2018

Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.

Neurodegener Dis 2017 11;17(6):304-312. Epub 2017 Nov 11.

Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

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http://dx.doi.org/10.1159/000481258DOI Listing
July 2018

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Cell Metab 2018 Jun 10;27(6):1263-1280.e6. Epub 2018 May 10.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990482PMC
June 2018

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis.

Hum Mol Genet 2018 04;27(8):1311-1331

Centre for MND Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia.

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https://academic.oup.com/hmg/article/27/8/1311/4835223
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http://dx.doi.org/10.1093/hmg/ddy041DOI Listing
April 2018

Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy.

PLoS One 2018 15;13(2):e0192779. Epub 2018 Feb 15.

Penn/CHOP Center of Excellence in Friedreich's Ataxia, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192779PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813973PMC
April 2018

Microbes vs. chemistry in the origin of the anaerobic gut lumen.

Proc Natl Acad Sci U S A 2018 04 2;115(16):4170-4175. Epub 2018 Apr 2.

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1718635115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910840PMC
April 2018

Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS.

J Lipid Res 2018 03 4;59(3):564-575. Epub 2018 Jan 4.

Institute for Translational Medicine and Therapeutics University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160

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http://www.jlr.org/lookup/doi/10.1194/jlr.D081414
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http://dx.doi.org/10.1194/jlr.D081414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832923PMC
March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Platelet Frataxin as a Protein Biomarker for the Rare Disease Friedreich's Ataxia.

Anal Chem 2018 02 11;90(3):2216-2223. Epub 2018 Jan 11.

Penn SRP Center and Center of Excellence in Environmental Toxicology Center, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b04590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817373PMC
February 2018

Bioorthogonal pro-metabolites for profiling short chain fatty acylation.

Chem Sci 2018 Feb 8;9(5):1236-1241. Epub 2017 Dec 8.

Chemical Biology Laboratory , Center for Cancer Research , National Cancer Institute , National Institutes of Health , Frederick , MD 21702 , USA . Email:

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http://dx.doi.org/10.1039/c7sc00247eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885804PMC
February 2018

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.

Cell Mol Life Sci 2018 01 29;75(2):335-354. Epub 2017 Aug 29.

Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, 2 Technology Place, North Ryde, NSW, 2109, Australia.

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http://dx.doi.org/10.1007/s00018-017-2632-8DOI Listing
January 2018

Accumulation of dysfunctional SOD1 protein in Parkinson's disease is not associated with mutations in the SOD1 gene.

Acta Neuropathol 2018 01 19;135(1):155-156. Epub 2017 Oct 19.

Discipline of Biomedical Science and Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1007/s00401-017-1779-6DOI Listing
January 2018

Potential Metabolic Activation of Representative Alkylated Polycyclic Aromatic Hydrocarbons 1-Methylphenanthrene and 9-Ethylphenanthrene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.

Chem Res Toxicol 2017 12 27;30(12):2140-2150. Epub 2017 Oct 27.

Synthetic Organic Chemistry Core, Center in Environmental Toxicology, University of Texas Medical Branch at Galveston , Galveston, Texas 77555-1110, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734992PMC
December 2017

On meta- and mega-analyses for gene-environment interactions.

Genet Epidemiol 2017 12 7;41(8):876-886. Epub 2017 Nov 7.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1002/gepi.22085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775907PMC
December 2017

Predictive genetic testing for amyotrophic lateral sclerosis and frontotemporal dementia: genetic counselling considerations.

Amyotroph Lateral Scler Frontotemporal Degener 2017 11 6;18(7-8):475-485. Epub 2017 Jun 6.

a Department of Clinical Medicine, Faculty of Medicine and Health Sciences , Macquarie University , Sydney , New South Wales , Australia and.

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http://dx.doi.org/10.1080/21678421.2017.1332079DOI Listing
November 2017

Metabolic tracing analysis reveals substrate-specific metabolic deficits in platelet storage lesion.

Transfusion 2017 11 23;57(11):2683-2689. Epub 2017 Aug 23.

A.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/trf.14292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787404PMC
November 2017

Vaginal microbiota and genitourinary menopausal symptoms: a cross-sectional analysis.

Menopause 2017 Oct;24(10):1160-1166

1Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 2Fred Hutchinson Cancer Research Center, Seattle, WA 3Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 4Department of Family Medicine and Public Health, University of California at San Diego, La Jolla, CA 5Department of Laboratory Medicine, University of Washington, Seattle, WA 6Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 7Group Health Research Institute, Seattle, WA 8Department of Obstetrics & Gynecology and Psychiatry, University of Pennsylvania, Philadelphia, PA 9Brigham and Women's Hospital and Dana Farber Cancer Center, Boston, MA 10Department of Psychiatry, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/GME.0000000000000904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607086PMC
October 2017

Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis.

Hum Mol Genet 2017 09;26(17):3452

Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, NSW 2109, Australia.

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http://dx.doi.org/10.1093/hmg/ddx268DOI Listing
September 2017

Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer.

Int J Biochem Cell Biol 2017 08 24;89:216-220. Epub 2017 Jun 24.

Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2017.06.011DOI Listing
August 2017

Testicular vs adrenal sources of hydroxy-androgens in prostate cancer.

Endocr Relat Cancer 2017 08 29;24(8):393-404. Epub 2017 Jun 29.

Department of Systems Pharmacology & Translational TherapeuticsPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1530/ERC-17-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593253PMC
August 2017

Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure.

Biomark Med 2017 Jul 23;11(7):547-556. Epub 2017 May 23.

Penn Superfund Research Program & Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.2217/bmm-2017-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619144PMC
July 2017

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.

Cell Metab 2017 Jun 13;25(6):1282-1293.e7. Epub 2017 Apr 13.

Division of Nephrology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462872PMC
June 2017

Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid.

Prostaglandins Other Lipid Mediat 2017 05 24;130:1-7. Epub 2017 Feb 24.

A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446925PMC
May 2017

Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.

Chem Res Toxicol 2017 04 22;30(4):1093-1101. Epub 2017 Mar 22.

Synthetic Organic Chemistry Core, Center in Environmental Toxicology, University of Texas Medical Branch at Galveston , Galveston, Texas 77555-1110, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593134PMC
April 2017

Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer.

Clin Lung Cancer 2017 03 26;18(2):e143-e149. Epub 2016 Oct 26.

Center of Excellence in Environmental Toxicology and Center for Cancer Pharmacology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.cllc.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346447PMC
March 2017

A novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro.

Amyotroph Lateral Scler Frontotemporal Degener 2017 Feb 18;18(1-2):126-133. Epub 2016 Aug 18.

a Faculty of Medicine and Health Sciences , Macquarie University , Sydney , New South Wales , Australia.

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http://dx.doi.org/10.1080/21678421.2016.1218517DOI Listing
February 2017

Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry.

J Steroid Biochem Mol Biol 2017 01 12;165(Pt B):342-355. Epub 2016 Aug 12.

Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Center for Cancer Pharmacology, Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146996PMC
January 2017

Mechanism of antineoplastic activity of lonidamine.

Biochim Biophys Acta 2016 12 4;1866(2):151-162. Epub 2016 Aug 4.

Laboratory of Molecular Imaging, Department of Radiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bbcan.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138080PMC
December 2016

Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease.

Clin Proteomics 2016 5;13:20. Epub 2016 Oct 5.

Penn SRP Center and Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104 USA ; BluePen Biomarkers, 3401 Grays Ferry Avenue, Philadelphia, PA 19146-2799 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050566PMC
http://dx.doi.org/10.1186/s12014-016-9121-1DOI Listing
October 2016

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.

Cell Rep 2016 10;17(4):1037-1052

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175409PMC
October 2016

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages.

FASEB J 2016 08 13;30(8):2885-98. Epub 2016 May 13.

Institute for Environmental Medicine, Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and

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http://dx.doi.org/10.1096/fj.201500146RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970605PMC
August 2016

Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing ultra-high-performance liquid chromatography/mass spectrometry for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism.

Rapid Commun Mass Spectrom 2016 08;30(16):1835-45

Penn SRP and Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1002/rcm.7667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970762PMC
August 2016

A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood.

JCI Insight 2016 Aug;1(12)

Department of Systems Pharmacology and Translational Therapeutics and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.87031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990354PMC
August 2016

(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism.

Front Oncol 2016 15;6:135. Epub 2016 Jun 15.

Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fonc.2016.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908130PMC
July 2016

Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.

Chem Res Toxicol 2016 06 1;29(6):991-1002. Epub 2016 May 1.

Center of Excellence in Environmental Toxicology and ‡Center for Cancer Pharmacology, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6160, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916485PMC
June 2016

Company profile: BluePen Biomarkers LLC – integrated biomarker solutions.

Future Sci OA 2016 06 9;2(2):FSO124. Epub 2016 Jun 9.

BluePen Biomarkers LLC, 3401 Grays Ferry Avenue, Building 212, Suite 132, Philadelphia, PA 19146-2701, USA; BluePrint Bio, Aliso Viejo, CA 92656, USA; BluePen Biomarkers LLC, 3401 Grays Ferry Avenue, Building 212, Suite 132, Philadelphia, PA 19146-2701, USA; BluePrint Bio, Aliso Viejo, CA 92656, USA.

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http://dx.doi.org/10.4155/fsoa-2016-0031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137845PMC
June 2016

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism.

J Vis Exp 2016 Apr 4(110):e53941. Epub 2016 Apr 4.

Center for Cancer Pharmacology, University of Pennsylvania; Center for Excellence in Environmental Toxicology, University of Pennsylvania;

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http://dx.doi.org/10.3791/53941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841355PMC
April 2016

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.

Nat Commun 2016 Apr 15;7:11253. Epub 2016 Apr 15.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

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http://dx.doi.org/10.1038/ncomms11253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835537PMC
April 2016

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.

Immunity 2016 Feb;44(2):380-90

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.021DOI Listing
February 2016

A dynamic career in MS: applications to biomedical research.

Authors:
Ian A Blair

Future Sci OA 2015 Nov 1;1(4):FSO52. Epub 2015 Nov 1.

Penn SRP Center & Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, 854 BRB II/III, 421 Curie Blvd, University of Pennsylvania, PA 19104, USA.

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http://dx.doi.org/10.4155/fso.15.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137938PMC
November 2015