Iain L C Chapple

Iain L C Chapple

UNVERIFIED PROFILE

Are you Iain L C Chapple?   Register this Author

Register author
Iain L C Chapple

Iain L C Chapple

Publications by authors named "Iain L C Chapple"

Are you Iain L C Chapple?   Register this Author

70Publications

1017Reads

40Profile Views

Periodontal care in general practice: 20 important FAQs - Part one.

Br Dent J 2019 Jun;226(11):850-854

Department of Periodontology, The School of Dentistry, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41415-019-0374-8DOI Listing
June 2019

Oral Neutrophils Characterized: Chemotactic, Phagocytic, and Neutrophil Extracellular Trap (NET) Formation Properties.

Front Immunol 2019 29;10:635. Epub 2019 Mar 29.

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.00635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449731PMC
March 2019

Nupharidine enhances Aggregatibacter actinomycetemcomitans clearance by priming neutrophils and augmenting their effector functions.

J Clin Periodontol 2019 Jan 18;46(1):62-71. Epub 2018 Dec 18.

Department of Periodontology, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jcpe.13036
Publisher Site
http://dx.doi.org/10.1111/jcpe.13036DOI Listing
January 2019

Perioperative supplementation with a fruit and vegetable juice powder concentrate and postsurgical morbidity: A double-blind, randomised, placebo-controlled clinical trial.

Clin Nutr 2018 Oct 10;37(5):1448-1455. Epub 2017 Aug 10.

Department of Oral Surgery, School of Dentistry, University of Birmingham, Birmingham, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clnu.2017.08.004DOI Listing
October 2018

Impact of Bariatric Surgical Intervention on Peripheral Blood Neutrophil (PBN) Function in Obesity.

Obes Surg 2018 06;28(6):1611-1621

Periodontal Research Group, School of Dentistry, Institute of Clinical Science, University of Birmingham and Birmingham Dental Hospital (Birmingham Community Healthcare Trust), 5 Mill Pool Way, Edgbaston, Birmingham, B5 7ET, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11695-017-3063-1
Publisher Site
http://dx.doi.org/10.1007/s11695-017-3063-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973997PMC
June 2018

Dental plaque-induced gingival conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S17-S27

Department of Periodontology, University of Birmingham School of Dentistry, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpe.12937DOI Listing
June 2018

Dental plaque-induced gingival conditions.

J Periodontol 2018 Jun;89 Suppl 1:S17-S27

Department of Periodontology, University of Birmingham School of Dentistry, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/JPER.17-0095DOI Listing
June 2018

Antioxidant Micronutrients and Oxidative Stress Biomarkers.

Methods Mol Biol 2017 ;1537:61-77

School of Dentistry, Institute of Clinical Sciences, Collegeof Medical and Dental Sciences, University of Birmingham, 5 Mill Pool Way, Edgbaston, Birmingham, B5 7EG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6685-1_4DOI Listing
January 2018

Oral Epithelial Cell Culture Model for Studying the Pathogenesis of Chronic Inflammatory Disease.

Methods Mol Biol 2017 ;1537:381-401

Institute of Clinical Sciences, College of Medical and Dental Sciences, The School of Dentistry, University of Birmingham, 5 Mill Pool Way, Edgbaston, Birmingham, B5 7EG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6685-1_22DOI Listing
January 2018

Characterization, Quantification, and Visualization of Neutrophil Extracellular Traps.

Methods Mol Biol 2017 ;1537:481-497

Institute of Clinical Sciences, College of Medical and Dental Sciences, The School of Dentistry, University of Birmingham, 5 Mill Pool Way, Edgbaston, Birmingham, B5 7EG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6685-1_29DOI Listing
January 2018

Modulation of Neutrophil Extracellular Trap and Reactive Oxygen Species Release by Periodontal Bacteria.

Infect Immun 2017 12 17;85(12). Epub 2017 Nov 17.

Periodontal Research Group, Birmingham Dental School and Hospital, Institute of Clinical Sciences, The University of Birmingham and Birmingham Community Health NHS Trust, Edgbaston, Birmingham, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/IAI.00297-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695129PMC
December 2017

INfluence of Successful Periodontal Intervention in REnal Disease (INSPIRED): study protocol for a randomised controlled pilot clinical trial.

Trials 2017 Nov 13;18(1):535. Epub 2017 Nov 13.

Periodontal Research Group, School of Dentistry, Institute of Clinical Sciences, Birmingham, B5 7EG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-017-2236-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683458PMC
November 2017

Impact of fibrinogen carbamylation on fibrin clot formation and stability.

Thromb Haemost 2017 05 6;117(5):899-910. Epub 2017 Apr 6.

Veronika Binder, Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, The Laboratory Building, 5th floor, Bergen, Norway, Tel.: +47 55 97 46 48, Fax: +47 55 97 58 17, E-mail:

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1160/TH16-09-0704
Publisher Site
http://dx.doi.org/10.1160/TH16-09-0704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442607PMC
May 2017

Effects of leukotoxin on neutrophil migration and extracellular trap formation.

J Oral Microbiol 2016 8;8:33070. Epub 2016 Nov 8.

Section Oral Microbiology, Department of Odontology, Umeå University, Umeå, Sweden.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103672PMC
http://dx.doi.org/10.3402/jom.v8.33070DOI Listing
November 2016

Neutrophil superoxide release and plasma C-reactive protein levels pre- and post-periodontal therapy.

J Clin Periodontol 2016 08 7;43(8):652-8. Epub 2016 Jun 7.

Periodontal Research Group and MRC Centre for Immune Regulation, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jcpe.12575
Publisher Site
http://dx.doi.org/10.1111/jcpe.12575DOI Listing
August 2016

Longitudinal quantification of the gingival crevicular fluid proteome during progression from gingivitis to periodontitis in a canine model.

J Clin Periodontol 2016 07 23;43(7):584-94. Epub 2016 May 23.

Periodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpe.12548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089638PMC
July 2016

Carbamylated LL-37 as a modulator of the immune response.

Innate Immun 2016 Apr 15;22(3):218-29. Epub 2016 Feb 15.

Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753425916631404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143673PMC
April 2016

Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study.

J Clin Periodontol 2016 Feb 18;43(2):104-13. Epub 2016 Feb 18.

Periodontal Research Group, School of Dentistry, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpe.12502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324563PMC
February 2016

Peripheral blood neutrophil cytokine hyper-reactivity in chronic periodontitis.

Innate Immun 2015 Oct 8;21(7):714-25. Epub 2015 Jun 8.

Periodontal Research Group and MRC Centre for Immune Regulation, College of Medical and Dental Sciences, The University of Birmingham, St Chad's Queensway, Birmingham B4 6NN, UK.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1753425915589387
Publisher Site
http://dx.doi.org/10.1177/1753425915589387DOI Listing
October 2015

Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients.

J Clin Periodontol 2015 Jan 8;42(1):1-11. Epub 2015 Jan 8.

Periodontal Research Group and MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpe.12326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340045PMC
January 2015

Prescribing for periodontal disease.

Prim Dent J 2014 Nov;3(4):38-43

Birmingham Dental Hospital, Birmingham Community Healthcare Trust, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1308/205016814813877234DOI Listing
November 2014

The multi-center randomized controlled trial (RCT) published by the journal of the American Medical Association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental problems.

J Evid Based Dent Pract 2014 Sep 21;14(3):127-32. Epub 2014 May 21.

Professor of Periodontology and Consultant in Restorative Dentistry, Periodontal Research Group & MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, St Chad's Queensway, Birmingham B4 6NN United Kingdom Tel.: +44 (0)121 466 5486. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jebdp.2014.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502578PMC
September 2014

Effects of C-reactive protein on the neutrophil respiratory burst in vitro.

Innate Immun 2014 May 9;20(4):339-49. Epub 2013 Jul 9.

Periodontal Research Group and MRC Centre for Immune Regulation, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1753425913493199
Publisher Site
http://dx.doi.org/10.1177/1753425913493199DOI Listing
May 2014

Hemoglobin A1c levels among patients with diabetes receiving nonsurgical periodontal treatment.

JAMA 2014 May;311(18):1919-20

Department of Oral Biology and Microbiology, State University of New York, Buffalo.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2014.2228DOI Listing
May 2014

Time to take periodontitis seriously.

Authors:
Iain L C Chapple

BMJ 2014 Apr 10;348:g2645. Epub 2014 Apr 10.

University of Birmingham Periodontal Research Group and MRC Centre for Immune Regulation, Dental School, Birmingham B4 6NN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.g2645DOI Listing
April 2014

The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis?

Ann Rheum Dis 2014 Mar 23;73(3):580-6. Epub 2013 Feb 23.

Rheumatology Research Group, School of Immunity & Infection, College of Medical & Dental Sciences, University of Birmingham, , Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2012-202701DOI Listing
March 2014

Periodontal disease and systemic disease.

J R Soc Med 2014 Mar;107(3):94

Denplan Ltd, Denplan Court, Victoria Road, Winchester, SO23 7RG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0141076813518770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938125PMC
March 2014

Multiple cerebral abscesses in Papillon-Lefèvre syndrome.

Childs Nerv Syst 2013 Aug 18;29(8):1227-9. Epub 2013 May 18.

Paediatric Intensive Care Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007%252Fs00381-013-
Web Search
http://link.springer.com/10.1007/s00381-013-2152-2
Publisher Site
http://dx.doi.org/10.1007/s00381-013-2152-2DOI Listing
August 2013

Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.

J Clin Periodontol 2013 Apr;40 Suppl 14:S106-12

Periodontal Research Group & MRC Centre for Immune Regulation, University of Birmingham School of Dentistry, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpe.12077DOI Listing
April 2013

Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.

J Periodontol 2013 Apr;84(4 Suppl):S106-12

Periodontal Research Group & MRC Centre for Immune Regulation, University of Birmingham School of Dentistry, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1902/jop.2013.1340011DOI Listing
April 2013

Neutrophil superoxide production in the presence of cigarette smoke extract, nicotine and cotinine.

J Clin Periodontol 2012 Jul 21;39(7):626-34. Epub 2012 May 21.

Periodontal Research Group and MRC Centre for Immune Regulation, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1600-051X.2012.01894.x
Publisher Site
http://dx.doi.org/10.1111/j.1600-051X.2012.01894.xDOI Listing
July 2012

Effect of nicotine, cotinine and cigarette smoke extract on the neutrophil respiratory burst.

J Clin Periodontol 2011 Mar 9;38(3):208-18. Epub 2011 Jan 9.

School of Dentistry, Periodontal Research Group, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1600-051X.2010.01676.x
Publisher Site
http://dx.doi.org/10.1111/j.1600-051X.2010.01676.xDOI Listing
March 2011

Biological approaches to the development of novel periodontal therapies--consensus of the Seventh European Workshop on Periodontology.

J Clin Periodontol 2011 Mar;38 Suppl 11:114-8

European Research Group on Periodontology, Genova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-051X.2010.01675.xDOI Listing
March 2011

Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines.

J Clin Periodontol 2011 Jan 21;38(1):1-7. Epub 2010 Oct 21.

School of Life and Health Sciences, Aston University, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-051X.2010.01628.xDOI Listing
January 2011

Oxygen tension modulates the cytokine response of oral epithelium to periodontal bacteria.

J Clin Periodontol 2010 Dec 18;37(12):1039-48. Epub 2010 Oct 18.

Periodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-051X.2010.01622.xDOI Listing
December 2010

Proteomic analysis of a noninvasive human model of acute inflammation and its resolution: the twenty-one day gingivitis model.

J Proteome Res 2010 Sep;9(9):4732-44

Periodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, St. Chads Queensway, Birmingham, B4 6NN, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr100446fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950674PMC
September 2010

Crevicular fluid glutathione levels in periodontitis and the effect of non-surgical therapy.

J Clin Periodontol 2010 Jan 24;37(1):17-23. Epub 2009 Nov 24.

Periodontology Research Group, School of Dentistry, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1600-051X.2009.01504.x
Publisher Site
http://dx.doi.org/10.1111/j.1600-051X.2009.01504.xDOI Listing
January 2010

Summary and conclusions: where now?

Authors:
Iain L C Chapple

J Dent 2009 Aug 22;37(8):S583-4. Epub 2009 May 22.

The Oral and Dental Research Trust, and The University of Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdent.2009.05.021DOI Listing
August 2009

The impact of oral disease upon systemic health-Symposium overview.

Authors:
Iain L C Chapple

J Dent 2009 Aug 22;37(8):S568-71. Epub 2009 May 22.

Oral and Dental Research Trust, and The University of Birmingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdent.2009.05.022DOI Listing
August 2009

Localized delivery of growth factors for periodontal tissue regeneration: role, strategies, and perspectives.

Med Res Rev 2009 May;29(3):472-513

Department of Periodontology and Oral Medicine, School of Stomatology, The Fourth Military Medical University, Shaanxi, People's Republic of China.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/med.20144
Publisher Site
http://dx.doi.org/10.1002/med.20144DOI Listing
May 2009

Periodontitis in systemic rheumatic diseases.

Nat Rev Rheumatol 2009 Apr;5(4):218-24

Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston Birmingham, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrrheum.2009.28
Publisher Site
http://dx.doi.org/10.1038/nrrheum.2009.28DOI Listing
April 2009

Potential mechanisms underpinning the nutritional modulation of periodontal inflammation.

Authors:
Iain L C Chapple

J Am Dent Assoc 2009 Feb;140(2):178-84

School of Dentistry, College of Medical and Dental Sciences, The University of Birmingham, St Chads Queensway, Birmingham, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14219/jada.archive.2009.0131DOI Listing
February 2009

Periodontitis associates with a type 1 IFN signature in peripheral blood neutrophils.

J Immunol 2008 Oct;181(8):5775-84

Periodontal Research Group, School of Dentistry, University of Birmingham, Birmingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.181.8.5775DOI Listing
October 2008

The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations.

J Nutr 2007 Mar;137(3):657-64

Periodontal Research Group, University of Birmingham, School of Dentistry, St. Chads Queensway, Birmingham, B4 6NN, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/jn/article/137/3/657/4664688
Publisher Site
http://dx.doi.org/10.1093/jn/137.3.657DOI Listing
March 2007

The role of reactive oxygen and antioxidant species in periodontal tissue destruction.

Periodontol 2000 2007 ;43:160-232

Unit of Periodontology, The University of Birmingham School of Dentistry, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-0757.2006.00178.xDOI Listing
February 2007

Prediction of serum total antioxidant activity from the concentration of individual serum antioxidants.

Clin Chim Acta 2006 Oct 6;372(1-2):188-94. Epub 2006 Jun 6.

Clinical Pharmacology Unit, The University of Edinburgh, Queens Medical Research Institute, Edinburgh, Scotland, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2006.04.015DOI Listing
October 2006

Crevicular fluid levels of TGFbeta1 in drug-induced gingival overgrowth.

Arch Oral Biol 2004 May;49(5):421-5

Periodontal Research Group, Unit of Oral Biology & Pathology, School of Dentistry, University of Birmingham, St. Chad's Queensway, Birmingham B4 6NN, UK.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S000399690300239
Publisher Site
http://dx.doi.org/10.1016/j.archoralbio.2003.09.002DOI Listing
May 2004

Questionnaire research: an easy option?

Authors:
Iain L C Chapple

Br Dent J 2003 Oct;195(7):359

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.bdj.4810554DOI Listing
October 2003