Hyunbum Jang

Hyunbum Jang

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Hyunbum Jang

Hyunbum Jang

Publications by authors named "Hyunbum Jang"

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83Publications

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Arl2-Mediated Allosteric Release of Farnesylated KRas4B from Shuttling Factor PDEδ.

J Phys Chem B 2018 Aug 18;122(30):7503-7513. Epub 2018 Jul 18.

Cancer and Inflammation Program , Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick , Frederick , Maryland 21702 , United States.

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August 2018

Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α.

J Phys Chem B 2018 Aug 8. Epub 2018 Aug 8.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc. , Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute , Frederick , Maryland 21702 , United States.

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August 2018

Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles.

Biophys J 2018 Aug 24;115(4):629-641. Epub 2018 Jul 24.

Cancer and Inflammation Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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August 2018

Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers.

Biochim Biophys Acta 2018 06 31;1864(6 Pt B):2304-2314. Epub 2017 Oct 31.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, United States.

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June 2018

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.

J Biol Chem 2018 Mar 22;293(10):3685-3699. Epub 2018 Jan 22.

the Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NCI-Frederick, Frederick, Maryland 21702,

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March 2018

Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling.

Structure 2018 Mar 8;26(3):513-525.e2. Epub 2018 Feb 8.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:

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March 2018

Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit.

Biochemistry 2018 03 19;57(12):1917-1928. Epub 2018 Mar 19.

Department of Biochemistry and Molecular Genetics , University of Illinois at Chicago, Chicago , Illinois 60607 , United States.

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March 2018

Oncogenic Ras Isoforms Signaling Specificity at the Membrane.

Cancer Res 2018 Feb 22;78(3):593-602. Epub 2017 Dec 22.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland.

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February 2018

Oncogenic KRas mobility in the membrane and signaling response.

Semin Cancer Biol 2018 Feb 27. Epub 2018 Feb 27.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, 21702, USA.

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February 2018

Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?

Semin Cancer Biol 2018 Jan 5. Epub 2018 Jan 5.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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January 2018

Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH Domains.

Biophys J 2017 Nov;113(9):1956-1967

Cancer and Inflammation Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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November 2017

Intrinsic protein disorder in oncogenic KRAS signaling.

Cell Mol Life Sci 2017 09 8;74(17):3245-3261. Epub 2017 Jun 8.

Department of Pathophysiology, Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.

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September 2017

Graphite-Templated Amyloid Nanostructures Formed by a Potential Pentapeptide Inhibitor for Alzheimer's Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations.

Langmuir 2017 07 27;33(27):6647-6656. Epub 2017 Jun 27.

Agricultural Nanocenter, School of Life Science, Inner Mongolia Agricultural University , 306 Zhaowuda Road, Hohhot 010018, China.

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July 2017

Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.

J Biol Chem 2017 07 16;292(30):12544-12559. Epub 2017 Jun 16.

From the Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NCI-Frederick, Frederick, Maryland 21702,

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July 2017

Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts.

ACS Chem Neurosci 2017 06 20;8(6):1348-1357. Epub 2017 Feb 20.

Cancer and Inflammation Program, National Cancer Institute at Frederick, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States.

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June 2017

PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization.

J Phys Chem B 2017 06 7;121(24):5917-5927. Epub 2017 Jun 7.

Cancer and Inflammation Program, National Cancer Institute at Frederick and Basic Science Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. , Frederick, Maryland 21702, United States.

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June 2017

A New View of Pathway-Driven Drug Resistance in Tumor Proliferation.

Trends Pharmacol Sci 2017 05 27;38(5):427-437. Epub 2017 Feb 27.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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May 2017

The dynamic mechanism of RASSF5 and MST kinase activation by Ras.

Phys Chem Chem Phys 2017 Mar;19(9):6470-6480

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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March 2017

Calmodulin and PI3K Signaling in Cancers.

Trends Cancer 2017 03 18;3(3):214-224. Epub 2017 Feb 18.

Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, IL 60607, U.S.A.

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March 2017

Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.

Expert Rev Proteomics 2015 23;12(6):669-82. Epub 2015 Oct 23.

c Departments of Chemical & Biological Engineering , Koc University , Istanbul , Turkey.

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January 2017

RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro.

Curr Opin Struct Biol 2016 12 17;41:217-224. Epub 2016 Sep 17.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:

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December 2016

Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation.

Semin Cell Dev Biol 2016 10 4;58:79-85. Epub 2016 Apr 4.

Department of Medical Chemistry, Semmelweis University, P.O. Box 2, H-1428 Budapest, Hungary.

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October 2016

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Chem Soc Rev 2016 09 11;45(18):4929-52. Epub 2016 Jul 11.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Children's Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200127, China.

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September 2016

Independent and core pathways in oncogenic KRAS signaling.

Expert Rev Proteomics 2016 08 18;13(8):711-6. Epub 2016 Jul 18.

a Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Cancer and Inflammation Program , National Cancer Institute at Frederick , Frederick , MD , USA.

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August 2016

Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.

Methods Mol Biol 2016 ;1345:251-68

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD, 21702, USA.

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July 2016

K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?

Expert Opin Ther Targets 2016 Jul 12;20(7):831-42. Epub 2016 Feb 12.

c Department of Chemical and Biological Engineering , Koc University , Istanbul , Turkey.

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July 2016

Ras Conformational Ensembles, Allostery, and Signaling.

Chem Rev 2016 06 27;116(11):6607-65. Epub 2016 Jan 27.

Department of Pathophysiology, Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine , Shanghai, 200025, China.

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June 2016

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers.

Biochem J 2016 06 7;473(12):1719-32. Epub 2016 Apr 7.

Cancer and Inflammation Program, National Cancer Institute at Frederick, Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, U.S.A. Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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June 2016

Inhibitors of Ras-SOS Interactions.

ChemMedChem 2016 Apr 2;11(8):814-21. Epub 2015 Dec 2.

Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory, National Cancer Institute, Frederick, MD, 21702, USA.

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April 2016

The higher level of complexity of K-Ras4B activation at the membrane.

FASEB J 2016 Apr 30;30(4):1643-55. Epub 2015 Dec 30.

*Basic Science Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, USA; Department of Chemistry, Department of Medicinal Chemistry, and Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, USA; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis, Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine, Shanghai, China; and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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April 2016

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.

Curr Opin Struct Biol 2016 Feb 20;36:10-7. Epub 2015 Dec 20.

Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address:

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February 2016

Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences.

J Phys Chem B 2016 Feb 27;120(4):667-79. Epub 2016 Jan 27.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick , Frederick, Maryland 21702, United States.

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February 2016

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.

Sci Rep 2016 Feb 23;6:21949. Epub 2016 Feb 23.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.

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February 2016

Plasma membrane regulates Ras signaling networks.

Cell Logist 2015 Oct-Dec;5(4):e1136374. Epub 2016 Feb 18.

Department of Biochemistry and Molecular Genetics; University of Illinois at Chicago ; Chicago, IL USA.

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February 2016

A New View of Ras Isoforms in Cancers.

Cancer Res 2016 Jan 10;76(1):18-23. Epub 2015 Dec 10.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland.

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January 2016

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

Biophys J 2015 Dec;109(12):2602-13

Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland. Electronic address:

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December 2015

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.

J Biol Chem 2015 Nov 9;290(48):28887-900. Epub 2015 Oct 9.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., NCI-Frederick, Frederick, Maryland 21702, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Sackler Institute of Molecular Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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November 2015

Dynamic multiprotein assemblies shape the spatial structure of cell signaling.

Prog Biophys Mol Biol 2014 Nov-Dec;116(2-3):158-64. Epub 2014 Jul 18.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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September 2015

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.

Mol Cancer Res 2015 Sep 17;13(9):1265-73. Epub 2015 Jun 17.

Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey.

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September 2015

GTP-Dependent K-Ras Dimerization.

Structure 2015 Jul 4;23(7):1325-35. Epub 2015 Jun 4.

Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:

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July 2015

Oligomerization and nanocluster organization render specificity.

Biol Rev Camb Philos Soc 2015 May 11;90(2):587-98. Epub 2014 Jun 11.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, National Cancer Institute, Frederick, MD 21702, U.S.A.; Department of Human Genetics and Molecular Medicine, Sackler Institute of Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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May 2015

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.

J Biol Chem 2015 Apr 24;290(15):9465-77. Epub 2015 Feb 24.

Departments of Biochemistry and Molecular Genetics and Medicinal Chemistry, University of Illinois, Chicago, Illinois 60607, and

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April 2015

Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.

Chem Soc Rev 2014 Oct;43(19):6750-64

Cancer and Inflammation Program, National Cancer Institute at Frederick, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.

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October 2014

The structural basis for cancer treatment decisions.

Oncotarget 2014 Sep;5(17):7285-302

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, U.S.A.

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September 2014

Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores.

J Phys Chem B 2014 Jul 24;118(26):7335-44. Epub 2014 Jun 24.

Department of Bioengineering, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.

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July 2014

Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability.

Biochemistry 2014 Jul 9;53(28):4704-14. Epub 2014 Jul 9.

Department of Bioengineering, University of California at San Diego , La Jolla, California 92093, United States.

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July 2014

Mechanism of membrane permeation induced by synthetic β-hairpin peptides.

Biophys J 2013 Nov;105(9):2093-103

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.

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November 2013

Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.

J Phys Chem B 2013 Oct 13;117(39):11518-29. Epub 2013 Sep 13.

Basic Science Program, SAIC-Frederick, Inc., Cancer and Inflammation Program, National Cancer Institute , Frederick, Maryland 21702, United States.

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October 2013

Alzheimer's disease: which type of amyloid-preventing drug agents to employ?

Phys Chem Chem Phys 2013 Jun 28;15(23):8868-77. Epub 2013 Feb 28.

Center for Cancer Research, Nanobiology Program, Basic Science Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702, USA.

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June 2013

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.

J Chem Theory Comput 2013 Jan 5;9(1):822-833. Epub 2012 Dec 5.

Basic Science Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.

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January 2013

Probing ion channel activity of human islet amyloid polypeptide (amylin).

Biochim Biophys Acta 2012 Dec 23;1818(12):3121-30. Epub 2012 Aug 23.

Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH 44325, USA.

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December 2012

Antimicrobial properties of amyloid peptides.

Mol Pharm 2012 Apr 29;9(4):708-17. Epub 2011 Nov 29.

Department of Psychiatry, David Geffen School of Medicine, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, California 90024, USA.

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April 2012

Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations.

Biochemistry 2012 Apr 28;51(14):3031-8. Epub 2012 Mar 28.

Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.

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April 2012

Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.

Biochemistry 2012 Jan 12;51(3):776-85. Epub 2012 Jan 12.

Department of Bioengineering, Department of Mechanical and Aerospace Engineering, and Material Science Program, University of California, San Diego, La Jolla, California 92093, United States.

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January 2012

Material properties of matrix lipids determine the conformation and intermolecular reactivity of diacetylenic phosphatidylcholine in the lipid bilayer.

Langmuir 2011 Dec 21;27(24):15120-8. Epub 2011 Nov 21.

Membrane Structure and Function Section, SAIC-Frederick, Inc., Nanobiology Program, Center for Cancer Research, Frederick, Maryland 21702, USA.

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December 2011

Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation.

Soft Matter 2011 May;7(11):5267-5273

Department of Bioengineering and Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093, U.S.A.

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May 2011

Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link.

Biophys J 2011 Apr;100(7):1775-83

Center for Cancer Research Nanobiology Program, National Cancer Institute-Frederick, SAIC-Frederick, Frederick, Maryland, USA.

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April 2011

β-Barrel topology of Alzheimer's β-amyloid ion channels.

J Mol Biol 2010 Dec 21;404(5):917-34. Epub 2010 Oct 21.

Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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December 2010

Structural convergence among diverse, toxic beta-sheet ion channels.

J Phys Chem B 2010 Jul;114(29):9445-51

Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.

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July 2010

Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies.

Biophys J 2010 Jun;98(11):2644-52

Center for Nanomedicine and Department of Medicine, University of Chicago, Chicago, Illinois, USA.

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June 2010

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Proc Natl Acad Sci U S A 2010 Apr 22;107(14):6538-43. Epub 2010 Mar 22.

Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA.

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April 2010

Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels.

Biophys J 2009 Dec;97(11):3029-37

Center for Cancer Research Nanobiology Program, NCI-Frederick, SAIC-Frederick, Frederick, Maryland, USA.

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December 2009

K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis.

J Am Chem Soc 2009 Oct;131(41):14938-45

Center for Nanomedicine and Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA.

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October 2009

Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels.

Biophys J 2008 Nov 15;95(10):4631-42. Epub 2008 Aug 15.

Center for Cancer Research Nanobiology Program, NCI-Frederick, SAIC-Frederick, Frederick, Maryland, USA.

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November 2008

How to lose a kink and gain a helix: pH independent conformational changes of the fusion domains from influenza hemagglutinin in heterogeneous lipid bilayers.

Proteins 2008 Jul;72(1):299-312

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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July 2008

Annular structures as intermediates in fibril formation of Alzheimer Abeta17-42.

J Phys Chem B 2008 Jun 6;112(22):6856-65. Epub 2008 May 6.

Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, USA.

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June 2008

New structures help the modeling of toxic amyloidbeta ion channels.

Trends Biochem Sci 2008 Feb 7;33(2):91-100. Epub 2008 Jan 7.

Center for Cancer Research Nanobiology Program, SAIC-Frederick Inc. NCI-Frederick, Frederick, MD 21702, USA.

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February 2008

Beta2-microglobulin amyloid fragment organization and morphology and its comparison to Abeta suggests that amyloid aggregation pathways are sequence specific.

Biochemistry 2008 Feb 24;47(8):2497-509. Epub 2008 Jan 24.

Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, USA.

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February 2008

Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities.

Biophys J 2007 Nov 3;93(9):3046-57. Epub 2007 Aug 3.

Basic Research Program, SAIC-Frederick Center for Cancer Research, Nanobiology Program, NCI-Frederick, Frederick, Maryland 21702, USA.

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November 2007

Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process.

Biophys J 2007 Sep 25;93(6):1938-49. Epub 2007 May 25.

Center for Cancer Research Nanobiology Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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September 2007

Conformational study of the protegrin-1 (PG-1) dimer interaction with lipid bilayers and its effect.

BMC Struct Biol 2007 Apr 2;7:21. Epub 2007 Apr 2.

Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.

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April 2007

Interaction of protegrin-1 with lipid bilayers: membrane thinning effect.

Biophys J 2006 Oct 21;91(8):2848-59. Epub 2006 Jul 21.

Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.

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October 2006

Multiple pathways in conformational transitions of the alanine dipeptide: an application of dynamic importance sampling.

J Comput Chem 2006 Aug;27(11):1136-41

Department of Physiology, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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August 2006

Stochastic dynamics and the dynamic phase transition in thin ferromagnetic films.

Phys Rev E Stat Nonlin Soft Matter Phys 2004 Oct 5;70(4 Pt 2):047101. Epub 2004 Oct 5.

Department of Physiology, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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October 2004

How environment supports a state: molecular dynamics simulations of two states in bacteriorhodopsin suggest lipid and water compensation.

Biophys J 2004 Jul;87(1):129-45

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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July 2004

Tools for channels: moving towards molecular calculations of gating and permeation in ion channel biophysics.

J Mol Graph Model 2004 May;22(5):359-68

Department of Physiology, Johns Hopkins University, School of Medicine, Biophysics 206, 725 N. Wolfe Street, Baltimore, MD 21205, USA.

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May 2004

Thermodynamics and stability of a beta-sheet complex: molecular dynamics simulations on simplified off-lattice protein models.

Protein Sci 2004 Jan;13(1):40-53

Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905, USA.

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January 2004

Assembly and kinetic folding pathways of a tetrameric beta-sheet complex: molecular dynamics simulations on simplified off-lattice protein models.

Biophys J 2004 Jan;86(1 Pt 1):31-49

Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905, USA.

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January 2004

Exchange anisotropy and the dynamic phase transition in thin ferromagnetic Heisenberg films.

Phys Rev E Stat Nonlin Soft Matter Phys 2003 Oct 15;68(4 Pt 2):046115. Epub 2003 Oct 15.

Department of Physiology, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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October 2003

Protein folding pathways and kinetics: molecular dynamics simulations of beta-strand motifs.

Biophys J 2002 Aug;83(2):819-35

Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA.

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August 2002

Folding thermodynamics of model four-strand antiparallel beta-sheet proteins.

Biophys J 2002 Feb;82(2):646-59

Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905, USA.

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February 2002