Publications

Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains.
Biophys J 2017 Nov;113(9):1956-1967
Cancer and Inflammation Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Intrinsic protein disorder in oncogenic KRAS signaling.
Cell Mol Life Sci 2017 Sep 8;74(17):3245-3261. Epub 2017 Jun 8.
Department of Pathophysiology, Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.

Graphite-Templated Amyloid Nanostructures Formed by a Potential Pentapeptide Inhibitor for Alzheimer's Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations.
Langmuir 2017 Jul 27;33(27):6647-6656. Epub 2017 Jun 27.
Agricultural Nanocenter, School of Life Science, Inner Mongolia Agricultural University , 306 Zhaowuda Road, Hohhot 010018, China.

Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts.
ACS Chem Neurosci 2017 Jun 20;8(6):1348-1357. Epub 2017 Feb 20.
Cancer and Inflammation Program, National Cancer Institute at Frederick, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States.

The dynamic mechanism of RASSF5 and MST kinase activation by Ras.
Phys Chem Chem Phys 2017 Mar;19(9):6470-6480
Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro.
Curr Opin Struct Biol 2016 Dec 17;41:217-224. Epub 2016 Sep 17.
Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers.
Biochem J 2016 Jun 7;473(12):1719-32. Epub 2016 Apr 7.
Cancer and Inflammation Program, National Cancer Institute at Frederick, Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, U.S.A. Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

The higher level of complexity of K-Ras4B activation at the membrane.
FASEB J 2016 Apr 30;30(4):1643-55. Epub 2015 Dec 30.
*Basic Science Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, USA; Department of Chemistry, Department of Medicinal Chemistry, and Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, USA; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis, Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine, Shanghai, China; and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
J Biol Chem 2015 Nov 9;290(48):28887-900. Epub 2015 Oct 9.
Cancer and Inflammation Program, Leidos Biomedical Research, Inc., NCI-Frederick, Frederick, Maryland 21702, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Sackler Institute of Molecular Medicine, Tel Aviv University, Tel Aviv 69978, Israel

GTP-Dependent K-Ras Dimerization.
Structure 2015 Jul 4;23(7):1325-35. Epub 2015 Jun 4.
Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:

Oligomerization and nanocluster organization render specificity.
Biol Rev Camb Philos Soc 2015 May 11;90(2):587-98. Epub 2014 Jun 11.
Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, National Cancer Institute, Frederick, MD 21702, U.S.A.; Department of Human Genetics and Molecular Medicine, Sackler Institute of Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.
J Phys Chem B 2013 Oct 13;117(39):11518-29. Epub 2013 Sep 13.
Basic Science Program, SAIC-Frederick, Inc., Cancer and Inflammation Program, National Cancer Institute , Frederick, Maryland 21702, United States.


Material properties of matrix lipids determine the conformation and intermolecular reactivity of diacetylenic phosphatidylcholine in the lipid bilayer.
Langmuir 2011 Dec 21;27(24):15120-8. Epub 2011 Nov 21.
Membrane Structure and Function Section, SAIC-Frederick, Inc., Nanobiology Program, Center for Cancer Research, Frederick, Maryland 21702, USA.

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