Publications by authors named "I German"

29 Publications

Fibrin Sealant Derived from Human Plasma as a Scaffold for Bone Grafts Associated with Photobiomodulation Therapy.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru 17012-901, Brazil.

Fibrin sealants derived from human blood can be used in tissue engineering to assist in the repair of bone defects. The objective of this study was to evaluate the support system formed by a xenograft fibrin sealant associated with photobiomodulation therapy of critical defects in rat calvaria. Thirty-six rats were divided into four groups: BC ( = 8), defect filled with blood clot; FSB ( = 10), filled with fibrin sealant and xenograft; BC ( = 8), blood clot and photobiomodulation; FSB ( = 10), fibrin sealant, xenograft, and photobiomodulation. The animals were killed after 14 and 42 days. In the histological and microtomographic analysis, new bone formation was observed in all groups, limited to the defect margins, and without complete wound closure. In the FSB group, bone formation increased between periods (4.3 ± 0.46 to 6.01 ± 0.32), yet with lower volume density when compared to the FSB (5.6 ± 0.45 to 10.64 ± 0.97) group. It was concluded that the support system formed by the xenograft fibrin sealant associated with the photobiomodulation therapy protocol had a positive effect on the bone repair process.
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http://dx.doi.org/10.3390/ijms20071761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479442PMC
April 2019

Inducing hardening and healability in poly(ethylene--acrylic acid) blending with complementary low molecular weight additives.

RSC Adv 2018 Dec 12;8(72):41445-41453. Epub 2018 Dec 12.

Department of Chemistry, University of Reading Whiteknights, Reading RG6 6AD UK +44 (0)118 378 6331 +44 (0)118 378 6491.

The design and synthesis of low molecular weight additives based on self-assembling nitroarylurea units, and their compatibility with poly(ethylene--acrylic acid) copolymers are reported. The self-assembly properties of the low molecular weight additives have been demonstrated in a series of gelation studies. Upon blending at low percentage weights (≤5%) with poly(ethylene--acrylic acid) the additives were capable of increasing the stress and strain to failure when compared to the parent copolymer. By varying the percentage weight of the additive as well as the type of additive the mechanical properties of poly(ethylene--acrylic acid) could be tailored. Finally, the healability characteristics of the blends were improved when compared to the original polymer the introduction of a supramolecular 'network within a network'.
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http://dx.doi.org/10.1039/c8ra09597cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091865PMC
December 2018

Stimulation of morphofunctional repair of the facial nerve with photobiomodulation, using the end-to-side technique or a new heterologous fibrin sealant.

J Photochem Photobiol B 2017 Oct 18;175:20-28. Epub 2017 Aug 18.

Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru, SP, Brazil; Human Morphophysiology (Anatomy), University of Marilia (UNIMAR), Marilia, SP, Brazil.

This research evaluated the influence of Photobiomodulation Therapy (PBMT) on lesions of the facial nerve repaired with the end-to-side technique or coaptation with a new heterologous fibrin sealant. Thirty-two Wistar rats were separated into 5 groups: Control group (CG), where the buccal branch of the facial nerve was collected; Experimental Suture Group (ESG) and Experimental Fibrin Group (EFG), in which the buccal branch was end-to-side sutured to the zygomatic branch on the right side of the face or coaptated with fibrin sealant on the left side; Experimental Suture Laser Group (ESLG) and Experimental Fibrin Laser Group (EFLG), in which the same procedures were performed as the ESG and EFG, associated with PBMT (wavelength of 830nm, energy density 6.2J/cm, power output 30mW, beam area of 0.116cm, power density 0.26W/cm, total energy per session 2.16J, cumulative dose of 34.56J). The laser was applied for 24s/site at 3 points on the skin's surface, for a total application time of 72s, performed immediately after surgery and 3 times a week for 5weeks. A statistically significant difference was observed in the fiber nerve area between the EFG and EFLG (57.49±3.13 and 62.52±3.56μm, respectively). For the area of the axon, fiber diameter, axon diameter, myelin sheath area and myelin sheath thickness no statistically significant differences were found (p<0.05). The functional recovery of whisker movement occurred faster in the ESLG and EFLG, which were associated with PBMT, with results closer to the CG. Therefore, PBMT accelerated morphological and functional nerve repair in both techniques.
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http://dx.doi.org/10.1016/j.jphotobiol.2017.08.023DOI Listing
October 2017

Halomethyl-cobalt(bis-acetylacetonate) for the controlled synthesis of functional polymers.

Chem Commun (Camb) 2015 Oct 14;51(76):14334-7. Epub 2015 Aug 14.

Center for Education and Research on Macromolecules (CERM), Chemistry Department, University of Liège, 4000 Liège, Belgium.

Novel organocobalt complexes featuring weak C-CoL2 bonds (L = acetylacetonate) are prepared and used as sources of halomethyl radicals. They permit the precision synthesis of α-halide functionalized and telechelic polymers in organic media or in water. Substitution of halide by azide allows derivatization of polymers using the CuAAC click reaction.
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http://dx.doi.org/10.1039/c5cc04714eDOI Listing
October 2015

Direct Route to Well-Defined Poly(ionic liquid)s by Controlled Radical Polymerization in Water.

ACS Macro Lett 2014 Dec 5;3(12):1276-1280. Epub 2014 Dec 5.

Center for Education and Research on Macromolecules (CERM), Chemistry Department, University of Liege (ULg), Sart-Tilman, B6a, 4000 Liege, Belgium.

The precision synthesis of poly(ionic liquid)s (PILs) in water is achieved for the first time by the cobalt-mediated radical polymerization (CMRP) of -vinyl-3-alkylimidazolium-type monomers following two distinct protocols. The first involves the CMRP of various 1-vinyl-3-alkylimidazolium bromides conducted in water in the presence of an alkyl-cobalt(III) complex acting as a monocomponent initiator and mediating agent. Excellent control over molar mass and dispersity is achieved at 30 °C. Polymerizations are complete in a few hours, and PIL chain-end fidelity is demonstrated up to high monomer conversions. The second route uses the commercially available bis(acetylacetonato)cobalt(II) (Co(acac)) in conjunction with a simple hydroperoxide initiator (-butyl hydroperoxide) at 30, 40, and 50 °C in water, facilitating the scaling-up of the technology. Both routes prove robust and straightforward, opening new perspectives onto the tailored synthesis of PILs under mild experimental conditions in water.
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http://dx.doi.org/10.1021/mz500721rDOI Listing
December 2014
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