Publications by authors named "I Bobyr"

18 Publications

Combined treatment of palmar hyperhidrosis with botulinum toxin type A and oxybutynin chloride: Results of a clinical, multicenter, prospective study.

Dermatol Ther 2020 11 7;33(6):e14039. Epub 2020 Sep 7.

Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, Italy.

Oxybutynin chloride and botulinum toxin type A (BTX-A) have demonstrated to be effective treatments for primary palmar hyperhidrosis (PPH); however, both of them are not completely free from local and/or generalized side effects. Primary aim of this study is to compare efficacy and safety of a sequencing administration of oral oxybutynin chloride after BTX-A injections vs oral oxybutynin chloride in monotherapy in patients with PPH. Secondary aim is to evaluate if the sequencing approach can allow the control of hyperhidrosis with lower dose of oral oxybutynin. Patients enrolled were compared for short- and long-term efficacy and safety of treatments. Effectiveness was evaluated through the Hyperhidrosis Disease Severity Scale (HDSS), and the Dermatology Life Quality Index (DLQI) score; safety was assessed through collection of the adverse events reported by patients both at baseline, at 24 and 52 weeks. Patients receiving sequencing treatment showed significant greater improvement than patients receiving oxybutynin chloride alone at T24 (HDSS P = .0076 and DLQI P = .0139) and T52 (HDSS P = .0387 and DLQI P = .0087). The dose of oxybutynin chloride useful to control hyperhidrosis was lower, and retention rate to the treatment was higher in patients receiving sequencing treatment (P = .001), than patients receiving monotherapy (P = .04). A sequencing therapeutic approach to palmar hyperhidrosis increases both efficacy and safety compared with the use of oral oxybutynin chloride alone, and allows clinicians to keep lower dosage of oxybutynin chloride reducing generalized side effects and increasing the retention rate to the treatment.
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http://dx.doi.org/10.1111/dth.14039DOI Listing
November 2020

Acne agminata in Crohn's disease: A diagnostic and therapeutic challenge case for dermatologists.

Dermatol Ther 2020 11 5;33(6):e13935. Epub 2020 Aug 5.

Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, School of Medicine, United Hospitals, Ancona, Italy.

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http://dx.doi.org/10.1111/dth.13935DOI Listing
November 2020

Global coronavirus pandemic (SARS-CoV-2): Past, present, and future of pediatric dermatology.

Dermatol Ther 2020 09 30;33(5):e13767. Epub 2020 Jun 30.

Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, Italy.

Two months have passed since the World Health Organization (WHO) declared the pandemic of the Coronavirus Disease 19 (COVID-19), caused by the SARS-CoV-2 virus, on 11 March 2020. Medical and healthcare workers have continued to be on the frontline to defeat this disease, however, continual changes are being made to their working habits which are proving to be difficult. Although the skin is not the main target of the SARS-CoV-2 infection, it is strongly involved both directly and indirectly, in many aspects of dermatological disease management, and particularly in pediatric dermatology. In this manuscript, our goal was to provide a "up-to-date" account on this topic, through analysis of current literature and sharing our experiences during this pandemic.
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http://dx.doi.org/10.1111/dth.13767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300526PMC
September 2020

Skin involvement in SARS-CoV-2 infection: Case series.

J Med Virol 2020 11 2;92(11):2332-2334. Epub 2020 Jun 2.

Department of Clinical and Molecular Sciences, Dermatological Clinic, Marche Polytechnic University, Ancona, Italy.

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http://dx.doi.org/10.1002/jmv.26012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272997PMC
November 2020

Mesenchymal stem cell profile in actinic keratosis and its modification after topical application of ingenol mebutate.

J Eur Acad Dermatol Venereol 2020 Mar;34(3):e148-e149

Department of Molecular and Clinical Sciences - Histology, Università Politecnica delle Marche, Ancona, Italy.

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http://dx.doi.org/10.1111/jdv.16058DOI Listing
March 2020