Publications by authors named "Hyo Jeong Hong"

58Publications

Generation and Characterization of Monoclonal Antibodies to the Ogawa Lipopolysaccharide of O1 from Phage-Displayed Human Synthetic Fab Library.

J Microbiol Biotechnol 2020 Nov;30(11):1760-1768

Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.

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November 2020

Generation of a Human Monoclonal Antibody to Cross-Reactive Material 197 (CRM₁₉₇) and Development of a Sandwich ELISA for CRM₁₉₇ Conjugate Vaccines.

J Microbiol Biotechnol 2018 Dec;28(12):2113-2120

Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.

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December 2018

Generation and Characterization of a Neutralizing Human Monoclonal Antibody to Hepatitis B Virus PreS1 from a Phage-Displayed Human Synthetic Fab Library.

J Microbiol Biotechnol 2018 Aug;28(8):1376-1383

Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.

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August 2018

Multi-paratopic VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-angiogenic activities.

Biomaterials 2018 07 16;171:34-45. Epub 2018 Apr 16.

Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea; Graduate School of Medical Science & Engineering, KAIST, Daejeon, 34141, South Korea. Electronic address:

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July 2018

Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab Library.

Mol Cells 2017 Sep 20;40(9):655-666. Epub 2017 Sep 20.

Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea.

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September 2017

L1 Cell Adhesion Molecule Promotes Migration and Invasion via JNK Activation in Extrahepatic Cholangiocarcinoma Cells with Activating Mutation.

Mol Cells 2017 May 24;40(5):363-370. Epub 2017 May 24.

Institute of Bioscience and Biotechnology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea.

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May 2017

Construction and Characterization of an Anti-Hepatitis B Virus preS1 Humanized Antibody that Binds to the Essential Receptor Binding Site.

J Microbiol Biotechnol 2017 Jul;27(7):1336-1344

Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.

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July 2017

Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody.

Biomaterials 2015 May 17;51:119-128. Epub 2015 Feb 17.

Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Biomolecular Science, University of Science & Technology, Daejeon, Republic of Korea. Electronic address:

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May 2015

Enhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen-antibody complex structure.

FEBS Lett 2015 Jan 4;589(2):193-200. Epub 2014 Dec 4.

Institute of Antibody Research, Kangwon National University, Chuncheon 200-701, Republic of Korea; Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon 200-701, Republic of Korea. Electronic address:

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January 2015

RNA recognition by a human antibody against brain cytoplasmic 200 RNA.

RNA 2014 Jun 23;20(6):805-14. Epub 2014 Apr 23.

Department of Chemistry, KAIST, Daejeon 305-701, Korea.

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June 2014

Combined blockade of HER2 and VEGF exerts greater growth inhibition of HER2-overexpressing gastric cancer xenografts than individual blockade.

Exp Mol Med 2013 Nov 1;45:e52. Epub 2013 Nov 1.

1] Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon, Korea [2] Institute of Antibody Research, Kangwon National University, Chuncheon, Korea.

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November 2013

Humanization by guided selections.

Methods Mol Biol 2012 ;907:247-57

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Gwahangno, Yuseong-gu, Daejeon, Republic of Korea.

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December 2012

Humanization by CDR grafting and specificity-determining residue grafting.

Methods Mol Biol 2012 ;907:237-45

Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Gangwon-do, Korea.

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December 2012

A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model.

Exp Mol Med 2012 Apr;44(4):293-302

Department of Systems Immunology and Institute of Antibody Research, College of Biomedical Science, Kangwon National University, Chuncheon 200-701, Korea.

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April 2012

L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells.

Cancer Lett 2012 Mar 25;316(1):70-6. Epub 2011 Oct 25.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.

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March 2012

L1 cell adhesion molecule as a novel independent poor prognostic factor in gallbladder carcinoma.

Hum Pathol 2011 Oct 14;42(10):1476-83. Epub 2011 Apr 14.

Department of Pathology, Chungnam National University School of Medicine, Daejeon, South Korea.

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October 2011

The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo.

Oncol Rep 2011 Apr 11;25(4):945-52. Epub 2011 Feb 11.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong, Yuseong-gu, Daejeon 305-333, Republic of Korea.

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April 2011

Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2.

Biochem Biophys Res Commun 2011 Feb 3;405(3):333-7. Epub 2010 Dec 3.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.

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February 2011

L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma.

Clin Cancer Res 2010 Jul 25;16(14):3571-80. Epub 2010 May 25.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungnam National University School of Medicine, Daejon, Korea.

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July 2010

Construction of a humanized antibody to hepatitis B surface antigen by specificity-determining residues (SDR)-grafting and de-immunization.

Biochem Biophys Res Commun 2010 May 23;396(2):231-7. Epub 2010 Apr 23.

College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.

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May 2010

L1 cell adhesion molecule is a novel independent poor prognostic factor of extrahepatic cholangiocarcinoma.

Clin Cancer Res 2009 Dec 17;15(23):7345-51. Epub 2009 Nov 17.

Department of Pathology and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Korea.

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December 2009

Broadly neutralizing anti-HBV antibody binds to non-epitope regions of preS1.

FEBS Lett 2009 Sep 29;583(18):3095-100. Epub 2009 Aug 29.

Medical Proteomics Research Center, KRIBB, Daejeon 305-806, Republic of Korea.

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September 2009

Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex.

Biomaterials 2008 Dec 30;29(36):4831-7. Epub 2008 Sep 30.

Laboratory of Excellency for Drug and Gene Delivery, College of Pharmacy, Seoul National University, 599 Kwanangno, Kwanak-gu, Seoul 151-742, Republic of Korea.

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December 2008

Guided selection of human antibody light chains against TAG-72 using a phage display chain shuffling approach.

J Microbiol 2007 Dec;45(6):572-7

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Republic of Korea.

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December 2007

Generation and characterization of a monoclonal antibody with specificity for Mycoplasma arginini.

J Microbiol 2007 Dec;45(6):547-52

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Republic of Korea.

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December 2007

Affinity maturation of an anti-hepatitis B virus PreS1 humanized antibody by phage display.

J Microbiol 2007 Dec;45(6):528-33

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon, Republic of Korea.

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December 2007

Selection of an affinity-matured antibody against a defined epitope by phage display of an immune antibody library.

J Immunol Methods 2008 Jan 9;329(1-2):176-83. Epub 2007 Nov 9.

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejon 305-333, South Korea.

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January 2008

FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly.

J Biol Chem 2007 Sep 7;282(38):27572-7. Epub 2007 Aug 7.

Research Center for Biomedicinal Resources, PaiChai University, Daejeon 302-735, Korea.

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September 2007

Broadly neutralizing anti-hepatitis B virus antibody reveals a complementarity determining region H3 lid-opening mechanism.

Proc Natl Acad Sci U S A 2007 May 17;104(22):9230-5. Epub 2007 May 17.

Center for Cellular Switch Protein Structure, Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.

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May 2007

Limitations to the development of humanized antibody producing Chinese hamster ovary cells using glutamine synthetase-mediated gene amplification.

Biotechnol Prog 2006 May-Jun;22(3):770-80

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Daejon 305-701, Korea.

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August 2006

Monoclonal anti-thrombopoietin antibodies generated by genetic immunization.

Hybridoma (Larchmt) 2006 Apr;25(2):75-9

Research and Development Center, Aprogen Inc., Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejon, South Korea.

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April 2006

COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model.

Proc Natl Acad Sci U S A 2006 Mar 16;103(13):4946-51. Epub 2006 Mar 16.

Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong-dong, Daejeon 305-701, Korea.

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March 2006

Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody.

J Biol Chem 2006 Mar 9;281(11):6985-92. Epub 2006 Jan 9.

Laboratory of Antibody Engineering, Aprogen Inc., Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong, Yuseong-gu, Daejon 305-333.

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March 2006

Polyhydroxyalkanoate chip for the specific immobilization of recombinant proteins and its applications in immunodiagnostics.

Biotechnol Bioprocess Eng 2006 ;11(2):173

1Department of Chemical and Biomolecular Engineering, Bioprocess Engineering Research Center, Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, 305-701 Daejeon, Korea.

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January 2006

Antibody engineering for the development of therapeutic antibodies.

Mol Cells 2005 Aug;20(1):17-29

Laboratory of Antibody Engineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.

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August 2005

An anthrax lethal factor-neutralizing monoclonal antibody protects rats before and after challenge with anthrax toxin.

Infect Immun 2005 Oct;73(10):6547-51

R&D Center, Aprogen, Inc., Bio Venture Center #311, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejon.

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October 2005

CDNA microarray analysis of nerve growth factor-regulated gene expression profile in rat PC12 cells.

Neurochem Res 2005 Apr;30(4):533-40

Graduate School of East-West Medical Science, Kyung Hee University, Korea.

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April 2005

Expression and purification of recombinant human angiopoietin-2 produced in Chinese hamster ovary cells.

Protein Expr Purif 2005 Feb;39(2):175-83

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-gu, Daejon 305-701, Republic of Korea.

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February 2005

The T-cell receptor beta variable gene promoter is required for efficient V beta rearrangement but not allelic exclusion.

Mol Cell Biol 2004 Aug;24(16):7015-23

Center for Cancer Research and Department of Biology, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.

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August 2004

In vivo neutralization of hepatitis B virus infection by an anti-preS1 humanized antibody in chimpanzees.

Virology 2004 Jan;318(1):134-41

Antibody Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-600, South Korea.

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January 2004

Neutralizing human monoclonal antibodies to hepatitis A virus recovered by phage display.

Virology 2004 Jan;318(2):598-607

Antibody Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-600, South Korea.

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January 2004

A new epitope tag from hepatitis B virus preS1 for immunodetection, localization and affinity purification of recombinant proteins.

J Immunol Methods 2003 Dec;283(1-2):77-89

R and D Center, Aprogen, Inc., Bio Venture Center No. 311, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yuseong, 305-600 Taejon, South Korea.

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December 2003

Stability of murine, chimeric and humanized antibodies against pre-S2 surface antigen of hepatitis B virus.

Biologicals 2003 Dec;31(4):295-302

Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Oun-dong, Yusong, 305-333, Taejon, South Korea.

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December 2003

The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination.

Proc Natl Acad Sci U S A 2003 Nov 30;100(23):13465-70. Epub 2003 Oct 30.

Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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November 2003

Molecular chaperone GRP78/BiP interacts with the large surface protein of hepatitis B virus in vitro and in vivo.

J Virol 2003 Feb;77(4):2784-8

Antibody Engineering Research Unit, Laboratory of Immunology, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305-600, Korea.

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February 2003