Publications by authors named "I Ismail"

638 Publications

Single dose of atezolizumab plus chemotherapy in active psoriasis with advanced non-small cell lung cancer.

J Oncol Pharm Pract 2021 Sep 25:10781552211038899. Epub 2021 Sep 25.

Department of Radiology, Kulliyyah of Medicine, 61774International Islamic University Malaysia, Kuantan, Pahang, Malaysia.

Introduction: Immunotherapy has been recognized as the standard of care in addition to chemotherapy in the treatment of advanced non-small cell lung cancer. Most immunotherapy trials, however, exclude patients with autoimmune disease owing to concerns of disease exacerbation.

Case Report: We report a case of a patient with advanced non-small cell lung cancer and underlying active psoriasis who experienced a remarkable response, without developing psoriasis flares, following treatment with a single dose of atezolizumab and first-line chemotherapy.

Management And Outcome: The patient remained asymptomatic 10 months since treatment discontinuation, without disease progression, despite having received only a single dose of atezolizumab and six cycles of chemotherapy.

Discussion: Little is known about the optimum duration required to achieve a durable response with immunotherapy. Patients with autoimmune disease are commonly excluded from immunotherapy trials owing to a higher risk of autoimmune disease flares or immune-related adverse events. The remarkable outcome observed in this case offers some insights into the possible durable response with limited doses of immunotherapy and a safer approach for administering immunotherapy in patients with autoimmune disease. Initiating chemotherapy to induce remission in active autoimmune disease prior to administering immunotherapy could potentially be an ideal approach that facilitates the use of immunotherapy in this patient population.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/10781552211038899DOI Listing
September 2021

An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases.

Biomed Pharmacother 2021 Sep 23;143:112207. Epub 2021 Sep 23.

Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Malaysia; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Malaysia. Electronic address:

Stevia rebaudiana Bertoni is a native plant to Paraguay. The extracts have been used as a famous sweetening agent, and the bioactive components derived from stevia possess a broad spectrum of therapeutical potential for various illnesses. Among its medicinal benefits are anti-hypertensive, anti-tumorigenic, anti-diabetic, and anti-hyperlipidemia. Statins (3-hydro-3-methylglutaryl-coenzyme A reductase inhibitor) are a class of drugs used to treat atherosclerosis. Statins are explicitly targeting the HMG-CoA reductase, an enzyme in the rate-limiting step of cholesterol biosynthesis. Despite being widely used in regulating plasma cholesterol levels, the adverse effects of the drug are a significant concern among clinicians and patients. Hence, steviol glycosides derived from stevia have been proposed as an alternative in replacing statins. Diterpene glycosides from stevia, such as stevioside and rebaudioside A have been evaluated for their efficacy in alleviating cholesterol levels. These glycosides are a potential candidate in treating and preventing atherosclerosis provoked by circulating lipid retention in the sub-endothelial lining of the artery. The present review is an effort to integrate the pathogenesis of atherosclerosis, involvement of lipid droplets biogenesis and its associated proteins in atherogenesis, current approaches to treat atherosclerosis, and pharmacological potential of stevia in treating the disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2021.112207DOI Listing
September 2021

Temperature, humidity and outdoor air quality indicators influence COVID-19 spread rate and mortality in major cities of Saudi Arabia.

Environ Res 2021 Sep 22:112071. Epub 2021 Sep 22.

Division of Biomedical and Life Sciences, Lancaster University, United Kingdom.

There is an increasing evidence that meteorological (temperature, humidity, dew) and air quality indicators (PM2.5, PM10, NO2, SO2, CO) are affecting the COVID-19 transmission rate and the number of deaths in many countries around the globe. However, there are contradictory results due to limited observations of these parameters and absence of conclusive evidence on such relationships in cold or hot arid tropical and subtropical desert climate of Gulf region. This is the first study exploring the relationships of the meteorological (temperature, humidity, dew) and air quality indicators (PM10, CO, and SO2) with daily COVID-19 infections and death cases for a period of six months (1st March to August 31, 2020) in six selected cities of the Kingdom of Saudi Arabia by using generalized additive model. The Akaike information criterion (AIC) was used to assess factors affecting the infections rate and deaths through the selection of best model whereas overfitting of multivariate model was avoided by usingcross-validation. Spearman correlation indicated that exponentially weighted moving average (EWMA) temperature and humidity (R > 0.5, P < 0.0001) are the main variables affecting the daily COVID-19 infections and deaths. EWMA temperature and humidity showed non linear relationships with the number of COVID-19 infections and deaths (DF > 1, P < 0.0001). Daily COVID-19 infections showed a positive relationship at temperature between 23 and 34.5 °C and humidity ranging from 30 to 60%; a negative relationship was found below and/or above these ranges. Similarly, the number of deaths had a positive relationship at temperature ˃28.7 °C and with humidity ˂40%, showing higher number of deaths above this temperature and below this humidity rate. All air quality indicators had linear relationships with the number of COVID-19 infections and deaths (P < 0.0001). Hence, variation in temperature, humidity and air pollution indicators could be important factors influencing the COVID-19 spread and mortality. Under the current scenario with rising temperature and humidity, the number of cases is increasing, hence it justifies an active government policy to lessen COVID-19 infection rate.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2021.112071DOI Listing
September 2021

Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway.

Aging (Albany NY) 2021 Sep 20;13(undefined). Epub 2021 Sep 20.

Laboratory of Biochemistry and Molecular Biology, University of Carthage, Faculty of Sciences of Bizerte, Zarzouna, Bizerte 7021, Tunisia.

Background: The aim of the study is to determine the anticancer activity of (TS) and its underlying mechanisms using and in animal models.

Methods: HCT116 cells were treated with TS essential oil alone or with TRAIL, and then its anticancer effect was determined by using MTT assay, live dead assay, caspase activation and PARP cleavage. Further mechanisms of its anticancer effects was determined by analyzing expression of death receptor signaling pathway using Western blotting. A mouse model was also used to assess the antitumor potential of thyme essential oil.

Results: TS oily fraction showed tumor growth inhibitory effect even at lower concentration. TS induces apoptotic cell death as indicated by cleavage of PARP, and activation of the initiator and effector caspases (caspase-3, -8 and -9). Further, results showed that TS increases the expression of death receptors (DRs) and reduces the expression of TRAIL decoy receptors (DcRs). In addition, upregulation of signaling molecules of MAPK pathway (p38 kinase, ERK, JNK), down-regulation of c-FLIP, and overexpression of SP1 and CHOP were observed by TS. Further in animal model, intragastric administration of TS (12.5 mg/ml and 50 mg/ml) prevented colorectal carcinogenesis by blocking multi-steps in carcinoma.

Conclusion: Overall, these results indicate that thymus essential oil promotes apoptosis in HCT116 cells and impedes tumorigenesis in animal model. Moreover, thyme potentiates TRAIL-induced cell death through upregulation of DRs, CHOP and SP1 as well as downregulation of antiapoptotic proteins in HCT116 cells. However, therapeutic potential of TS needs to be further explored.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.203552DOI Listing
September 2021

Biosynthesis of silver nanoparticles by Nocardiopsis sp.-MW279108 and its antimicrobial activity.

J Basic Microbiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Biology, College of Science, Taif University, Taif, Saudi Arabia.

The utilization of microorganisms like bacteria in the biological synthesis of silver nanoparticles (AgNPs) has attracted widespread attention due to their ability to synthesize different shape sizes, states, and morphology nanoparticles. In the current study, the green synthesis of AgNPs by Nocardiopsis sp. 16S ribosomal RNA analysis was used to characterize the Nocardiopsis sp. The synthesized AgNPs were characterized through multi-instrument platforms such as transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, scanning electron microscope (SEM), and X-ray diffraction analysis (XRD). The antimicrobial activity of the synthesized AgNPs was determined by the agar plate diffusion method. The UV-Vis absorbance analysis of the synthesized AgNPs has a significant absorbance at 384 nm, confirming the AgNPs' surface plasmon resonance. The SEM and TEM characterizations indicate that the particle size ranges from 2 to 10 nm and is spherical. Additionally, the FTIR spectra revealed bands from 476 to 3819cm , respectively. The XRD planes study pronounced strong bands ranging are between 111 and 311 corresponding to cubic face-center of the silver. Also, the antimicrobial activity of AgNPs indicated the biogenic AgNPs could control the growth of the clinical isolates. The AgNPs produced by Nocardiopsis sp. supernatant could be used in different nanomedicinal applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/jobm.202100248DOI Listing
September 2021
-->