Publications by authors named "Huiqing Zhou"

78Publications

Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.

Exp Dermatol 2020 Jul 17. Epub 2020 Jul 17.

Department of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center (Radboudumc), Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/exd.14153DOI Listing
July 2020

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis.

J Vis Exp 2020 May 16(159). Epub 2020 May 16.

Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands;

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http://dx.doi.org/10.3791/60905DOI Listing
May 2020

Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.

Cell Rep 2020 01;30(1):173-186.e6

Department of Cognitive Neuroscience, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, 6525 HR Nijmegen, the Netherlands; Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.002DOI Listing
January 2020

Deregulated Adhesion Program in Palatal Keratinocytes of Orofacial Cleft Patients.

Genes (Basel) 2019 10 23;10(11). Epub 2019 Oct 23.

Department of Dentistry, Section Orthodontics and Craniofacial Biology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.3390/genes10110836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895790PMC
October 2019

TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain.

Cell Death Dis 2019 09 17;10(10):686. Epub 2019 Sep 17.

Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance and Cluster of Excellence Macromolecular Complexes (CEF), Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1038/s41419-019-1936-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746776PMC
September 2019

Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome.

Proc Natl Acad Sci U S A 2019 08 14;116(35):17361-17370. Epub 2019 Aug 14.

Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, 6525GA Nijmegen, The Netherlands;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1908180116
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http://dx.doi.org/10.1073/pnas.1908180116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717277PMC
August 2019

Programmable RNA-Guided RNA Effector Proteins Built from Human Parts.

Cell 2019 06 20;178(1):122-134.e12. Epub 2019 Jun 20.

Department of Chemistry, The University of Chicago, Chicago, Illinois, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193062
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http://dx.doi.org/10.1016/j.cell.2019.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657360PMC
June 2019

p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytes.

Epigenetics Chromatin 2019 06 4;12(1):31. Epub 2019 Jun 4.

Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s13072-019-0280-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547520PMC
June 2019

Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape.

Cell Rep 2018 12;25(12):3490-3503.e4

Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183180
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http://dx.doi.org/10.1016/j.celrep.2018.11.039DOI Listing
December 2018

Splicing and Chromatin Factors Jointly Regulate Epidermal Differentiation.

Cell Rep 2018 10;25(5):1292-1303.e5

Faculty of Science, Radboud University, Nijmegen, the Netherlands; Department of Molecular Developmental Biology, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183158
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http://dx.doi.org/10.1016/j.celrep.2018.10.017DOI Listing
October 2018

An FEVR-associated mutation in ZNF408 alters the expression of genes involved in the development of vasculature.

Hum Mol Genet 2018 10;27(20):3519-3527

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.1093/hmg/ddy244DOI Listing
October 2018

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response.

Nat Commun 2018 03 9;9(1):1021. Epub 2018 Mar 9.

Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK.

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http://dx.doi.org/10.1038/s41467-018-03470-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844915PMC
March 2018

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis.

Proc Natl Acad Sci U S A 2017 12 21;114(50):13254-13259. Epub 2017 Nov 21.

Institute of Cell Biology and Neurobiology, National Research Council of Italy (CNR), 00015 Monterotondo (Rome), Italy;

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http://dx.doi.org/10.1073/pnas.1711777114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740608PMC
December 2017

Master regulatory role of p63 in epidermal development and disease.

Cell Mol Life Sci 2018 04 4;75(7):1179-1190. Epub 2017 Nov 4.

Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, 274, Postbus 9101, 6500HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00018-017-2701-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843667PMC
April 2018

Transcriptome Analysis Identifies Multifaceted Regulatory Mechanisms Dictating a Genetic Switch from Neuronal Network Establishment to Maintenance During Postnatal Prefrontal Cortex Development.

Cereb Cortex 2018 03;28(3):833-851

Department of Human Genetics, Centre for Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/cercor/bhw407DOI Listing
March 2018

Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling.

Neuron 2016 07 30;91(2):341-55. Epub 2016 Jun 30.

Department of Cognitive Neuroscience, Radboudumc, 6500 HB Nijmegen, the Netherlands; Department of Human Genetics, Radboudumc, 6500 HB Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.06.003DOI Listing
July 2016

Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate.

Differentiation 2016 12 26;92(5):326-335. Epub 2016 May 26.

Department of Orthodontics and Craniofacial Biology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2016.05.001DOI Listing
December 2016

Perinatal reduction of functional serotonin transporters results in developmental delay.

Neuropharmacology 2016 10 18;109:96-111. Epub 2016 May 18.

Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Medical Center, 6525 EZ Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.neuropharm.2016.05.012DOI Listing
October 2016

CTCF-mediated chromatin loops enclose inducible gene regulatory domains.

BMC Genomics 2016 Mar 22;17:252. Epub 2016 Mar 22.

Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s12864-016-2516-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804521PMC
March 2016

Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts.

Hum Genet 2016 Jan 11;135(1):41-59. Epub 2015 Nov 11.

Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00439-015-1606-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698300PMC
January 2016

Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes.

Genom Data 2015 Sep 9;5:159-63. Epub 2015 Jun 9.

Radboud University, Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands ; Radboud University Medical Center, Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.gdata.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584025PMC
September 2015

Choices for Induction of Pluripotency: Recent Developments in Human Induced Pluripotent Stem Cell Reprogramming Strategies.

Stem Cell Rev Rep 2016 Feb;12(1):54-72

Department of Cognitive Neuroscience, Radboudumc, Nijmegen, 6500, HB, The Netherlands.

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http://dx.doi.org/10.1007/s12015-015-9622-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720703PMC
February 2016

p63 supports aerobic respiration through hexokinase II.

Proc Natl Acad Sci U S A 2015 Sep 31;112(37):11577-82. Epub 2015 Aug 31.

Department of Experimental Medicine and Surgery, University of "Tor Vergata", 00133 Rome, Italy; Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, 00167 Rome, Italy

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http://dx.doi.org/10.1073/pnas.1508871112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577137PMC
September 2015

Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation.

EMBO Rep 2015 Jul 1;16(7):863-78. Epub 2015 Jun 1.

Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences Radboud University, Nijmegen, The Netherlands

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http://dx.doi.org/10.15252/embr.201439941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515125PMC
July 2015

New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey.

Nucleic Acids Res 2015 Apr 26;43(7):3420-33. Epub 2015 Mar 26.

Department of Biochemistry, Duke University, Durham, NC 27710, USA Department of Chemistry, Duke University, Durham, NC 27708, USA

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http://dx.doi.org/10.1093/nar/gkv241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402545PMC
April 2015

Gene regulatory mechanisms orchestrated by p63 in epithelial development and related disorders.

Biochim Biophys Acta 2015 Jun 19;1849(6):590-600. Epub 2015 Mar 19.

Radboud University, Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands; Radboud university medical center, Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2015.03.003DOI Listing
June 2015

p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling.

Proc Natl Acad Sci U S A 2015 Mar 4;112(11):3499-504. Epub 2015 Mar 4.

Biochemistry Laboratory, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata," 00133 Rome, Italy; Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy;

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http://dx.doi.org/10.1073/pnas.1500762112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372004PMC
March 2015

A mutation in TP63 causing a mild ectodermal dysplasia phenotype.

J Invest Dermatol 2014 Aug 27;134(8):2277-2280. Epub 2014 Mar 27.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

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http://dx.doi.org/10.1038/jid.2014.159DOI Listing
August 2014

Effects of retinoic acid on proliferation and gene expression of cleft and non-cleft palatal keratinocytes.

Eur J Orthod 2014 Dec 7;36(6):727-34. Epub 2014 Feb 7.

*Department of Orthodontics and Craniofacial Biology, Radboud University Nijmegen Medical Centre, Nijmegen,

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http://ejo.oxfordjournals.org/content/eortho/36/6/727.full.p
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http://ejo.oxfordjournals.org/cgi/doi/10.1093/ejo/cjt104
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http://dx.doi.org/10.1093/ejo/cjt104DOI Listing
December 2014

Constant pH molecular dynamics of proteins in explicit solvent with proton tautomerism.

Proteins 2014 Jul 15;82(7):1319-31. Epub 2014 Jan 15.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan, 48109.

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http://doi.wiley.com/10.1002/prot.24499
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http://dx.doi.org/10.1002/prot.24499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394622PMC
July 2014

Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice.

Dev Biol 2014 Feb 19;386(2):395-407. Epub 2013 Dec 19.

Department of Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands; Department of Cognitive Neurosciences, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ydbio.2013.12.016DOI Listing
February 2014

Angiomodulin is required for cardiogenesis of embryonic stem cells and is maintained by a feedback loop network of p63 and Activin-A.

Stem Cell Res 2014 Jan 6;12(1):49-59. Epub 2013 Oct 6.

INSERTECH, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; INSERM U976, Paris, France; University of Paris Diderot, France. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2013.09.015DOI Listing
January 2014

Genomic approaches for studying craniofacial disorders.

Am J Med Genet C Semin Med Genet 2013 Nov 18;163C(4):218-31. Epub 2013 Oct 18.

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http://dx.doi.org/10.1002/ajmg.c.31379DOI Listing
November 2013

A historical account of Hoogsteen base-pairs in duplex DNA.

Biopolymers 2013 Dec;99(12):955-68

Department of Chemistry & Biophysics, The University of Michigan, 930 North University Avenue, Ann Arbor, MI, 48109-1055; Integrative Structural & Computational Biology Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037.

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http://dx.doi.org/10.1002/bip.22334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844552PMC
December 2013

A step closer toward therapies for p63-related disorders.

Rare Dis 2013 12;1:e24247. Epub 2013 Mar 12.

INSERM UMR-S 976; Paris, France ; University of Paris-Diderot; Paris, France.

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http://dx.doi.org/10.4161/rdis.24247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932939PMC
July 2014

The genetics of selective serotonin reuptake inhibitors.

Pharmacol Ther 2012 Dec 1;136(3):375-400. Epub 2012 Sep 1.

Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, 6525 EZ Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.pharmthera.2012.08.015DOI Listing
December 2012

p63-microRNA feedback in keratinocyte senescence.

Proc Natl Acad Sci U S A 2012 Jan 6;109(4):1133-8. Epub 2012 Jan 6.

Istituto Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico, Laboratory of Biochemistry, Department of Experimental Medicine and Biochemical Sciences, and University of Rome Tor Vergata, 00133 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.1112257109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268329PMC
January 2012

Vitamin A and clefting: putative biological mechanisms.

Nutr Rev 2011 Oct;69(10):613-24

Department of Orthodontics and Craniofacial Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/j.1753-4887.2011.00425.xDOI Listing
October 2011

Prevalence and associated factors of functional gastrointestinal disorders and bowel habits in Chinese adolescents: a school-based study.

J Pediatr Gastroenterol Nutr 2011 Aug;53(2):168-73

Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

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http://dx.doi.org/10.1097/MPG.0b013e3182125388DOI Listing
August 2011

Epigenetic regulation of learning and memory by Drosophila EHMT/G9a.

PLoS Biol 2011 Jan 4;9(1):e1000569. Epub 2011 Jan 4.

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1371/journal.pbio.1000569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014924PMC
January 2011

Ultrasensitively sensing acephate using molecular imprinting techniques on a surface plasmon resonance sensor.

Talanta 2011 Feb 19;83(5):1422-7. Epub 2010 Nov 19.

College of Chemistry and Material Science, Shandong Agricultural University, Taian, Shandong, PR China.

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http://dx.doi.org/10.1016/j.talanta.2010.11.034DOI Listing
February 2011

Regulation of vitamin metabolism by p53 and p63 in development and cancer.

Cell Cycle 2010 Jul 15;9(14):2709. Epub 2010 Jul 15.

Radboud University Nijmegen Medical Centre, The Netherlands.

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July 2010

Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.

J Clin Invest 2010 May 26;120(5):1561-9. Epub 2010 Apr 26.

Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1172/JCI40266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860913PMC
May 2010

A facelift for the general transcription factor TFIIA.

Biochim Biophys Acta 2007 Jul-Aug;1769(7-8):429-36. Epub 2007 May 5.

NCMLS, Department of Molecular Biology, 191, Radboud University of Nijmegen, PO Box 91001, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbaexp.2007.04.008DOI Listing
September 2007

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.

Mol Cell Biol 2006 Apr;26(7):2728-35

NCMLS, Department of Molecular Biology, 191, Radboud University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/MCB.26.7.2728-2735.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430320PMC
April 2006

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

EMBO J 2004 Aug 15;23(15):3083-91. Epub 2004 Jul 15.

NCMLS, Department of Molecular Biology, HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/sj.emboj.7600304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514921PMC
August 2004