Publications by authors named "Hyemyung Seo"

52Publications

Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.

Int J Mol Sci 2020 May 14;21(10). Epub 2020 May 14.

Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.

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http://dx.doi.org/10.3390/ijms21103455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278941PMC
May 2020

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease.

N Engl J Med 2020 05;382(20):1926-1932

From the Departments of Neurosurgery (J.S.S., B.S.C.), Neurology (T.M.H.), and Radiology (K.K., Q.L.), the Gordon Center for Medical Imaging (K.K., Q.L.), and the Division of Neuroradiology (O.R.), Massachusetts General Hospital, the Department of Pediatrics, Computational Health Informatics Program, Boston Children's Hospital (I.-H.L., S.-W.K.), and the Connell and O'Reilly Families Cell Manipulation Core Facility, Dana-Farber/Harvard Cancer Center (J.R.), Boston, and the Department of Psychiatry (B.M.C.) and the Molecular Neurobiology Laboratory (B.S., T.-Y.P., N.L., S.K., J.J., Y.C., H.S., J.K., T.K., P.L., K.-S.K.), McLean Hospital, Belmont - all in Massachusetts; the Departments of Neurology (C.H.) and Neurosurgery (M.K.) and the Brain and Mind Research Institute (G.A.P.), Weill Cornell Medical College, New York; the Department of Neurology, Kaiser Permanente, Irvine, CA (C.N.); and the Department of Molecular and Life Sciences, Hanyang University, Seoul, South Korea (H.S.).

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http://dx.doi.org/10.1056/NEJMoa1915872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288982PMC
May 2020

Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity.

Anim Cells Syst (Seoul) 2018 12;22(5):273-280. Epub 2018 Sep 12.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunpo-si, Republic of Korea.

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http://dx.doi.org/10.1080/19768354.2018.1518262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171436PMC
September 2018

Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson's Disease.

Parkinsons Dis 2018 14;2018:1241757. Epub 2018 May 14.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbon-ro, Gunpo-si, Gyeonggido, Republic of Korea.

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http://dx.doi.org/10.1155/2018/1241757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985070PMC
May 2018

Age-associated bimodal transcriptional drift reduces intergenic disparities in transcription.

Aging (Albany NY) 2018 04;10(4):789-807

Development and Differentiation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, South Korea.

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http://dx.doi.org/10.18632/aging.101428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940109PMC
April 2018

Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21 expression.

Mol Brain 2017 10 6;10(1):48. Epub 2017 Oct 6.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, 321 Sanbon-ro, Gunposhi, Gyeonggido, Republic of Korea.

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http://dx.doi.org/10.1186/s13041-017-0327-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629783PMC
October 2017

Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide.

Biochem Biophys Res Commun 2017 11 25;493(2):879-886. Epub 2017 Sep 25.

Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.09.129DOI Listing
November 2017

Age-associated chromatin relaxation is enhanced in Huntington's disease mice.

Aging (Albany NY) 2017 03;9(3):803-822

Development and Differentiation Research Center, KRIBB, Yuseong-gu, Daejeon, 305-806, South Korea.

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http://dx.doi.org/10.18632/aging.101193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391233PMC
March 2017

Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway.

Mol Neurobiol 2018 02 11;55(2):1607-1619. Epub 2017 Feb 11.

College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam, 13488, Republic of Korea.

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http://dx.doi.org/10.1007/s12035-016-0370-9DOI Listing
February 2018

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.

Hum Mol Genet 2017 01;26(1):1-18

Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

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http://hmg.oxfordjournals.org/content/early/2016/10/24/hmg.d
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http://dx.doi.org/10.1093/hmg/ddw363DOI Listing
January 2017

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity.

Biomed Res Int 2016 25;2016:7917128. Epub 2016 May 25.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido 15865, Republic of Korea.

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http://dx.doi.org/10.1155/2016/7917128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897664PMC
February 2017

β-Lapachone increases phase II antioxidant enzyme expression via NQO1-AMPK/PI3K-Nrf2/ARE signaling in rat primary astrocytes.

Free Radic Biol Med 2016 08 28;97:168-178. Epub 2016 May 28.

Department of Molecular Medicine, Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.05.024DOI Listing
August 2016

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression.

Mol Brain 2015 Sep 18;8:54. Epub 2015 Sep 18.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, 321 Sanbon-ro, Gunposhi, Gyeonggido, Republic of Korea.

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http://dx.doi.org/10.1186/s13041-015-0145-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575451PMC
September 2015

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.

Nat Commun 2015 Sep 14;6:8255. Epub 2015 Sep 14.

Department of Biomedical Sciences, Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Gyeonggi-do 443-380, Korea.

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http://dx.doi.org/10.1038/ncomms9255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647842PMC
September 2015

Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease.

PLoS One 2015 28;10(8):e0136950. Epub 2015 Aug 28.

Department of Biochemistry and Molecular Biology, Neurodegeneration Control Research Center, School of Medicine, Kyung Hee University, Seoul, Korea; Institute for Brain Science and Technology, Inje University, Busan, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552876PMC
May 2016

Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease.

Brain 2015 Oct 30;138(Pt 10):3030-47. Epub 2015 Jun 30.

1 Department of Physiology and Institute of Dermatological Science, Seoul National University College of Medicine, Seoul, 110-799, South Korea

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http://dx.doi.org/10.1093/brain/awv188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643628PMC
October 2015

Reduction of Nfia gene expression and subsequent target genes by binge alcohol in the fetal brain.

Neurosci Lett 2015 Jun 14;598:73-8. Epub 2015 May 14.

Department of Molecular and Life Sciences, Hanyang University, Ansan, Republic of Korea; Department of Nanobiotechnology, Hanyang University, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.05.016DOI Listing
June 2015

Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington's Disease Mouse Model.

Mol Neurobiol 2016 May 15;53(4):2276-86. Epub 2015 May 15.

Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791, South Korea.

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http://dx.doi.org/10.1007/s12035-015-9214-2DOI Listing
May 2016

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.

J Biochem 2015 Jun 19;157(6):485-95. Epub 2015 Jan 19.

Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea Institute for Brain Science and Technology, Inje University, Gaegumdong, Busanjingu, Busan, South Korea; InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea; Department of Molecular and Life Sciences, Hanyang University, Ansanshi, Gyeonggido, South Korea; and Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbondong, Gunposhi, Gyeonggido, South Korea

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http://dx.doi.org/10.1093/jb/mvv005DOI Listing
June 2015

Increased DJ-1 in urine exosome of Korean males with Parkinson's disease.

Biomed Res Int 2014 13;2014:704678. Epub 2014 Nov 13.

InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Sanbon-dong, Gunpo-si, Gyeonggi-do, Republic of Korea.

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http://dx.doi.org/10.1155/2014/704678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247948PMC
July 2015

MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.

Mol Neurobiol 2016 Jan 19;53(1):95-108. Epub 2014 Nov 19.

Department of Psychiatry, McLean Hospital, Harvard Medical School, MRC 223, 115 Mill Street, Belmont, MA, 02478, USA.

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http://dx.doi.org/10.1007/s12035-014-8989-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437970PMC
January 2016

JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells.

Exp Cell Res 2014 Nov 1;328(2):361-78. Epub 2014 Sep 1.

Department of Bionanotechnology, Hanyang University, Seoul 133-791, Republic of Korea; Department of Molecular & Life Science, Hanyang University, 1271 Sa 3-dong, Ansan 426-791, Gyeonggi-do, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.08.029DOI Listing
November 2014

Prediction of miRNA-mRNA associations in Alzheimer's disease mice using network topology.

BMC Genomics 2014 Aug 3;15:644. Epub 2014 Aug 3.

Department of Molecular & Life Sciences, Hanyang University, 1271 Sa-dong, Sangrok-gu, Ansan, Gyeonggi-do, South Korea.

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http://dx.doi.org/10.1186/1471-2164-15-644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132902PMC
August 2014

Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain.

Neurochem Int 2014 Apr 7;69:35-40. Epub 2014 Mar 7.

Department of Molecular & Life Sciences, Hanyang University, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01970186140003
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http://dx.doi.org/10.1016/j.neuint.2014.02.008DOI Listing
April 2014

Development of electrochemical microbiochip for the biological diagnosis of Neisseria gonorrhoeae.

Anal Sci 2013 ;29(12):1203-8

Department of Bio-Nanotechnology, Graduate School, Hanyang University.

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http://dx.doi.org/10.2116/analsci.29.1203DOI Listing
September 2014

Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice.

Biochem Biophys Res Commun 2014 Jan 12;443(2):706-11. Epub 2013 Dec 12.

Department of Molecular & Life Sciences, Hanyang University, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2013.12.034DOI Listing
January 2014

EPITRANS: a database that integrates epigenome and transcriptome data.

Mol Cells 2013 Nov 8;36(5):472-5. Epub 2013 Nov 8.

Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Research Institute for Veterinary Science, Brain Korea 21 Program for Veterinary Science, Seoul, Korea.

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http://dx.doi.org/10.1007/s10059-013-0249-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887936PMC
November 2013

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.

Exp Mol Med 2013 Aug 16;45:e36. Epub 2013 Aug 16.

Institute for Brain Science and Technology, Inje University, Gaegumdong, South Korea.

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http://dx.doi.org/10.1038/emm.2013.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789260PMC
August 2013

The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome.

J Neurochem 2010 Sep 3;114(6):1819-26. Epub 2010 Aug 3.

Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06902.xDOI Listing
September 2010

Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.

J Biol Chem 2010 Oct 9;285(41):31895-906. Epub 2010 Aug 9.

Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.

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http://dx.doi.org/10.1074/jbc.M110.147520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951261PMC
October 2010

Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients.

Hum Mol Genet 2008 Oct 17;17(20):3144-53. Epub 2008 Jul 17.

Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital, Harvard MedicalSchool, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1093/hmg/ddn211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556853PMC
October 2008

Regulation of functional phenotypes of cord blood derived eosinophils by gamma-secretase inhibitor.

Am J Respir Cell Mol Biol 2007 Nov 28;37(5):571-7. Epub 2007 Jun 28.

Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, South Korea.

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http://dx.doi.org/10.1165/rcmb.2006-0412OCDOI Listing
November 2007

Proteasome activator enhances survival of Huntington's disease neuronal model cells.

PLoS One 2007 Feb 28;2(2):e238. Epub 2007 Feb 28.

Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital and Harvard Medical School, Belmont, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000238PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800909PMC
February 2007

SB203580 enhances interleukin-1 receptor antagonist gene expression in IFN-gamma-stimulated BV2 microglial cells through a composite nuclear factor-kappaB/PU.1 binding site.

Neurosci Lett 2007 Apr 7;416(2):169-74. Epub 2007 Feb 7.

Department of Neuroscience and Medical Research Institute, College of Medicine, Ewha Womans University, Seoul, South Korea.

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http://dx.doi.org/10.1016/j.neulet.2007.02.005DOI Listing
April 2007

Efficient induction of oligodendrocytes from human embryonic stem cells.

Stem Cells 2007 Feb 19;25(2):419-24. Epub 2006 Oct 19.

Department of Physiology, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1634/stemcells.2005-0482DOI Listing
February 2007

Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.

Hum Mol Genet 2005 Jul 11;14(13):1709-25. Epub 2005 May 11.

Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1093/hmg/ddi178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674782PMC
July 2005

Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice.

Exp Neurol 2005 Jun;193(2):469-80

Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.expneurol.2004.11.017DOI Listing
June 2005

Generalized brain and skin proteasome inhibition in Huntington's disease.

Ann Neurol 2004 Sep;56(3):319-28

Neuroregeneration Laboratories, Departments of Neurology and Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1002/ana.20207DOI Listing
September 2004

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

Hippocampus 2003 ;13(8):905-14

Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://doi.wiley.com/10.1002/hipo.10130
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http://dx.doi.org/10.1002/hipo.10130DOI Listing
March 2004

Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome.

Neurosci Res 2003 Apr;45(4):437-45

Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/s0168-0102(03)00005-1DOI Listing
April 2003

Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats.

Neurosci Lett 2002 Aug;328(1):50-4

Department of Physiology and Neuroscience and the Center for Studies on Aging, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/s0304-3940(02)00442-1DOI Listing
August 2002

A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination.

J Neurochem 2002 Mar;80(5):905-16

Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1046/j.0022-3042.2002.00782.xDOI Listing
March 2002

Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice.

Eur J Neurosci 2002 Feb;15(3):498-506

Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1046/j.0953-816x.2001.01884.xDOI Listing
February 2002

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

Trends Neurosci 2002 Feb;25(2):79-84

Neuroregeneration Laboratory, McLean Hospital, Program in Neuroscience and Dept of Neurology, Harvard Medical School, Belmont, MA 02478-9106, USA.

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http://dx.doi.org/10.1016/s0166-2236(02)02037-4DOI Listing
February 2002