Publications by authors named "Hyelim Kang"

9 Publications

  • Page 1 of 1

Nutrition Intervention through Interdisciplinary Medical Treatment in Hospice Patients: From Admission to Death.

Clin Nutr Res 2018 Apr 17;7(2):146-152. Epub 2018 Apr 17.

Department of Nutrition, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul 07345, Korea.

The demand for hospice services as well as for 'well-dying' of terminal patients is increasing as patient financial burden is decreasing due to National Health Insurance coverage for hospice care. Hospice institutions utilize interdisciplinary teams comprising doctors, nurses, dietitians, and other health staffs to provide comprehensive patient management. This report examined the nutritional status of a hospice patient from admission to death as well as the nutrition management of this patient in the hospice ward through nutrition interventions performed by a dietitian in the interdisciplinary team. The patient in the present case was a 74-year-old man diagnosed with pancreatic head cancer who died after 26 days of hospice care following transfer from the general ward. During hospice care, the dietitian monitored the patient's nutritional status and performed 8 nutrition interventions, but his oral intake decreased as the patient's symptoms worsened. The average energy intake rates were 30% and 17% of required rates for oral and artificial nutrition, respectively. In line with a report suggesting that the main focus of nutrition in palliative care should be on improving the quality of life and reducing worry in patients, rather than aggressive nutritional management, there is a need for nutrition interventions that are personalized to individual patients by monitoring progress and offering continuous counseling from the time of admission. In addition, further studies such as comparative analysis of nutritional management in Korean hospice ward will be needed for better nutrition management for terminally ill patients.
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http://dx.doi.org/10.7762/cnr.2018.7.2.146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921332PMC
April 2018

Enhanced DC-Operated Electroluminescence of Forwardly Aligned   p/MQW/n InGaN Nanorod LEDs via DC Offset-AC Dielectrophoresis.

ACS Appl Mater Interfaces 2017 Nov 19;9(43):37912-37920. Epub 2017 Oct 19.

Department of Chemistry, Kookmin University , Seoul 02707, Republic of Korea.

We introduce an orientation-controlled alignment process of p-GaN/InGaN multiquantum-well/n-GaN (p/MQW/n InGaN) nanorod light-emitting diodes (LEDs) by applying the direct current (DC) offset-alternating current (AC) or pulsed DC electric fields across interdigitated metal electrodes. The as-forwardly aligned p/MQW/n InGaN nanorod LEDs by a pulsed DC dielectrophoresis (DEP) assembly process improve the electroluminescence (EL) intensities by 1.8 times compared to the conventional AC DEP assembly process under DC electric field operation and exhibit an enhanced applied current and EL brightness in the current-voltage and EL intensity-voltage curves, which can be directly used as the fundamental data to construct DC-operated nanorod LED devices, such as LED areal surface lightings, scalable lightings (micrometers to inches) and formable surface lightings. The enhancement in the applied current, the improved EL intensity, and the increased number of forwardly aligned p/MQW/n InGaN nanorods in panchromatic cathodoluminescence images confirm the considerable enhancement of forwardly aligned one-dimensional nanorod LEDs between two opposite electrodes using DC offset-AC or a pulsed DC electric field DEP assembly process. These DC offset-AC or pulsed DC electric field DEP assembly processes suggest that designing for these types of interactions could yield new ways to control the orientation of asymmetric p/MQW/n InGaN diode-type LED nanorods with a relatively low aspect ratio.
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http://dx.doi.org/10.1021/acsami.7b09794DOI Listing
November 2017

Droplet-Guiding Superhydrophobic Arrays of Plasmonic Microposts for Molecular Concentration and Detection.

ACS Appl Mater Interfaces 2017 Oct 10;9(42):37201-37209. Epub 2017 Oct 10.

Department of Chemical and Biomolecular Engineering (BK21+ Program), KAIST , Daejeon 34141, Korea.

Droplet-guiding superhydrophobic SERS substrates are created by a combinatorial lithographic technique. Photolithography defines the pattern of a micropillar array with a radial density gradient, whereas colloidal lithography features a nanotip array on the top surface of each micropillar. The nanotip array renders the surface superhydrophobic, and the pattern of micropillars endows the radial gradient of the contact angle, enabling the spontaneous droplet migration toward the center of the pattern. Water droplets containing target molecules are guided to the center, and the molecules dissolved in the droplets are concentrated at the surface of the central micropillar during droplet evaporation. Therefore, the molecules can be analyzed at the predefined position by Raman spectra without scanning the entire substrate. At the same time, the SERS-active nanotip array provides high sensitivity of Raman measurement.
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http://dx.doi.org/10.1021/acsami.7b11506DOI Listing
October 2017

Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes.

PLoS One 2017 14;12(7):e0179762. Epub 2017 Jul 14.

Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, United States of America.

During rheumatoid arthritis (RA), Tumor Necrosis Factor (TNF) activates fibroblast-like synoviocytes (FLS) inducing in a temporal order a constellation of genes, which perpetuate synovial inflammation. Although the molecular mechanisms regulating TNF-induced transcription are well characterized, little is known about the impact of mRNA stability on gene expression and the impact of TNF on decay rates of mRNA transcripts in FLS. To address these issues we performed RNA sequencing and genome-wide analysis of the mRNA stabilome in RA FLS. We found that TNF induces a biphasic gene expression program: initially, the inducible transcriptome consists primarily of unstable transcripts but progressively switches and becomes dominated by very stable transcripts. This temporal switch is due to: a) TNF-induced prolonged stabilization of previously unstable transcripts that enables progressive transcript accumulation over days and b) sustained expression and late induction of very stable transcripts. TNF-induced mRNA stabilization in RA FLS occurs during the late phase of TNF response, is MAPK-dependent, and involves several genes with pathogenic potential such as IL6, CXCL1, CXCL3, CXCL8/IL8, CCL2, and PTGS2. These results provide the first insights into genome-wide regulation of mRNA stability in RA FLS and highlight the potential contribution of dynamic regulation of the mRNA stabilome by TNF to chronic synovitis.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510804PMC
September 2017

Lithographically Encrypted Inverse Opals for Anti-Counterfeiting Applications.

Small 2016 Jul 3;12(28):3819-26. Epub 2016 Jun 3.

Department of Chemical and Biomolecular Engineering (BK21+ Program), KAIST, Daejeon, 305-701, South Korea.

Colloidal photonic crystals possess inimitable optical properties of iridescent structural colors and unique spectral shape, which render them useful for security materials. This work reports a novel method to encrypt graphical and spectral codes in polymeric inverse opals to provide advanced security. To accomplish this, this study prepares lithographically featured micropatterns on the top surface of hydrophobic inverse opals, which serve as shadow masks against the surface modification of air cavities to achieve hydrophilicity. The resultant inverse opals allow rapid infiltration of aqueous solution into the hydrophilic cavities while retaining air in the hydrophobic cavities. Therefore, the structural color of inverse opals is regioselectively red-shifted, disclosing the encrypted graphical codes. The decoded inverse opals also deliver unique reflectance spectral codes originated from two distinct regions. The combinatorial code composed of graphical and optical codes is revealed only when the aqueous solution agreed in advance is used for decoding. In addition, the encrypted inverse opals are chemically stable, providing invariant codes with high reproducibility. In addition, high mechanical stability enables the transfer of the films onto any surfaces. This novel encryption technology will provide a new opportunity in a wide range of security applications.
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http://dx.doi.org/10.1002/smll.201601140DOI Listing
July 2016

Liquid-impermeable inverse opals with invariant photonic bandgap.

Adv Mater 2015 Feb 10;27(7):1282-7. Epub 2014 Dec 10.

Department of Chemical and Biomolecular Engineering (BK21+ Program), KAIST, Daejeon, 305-701, South Korea.

Omniphobic inverse opals are created by structurally and chemically modifying the surface of inverse opals through reactive ion etching. During the etching, void arrays of the inverse opal surface evolves to a triangular post array with re-entrant geometry. The elaborate structure can efficiently pin the air-liquid interface and retain air cavities against water and oil, thereby providing liquid-impermeable inverse opals with invariant photonic bandgap.
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http://dx.doi.org/10.1002/adma.201404706DOI Listing
February 2015

Bio-inspired nanotadpoles with component-specific functionality.

J Mater Chem B 2014 Oct 14;2(38):6462-6466. Epub 2014 Aug 14.

Department of Chemical and Biomolecular Engineering (BK21+ Program), KAIST, Daejeon, South Korea.

We report a new class of bio-inspired nanotadpoles (NTPs) with component-specific functionalities. The plasmonic NTPs with a gold-coated head and a reactive ion etching-treated tail showed the tail length dependence of their cellular uptake, enabling the photothermal treatment of cancer cells with high efficacy.
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http://dx.doi.org/10.1039/c4tb00964aDOI Listing
October 2014

Colloidal assembly in Leidenfrost drops for noniridescent structural color pigments.

Langmuir 2014 Jul 11;30(28):8350-6. Epub 2014 Jul 11.

Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology , Daejeon 305-701, Korea.

Noniridescent structural color pigments have great potential as alternatives to conventional chemical color pigments in many coloration applications due to their nonbleaching and color-tunable properties. In this work, we report a novel method to create photonic microgranules composed of glassy packing of silica particles and small fraction of carbon black nanoparticles, which show pronounced structural colors with low angle-dependency. To prepare isotropic random packing in each microgranule, a Leidenfrost drop, which is a drop levitated by its own vapor on a hot surface, is employed as a template for fast consolidation of silica particles. The drop randomly migrates over the hot surface and rapidly shrinks, while maintaining its spherical shape, thereby consolidating silica particles to granular structures. Carbon black nanoparticles incorporated in the microgranules suppress incoherent multiple scattering, thereby providing improved color contrast. Therefore, photonic microgranules in a full visible range can be prepared by adjusting the size of silica particles with insignificant whitening.
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http://dx.doi.org/10.1021/la502157pDOI Listing
July 2014

Durable plasmonic cap arrays on flexible substrate with real-time optical tunability for high-fidelity SERS devices.

ACS Appl Mater Interfaces 2013 Jun 17;5(11):4569-74. Epub 2013 May 17.

Active tunable plasmonic cap arrays were fabricated on a flexible stretchable substrate using a combination of colloidal lithography, lift-up soft lithography, and subsequent electrostatic assembly of gold nanoparticles. The arrangement of the plasmonic caps could be tuned under external strain to deform the substrate in reversible. Real-time variation in the arrangement could be used to tune the optical properties and the electromagnetic field enhancement, thereby a proving a promising mechanism for optimizing the SERS sensitivity.
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http://dx.doi.org/10.1021/am400019vDOI Listing
June 2013