I-Te Lee

I-Te Lee

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I-Te Lee

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Magnesium-responsive genes are downregulated in diabetic patients after a three-month exercise program on a bicycle ergometer.

J Chin Med Assoc 2019 Jun;82(6):495-499

Department of Physical Medicine and Rehabilitation, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, ROC.

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http://dx.doi.org/10.1097/JCMA.0000000000000112DOI Listing
June 2019

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Authors:
Amy R Bentley Yun J Sung Michael R Brown Thomas W Winkler Aldi T Kraja Ioanna Ntalla Karen Schwander Daniel I Chasman Elise Lim Xuan Deng Xiuqing Guo Jingmin Liu Yingchang Lu Ching-Yu Cheng Xueling Sim Dina Vojinovic Jennifer E Huffman Solomon K Musani Changwei Li Mary F Feitosa Melissa A Richard Raymond Noordam Jenna Baker Guanjie Chen Hugues Aschard Traci M Bartz Jingzhong Ding Rajkumar Dorajoo Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Wei Zhao Mariaelisa Graff Maris Alver Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Yi-Jen Hung Anne U Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Karin Leander Keng-Hung Lin Jian'an Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja M Nolte Maik Pietzner Bram Prins Muhammad Riaz Antonietta Robino M Abdullah Said Nicole Schupf Robert A Scott Tamar Sofer Alena Stancáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Tzung-Dau Wang Yajuan Wang Erin B Ware Wanqing Wen Yong-Bing Xiang Lisa R Yanek Weihua Zhang Jing Hua Zhao Adebowale Adeyemo Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Zorayr Arzumanyan Tin Aung Christie Ballantyne R Graham Barr Lawrence F Bielak Eric Boerwinkle Erwin P Bottinger Ulrich Broeckel Morris Brown Brian E Cade Archie Campbell Mickaël Canouil Sabanayagam Charumathi Yii-Der Ida Chen Kaare Christensen Maria Pina Concas John M Connell Lisa de Las Fuentes H Janaka de Silva Paul S de Vries Ayo Doumatey Qing Duan Charles B Eaton Ruben N Eppinga Jessica D Faul James S Floyd Nita G Forouhi Terrence Forrester Yechiel Friedlander Ilaria Gandin He Gao Mohsen Ghanbari Sina A Gharib Bruna Gigante Franco Giulianini Hans J Grabe C Charles Gu Tamara B Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E Hixson M Arfan Ikram Yucheng Jia Roby Joehanes Craig Johnson Jost Bruno Jonas Anne E Justice Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Ivana Kolcic Charles Kooperberg Jose E Krieger Stephen B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Cora E Lewis Yize Li Jingjing Liang Shiow Lin Ching-Ti Liu Jianjun Liu Kiang Liu Marie Loh Kurt K Lohman Tin Louie Anna Luzzi Reedik Mägi Anubha Mahajan Ani W Manichaikul Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Yukihide Momozawa Andrew P Morris Alison D Murray Mike A Nalls Matthias Nauck Christopher P Nelson Kari E North Jeffrey R O'Connell Nicholette D Palmer George J Papanicolau Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Neil Poulter Olli T Raitakari Alex P Reiner Frida Renström Treva K Rice Stephen S Rich Jennifer G Robinson Lynda M Rose Frits R Rosendaal Igor Rudan Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Yuan Shi Stephen Sidney Mario Sims Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Heather M Stringham Nicholas Y Q Tan Hua Tang Kent D Taylor Yik Ying Teo Yih Chung Tham Henning Tiemeier Stephen T Turner André G Uitterlinden Diana van Heemst Melanie Waldenberger Heming Wang Lan Wang Lihua Wang Wen Bin Wei Christine A Williams Gregory Wilson Mary K Wojczynski Jie Yao Kristin Young Caizheng Yu Jian-Min Yuan Jie Zhou Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Richard S Cooper Ulf de Faire Ian J Deary Paul Elliott Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo L Horta Jyh-Ming Jimmy Juang Yoichiro Kamatani Candace M Kammerer Norihiro Kato Jaspal S Kooner Markku Laakso Cathy C Laurie I-Te Lee Terho Lehtimäki Patrik K E Magnusson Albertine J Oldehinkel Brenda W J H Penninx Alexandre C Pereira Rainer Rauramaa Susan Redline Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Jun-Sing Wang Ya Xing Wang Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Tangchun Wu Eleftheria Zeggini Wei Zheng Claude Bouchard Michele K Evans Vilmundur Gudnason Sharon L R Kardia Yongmei Liu Bruce M Psaty Paul M Ridker Rob M van Dam Dennis O Mook-Kanamori Myriam Fornage Michael A Province Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Ruth J F Loos Nora Franceschini Jerome I Rotter Xiaofeng Zhu Laura J Bierut W James Gauderman Kenneth Rice Patricia B Munroe Alanna C Morrison Dabeeru C Rao Charles N Rotimi L Adrienne Cupples

Nat Genet 2019 04 29;51(4):636-648. Epub 2019 Mar 29.

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41588-019-0378-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467258PMC
April 2019

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Diabetes 2019 02 28;68(2):441-456. Epub 2018 Nov 28.

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db18-0567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341299PMC
February 2019

Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance.

J Endocr Soc 2019 Feb 21;3(2):403-410. Epub 2018 Dec 21.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1210/js.2018-00359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364621PMC
February 2019

Gene Is Associated With Triglyceride Levels In Subjects With Family History Of Hypertension From The SAPPHIRe And TWB Projects.

Int J Med Sci 2018 14;15(10):1035-1042. Epub 2018 Jun 14.

Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan.

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http://dx.doi.org/10.7150/ijms.25742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036157PMC
January 2019

Negative association between serum aryl hydrocarbon receptor concentrations and β-cell function in patients with no history of diabetes undergoing coronary angiography.

J Diabetes 2018 Dec 27;10(12):958-964. Epub 2018 Jun 27.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://doi.wiley.com/10.1111/1753-0407.12784
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http://dx.doi.org/10.1111/1753-0407.12784DOI Listing
December 2018

Serum Renalase Levels Are Predicted by Brain-Derived Neurotrophic Factor and Associated with Cardiovascular Events and Mortality after Percutaneous Coronary Intervention.

J Clin Med 2018 Nov 12;7(11). Epub 2018 Nov 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

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http://dx.doi.org/10.3390/jcm7110437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262591PMC
November 2018

Prevalence and biochemical risk factors of diabetic peripheral neuropathy with or without neuropathic pain in Taiwanese adults with type 2 diabetes mellitus.

Diabetes Metab Syndr 2018 Apr - Jun;12(2):111-116. Epub 2017 Sep 28.

Neurological Institute, Taichung Veterans General Hospital, No. 1650, Taiwan Boulevard, Sec. 4, Taichung City 40705, Taiwan; Department of Neurology, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei City 112, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18714021173031
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http://dx.doi.org/10.1016/j.dsx.2017.09.013DOI Listing
September 2018

Combination of the ankle-brachial index and percentage of mean arterial pressure to improve diagnostic sensitivity for peripheral artery disease: An observational study.

Medicine (Baltimore) 2018 Sep;97(39):e12644

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City.

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http://dx.doi.org/10.1097/MD.0000000000012644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181478PMC
September 2018

Levels of serum high mobility group box 1 were independently associated with cardiovascular risk in patients undergoing coronary angiography.

Clin Chim Acta 2018 Aug 26;483:130-134. Epub 2018 Apr 26.

Department of Medical Research; Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Taipei Medical University, Taipei, Taiwan; Healthcare and Services Center, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2018.04.032DOI Listing
August 2018

Kallmann Syndrome With Micropenis.

Authors:
Chia-Po Fu I-Te Lee

Am J Med Sci 2018 08 13;356(2):e23. Epub 2018 Mar 13.

Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2018.03.011DOI Listing
August 2018

Testing for HbA1c, in addition to the oral glucose tolerance test, in screening for abnormal glucose regulation helps to reveal patients with early β-cell function impairment.

Clin Chem Lab Med 2018 07;56(8):1345-1352

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1515/cclm-2017-0846DOI Listing
July 2018

Effects of retinopathy and chronic kidney disease on long-term mortality in type 2 diabetic inpatients with normal urinary albumin or protein: a retrospective cohort study.

BMJ Open 2018 07 25;8(7):e021655. Epub 2018 Jul 25.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1136/bmjopen-2018-021655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067336PMC
July 2018

Synergistic effect of renalase and chronic kidney disease on endothelin-1 in patients with coronary artery disease ‒ a cross-sectional study.

Sci Rep 2018 May 9;8(1):7378. Epub 2018 May 9.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan.

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http://dx.doi.org/10.1038/s41598-018-25763-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943599PMC
May 2018

Trajectories of fasting plasma glucose variability and mortality in type 2 diabetes.

Diabetes Metab 2018 Mar 9;44(2):121-128. Epub 2017 Oct 9.

Department of Public Health, College of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.diabet.2017.09.001DOI Listing
March 2018

Variability of fasting plasma glucose and the risk of painful diabetic peripheral neuropathy in patients with type 2 diabetes.

Diabetes Metab 2018 Mar 4;44(2):129-134. Epub 2018 Feb 4.

Neurological Institute, Taichung Veterans General Hospital, No. 1650, Taiwan Boulevard, Sec. 4, Taichung City 40705, Taiwan; Department of Neurology, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei City 112, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.diabet.2018.01.015DOI Listing
March 2018

The association between brain-derived neurotrophic factor and central pulse pressure after an oral glucose tolerance test.

Clin Chim Acta 2018 Jan 10;476:1-8. Epub 2017 Nov 10.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2017.10.023DOI Listing
January 2018

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

Nat Genet 2017 Oct 4;49(10):1450-1457. Epub 2017 Sep 4.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844224PMC
October 2017

Hemoglobin glycation index as a useful predictor of therapeutic responses to dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes.

PLoS One 2017 9;12(2):e0171753. Epub 2017 Feb 9.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171753PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300176PMC
September 2017

Associations of fibroblast growth factor 21 with cardiovascular risk and β-cell function in patients who had no history of diabetes.

Clin Chim Acta 2017 Sep 19;472:80-85. Epub 2017 Jul 19.

Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Taipei Medical University, Taipei, Taiwan; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00098981173027
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http://dx.doi.org/10.1016/j.cca.2017.07.017DOI Listing
September 2017

The synergistic effect of inflammation and metabolic syndrome on intraocular pressure: A cross-sectional study.

Medicine (Baltimore) 2017 Sep;96(36):e7851

aDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung bSchool of Medicine, National Yang-Ming University, Taipei cSchool of Medicine, Chung Shan Medical University, Taichung dDepartment of Ophthalmology, Taichung Veterans General Hospital, Taichung eDepartment of Optometry, Central Taiwan University of Science and Technology, Taichung fDepartment of Medical Research, Taichung Veterans General Hospital, Taichung gCenter for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1097/MD.0000000000007851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392572PMC
September 2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Nat Genet 2017 Jul 22;49(7):1113-1119. Epub 2017 May 22.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555387PMC
July 2017

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

N Engl J Med 2017 07 24;377(3):211-221. Epub 2017 May 24.

From Regeneron Genetics Center (F.E.D., C.O., C.S., O.G., S.M., C.V.V.H., S.B., L.H., A.L., J.P., N.S., A.J.M., J.D.O., J.G.R., A.R.S., I.B.B., T.M.T., G.D.Y., S.J.M., A. Baras) and Regeneron Pharmaceuticals (V.G., H.M.D., A.Z., W.S., N.S., A.J.M., S.H., A. Bouzelmat, R.Z., B.S., R.P., D.G., G.A.H., W.J.S., P.B., G.D.Y., S.J.M., J.G.) Tarrytown, NY; the Department of Medicine, Division of Translational Medicine and Human Genetics (R.L.D.), and Departments of Surgery (S.D.) and Genetics and Medicine (A.S., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, and Geisinger Health System, Danville (J.B.L., M.F.M., M.D.R., H.L.K., D.H.L., D.J.C.) - both in Pennsylvania; the Division of Endocrinology and Metabolism, Department of Internal Medicine (W.H.H.S., I.-T.L.) and Cardiovascular Center (K.-W.L.), Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), School of Medicine, Chung Shan Medical University (I.-T.L.), and the Department of Medicine, China Medical University (K.-W.L.), Taichung, and School of Medicine, National Yang-Ming University (W.H.H.S., I.-T.L., K.-W.L.), and School of Medicine, National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (X.G., J.I.R., Y.-D.I.C.); the Division of Cardiology, Department of Medicine, Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC (W.E.K., S.H.S.); the Department of Clinical Biochemistry, Rigshospitalet (A.B.W., B.G.N., A.T.-H.), the Copenhagen General Population Study (B.G.N., A.T.-H.) and Department of Clinical Biochemistry (B.G.N.), Herlev and Gentofte Hospital, and the Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, and Faculty of Health and Medical Sciences, University of Copenhagen (B.G.N., A.T.-H.) - all in Copenhagen; and TNO Metabolic Health Research, Gaubius Laboratory, Leiden, the Netherlands (A.M.H., H.M.G.P.).

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http://dx.doi.org/10.1056/NEJMoa1612790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800308PMC
July 2017

Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci.

Hum Genet 2017 06 8;136(6):771-800. Epub 2017 Apr 8.

Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/s00439-017-1787-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485655PMC
June 2017

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

Authors:
Cassandra N Spracklen Peng Chen Young Jin Kim Xu Wang Hui Cai Shengxu Li Jirong Long Ying Wu Ya Xing Wang Fumihiko Takeuchi Jer-Yuarn Wu Keum-Ji Jung Cheng Hu Koichi Akiyama Yonghong Zhang Sanghoon Moon Todd A Johnson Huaixing Li Rajkumar Dorajoo Meian He Maren E Cannon Tamara S Roman Elias Salfati Keng-Hung Lin Xiuqing Guo Wayne H H Sheu Devin Absher Linda S Adair Themistocles L Assimes Tin Aung Qiuyin Cai Li-Ching Chang Chien-Hsiun Chen Li-Hsin Chien Lee-Ming Chuang Shu-Chun Chuang Shufa Du Qiao Fan Cathy S J Fann Alan B Feranil Yechiel Friedlander Penny Gordon-Larsen Dongfeng Gu Lixuan Gui Zhirong Guo Chew-Kiat Heng James Hixson Xuhong Hou Chao Agnes Hsiung Yao Hu Mi Yeong Hwang Chii-Min Hwu Masato Isono Jyh-Ming Jimmy Juang Chiea-Chuen Khor Yun Kyoung Kim Woon-Puay Koh Michiaki Kubo I-Te Lee Sun-Ju Lee Wen-Jane Lee Kae-Woei Liang Blanche Lim Sing-Hui Lim Jianjun Liu Toru Nabika Wen-Harn Pan Hao Peng Thomas Quertermous Charumathi Sabanayagam Kevin Sandow Jinxiu Shi Liang Sun Pok Chien Tan Shu-Pei Tan Kent D Taylor Yik-Ying Teo Sue-Anne Toh Tatsuhiko Tsunoda Rob M van Dam Aili Wang Feijie Wang Jie Wang Wen Bin Wei Yong-Bing Xiang Jie Yao Jian-Min Yuan Rong Zhang Wanting Zhao Yii-Der Ida Chen Stephen S Rich Jerome I Rotter Tzung-Dau Wang Tangchun Wu Xu Lin Bok-Ghee Han Toshihiro Tanaka Yoon Shin Cho Tomohiro Katsuya Weiping Jia Sun-Ha Jee Yuan-Tsong Chen Norihiro Kato Jost B Jonas Ching-Yu Cheng Xiao-Ou Shu Jiang He Wei Zheng Tien-Yin Wong Wei Huang Bong-Jo Kim E-Shyong Tai Karen L Mohlke Xueling Sim

Hum Mol Genet 2017 05;26(9):1770-1784

Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1093/hmg/ddx062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075203PMC
May 2017

Inpatient screening for albuminuria and retinopathy to predict long-term mortality in type 2 diabetic patients: a retrospective cohort study.

Diabetol Metab Syndr 2017 3;9:29. Epub 2017 May 3.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, No. 1650 Taiwan Boulevard, Sect. 4, Taichung, 40705, Taiwan.

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http://dx.doi.org/10.1186/s13098-017-0229-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415718PMC
May 2017

Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.

Circ Cardiovasc Genet 2017 Apr;10(2):e001527

From the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Center for Genome Science, Korea National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Korea (Y.K.K., J.L., S.H., B.-G.H., S.M., B.-J.K.); Genome Institute of Singapore, Agency for Science, Technology and Research (R.D., J.L., Y.-Y.T.); Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences (H.L., Y.H., Y.W., L.S., X.L.); National Yang-Ming University Hospital, Taipei, Taiwan (I-T.L.); National Yang-Ming University Hospital, Taipei, Taiwan; Singapore Eye Research Institute, Singapore National Eye Center (Y.C., Y.K., Y.Z., N.K., T.Y.W.); Duke-NUS Graduate Medical School, National University of Singapore, (Y.C., N.K., T.Y.W., E-S.T.); Department of Ophthalmology (Y.C., T.Y.W.), Department of Statistics and Applied Probability (Y.-Y.T.), Life Sciences Institute (Y.-Y.T.), NUS Graduate School for Integrative Science and Engineering (Y.-Y.T.), Department of Medicine, National University Health System, Singapore (E-S.T.); MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.H., H.H., L.G., Y.H., T.W.); Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, Taiwan (I-T.L., W.H-h.S); School of Medicine, National Yang-Ming University, Taipei, Taiwan (W.H-h.S., K.-W.L.); Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., K.D.T., J.I.R., Y.-d.I.C.); Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, Ann Arbor (S.K.G.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.L., Y.-Y.T., X.S., E-S.T.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R.); Department of Medical Genetics (F.-J.T.) and School of Chinese Medicine (C.-H.C., J.-Y.W.), China Medical University Hospital, Taichung, Taiwan; Department of Medicine, Columbia University Medical Center, New York, NY (W.P.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Department of Internal Medicine, Ditmanson Medical Foundation, Chiayi Christian Hospital, Taiwan (C.H.L.); Department of Business Administration, National Chung Cheng University, Chia-yi, Taiwan (C.H.L.); Department of Nursing, DaYeh University, Changhua, Taiwan (C.H.L.); Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan (W.-J.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (C.-H.C., J.-Y.W.); Department of Ophthalmology and Visual Science, Khoo Teck Puat Hospital, Singapore, Singapore (N.K.); Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA (L.J.R.); and Department of Epidemiology and Biostatistics, University of Georgia at Athens, Athens (C.L.); Department of Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan (K.-W.L.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704911PMC
April 2017

Glycemic excursions are positively associated with HbA1c reduction from baseline after treatment with acarbose in patients with type 2 diabetes on metformin monotherapy.

J Diabetes 2017 Mar 31;9(3):248-255. Epub 2016 May 31.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1111/1753-0407.12406DOI Listing
March 2017

The synergistic effect of vascular cell adhesion molecule-1 and coronary artery disease on brain-derived neurotrophic factor.

Clin Chim Acta 2017 Mar 25;466:194-200. Epub 2017 Jan 25.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2017.01.026DOI Listing
March 2017

Rare and low-frequency coding variants alter human adult height.

Authors:
Eirini Marouli Mariaelisa Graff Carolina Medina-Gomez Ken Sin Lo Andrew R Wood Troels R Kjaer Rebecca S Fine Yingchang Lu Claudia Schurmann Heather M Highland Sina Rüeger Gudmar Thorleifsson Anne E Justice David Lamparter Kathleen E Stirrups Valérie Turcot Kristin L Young Thomas W Winkler Tõnu Esko Tugce Karaderi Adam E Locke Nicholas G D Masca Maggie C Y Ng Poorva Mudgal Manuel A Rivas Sailaja Vedantam Anubha Mahajan Xiuqing Guo Goncalo Abecasis Katja K Aben Linda S Adair Dewan S Alam Eva Albrecht Kristine H Allin Matthew Allison Philippe Amouyel Emil V Appel Dominique Arveiler Folkert W Asselbergs Paul L Auer Beverley Balkau Bernhard Banas Lia E Bang Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Heiner Boeing Eric Boerwinkle Carsten A Böger Lori L Bonnycastle Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Amber A Burt Adam S Butterworth David J Carey Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox Gabriel Cuellar-Partida John Danesh Gail Davies Paul I W de Bakker Gert J de Borst Simon de Denus Mark C H de Groot Renée de Mutsert Ian J Deary George Dedoussis Ellen W Demerath Anneke I den Hollander Joe G Dennis Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Alison M Dunning Douglas F Easton Tapani Ebeling Todd L Edwards Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki Jessica D Faul Mary F Feitosa Shuang Feng Ele Ferrannini Marco M Ferrario Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Paul W Franks Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Ayush Giri Giorgia Girotto Scott D Gordon Penny Gordon-Larsen Mathias Gorski Niels Grarup Megan L Grove Vilmundur Gudnason Stefan Gustafsson Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Caroline Hayward Liang He Iris M Heid Kauko Heikkilä Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Lynne J Hocking Mette Hollensted Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Carel B Hoyng Paul L Huang Kristian Hveem M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Min A Jhun Yucheng Jia Xuejuan Jiang Stefan Johansson Marit E Jørgensen Torben Jørgensen Pekka Jousilahti J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Frank Kee Renske Keeman Lambertus A Kiemeney Hidetoshi Kitajima Kirsten B Kluivers Thomas Kocher Pirjo Komulainen Jukka Kontto Jaspal S Kooner Charles Kooperberg Peter Kovacs Jennifer Kriebel Helena Kuivaniemi Sébastien Küry Johanna Kuusisto Martina La Bianca Markku Laakso Timo A Lakka Ethan M Lange Leslie A Lange Carl D Langefeld Claudia Langenberg Eric B Larson I-Te Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Yeheng Liu Yongmei Liu Artitaya Lophatananon Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen David A Mackey Pamela A F Madden Alisa K Manning Satu Männistö Gaëlle Marenne Jonathan Marten Nicholas G Martin Angela L Mazul Karina Meidtner Andres Metspalu Paul Mitchell Karen L Mohlke Dennis O Mook-Kanamori Anna Morgan Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Matthias Nauck Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Ioanna Ntalla Jeffrey R O'Connel Heikki Oksa Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Thomas N Person Ailith Pirie Ozren Polasek Danielle Posthuma Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Paul M Ridker John D Rioux Neil Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Kevin Sandow Yadav Sapkota Naveed Sattar Marjanka K Schmidt Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati Shah Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert Vernon Smith Jennifer A Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Valgerdur Steinthorsdottir Heather M Stringham Michael Stumvoll Praveen Surendran Leen M 't Hart Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Sheila Ulivi Sander W van der Laan Andries R Van Der Leij Cornelia M van Duijn Natasja M van Schoor Jessica van Setten Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Henrik Vestergaard Veronique Vitart Thomas F Vogt Diego Vozzi Mark Walker Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Nicholas J Wareham Helen R Warren Jennifer Wessel Sara M Willems James G Wilson Daniel R Witte Michael O Woods Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao He Zheng Wei Zhou Jerome I Rotter Michael Boehnke Sekar Kathiresan Mark I McCarthy Cristen J Willer Kari Stefansson Ingrid B Borecki Dajiang J Liu Kari E North Nancy L Heard-Costa Tune H Pers Cecilia M Lindgren Claus Oxvig Zoltán Kutalik Fernando Rivadeneira Ruth J F Loos Timothy M Frayling Joel N Hirschhorn Panos Deloukas Guillaume Lettre

Nature 2017 02 1;542(7640):186-190. Epub 2017 Feb 1.

Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.

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http://dx.doi.org/10.1038/nature21039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302847PMC
February 2017

Physical activity and albuminuria were associated with painful diabetic polyneuropathy in type 2 diabetes in an ethnic Chinese population.

Clin Chim Acta 2016 Nov 1;462:55-59. Epub 2016 Sep 1.

Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC; School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, ROC; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.08.022DOI Listing
November 2016

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.

Nat Genet 2016 10 12;48(10):1162-70. Epub 2016 Sep 12.

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320952PMC
October 2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Authors:
Georg B Ehret Teresa Ferreira Daniel I Chasman Anne U Jackson Ellen M Schmidt Toby Johnson Gudmar Thorleifsson Jian'an Luan Lousie A Donnelly Stavroula Kanoni Ann-Kristin Petersen Vasyl Pihur Rona J Strawbridge Dmitry Shungin Maria F Hughes Osorio Meirelles Marika Kaakinen Nabila Bouatia-Naji Kati Kristiansson Sonia Shah Marcus E Kleber Xiuqing Guo Leo-Pekka Lyytikäinen Cristiano Fava Niclas Eriksson Ilja M Nolte Patrik K Magnusson Elias L Salfati Loukianos S Rallidis Elizabeth Theusch Andrew J P Smith Lasse Folkersen Kate Witkowska Tune H Pers Roby Joehanes Stuart K Kim Lazaros Lataniotis Rick Jansen Andrew D Johnson Helen Warren Young Jin Kim Wei Zhao Ying Wu Bamidele O Tayo Murielle Bochud Devin Absher Linda S Adair Najaf Amin Dan E Arking Tomas Axelsson Damiano Baldassarre Beverley Balkau Stefania Bandinelli Michael R Barnes Inês Barroso Stephen Bevan Joshua C Bis Gyda Bjornsdottir Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Stefan R Bornstein Morris J Brown Michel Burnier Claudia P Cabrera John C Chambers I-Shou Chang Ching-Yu Cheng Peter S Chines Ren-Hua Chung Francis S Collins John M Connell Angela Döring Jean Dallongeville John Danesh Ulf de Faire Graciela Delgado Anna F Dominiczak Alex S F Doney Fotios Drenos Sarah Edkins John D Eicher Roberto Elosua Stefan Enroth Jeanette Erdmann Per Eriksson Tonu Esko Evangelos Evangelou Alun Evans Tove Fall Martin Farrall Janine F Felix Jean Ferrières Luigi Ferrucci Myriam Fornage Terrence Forrester Nora Franceschini Oscar H Franco Duran Anders Franco-Cereceda Ross M Fraser Santhi K Ganesh He Gao Karl Gertow Francesco Gianfagna Bruna Gigante Franco Giulianini Anuj Goel Alison H Goodall Mark O Goodarzi Mathias Gorski Jürgen Gräßler Christopher Groves Vilmundur Gudnason Ulf Gyllensten Göran Hallmans Anna-Liisa Hartikainen Maija Hassinen Aki S Havulinna Caroline Hayward Serge Hercberg Karl-Heinz Herzig Andrew A Hicks Aroon D Hingorani Joel N Hirschhorn Albert Hofman Jostein Holmen Oddgeir Lingaas Holmen Jouke-Jan Hottenga Phil Howard Chao A Hsiung Steven C Hunt M Arfan Ikram Thomas Illig Carlos Iribarren Richard A Jensen Mika Kähönen Hyun Kang Sekar Kathiresan Brendan J Keating Kay-Tee Khaw Yun Kyoung Kim Eric Kim Mika Kivimaki Norman Klopp Genovefa Kolovou Pirjo Komulainen Jaspal S Kooner Gulum Kosova Ronald M Krauss Diana Kuh Zoltan Kutalik Johanna Kuusisto Kirsti Kvaløy Timo A Lakka Nanette R Lee I-Te Lee Wen-Jane Lee Daniel Levy Xiaohui Li Kae-Woei Liang Honghuang Lin Li Lin Jaana Lindström Stéphane Lobbens Satu Männistö Gabriele Müller Martina Müller-Nurasyid François Mach Hugh S Markus Eirini Marouli Mark I McCarthy Colin A McKenzie Pierre Meneton Cristina Menni Andres Metspalu Vladan Mijatovic Leena Moilanen May E Montasser Andrew D Morris Alanna C Morrison Antonella Mulas Ramaiah Nagaraja Narisu Narisu Kjell Nikus Christopher J O'Donnell Paul F O'Reilly Ken K Ong Fred Paccaud Cameron D Palmer Afshin Parsa Nancy L Pedersen Brenda W Penninx Markus Perola Annette Peters Neil Poulter Peter P Pramstaller Bruce M Psaty Thomas Quertermous Dabeeru C Rao Asif Rasheed N William N W R Rayner Frida Renström Rainer Rettig Kenneth M Rice Robert Roberts Lynda M Rose Jacques Rossouw Nilesh J Samani Serena Sanna Jouko Saramies Heribert Schunkert Sylvain Sebert Wayne H-H Sheu Young-Ah Shin Xueling Sim Johannes H Smit Albert V Smith Maria X Sosa Tim D Spector Alena Stančáková Alice Stanton Kathleen E Stirrups Heather M Stringham Johan Sundstrom Amy J Swift Ann-Christine Syvänen E-Shyong Tai Toshiko Tanaka Kirill V Tarasov Alexander Teumer Unnur Thorsteinsdottir Martin D Tobin Elena Tremoli Andre G Uitterlinden Matti Uusitupa Ahmad Vaez Dhananjay Vaidya Cornelia M van Duijn Erik P A van Iperen Ramachandran S Vasan Germaine C Verwoert Jarmo Virtamo Veronique Vitart Benjamin F Voight Peter Vollenweider Aline Wagner Louise V Wain Nicholas J Wareham Hugh Watkins Alan B Weder Harm-Jan Westra Rainford Wilks Tom Wilsgaard James F Wilson Tien Y Wong Tsun-Po Yang Jie Yao Loic Yengo Weihua Zhang Jing Hua Zhao Xiaofeng Zhu Pascal Bovet Richard S Cooper Karen L Mohlke Danish Saleheen Jong-Young Lee Paul Elliott Hinco J Gierman Cristen J Willer Lude Franke G Kees Hovingh Kent D Taylor George Dedoussis Peter Sever Andrew Wong Lars Lind Themistocles L Assimes Inger Njølstad Peter Eh Schwarz Claudia Langenberg Harold Snieder Mark J Caulfield Olle Melander Markku Laakso Juha Saltevo Rainer Rauramaa Jaakko Tuomilehto Erik Ingelsson Terho Lehtimäki Kristian Hveem Walter Palmas Winfried März Meena Kumari Veikko Salomaa Yii-Der I Chen Jerome I Rotter Philippe Froguel Marjo-Riitta Jarvelin Edward G Lakatta Kari Kuulasmaa Paul W Franks Anders Hamsten H-Erich Wichmann Colin N A Palmer Kari Stefansson Paul M Ridker Ruth J F Loos Aravinda Chakravarti Panos Deloukas Andrew P Morris Christopher Newton-Cheh Patricia B Munroe

Nat Genet 2016 10 12;48(10):1171-1184. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/ng.3667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042863PMC
October 2016

Relationship between body weight and the increment in serum brain-derived neurotrophic factor after oral glucose challenge in men with obesity and metabolic syndrome: A prospective study.

Medicine (Baltimore) 2016 Oct;95(43):e5260

aDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung bSchool of Medicine, National Yang-Ming University, Taipei cSchool of Medicine, Chung Shan Medical University dCenter for Geriatrics and Gerontology, Taichung Veterans General Hospital eInstitute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan.

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http://Insights.ovid.com/crossref?an=00005792-201610250-0003
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http://dx.doi.org/10.1097/MD.0000000000005260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089118PMC
October 2016

Statin treatment is associated with a negative correlation between NT-proBNP and insulin resistance in patients without history of heart failure.

Clin Chim Acta 2016 Aug 21;459:84-88. Epub 2016 May 21.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Medical Technology, College of Life Science, National Chung-Hsing University, Taichung, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.05.019DOI Listing
August 2016

Glycemic excursions are positively associated with changes in duration of asymptomatic hypoglycemia after treatment intensification in patients with type 2 diabetes.

Diabetes Res Clin Pract 2016 Mar 13;113:108-15. Epub 2016 Jan 13.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Medical Technology, College of Life Science, National Chung-Hsing University, Taichung, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2015.12.010DOI Listing
March 2016

Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients.

Oncotarget 2016 Mar;7(10):10976-89

Immunology Research Center, National Health Research Institutes, Zhunan, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.7686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905452PMC
March 2016

Relationship between percentage of mean arterial pressure at the ankle and mortality in participants with normal ankle-brachial index: an observational study.

BMJ Open 2016 Mar 25;6(3):e010540. Epub 2016 Mar 25.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan School of Medicine, National Yang-Ming University, Taipei City, Taiwan School of Medicine, Chung Shan Medical University, Taichung City, Taiwan.

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http://dx.doi.org/10.1136/bmjopen-2015-010540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809088PMC
March 2016

The Impact of Creatinine Clearance Rate, Daily Urinary Albumin, and Their Joint Effect on Predicting Death in Diabetic Inpatients After Discharge: An Observational Study.

Medicine (Baltimore) 2016 Feb;95(6):e2804

From the Department of Internal Medicine, Division of Endocrinology and Metabolism, Taichung Veterans General Hospital (ITL, WHHS, SYL); Chung Shan Medical University, Taichung (ITL, WHHS); School of Medicine, National Yang-Ming University, Taipei (ITL, WHHS); and Center for Geriatrics and Gerontology Taichung Veterans General Hospital (SYL), Taichung, Taiwan..

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http://dx.doi.org/10.1097/MD.0000000000002804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753942PMC
February 2016

Association of MMP-9 to TIMP-1 ratio with long-term body weight and waist circumference after dietary weight reduction in men with metabolic syndrome.

Clin Chim Acta 2016 Jan 26;452:182-4. Epub 2015 Nov 26.

Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Medical Technology, College of Life Science, National Chung-Hsing University, Taichung, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2015.11.024DOI Listing
January 2016

Association between Albuminuria and Different Body Constitution in Type 2 Diabetes Patients: Taichung Diabetic Body Constitution Study.

Evid Based Complement Alternat Med 2015 26;2015:603048. Epub 2015 Oct 26.

Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan ; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.

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http://dx.doi.org/10.1155/2015/603048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637481PMC
November 2015

Factors associated with fibroblast growth factor 19 increment after oral glucose loading in patients who were previously admitted for coronary angiography.

Clin Chim Acta 2015 Oct 5;450:237-42. Epub 2015 Sep 5.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, School of Medicine, Natonal Yang-Ming University, Taipei, Taiwan; Department of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Institute of Medical Technology, College of Life Science, National Chung-Hsing University, Taichung, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00098981150041
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http://dx.doi.org/10.1016/j.cca.2015.09.006DOI Listing
October 2015

Circulating adipokines and insulin resistance in subjects with combined cardiac and metabolic syndrome X.

Diabetol Metab Syndr 2015 24;7:83. Epub 2015 Sep 24.

School of Medicine, National Yang Ming University, Taipei, Taiwan ; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Sec. 4, Taichung, 40705 Taiwan ; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan ; School of Medicine, National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1186/s13098-015-0078-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583190PMC
September 2015

Value of Chromosome 9p21 Polymorphism for Prediction of Cardiovascular Mortality in Han Chinese Without Coronary Lesions: An Observational Study.

Medicine (Baltimore) 2015 Sep;94(39):e1538

From the Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung (ITL, JSW, SYL, WHHS); School of Medicine, National Yang-Ming University, Taipei (ITL, KWL, SYL, WLL, WHHS); School of Medicine, Chung Shan Medical University (ITL, WHHS); Cardiovascular Center, Taichung Veterans General Hospital (KWL, WLL); Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan (WJL); and Institute for Translational Genomics and Population Sciences, Harbor-UCLA Medical Center, Torrance, California, USA (YDIC).

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http://dx.doi.org/10.1097/MD.0000000000001538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616868PMC
September 2015

Yang Deficiency Body Constitution Acts as a Predictor of Diabetic Retinopathy in Patients with Type 2 Diabetes: Taichung Diabetic Body Constitution Study.

Evid Based Complement Alternat Med 2015 8;2015:940898. Epub 2015 Jun 8.

Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan ; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.

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http://search.proquest.com/openview/0ded1217bd95ccbaf2ec8b97
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http://www.hindawi.com/journals/ecam/2015/940898/
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475744PMC
July 2015

Coronary severity score and C-reactive protein predict major adverse cardiovascular events in patients with stable coronary artery disease (from the Taichung CAD study).

Clin Chim Acta 2015 May 27;445:93-100. Epub 2015 Mar 27.

Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang Ming University, Taipei, Taiwan; Department of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2015.03.029DOI Listing
May 2015

Brain-derived neurotrophic factor correlated with muscle strength in subjects undergoing stationary bicycle exercise training.

J Diabetes Complications 2015 Apr 7;29(3):367-71. Epub 2015 Feb 7.

Division of Endocrinology and Metabolism, Department of Internal Medicine, TaichungVeterans General Hospital, Taichung 407, Taiwan; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2015.01.014DOI Listing
April 2015

The chromosome 9p21 variant not predicting long-term cardiovascular mortality in Chinese with established coronary artery disease: an eleven-year follow-up study.

Biomed Res Int 2014 2;2014:626907. Epub 2014 Apr 2.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.

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http://dx.doi.org/10.1155/2014/626907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996981PMC
January 2015

Insulinoma in a young female patient with systemic lupus erythematosus: a case report.

Endocr Pract 2014 Dec;20(12):e256-9

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan School of Medicine, National Yang-Ming University, Taipei, Taiwan School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

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http://journals.aace.com/doi/abs/10.4158/EP14181.CR
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December 2014

Correlation between reduction of superior interventricular groove epicardial fat thickness and improvement of insulin resistance after weight loss in obese men.

Diabetol Metab Syndr 2014 29;6(1):115. Epub 2014 Oct 29.

Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan ; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan ; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan ; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan ; Taichung Veterans General Hospital, No.1650 Section 4, Taiwan Boulevard, Taichung, 40705 Taiwan.

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http://dx.doi.org/10.1186/1758-5996-6-115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223841PMC
November 2014

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

Hum Mol Genet 2014 Oct 26;23(20):5492-504. Epub 2014 May 26.

Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan.

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http://hmg.oxfordjournals.org/content/early/2014/06/20/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu248
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http://dx.doi.org/10.1093/hmg/ddu248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168820PMC
October 2014

Reduced health-related quality of life in body constitutions of yin-xu, and yang-xu, stasis in patients with type 2 diabetes: taichung diabetic body constitution study.

Evid Based Complement Alternat Med 2014 29;2014:309403. Epub 2014 Jun 29.

Graduate Institute of Biostatistics, College of Management, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan ; Research Center for Chinese Medicine & Acupuncture, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan ; Department of Healthcare Administration, College of Health Science, Asia University, Taichung 41354, Taiwan.

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https://www.hindawi.com/journals/ecam/2014/309403/
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100449PMC
August 2014

Effect of prescription refill on quality of care among patients with type 2 diabetes: an exploratory study.

Diabetes Res Clin Pract 2014 Jul 18;105(1):110-8. Epub 2014 Apr 18.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2014.04.001DOI Listing
July 2014

Post-meal β-cell function predicts the efficacy of glycemic control in patients with type 2 diabetes inadequately controlled by metformin monotherapy after addition of glibenclamide or acarbose.

Diabetol Metab Syndr 2014 31;6:68. Epub 2014 May 31.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, No. 1650, Sect. 4, Taiwan Boulevard, Taichung 40705, Taiwan.

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http://dx.doi.org/10.1186/1758-5996-6-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057801PMC
June 2014

Brain-derived neurotrophic factor, but not body weight, correlated with a reduction in depression scale scores in men with metabolic syndrome: a prospective weight-reduction study.

Diabetol Metab Syndr 2014 Feb 13;6(1):18. Epub 2014 Feb 13.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, No, 1650, Section 4, Taiwan Boulevard, Taichung 40705, Taiwan.

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http://dx.doi.org/10.1186/1758-5996-6-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925444PMC
February 2014

High triglyceride-to-HDL cholesterol ratio associated with albuminuria in type 2 diabetic subjects.

J Diabetes Complications 2013 May-Jun;27(3):243-7. Epub 2012 Dec 29.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.

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https://linkinghub.elsevier.com/retrieve/pii/S10568727120033
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http://dx.doi.org/10.1016/j.jdiacomp.2012.11.004DOI Listing
November 2013

Dynamic and dual effects of glycated hemoglobin on estimated glomerular filtration rate in type 2 diabetic outpatients.

Am J Nephrol 2013 25;38(1):19-26. Epub 2013 Jun 25.

Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.

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http://dx.doi.org/10.1159/000351803DOI Listing
October 2013

Chinese Medicinal Formula (MHGWT) for Relieving Diabetic Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.

Evid Based Complement Alternat Med 2013 25;2013:767498. Epub 2013 Aug 25.

Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan ; Department of Traditional Chinese Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan ; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.

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http://dx.doi.org/10.1155/2013/767498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766986PMC
September 2013

Effects of weight loss on epicardial adipose tissue thickness and its relationship between serum soluble CD40 ligand levels in obese men.

Clin Chim Acta 2013 Jun 13;421:98-103. Epub 2013 Mar 13.

Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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https://linkinghub.elsevier.com/retrieve/pii/S00098981130009
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http://dx.doi.org/10.1016/j.cca.2013.03.005DOI Listing
June 2013

Shorter GT repeats in the heme oxygenase-1 gene promoter are associated with a lower severity score in coronary artery disease.

J Chin Med Assoc 2013 Jun 18;76(6):312-8. Epub 2013 Apr 18.

Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.jcma.2013.03.005DOI Listing
June 2013

Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.

PLoS Genet 2013 Mar 21;9(3):e1003379. Epub 2013 Mar 21.

Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1003379
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http://dx.doi.org/10.1371/journal.pgen.1003379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605054PMC
March 2013

Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X.

Biomarkers 2013 Feb 15;18(1):44-50. Epub 2012 Oct 15.

Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.3109/1354750X.2012.730550DOI Listing
February 2013

The levels of circulating and urinary monocyte chemoattractant protein-1 are associated with chronic renal injury in obese men.

Clin Chim Acta 2012 Oct 15;413(19-20):1647-51. Epub 2012 May 15.

Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1016/j.cca.2012.05.008DOI Listing
October 2012

Brain-derived neurotrophic factor not associated with metabolic syndrome but inversely correlated with vascular cell adhesion molecule-1 in men without diabetes.

Clin Chim Acta 2012 May 21;413(9-10):944-8. Epub 2012 Feb 21.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1016/j.cca.2012.02.013DOI Listing
May 2012

MRI measured epicardial adipose tissue thickness at the right AV groove differentiates inflammatory status in obese men with metabolic syndrome.

Obesity (Silver Spring) 2012 Mar 9;20(3):525-32. Epub 2011 Jun 9.

Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1038/oby.2011.155DOI Listing
March 2012

Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome.

Nutr Res 2012 Feb;32(2):85-92

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1016/j.nutres.2011.12.011DOI Listing
February 2012

Low estimated glomerular filtration rate is a major determinant of low ankle-brachial index and toe-brachial index in type 2 diabetes.

Angiology 2012 Jan 3;63(1):55-61. Epub 2011 Jun 3.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Hospital Department of Health, Executive Yuan, Taichung, Taiwan, Republic of China.

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http://dx.doi.org/10.1177/0003319711406709DOI Listing
January 2012

Spirulina prevents memory dysfunction, reduces oxidative stress damage and augments antioxidant activity in senescence-accelerated mice.

J Nutr Sci Vitaminol (Tokyo) 2011 ;57(2):186-91

Department of Otolaryngology, Buddhist Dalin Tzu-Chi General Hospital, Chiayi, Taiwan.

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December 2011

Effects of acarbose versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients inadequately controlled by metformin: a 24-week, randomized, open-label, parallel-group comparison.

Clin Ther 2011 Dec 10;33(12):1932-42. Epub 2011 Nov 10.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1016/j.clinthera.2011.10.014DOI Listing
December 2011

Modulation of immune response and T-cell regulation by donor adipose-derived stem cells in a rodent hind-limb allotransplant model.

Plast Reconstr Surg 2011 Dec;128(6):661e-72e

Department of Plastic and Reconstructive Surgery, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1097/PRS.0b013e318230c60bDOI Listing
December 2011

Metabolic syndrome exacerbating ankle-brachial index in asian type 2 diabetic patients.

Angiology 2010 Jul 14;61(5):482-6. Epub 2010 Apr 14.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1177/0003319709354750DOI Listing
July 2010

Sesamin mitigates inflammation and oxidative stress in endothelial cells exposed to oxidized low-density lipoprotein.

J Agric Food Chem 2009 Dec;57(23):11406-17

Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1021/jf902876pDOI Listing
December 2009

Improvement in health-related quality of life, independent of fasting glucose concentration, via insulin pen device in diabetic patients.

J Eval Clin Pract 2009 Aug;15(4):699-703

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1111/j.1365-2753.2008.01086.xDOI Listing
August 2009

Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells.

J Appl Physiol (1985) 2009 May 19;106(5):1674-85. Epub 2009 Feb 19.

Division of Endocrinology and Metabolism, Dept. of Internal Medicine, Taichung Veterans General Hospital, No. 160, Sec. 3, Taichung-Kang Road, Taichung 407, Taiwan.

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http://dx.doi.org/10.1152/japplphysiol.91415.2008DOI Listing
May 2009

Effects of patient volume on quality of outpatient diabetes care.

Diabetes Res Clin Pract 2009 May 9;84(2):e27-9. Epub 2009 Mar 9.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1016/j.diabres.2009.02.010DOI Listing
May 2009

Metabolic syndrome abating the beneficial effect of pravastatin treatment on adhesion of endothelium by monocytes in subjects with hypercholesterolemia.

Metabolism 2009 Mar;58(3):416-20

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.

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http://dx.doi.org/10.1016/j.metabol.2008.10.019DOI Listing
March 2009

Effects of xylooligosaccharides in type 2 diabetes mellitus.

J Nutr Sci Vitaminol (Tokyo) 2008 Oct;54(5):396-401

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

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October 2008