Publications by authors named "Iain Hargreaves"

100Publications

Effects of Feeding Coenzyme Q10-Ubiquinol on Plasma Coenzyme Q10 Concentrations and Semen Quality in Stallions.

J Equine Vet Sci 2021 Jan 15;96:103303. Epub 2020 Oct 15.

Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA. Electronic address:

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January 2021

The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme Q Status and Mitochondrial Function.

Int J Mol Sci 2020 Nov 30;21(23). Epub 2020 Nov 30.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.

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November 2020

Disorders of Human Coenzyme Q10 Metabolism: An Overview.

Int J Mol Sci 2020 Sep 13;21(18). Epub 2020 Sep 13.

Pharma Nord (UK) Ltd., Telford Court, Morpeth, NE61 2DB Northumberland, UK.

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September 2020

Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review.

J Clin Med 2020 Aug 11;9(8). Epub 2020 Aug 11.

School of Pharmacy, Liverpool John Moore University, Byrom Street, Liverpool L3 3AF, UK.

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August 2020

The Effect of Cellular Coenzyme Q Deficiency on Lysosomal Acidification.

J Clin Med 2020 Jun 19;9(6). Epub 2020 Jun 19.

School of Pharmacy, Liverpool John Moore University, Byrom Street, Liverpool L3 3AF, UK.

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June 2020

Multisystem mitochondrial disease caused by a rare m.10038G>A mitochondrial tRNA () variant.

Neurol Genet 2020 Apr 18;6(2):e413. Epub 2020 Mar 18.

Department of Neuromuscular Diseases (O.V.P., A.H., E.B., R.Q., M.G.H., R.D.S.P.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, United Kingdom; Wellcome Centre for Mitochondrial Research (S.A.H., R.W.T.), Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne; Neurogenetics Unit (C.E.W.), and Neurometabolic Unit (I.P.H.), The National Hospital for Neurology and Neurosurgery; Division of Neuropathology (A.M.), UCL Queen Square Institute of Neurology; Department of Histopathology (A.M.), Camelia Botnar Laboratory, Great Ormond Street Hospital; and Dubowitz Neuromuscular Centre (R.Q.), Great Ormond Street Hospital, London, United Kingdom.

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April 2020

The Effect of Organophosphate Exposure on Neuronal Cell Coenzyme Q Status.

Neurochem Res 2020 Apr 18. Epub 2020 Apr 18.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.

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April 2020

Coenzyme Q Assessment and the Establishment of a Neuronal Cell Model of CoQ Deficiency.

Methods Mol Biol 2020 ;2138:277-287

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.

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January 2020

Production of Mannosylerythritol Lipids (MELs) to be Used as Antimicrobial Agents Against S. aureus ATCC 6538.

Curr Microbiol 2020 Aug 2;77(8):1373-1380. Epub 2020 Mar 2.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building 10.05C, Byrom Street, Liverpool, L3 3AF, UK.

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August 2020

Expanding the molecular and phenotypic spectrum of truncating mutations.

Neurol Genet 2020 Feb 7;6(1):e381. Epub 2020 Jan 7.

Department of Neuromuscular Diseases (E. Bugiardini, O.V.P, A.H., H.H., R.Q., M.G.H., R.D.S.P.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, United Kingdom; Mitochondrial Medicine Group (E. Bottani, C.B., M.Z.), Medical Research Council Mitochondrial Biology Unit, Cambridge, United Kingdom; Department of Molecular and Translational Medicine (E. Bottani, A.V.), University of Brescia; Medical Genetics and Neurogenetics Unit (S.M., E.L., C.L.), Fondazione IRCCS Istituto Neurologico, "C. Besta," Milan, Italy; Neurogenetics Unit (C.W.), and Neurometabolic Unit (A.L., I.H., A.C.), The National Hospital for Neurology and Neurosurgery; Division of Neuropathology (K.V., J.L.H.), UCL Queen Square Institute of Neurology; and Dubowitz Neuromuscular Centre (R.Q.), Great Ormond Street Hospital, London, United Kingdom.

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February 2020

Assessment of Mitochondrial Dysfunction in Experimental Autoimmune Encephalomyelitis (EAE) Models of Multiple Sclerosis.

Int J Mol Sci 2019 Oct 9;20(20). Epub 2019 Oct 9.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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October 2019

Coenzyme Q10 Supplementation in Fibrosis and Aging.

Adv Exp Med Biol 2019 ;1178:103-112

Pharma Nord (UK) Ltd, Morpeth, Newcastle, UK.

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September 2019

Autosomal dominant optic atrophy and cataract "plus" phenotype including axonal neuropathy.

Neurol Genet 2019 Apr 1;5(2):e322. Epub 2019 Apr 1.

Department of Neuromuscular Diseases (A.H., A.C., M.G.H., M.M.R.), UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, University College London Hospitals; Department of Molecular Neuroscience (A.M.P., H.H.), UCL Queen Square Institute of Neurology; Department of Neuro-ophthalmology (F.B.F.R.C.O.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals; Division of Neuropathology (Z.J., S.B.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals; Department of Clinical and Movement Neurosciences (Z.J.), UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (L.D., S.S.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Human Genetics and Hussman Institute for Human Genomics (A.P.R., S.Z.), University of Miami, FL; Department of Neurogenetics (C.E.W., J.M.P.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals; Neurometabolic Unit (I.P.H.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals; and Department of Neurodegenerative Disease (S.B.), UCL Queen Square Institute of Neurology, London, United Kingdom.

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April 2019

Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson's disease.

Sci Rep 2019 04 25;9(1):6559. Epub 2019 Apr 25.

Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.

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April 2019

Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.

Antioxidants (Basel) 2019 Feb 16;8(2). Epub 2019 Feb 16.

School of Pharmacy, Liverpool John Moores University, L3 5UA Liverpool, UK.

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February 2019

Biochemical Assessment and Monitoring of Mitochondrial Disease.

J Clin Med 2018 Mar 29;7(4). Epub 2018 Mar 29.

Department of Pharmacy and Biomolecular Science, Liverpool John Moores University, Byrom Street, Liverpool L3 5UA, UK.

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March 2018

Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease.

J Clin Med 2017 Oct 27;6(11). Epub 2017 Oct 27.

Department of Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.

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October 2017

Measurement of Respiratory Chain Enzyme Activity in Human Renal Biopsy Specimens.

J Clin Med 2017 Sep 19;6(9). Epub 2017 Sep 19.

Department of Nephrology, Birmingham Children's Hospital, Birmingham B4 6NH, UK.

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September 2017

Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders.

J Clin Med 2017 Jul 19;6(7). Epub 2017 Jul 19.

School of Pharmacy, Liverpool John Moore University, Byrom Street, Liverpool L3 3AF, UK.

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July 2017

Clinicopathologic and molecular spectrum of -related mitochondrial disease.

Neurol Genet 2017 Jun 2;3(3):e149. Epub 2017 May 2.

MRC Centre for Neuromuscular Diseases (E.B., O.V.P., A.M., A.H., J.L.H., H.H., M.G.H., R.D.S.P.), UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery; Department of Molecular Neuroscience (A.M., A.M.P., J.L.H., H.H., M.G.H.), Division of Neuropathology (J.L.H.), Department of Clinical Neuroscience (J.-W.T., A.S., I.J.H.), UCL Institute of Neurology; Neurometabolic Unit (I.H.), Neurogenetics Unit (C.E.W., M.G.S.), Department of Neuro-ophthalmology (G.T.P.), National Hospital for Neurology and Neurosurgery, London; Nuffield Department of Obstetrics and Gynaecology (J.P.), University of Oxford; MRC-Mitochondrial Biology Unit (M.Z.), Cambridge, UK; Unit of Molecular Neurogenetics (D.G.), Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan, Italy; Oxford Medical Genetics Laboratories (J.T., C.S., C.F.), Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, UK; Department of Neurology (M.A.K.), Nizam's Institute of Medical Sciences; CSIR-Centre for Cellular and Molecular Biology (A.P., K.T.), Hyderabad, Telangana, India; MRC Mill Hill Laboratory (I.J.H.), London, UK; Biodonostia Research Institute (I.J.H.), San Sebastián, Spain; and Department of Basic and Clinical Neuroscience (R.D.S.P.), Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

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June 2017

Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats.

Dis Model Mech 2016 10 1;9(10):1221-1229. Epub 2016 Sep 1.

University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Hills Road, Cambridge CB2 OQQ, UK.

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October 2016

Incidence of Primary Mitochondrial Disease in Children Younger Than 2 Years Presenting With Acute Liver Failure.

J Pediatr Gastroenterol Nutr 2016 12;63(6):592-597

*Liver Unit, Birmingham Children's Hospital †University of Birmingham ‡Department of Clinical IMD §Department of Radiology, Birmingham Children's Hospital, Birmingham ||Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust ¶Nuffield Department of Obstetrics and Gynaecology, University of Oxford #Wellcome Trust Centre for Mitochondrial Research and Highly Specialised Rare Mitochondrial Disease Service, Newcastle University **Genetics and Genomic Medicine, UCL Institute of Child Health, London, United Kingdom.

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December 2016

The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy.

Neurology 2016 05 22;86(20):1921-3. Epub 2016 Apr 22.

From the University of Oxford (E.D., A.D., K.M., J.C., T.L., C.L., R.M., S.M.D., J.P.); Churchill Hospital (C.F.), Oxford; Newcastle University (Y.S.N., E.L.B., M.A.-D., P.Y.-W.-M., R.W.T.), Newcastle upon Tyne; National Hospital for Neurology and Neurosurgery (I.H.), UCLH, Queen Square, London; Stoke Mandeville Hospital (G.S.), Aylesbury; Royal Hallamshire Hospital (S.J.H.), Sheffield; John Radcliffe Hospital (S.J.), Oxford; Royal Victoria Infirmary (P.Y.-W.-M.), Newcastle upon Tyne; and Moorfields Eye Hospital and UCL Institute of Ophthalmology (P.Y.-W.-M.), London, UK.

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May 2016

Drug-Induced Mitochondrial Toxicity.

Drug Saf 2016 07;39(7):661-74

Neurometabolic Unit. Box 105, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK.

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July 2016

Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients.

PLoS One 2016 19;11(2):e0149557. Epub 2016 Feb 19.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom.

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July 2016

Pontocerebellar hypoplasia type 2D and optic nerve atrophy further expand the spectrum associated with selenoprotein biosynthesis deficiency.

Eur J Paediatr Neurol 2016 May 11;20(3):483-8. Epub 2016 Jan 11.

Department of Paediatric Neurology, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, United Kingdom; The Portland Hospital for Women and Children, 205-209 Great Portland St, London, W1W 5AH, United Kingdom. Electronic address:

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May 2016

Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth.

Am J Clin Nutr 2016 Feb 30;103(2):579-88. Epub 2015 Dec 30.

University of Cambridge Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom; and.

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February 2016

Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth.

Endocrinology 2015 Oct 27;156(10):3528-37. Epub 2015 Jul 27.

University of Cambridge Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit (J.L.T.-A., D.S.F.-T., R.M., J.-H.C., A.C., J.M.M., S.E.O.), Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge CB2 OQQ, United Kingdom; and Neurometabolic Unit (I.P.H.), National Hospital, University College London, London WC1N 3BG, United Kingdom.

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October 2015

Can folic acid have a role in mitochondrial disorders?

Drug Discov Today 2015 Nov 14;20(11):1349-54. Epub 2015 Jul 14.

Clinical Biochemistry Department, Hospital Sant Joan de Déu, Center for Biomedical Research in Rare Diseases, Barcelona, Spain; CIBERER-ISCIII, Madrid, Spain. Electronic address:

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November 2015

Neuropathologic Characterization of Pontocerebellar Hypoplasia Type 6 Associated With Cardiomyopathy and Hydrops Fetalis and Severe Multisystem Respiratory Chain Deficiency due to Novel RARS2 Mutations.

J Neuropathol Exp Neurol 2015 Jul;74(7):688-703

From the Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, UK (NZL, CLA, LH, GF, RM, RWT); East Anglian Medical Genetics Service, Cambridge University Hospital NHS foundations Trust, Cambridge Biomedical Campus, Cambridge, UK (KS, SP); Department of Paediatric Neurology, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge UK (DK); Neonatal Unit, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK (AO); The Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Du Cane Road, London, UK (CL); Department of Clinical Neurosciences, Institute of Neurology, University College London, London, UK (RHK); Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, London, UK (IPH); Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Trust, Oxford, UK (GKB); and Department of Histopathology, Cambridge University Hospital NHS foundations Trust, Cambridge, UK (AFD).

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July 2015

Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.

Endocrinology 2015 Mar 29;156(3):975-86. Epub 2014 Dec 29.

Department of Physiology (P.V.L., D.G.-T., B.P.C., R.N., C.D.), Centre for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela and Institute of Health Sciences, and Department of Morphological Sciences (P.V., T.G.-C.), School of Medicine and University Clinical Hospital, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; Department of Pharmacology (P.V.L., R.T., P.W.T., J.P.), Oxford University, Oxford OX1 3QT, United Kingdom; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (D.G.-T., B.P.C., R.N., C.D.), 15706, Santiago de Compostela, Spain; Department of Physiology, Anatomy, and Genetics (V.G., H.C.C.), Oxford University, Oxford OX1 3QX, United Kingdom; and Neurometabolic Unit (E.R., A.C., I.P.H.), National Hospital for Neurology and Neurosurgery, University College London Hospitals, Queen Square, London WC1N 3BG, United Kingdom.

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March 2015

Zellweger syndrome and secondary mitochondrial myopathy.

Eur J Pediatr 2015 Apr 7;174(4):557-63. Epub 2014 Oct 7.

Department of Paediatric Neurology, Chelsea and Westminster NHS Foundation Trust, London, UK,

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April 2015

Nutritional programming of coenzyme Q: potential for prevention and intervention?

FASEB J 2014 Dec 29;28(12):5398-405. Epub 2014 Aug 29.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; and.

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December 2014

Biochemical diagnosis of coenzyme q10 deficiency.

Mol Syndromol 2014 Jul;5(3-4):147-55

Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, London, UK.

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July 2014

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells.

J Neurochem 2014 May 25;129(3):426-33. Epub 2014 Jan 25.

Clinical and Molecular Genetics Unit, UCL Institute of Child Health, London, UK; Chemical Pathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

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May 2014

Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth.

Mol Metab 2013 27;2(4):480-90. Epub 2013 Sep 27.

University of Cambridge, Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust - MRC Institute of Metabolic Science, Level 4, Box 289, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.

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December 2013

Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy.

J Neurol Neurosurg Psychiatry 2014 May 6;85(5):486-92. Epub 2013 Nov 6.

Department of Molecular Neuroscience and Reta Lila Weston Research Laboratories, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, , London, UK.

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May 2014

Levels of 5-methyltetrahydrofolate and ascorbic acid in cerebrospinal fluid are correlated: implications for the accelerated degradation of folate by reactive oxygen species.

Neurochem Int 2013 Dec 15;63(8):750-5. Epub 2013 Oct 15.

Clinical and Molecular Genetics Unit, UCL Institute of Child Health, London, UK; Chemical Pathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

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December 2013

COX10 mutations resulting in complex multisystem mitochondrial disease that remains stable into adulthood.

JAMA Neurol 2013 Dec;70(12):1556-61

Medical Research Council Centre for Neuromuscular Diseases, University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, England13Department of Molecular Neuroscience, University College London Institute o.

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December 2013

Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease.

Cell Metab 2013 Jun 23;17(6):941-953. Epub 2013 May 23.

Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK; UCL Consortium for Mitochondrial Research, University College London, London WC1E 6BT, UK. Electronic address:

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June 2013

Coenzyme Q₁₀ deficiency in mitochondrial DNA depletion syndromes.

Mitochondrion 2013 Jul 11;13(4):337-41. Epub 2013 Apr 11.

Clinical Chemistry, Pathology and Neurology Departments, Hospital Sant Joan de Déu, Barcelona, Spain.

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July 2013

Dopamine but not l-dopa stimulates neural glutathione metabolism. Potential implications for Parkinson's and other dopamine deficiency states.

Neurochem Int 2013 Apr 19;62(5):684-94. Epub 2012 Dec 19.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square House, Queen Square, London WC1N 3BG, UK.

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April 2013

Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress, and oxidative defense capacity in rat heart.

FASEB J 2013 Jan 27;27(1):379-90. Epub 2012 Sep 27.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Box 289, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Hills Rd., Cambridge, CB2 OQQ, UK.

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January 2013

Distal myopathy with cachexia: an unrecognised phenotype caused by dominantly-inherited mitochondrial polymerase γ mutations.

J Neurol Neurosurg Psychiatry 2013 Jan 29;84(1):107-10. Epub 2012 Aug 29.

MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

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January 2013

Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment.

J Inherit Metab Dis 2013 Jan 6;36(1):63-73. Epub 2012 Jul 6.

Department of Molecular Neuroscience, UCL Institute of Neurology and Neurometabolic Unit, National Hospital for Neurology, Queen Square, London WC1N 3BG, UK.

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January 2013

Ubiquinone in cardiac arrest: from bathroom to bedside.

Resuscitation 2012 Aug 26;83(8):928-9. Epub 2012 May 26.

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August 2012

Mutations in the mitochondrial complex I assembly factor NDUFAF1 cause fatal infantile hypertrophic cardiomyopathy.

J Med Genet 2011 Oct;48(10):691-7

Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

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October 2011

The pathogenic m.3243A>T mitochondrial DNA mutation is associated with a variable neurological phenotype.

Neuromuscul Disord 2010 Jun 14;20(6):403-6. Epub 2010 May 14.

Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle upon Tyne, UK.

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June 2010

A novel mitochondrial MTND5 frameshift mutation causing isolated complex I deficiency, renal failure and myopathy.

Neuromuscul Disord 2010 Feb 16;20(2):131-5. Epub 2009 Dec 16.

Mitochondrial Research Group and NCG Rare Mitochondrial Disorders of Adults and Children Service, Newcastle University, Newcastle upon Tyne, UK.

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February 2010

Decreased ubiquinone availability and impaired mitochondrial cytochrome oxidase activity associated with statin treatment.

Toxicol Mech Methods 2009 Jan;19(1):44-50

Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 1BG, UK.

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January 2009

Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice.

Am J Physiol Regul Integr Comp Physiol 2009 Sep 17;297(3):R675-81. Epub 2009 Jun 17.

Division of Reproduction and Endocrinology, King's College London, St. Thomas's Hospital, London, UK.

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September 2009

The coenzyme Q10 status of the brain regions of Parkinson's disease patients.

Neurosci Lett 2008 Dec 30;447(1):17-9. Epub 2008 Sep 30.

Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK.

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December 2008

Protection of respiratory chain enzymes from ischaemic damage in adult rat brain slices.

Neurochem Res 2008 Sep 12;33(9):1711-6. Epub 2008 Mar 12.

Department of Neurochemistry, The Institute of Neurology, University College, London, UK.

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September 2008

Coenzyme Q10 in phenylketonuria and mevalonic aciduria.

Mitochondrion 2007 Jun 16;7 Suppl:S175-80. Epub 2007 Mar 16.

Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

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June 2007

Some observations upon biochemical causes of ataxia and a new disease entity ubiquinone, CoQ10 deficiency.

Neurochem Res 2007 Apr-May;32(4-5):837-43. Epub 2006 Dec 21.

Neurometabolic Unit Box 105, National Hospital for Neurology & Neurosurgery, Queen Square, London, WC1N 3BG, UK.

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May 2007

Phenotypic variability of mitochondrial disease caused by a nuclear mutation in complex II.

Mol Genet Metab 2006 Nov 23;89(3):214-21. Epub 2006 Jun 23.

Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College London, UK.

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November 2006

Glutathione depletion and increased apoptosis rate in human cystinotic proximal tubular cells.

Pediatr Nephrol 2006 Apr 1;21(4):503-9. Epub 2006 Mar 1.

Nephro-urology Unit, Institute of Child Health, University College London Medical School, London, UK.

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April 2006

The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications.

Drug Saf 2005 ;28(8):659-76

Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.

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October 2005