Publications by authors named "Huw Thomas"

100Publications

Modelling the developmental spliceosomal craniofacial disorder Burn-McKeown syndrome using induced pluripotent stem cells.

PLoS One 2020 31;15(7):e0233582. Epub 2020 Jul 31.

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394406PMC
September 2020

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.

Genet Med 2020 Sep;22(9):1569

Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41436-020-0892-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462742PMC
September 2020

Interprofessional Collaboration in the Assessment and Management of Substance Use Risk.

Dent Clin North Am 2020 07 21;64(3):571-583. Epub 2020 Apr 21.

Tufts University School of Dental Medicine, One Kneeland Street, Room 1163, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.cden.2020.02.006DOI Listing
July 2020

EFTUD2 missense variants disrupt protein function and splicing in mandibulofacial dysostosis Guion-Almeida type.

Hum Mutat 2020 Aug 3;41(8):1372-1382. Epub 2020 May 3.

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/humu.24027DOI Listing
August 2020

IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway.

Nucleic Acids Res 2020 06;48(10):5366-5382

Solid Tumour Target Discovery Laboratory, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gkaa271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261174PMC
June 2020

Advanced Methods for the Analysis of Altered Pre-mRNA Splicing in Yeast and Disease.

Methods Mol Biol 2019 ;2049:131-140

Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/978-1-4939-9736-7_8DOI Listing
June 2020

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

J Clin Invest 2020 01;130(1):258-271

Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1172/JCI127483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934184PMC
January 2020

A homozygous missense variant in CHRM3 associated with familial urinary bladder disease.

Clin Genet 2019 12 11;96(6):515-520. Epub 2019 Sep 11.

Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Health Innovation Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/cge.13631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899476PMC
December 2019

The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer.

Cancers (Basel) 2019 Aug 6;11(8). Epub 2019 Aug 6.

Biomedical Sciences, Faculty of Health Sciences, University of Hull, Hull HU6 7RX, UK.

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http://dx.doi.org/10.3390/cancers11081122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721541PMC
August 2019

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.

Genet Med 2020 01 24;22(1):15-25. Epub 2019 Jul 24.

Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41436-019-0596-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371626PMC
January 2020

Disease modeling of core pre-mRNA splicing factor haploinsufficiency.

Hum Mol Genet 2019 11;28(22):3704-3723

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester.

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http://dx.doi.org/10.1093/hmg/ddz169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935387PMC
November 2019

Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report.

Hered Cancer Clin Pract 2019 28;17. Epub 2019 Feb 28.

4Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.

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https://hccpjournal.biomedcentral.com/articles/10.1186/s1305
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http://dx.doi.org/10.1186/s13053-019-0106-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394091PMC
February 2019

Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma.

Int J Cancer 2019 06 9;144(12):3146-3159. Epub 2019 Jan 9.

Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/ijc.32058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491995PMC
June 2019

Massachusetts Dental Schools Respond to the Prescription Opioid Crisis: A Statewide Collaboration.

J Dent Educ 2017 Dec;81(12):1388-1394

Dr. Keith is Professor of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine and Visiting Oral and Maxillofacial Surgeon, Massachusetts General Hospital; Dr. Kulich is Professor, Tufts University School of Dental Medicine and the Pain Center, Massachusetts General Hospital; Dr. Bharel is Commissioner, Massachusetts Department of Public Health; Dr. Boose is Executive Director, Massachusetts Dental Society; Dr. Brownstein is with Harvard Vanguard Medical Associates; Dr. Da Silva is Vice Dean and Associate Professor of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine; Dr. D'Innocenzo is Clinical Professor and Director of Predoctoral Oral Surgery Education, Boston University Henry M. Goldman School of Dental Medicine; Dr. Donoff is Dean and Guralnick Distinguished Professor of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine; Ms. Factor is Director of Dental Practice and Membership Engagement Services, Massachusetts Dental Society; Dr. Hutter is Dean and Spencer N. Frankl Professor in Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine; Dr. Shaefer is Assistant Professor of Oral and Maxillofacial Surgery and Director of Anesthesia and Pain Management Education, Harvard School of Dental Medicine Clinic; Dr. Karimbux is Associate Dean of Academic Affairs and Professor of Periodontology, Tufts University School of Dental Medicine; Ms. Jack is a student, Harvard Medical School Class of 2018; and Dr. Thomas is Dean, Tufts University School of Dental Medicine.

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http://dx.doi.org/10.21815/JDE.017.098DOI Listing
December 2017

PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS.

NMR Biomed 2017 Sep 22;30(9). Epub 2017 May 22.

Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1002/nbm.3736DOI Listing
September 2017

Functional characterisation of a novel ovarian cancer cell line, NUOC-1.

Oncotarget 2017 Apr;8(16):26832-26844

Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.

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http://dx.doi.org/10.18632/oncotarget.15821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432300PMC
April 2017

Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037.

Cancer Chemother Pharmacol 2016 Dec 11;78(6):1269-1281. Epub 2016 Nov 11.

Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s00280-016-3186-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114336PMC
December 2016

Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.

Br J Cancer 2016 09 16;115(6):682-90. Epub 2016 Aug 16.

Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Bedson Building, Newcastle NE1 7RU, UK.

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http://dx.doi.org/10.1038/bjc.2016.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023777PMC
September 2016

Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent.

Eur J Cancer 2016 Mar 25;56:69-76. Epub 2016 Jan 25.

Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.12.012DOI Listing
March 2016

Address by Chair-elect of the ADEA Board of Directors.

Authors:
Huw F Thomas

J Dent Educ 2015 Jul;79(7):738-40

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July 2015

Whose Gene Is It Anyway? The Effect of Preparation Purity on Neutrophil Transcriptome Studies.

PLoS One 2015 24;10(9):e0138982. Epub 2015 Sep 24.

Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138982PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581699PMC
June 2016

Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study.

J Clin Oncol 2015 Nov 17;33(31):3591-7. Epub 2015 Aug 17.

Mohammad Movahedi, Beheshti University of Medical Sciences, Tehran, Iran; Mohammad Movahedi and D. Timothy Bishop, University of Leeds, Leeds; Diana Eccles, University of Southampton, Southampton; D. Gareth Evans, St Mary's Hospital, Manchester; Eamonn R. Maher, University of Birmingham, Birmingham; Malcolm G. Dunlop, Western General Hospital, Edinburgh; Shirley V. Hodgson, St George's Hospital; Lucy Side, University College London; Huw J.W. Thomas, St Mark's Hospital, Imperial College, London; Patrick J. Morrison, Queens University Belfast, Belfast City Hospital Health and Social Care Trust, Belfast; Victoria Murday, Yorkhill Hospital, Glasgow; John Burn and John C. Mathers, Newcastle University, Newcastle upon Tyne, United Kingdom; Finlay Macrae, Royal Melbourne Hospital, Melbourne, Victoria; Rodney J. Scott, John Hunter Hospital, New Lambton, New South Wales, Australia; Jukka-Pekka Mecklin, Jyväskylä Central Hospital, Jyväskylä, Finland; Gabriela Moeslein, HELIOS St Josefs Hospital, Bochum-Linden, Germany; Sylviane Olschwang, Institut Paoli Calmettes, Marseille, France; Lucio Bertario, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy; Marie-Luise Bisgaard, University of Copenhagen, Hvidovre, Denmark; Judy W.C. Ho, Queen Mary Hospital, Hong Kong, Special Administrative Region, People's Republic of China; Annika Lindblom, Karolinska Institutet, Stockholm, Sweden; Jan Lubinski, International Hereditary Cancer Centre, Szczecin, Poland; Raj S. Ramesar, University of Cape Town, South Africa; and Hans F. Vasen, Netherlands Foundation of the Detection of Hereditary Tumours and Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2014.58.9952DOI Listing
November 2015

Heparin derivatives for the targeting of multiple activities in the inflammatory response.

Carbohydr Polym 2015 Mar 7;117:400-7. Epub 2014 Oct 7.

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2014.09.079DOI Listing
March 2015

DNA-PK-A candidate driver of hepatocarcinogenesis and tissue biomarker that predicts response to treatment and survival.

Clin Cancer Res 2015 Feb 5;21(4):925-33. Epub 2014 Dec 5.

Northern Institute for Cancer Research, Framlington Place, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom. Hepatopancreatobiliary Team, The Freeman Hospital, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335075PMC
February 2015

A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry.

Immunol Lett 2014 Dec 28;162(2 Pt B):194-8. Epub 2014 Oct 28.

Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2014.10.025DOI Listing
December 2014

Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy.

Rheumatology (Oxford) 2015 Jan 13;54(1):188-93. Epub 2014 Aug 13.

Institute of Integrative Biology, University of Liverpool and Institute of Ageing and Chronic Disease, University Hospital Aintree, Liverpool, Merseyside, UK.

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/keu299DOI Listing
January 2015

The conditioned place preference test for assessing welfare consequences and potential refinements in a mouse bladder cancer model.

PLoS One 2014 6;9(8):e103362. Epub 2014 Aug 6.

Research Institute of Pharmaceutical Sciences and Departments of Psychology and Pharmacology, Peabody Building, University of Mississippi, Oxford, Mississippi, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103362PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123882PMC
April 2015

Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP.

Eur J Hum Genet 2015 Feb 7;23(2):260-3. Epub 2014 May 7.

1] Molecular and Population Genetics Laboratory, Nuffield Department of Clinical Medicine, Wellcome Trust Centre for Human Genetics, Oxford, UK [2] Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1038/ejhg.2014.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140766PMC
February 2015

The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice.

PLoS One 2013 10;8(12):e81763. Epub 2013 Dec 10.

Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081763PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858267PMC
September 2014

Rectal endoscopic submucosal dissection made easy: a solution to the retraction problem.

Gastroenterology 2013 Nov 5;145(5):939-41. Epub 2013 Sep 5.

Wolfson unit for Endoscopy, St Mark's Hospital and Academic Institute, Harrow, London, UK. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.08.057DOI Listing
November 2013

A pooled analysis of the outcome of prospective colonoscopic surveillance for familial colorectal cancer.

Int J Cancer 2014 Feb 29;134(4):939-47. Epub 2013 Aug 29.

Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, United Kingdom.

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http://dx.doi.org/10.1002/ijc.28397DOI Listing
February 2014

Cell survival signalling through PPARδ and arachidonic acid metabolites in neuroblastoma.

PLoS One 2013 9;8(7):e68859. Epub 2013 Jul 9.

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068859PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706415PMC
February 2014

RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming.

PLoS One 2013 6;8(3):e58598. Epub 2013 Mar 6.

Institute of Integrative Biology, University of Liverpool, Liverpool, Merseyside, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058598PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590155PMC
September 2013

Reply to "The classification of intestinal polyposis".

Nat Genet 2013 Jan;45(1):2-3

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http://dx.doi.org/10.1038/ng.2475DOI Listing
January 2013

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.

Biochem Pharmacol 2013 Jan 11;85(1):29-37. Epub 2012 Oct 11.

Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.bcp.2012.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545186PMC
January 2013

Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water soluble prodrug NU6301.

Eur J Cancer 2011 Sep 12;47(13):2052-9. Epub 2011 May 12.

Newcastle Cancer Centre at the Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.ejca.2011.04.008DOI Listing
September 2011

Nucleoside transport inhibitors: structure-activity relationships for pyrimido[5,4-d]pyrimidine derivatives that potentiate pemetrexed cytotoxicity in the presence of α1-acid glycoprotein.

J Med Chem 2011 Mar 2;54(6):1847-59. Epub 2011 Mar 2.

Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.

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http://dx.doi.org/10.1021/jm101493zDOI Listing
March 2011

VDR deficiency affects alveolar bone and cementum apposition in mice.

Arch Oral Biol 2011 Jul 24;56(7):672-7. Epub 2010 Dec 24.

Department of Prosthodontics, School of Dentistry, University of Alabama at Birmingham, 1530 rd Ave S, Birmingham, AL 35294-0007, United States.

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http://dx.doi.org/10.1016/j.archoralbio.2010.12.004DOI Listing
July 2011

Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2.

J Natl Cancer Inst 2011 Feb 23;103(4):334-46. Epub 2010 Dec 23.

Northern Institute for Cancer Research, University of Newcastle Upon Tyne, Medical School, Newcastle Upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1093/jnci/djq509DOI Listing
February 2011

Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials.

Cancer Chemother Pharmacol 2010 Sep 21;66(4):807-12. Epub 2010 May 21.

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00280-010-1359-0DOI Listing
September 2010

Talk about values in the British National Health Service.

Commun Med 2010 ;7(2):197-202

School of City and Regional Planning, Cardiff University, Cardiff, UK.

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November 2011

Normalisation of calcium status reverses the phenotype in dentin, but not in enamel of VDR-deficient mice.

Arch Oral Biol 2009 Dec 21;54(12):1105-10. Epub 2009 Oct 21.

Department of Prosthodontics, University of Alabama at Birmingham, 35294-2170, USA.

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http://dx.doi.org/10.1016/j.archoralbio.2009.09.004DOI Listing
December 2009

What the ADEA CCI series of articles means to me: reflections of a dental school dean.

Authors:
Huw F Thomas

J Dent Educ 2009 Feb;73(2):172-6

School of Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294-0007, USA.

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February 2009

Different enamel and dentin mineralization observed in VDR deficient mouse model.

Arch Oral Biol 2009 Apr 6;54(4):299-305. Epub 2009 Feb 6.

Department of Prosthodontics, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL 35294-0009, United States.

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http://dx.doi.org/10.1016/j.archoralbio.2009.01.002DOI Listing
April 2009

Comparison of demineralisation rates in pre- and postnatal enamel and at the neonatal line.

Arch Oral Biol 2009 Dec 6;54 Suppl 1:S101-6. Epub 2008 Nov 6.

Centre for Oral Growth & Development, Barts and The London School of Medicine and Dentistry, London, UK.

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http://dx.doi.org/10.1016/j.archoralbio.2008.09.013DOI Listing
December 2009

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Nat Genet 2008 May 30;40(5):623-30. Epub 2008 Mar 30.

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK.

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http://dx.doi.org/10.1038/ng.111DOI Listing
May 2008

Vitamin D receptor deficiency affects dentin maturation in mice.

Arch Oral Biol 2007 Dec 17;52(12):1172-9. Epub 2007 Aug 17.

Department of Prosthodontics, School of Dentistry, University of Alabama at Birmingham, USA.

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http://dx.doi.org/10.1016/j.archoralbio.2007.06.010DOI Listing
December 2007

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

Mol Cancer Ther 2007 Mar;6(3):945-56

Newcastle University, Northern Institute for Cancer Research, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0552DOI Listing
March 2007

The management of families affected by hereditary non-polyposis colorectal cancer (HNPCC).

Fam Cancer 2007 ;6(1):13-9

Department of Medical Genetics, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.

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http://link.springer.com/10.1007/s10689-006-9000-4
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http://dx.doi.org/10.1007/s10689-006-9000-4DOI Listing
September 2007

Prospective results of surveillance colonoscopy in dominant familial colorectal cancer with and without Lynch syndrome.

Gastroenterology 2006 Jun;130(7):1995-2000

Family Cancer Group, Cancer Research, UK Colorectal Cancer Unit, St. Mark's Hospital, Watford Road, Harrow, Middlesex, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2006.03.018DOI Listing
June 2006

An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.

Cancer Chemother Pharmacol 2007 Feb 24;59(2):197-206. Epub 2006 May 24.

Northern Institute for Cancer Research, Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s00280-006-0258-xDOI Listing
February 2007

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

Cancer Res 2006 May;66(10):5354-62

Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4275DOI Listing
May 2006

Biliary excretion of etoposide in children with cancer.

Cancer Chemother Pharmacol 2006 Sep 18;58(3):415-7. Epub 2006 Jan 18.

Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, University of Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00280-005-0180-7DOI Listing
September 2006

Prevention of colorectal cancer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up study.

BMJ 2005 Nov 21;331(7524):1047. Epub 2005 Oct 21.

Family Cancer Group, Cancer Research UK Colorectal Cancer Unit, St Mark's Hospital, Harrow, Middlesex HA1 3UJ.

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http://dx.doi.org/10.1136/bmj.38606.794560.EBDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283179PMC
November 2005

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

Nature 2005 Apr;434(7035):913-7

The Institute for Cancer Studies, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK.

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http://dx.doi.org/10.1038/nature03443DOI Listing
April 2005