Ian A Blair

Ian A Blair

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Ian A Blair

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Evaluation of antibodies for western blot analysis of frataxin protein isoforms.

J Immunol Methods 2019 Nov 4;474:112629. Epub 2019 Jul 4.

Penn/CHOP Center of Excellence in Friedreich's Ataxia, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn SRP Center and Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2019.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829029PMC
November 2019

In Vitro Biotransformation of the Nrf2 Activator Bardoxolone: Formation of an Epoxide Metabolite That Undergoes Two Novel Glutathione-Mediated Metabolic Pathways: Epoxide Reduction and Oxidative Elimination of Nitrile Moiety.

Chem Res Toxicol 2019 Nov 25;32(11):2268-2280. Epub 2019 Oct 25.

Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics , University of Pennsylvania , Philadelphia , Pennsylvania 19104-6606 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00289DOI Listing
November 2019

Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth.

Am J Obstet Gynecol 2019 Nov 20. Epub 2019 Nov 20.

Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1016/j.ajog.2019.11.1252DOI Listing
November 2019

Analytical Methods for Mass Spectrometry-Based Metabolomics Studies.

Adv Exp Med Biol 2019 ;1140:635-647

Penn SRP Center and Center of Excellence in Environmental Toxicology Center, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-3-030-15950-4_38DOI Listing
September 2019

The proteome and its dynamics: A missing piece for integrative multi-omics in schizophrenia.

Schizophr Res 2019 Aug 12. Epub 2019 Aug 12.

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09209964193030
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http://dx.doi.org/10.1016/j.schres.2019.07.025DOI Listing
August 2019

The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting.

Future Sci OA 2019 Jun 28;5(6):FSO398. Epub 2019 Jun 28.

Department of Neurology McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

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http://dx.doi.org/10.2144/fsoa-2019-0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609901PMC
June 2019

Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome.

Clin Endocrinol (Oxf) 2019 01 25;90(1):155-161. Epub 2018 Oct 25.

Penn SRP Center and Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/cen.13869DOI Listing
January 2019

Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone.

Chem Res Toxicol 2018 11 8;31(11):1277-1288. Epub 2018 Nov 8.

Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer-Foundation , Grosshansdorf 22927 , Germany.

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http://dx.doi.org/10.1021/acs.chemrestox.8b00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319660PMC
November 2018

Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes.

Sci Rep 2018 11 19;8(1):17043. Epub 2018 Nov 19.

Penn SRP Center and Center of Excellence in Environmental Toxicology Center, Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.

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http://www.nature.com/articles/s41598-018-35346-y
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http://dx.doi.org/10.1038/s41598-018-35346-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242848PMC
November 2018

Effect of a tissue selective estrogen complex on breast cancer: Role of unique properties of conjugated equine estrogen.

Int J Cancer 2018 09 16;143(5):1259-1268. Epub 2018 Apr 16.

Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Systems, Charlottesville, VA.

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http://dx.doi.org/10.1002/ijc.31401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377943PMC
September 2018

Gestational Diabetes Alters the Metabolomic Profile in 2nd Trimester Amniotic Fluid in a Sex-Specific Manner.

Int J Mol Sci 2018 Sep 10;19(9). Epub 2018 Sep 10.

Center for Research in Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.mdpi.com/1422-0067/19/9/2696
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http://dx.doi.org/10.3390/ijms19092696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165183PMC
September 2018

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Cell Metab 2018 Jun 10;27(6):1263-1280.e6. Epub 2018 May 10.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990482PMC
June 2018

Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy.

PLoS One 2018 15;13(2):e0192779. Epub 2018 Feb 15.

Penn/CHOP Center of Excellence in Friedreich's Ataxia, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192779PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813973PMC
April 2018

Microbes vs. chemistry in the origin of the anaerobic gut lumen.

Proc Natl Acad Sci U S A 2018 04 2;115(16):4170-4175. Epub 2018 Apr 2.

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1718635115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910840PMC
April 2018

Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS.

J Lipid Res 2018 03 4;59(3):564-575. Epub 2018 Jan 4.

Institute for Translational Medicine and Therapeutics University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160

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http://www.jlr.org/lookup/doi/10.1194/jlr.D081414
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http://dx.doi.org/10.1194/jlr.D081414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832923PMC
March 2018

Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Platelet Frataxin as a Protein Biomarker for the Rare Disease Friedreich's Ataxia.

Anal Chem 2018 02 11;90(3):2216-2223. Epub 2018 Jan 11.

Penn SRP Center and Center of Excellence in Environmental Toxicology Center, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b04590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817373PMC
February 2018

Bioorthogonal pro-metabolites for profiling short chain fatty acylation.

Chem Sci 2018 Feb 8;9(5):1236-1241. Epub 2017 Dec 8.

Chemical Biology Laboratory , Center for Cancer Research , National Cancer Institute , National Institutes of Health , Frederick , MD 21702 , USA . Email:

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http://dx.doi.org/10.1039/c7sc00247eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885804PMC
February 2018

Potential Metabolic Activation of Representative Alkylated Polycyclic Aromatic Hydrocarbons 1-Methylphenanthrene and 9-Ethylphenanthrene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.

Chem Res Toxicol 2017 12 27;30(12):2140-2150. Epub 2017 Oct 27.

Synthetic Organic Chemistry Core, Center in Environmental Toxicology, University of Texas Medical Branch at Galveston , Galveston, Texas 77555-1110, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734992PMC
December 2017

On meta- and mega-analyses for gene-environment interactions.

Genet Epidemiol 2017 12 7;41(8):876-886. Epub 2017 Nov 7.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1002/gepi.22085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775907PMC
December 2017

Metabolic tracing analysis reveals substrate-specific metabolic deficits in platelet storage lesion.

Transfusion 2017 11 23;57(11):2683-2689. Epub 2017 Aug 23.

A.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/trf.14292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787404PMC
November 2017

Vaginal microbiota and genitourinary menopausal symptoms: a cross-sectional analysis.

Menopause 2017 Oct;24(10):1160-1166

1Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 2Fred Hutchinson Cancer Research Center, Seattle, WA 3Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 4Department of Family Medicine and Public Health, University of California at San Diego, La Jolla, CA 5Department of Laboratory Medicine, University of Washington, Seattle, WA 6Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 7Group Health Research Institute, Seattle, WA 8Department of Obstetrics & Gynecology and Psychiatry, University of Pennsylvania, Philadelphia, PA 9Brigham and Women's Hospital and Dana Farber Cancer Center, Boston, MA 10Department of Psychiatry, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/GME.0000000000000904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607086PMC
October 2017

Testicular vs adrenal sources of hydroxy-androgens in prostate cancer.

Endocr Relat Cancer 2017 08 29;24(8):393-404. Epub 2017 Jun 29.

Department of Systems Pharmacology & Translational TherapeuticsPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1530/ERC-17-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593253PMC
August 2017

Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure.

Biomark Med 2017 Jul 23;11(7):547-556. Epub 2017 May 23.

Penn Superfund Research Program & Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.2217/bmm-2017-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619144PMC
July 2017

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.

Cell Metab 2017 Jun 13;25(6):1282-1293.e7. Epub 2017 Apr 13.

Division of Nephrology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462872PMC
June 2017

Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid.

Prostaglandins Other Lipid Mediat 2017 05 24;130:1-7. Epub 2017 Feb 24.

A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446925PMC
May 2017

Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.

Chem Res Toxicol 2017 04 22;30(4):1093-1101. Epub 2017 Mar 22.

Synthetic Organic Chemistry Core, Center in Environmental Toxicology, University of Texas Medical Branch at Galveston , Galveston, Texas 77555-1110, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593134PMC
April 2017

Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer.

Clin Lung Cancer 2017 03 26;18(2):e143-e149. Epub 2016 Oct 26.

Center of Excellence in Environmental Toxicology and Center for Cancer Pharmacology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.cllc.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346447PMC
March 2017

Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry.

J Steroid Biochem Mol Biol 2017 01 12;165(Pt B):342-355. Epub 2016 Aug 12.

Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Center for Cancer Pharmacology, Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146996PMC
January 2017

Mechanism of antineoplastic activity of lonidamine.

Biochim Biophys Acta 2016 12 4;1866(2):151-162. Epub 2016 Aug 4.

Laboratory of Molecular Imaging, Department of Radiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bbcan.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138080PMC
December 2016

Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease.

Clin Proteomics 2016 5;13:20. Epub 2016 Oct 5.

Penn SRP Center and Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104 USA ; BluePen Biomarkers, 3401 Grays Ferry Avenue, Philadelphia, PA 19146-2799 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050566PMC
http://dx.doi.org/10.1186/s12014-016-9121-1DOI Listing
October 2016

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.

Cell Rep 2016 10;17(4):1037-1052

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175409PMC
October 2016

Serum apolipoprotein A-1 quantification by LC-MS with a SILAC internal standard reveals reduced levels in smokers.

Bioanalysis 2015 22;7(22):2895-911. Epub 2015 Sep 22.

Center of Excellence in Environmental Toxicology & Penn SRP Center, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4155/bio.15.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737526PMC
September 2016

Ultra-high sensitivity analysis of estrogens for special populations in serum and plasma by liquid chromatography-mass spectrometry: Assay considerations and suggested practices.

J Steroid Biochem Mol Biol 2016 09 6;162:70-9. Epub 2016 Jan 6.

Center of Excellence in Environmental Toxicology and Penn SRP Center, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, United States; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931956PMC
September 2016

The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages.

FASEB J 2016 08 13;30(8):2885-98. Epub 2016 May 13.

Institute for Environmental Medicine, Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and

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http://dx.doi.org/10.1096/fj.201500146RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970605PMC
August 2016

Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing ultra-high-performance liquid chromatography/mass spectrometry for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism.

Rapid Commun Mass Spectrom 2016 08;30(16):1835-45

Penn SRP and Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1002/rcm.7667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970762PMC
August 2016

A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood.

JCI Insight 2016 Aug;1(12)

Department of Systems Pharmacology and Translational Therapeutics and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.87031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990354PMC
August 2016

Oncology bioanalysis: from biomarkers to drug discovery.

Biomark Med 2015 2;9(9):819-20. Epub 2015 Sep 2.

Penn SRP Center, Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.2217/bmm.15.54DOI Listing
July 2016

Translational metabolomics in cancer research.

Biomark Med 2015 1;9(9):821-34. Epub 2015 Sep 1.

Penn SRP Center & Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania, PA 19104, USA.

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http://dx.doi.org/10.2217/bmm.15.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718447PMC
July 2016

(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism.

Front Oncol 2016 15;6:135. Epub 2016 Jun 15.

Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fonc.2016.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908130PMC
July 2016

Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.

Chem Res Toxicol 2016 06 1;29(6):991-1002. Epub 2016 May 1.

Center of Excellence in Environmental Toxicology and ‡Center for Cancer Pharmacology, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6160, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916485PMC
June 2016

Company profile: BluePen Biomarkers LLC – integrated biomarker solutions.

Future Sci OA 2016 06 9;2(2):FSO124. Epub 2016 Jun 9.

BluePen Biomarkers LLC, 3401 Grays Ferry Avenue, Building 212, Suite 132, Philadelphia, PA 19146-2701, USA; BluePrint Bio, Aliso Viejo, CA 92656, USA; BluePen Biomarkers LLC, 3401 Grays Ferry Avenue, Building 212, Suite 132, Philadelphia, PA 19146-2701, USA; BluePrint Bio, Aliso Viejo, CA 92656, USA.

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http://dx.doi.org/10.4155/fsoa-2016-0031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137845PMC
June 2016

Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich's ataxia platelets.

Bioanalysis 2015 ;7(15):1843-55

Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4155/bio.15.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620983PMC
May 2016

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism.

J Vis Exp 2016 Apr 4(110):e53941. Epub 2016 Apr 4.

Center for Cancer Pharmacology, University of Pennsylvania; Center for Excellence in Environmental Toxicology, University of Pennsylvania;

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http://dx.doi.org/10.3791/53941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841355PMC
April 2016

Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells.

J Biol Chem 2016 Mar 24;291(10):5157-71. Epub 2015 Dec 24.

From the Department of Radiology, Laboratory of Molecular Imaging, Departments of Biochemistry and Biophysics and

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http://dx.doi.org/10.1074/jbc.M115.701862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777850PMC
March 2016

Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure.

Bioanalysis 2015 ;7(9):1157-73

1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.4155/bio.15.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487641PMC
February 2016

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Circulation 2016 Feb 27;133(8):706-16. Epub 2016 Jan 27.

From Cardiovascular Institute University of Pennsylvania Perelman School of Medicine, Smilow Translational Research Center, Philadelphia, PA (K.C.B., J.B., A.J., K.B.M., J.E.R.); A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA (N.W.S.); and Center of Cancer Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (M.A., C.M., A.J.W., L.L.W., I.A.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.017545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779339PMC
February 2016

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.

Immunity 2016 Feb;44(2):380-90

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.021DOI Listing
February 2016

Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine.

J Biol Chem 2016 Jan 31;291(1):42-57. Epub 2015 Oct 31.

From the Penn Superfund Research and Training Program Center, Center of Excellence in Environmental Toxicology, and Department of Systems Pharmacology and Translational Therapeutics and

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http://dx.doi.org/10.1074/jbc.M115.697516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697178PMC
January 2016

A dynamic career in MS: applications to biomedical research.

Authors:
Ian A Blair

Future Sci OA 2015 Nov 1;1(4):FSO52. Epub 2015 Nov 1.

Penn SRP Center & Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, 854 BRB II/III, 421 Curie Blvd, University of Pennsylvania, PA 19104, USA.

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http://dx.doi.org/10.4155/fso.15.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137938PMC
November 2015

Metabolism of an Alkylated Polycyclic Aromatic Hydrocarbon 5-Methylchrysene in Human Hepatoma (HepG2) Cells.

Chem Res Toxicol 2015 Oct 5;28(10):2045-58. Epub 2015 Oct 5.

Synthetic Organic Chemistry Core, Center in Environmental Toxicology, University of Texas Medical Branch at Galveston , Galveston, Texas 77555-1110, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.5b00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709222PMC
October 2015

What are the main considerations for bioanalysis of estrogens and androgens in plasma and serum samples from postmenopausal women?

Bioanalysis 2014 ;6(23):3073-5

Department of Systems Pharmacology & Translational Therapeutics, Penn SRP Center & Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4863, USA.

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http://dx.doi.org/10.4155/bio.14.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278565PMC
August 2015

Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.

Biochem Pharmacol 2015 Aug 29;96(3):247-55. Epub 2015 May 29.

Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830392PMC
August 2015

Analysis of estrogens and androgens in postmenopausal serum and plasma by liquid chromatography-mass spectrometry.

Steroids 2015 Jul 20;99(Pt A):76-83. Epub 2014 Aug 20.

Centers of Excellence in Environmental Toxicology and Cancer Pharmacology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4863, USA. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2014.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336238PMC
July 2015

15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.

Chem Biol Interact 2015 Jun 4;234:144-53. Epub 2014 Nov 4.

University of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA 15261, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00092797140032
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http://dx.doi.org/10.1016/j.cbi.2014.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414684PMC
June 2015

Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls.

J Clin Endocrinol Metab 2015 Jun 9;100(6):2322-8. Epub 2015 Apr 9.

Division of Endocrinology, Diabetes, and Metabolism (N.M.), Nemours Children's Health System, Jacksonville, Florida 32207; Division of Endocrinology (R.J.S.), University of Virginia, Charlottesville, Virginia 22908; Division of Hematology and Oncology (G.C.-O.), Mayo Clinic, Jacksonville, Florida 32224; Department of Statistics and Bioinformatics (J.H.), Dupont Hospital for Children, Wilmington, Delaware 19803; and Center for Excellence in Environmental Toxicology (Q.W., C.M., I.A.B.), Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1210/jc.2015-1495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454805PMC
June 2015

Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells.

Chem Res Toxicol 2015 May 8;28(5):948-54. Epub 2015 Apr 8.

∥A.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/tx500535cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721232PMC
May 2015

ATM couples replication stress and metabolic reprogramming during cellular senescence.

Cell Rep 2015 May 30;11(6):893-901. Epub 2015 Apr 30.

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431925PMC
May 2015

Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture.

Anal Biochem 2015 Apr 6;474:59-65. Epub 2015 Jan 6.

Penn SRP Center and Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2014.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413507PMC
April 2015

Ultrasensitive quantification of serum estrogens in postmenopausal women and older men by liquid chromatography-tandem mass spectrometry.

Steroids 2015 Apr 29;96:140-52. Epub 2015 Jan 29.

Center of Excellence in Environmental Toxicology and Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2015.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369926PMC
April 2015

Metabolism of propionic acid to a novel acyl-coenzyme A thioester by mammalian cell lines and platelets.

J Lipid Res 2015 Jan 25;56(1):142-50. Epub 2014 Nov 25.

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M055384
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http://dx.doi.org/10.1194/jlr.M055384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274062PMC
January 2015

Maternal serum serpin B7 is associated with early spontaneous preterm birth.

Am J Obstet Gynecol 2014 Dec 19;211(6):678.e1-12. Epub 2014 Jun 19.

Center for Cancer Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.ajog.2014.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254341PMC
December 2014

Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.

J Biol Chem 2014 Sep 12;289(39):26895-903. Epub 2014 Aug 12.

From the Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.591354
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http://dx.doi.org/10.1074/jbc.M114.591354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175330PMC
September 2014

Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium- and long-chain acyl-coenzyme A thioesters.

Rapid Commun Mass Spectrom 2014 Aug;28(16):1840-8

Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, and Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104-4863, USA.

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http://dx.doi.org/10.1002/rcm.6958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286313PMC
August 2014

Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells.

Eur J Pharmacol 2014 Jun 18;732:60-7. Epub 2014 Mar 18.

Centers for Cancer Pharmacology, Pharmacogenetics, and Excellence in Environmental Toxicology, Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402228PMC
June 2014

Metabolism of a representative oxygenated polycyclic aromatic hydrocarbon (PAH) phenanthrene-9,10-quinone in human hepatoma (HepG2) cells.

Chem Res Toxicol 2014 May 31;27(5):852-63. Epub 2014 Mar 31.

Center of Excellence in Environmental Toxicology and ‡Center for Cancer Pharmacology, Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6160, United States.

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http://dx.doi.org/10.1021/tx500031pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028327PMC
May 2014

Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and LC-MS.

Bioanalysis 2013 Dec;5(24):3009-21

Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.future-science.com/doi/10.4155/bio.13.269
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http://dx.doi.org/10.4155/bio.13.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912754PMC
December 2013

Cellular uptake and antiproliferative effects of 11-oxo-eicosatetraenoic acid.

J Lipid Res 2013 Nov 14;54(11):3070-7. Epub 2013 Aug 14.

Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1194/jlr.M040741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793611PMC
November 2013

Interception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cells.

Chem Res Toxicol 2013 Oct 3;26(10):1570-8. Epub 2013 Oct 3.

Center of Excellence in Environmental Toxicology and ‡Center for Cancer Pharmacology, Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6160, United States.

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http://dx.doi.org/10.1021/tx400268qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829198PMC
October 2013