Publications by authors named "I O Gabitova"

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Role of HS in Regulation of Vascular Tone in Metabolic Disorders.

Bull Exp Biol Med 2021 Aug 20;171(4):431-434. Epub 2021 Sep 20.

Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.

We studied the effect of the HS donor (NaHS, 1-500 μM) on the contractile responses of isolated aortic smooth muscle segments from rats with metabolic syndrome induced by high-fat, high-carbohydrate diet. It was found that the vasorelaxing effect of NaHS (5-100 μM) decreased in under conditions of MS. The endothelial NO synthase inhibitor L-NAME (100 μM) suppressed the effect of NaHS, while cystathionine-gamma-lyase inhibitor PAG (100 μM) decreased the vasodilating effects of acetylcholine (0.1-100 μM). Application of endogenous NO precursor L-arginine (1 mM) potentiated in the effects of HS donor NaHS. Thus, the contractile activity of vascular smooth muscles in metabolic syndrome is determined by not only the effect of HS, but also the influence of NO.
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August 2021