Publications by authors named "Huilin Liu"

89 Publications

Publisher Correction: Cause analysis of PM pollution during the COVID-19 lockdown in Nanning, China.

Sci Rep 2021 Jul 27;11(1):15632. Epub 2021 Jul 27.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Fudan University, No. 220 Handan Road, Shanghai, 200433, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-021-94322-1DOI Listing
July 2021

Synergic fabrication of pembrolizumab loaded doxorubicin incorporating microbubbles delivery for ultrasound contrast agents mediated anti-proliferation and apoptosis.

Drug Deliv 2021 Dec;28(1):1466-1477

Department of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar City, PR China.

This study evaluated pembrolizumab-conjugated, doxorubicin (DOX)-loaded microbubbles (PDMs) in combination with ultrasound (US) as molecular imaging agents for early diagnosis of B cell lymphomas, and as a targeted drug delivery system. Pembrolizumab, a monoclonal CD20 antibody, was attached to the surfaces of DOX-loaded microbubbles. PDM binding to B cell lymphoma cells was assessed using immunofluorescence. The cytotoxic effects of PDMs in combination with ultrasound (PDMs + US) were evaluated in CD20+ and CD20- cell lines, and its antitumor activities were assessed in Raji (CD20+) and Jurkat (CD20-) lymphoma cell-grafted mice. PDMs specifically bound to CD20+ cells and . Contrast enhancement was monitored US. PDM peak intensities and contrast enhancement durations were higher in Raji than in Jurkat cell-grafted mice ( < 0.05). PDMs + US treatment resulted in improved antitumor effects and reduced systemic toxicity in Raji cell-grafted mice compared with other treatments ( < .05). Our results showed that PDMs + US enhanced tumor targeting, reduced systemic toxicity, and inhibited CD20+ B cell lymphoma growth . Targeted PDMs could be employed as US molecular imaging agents for early diagnosis, and are an effective targeted drug delivery system in combination with US for CD20+ B cell malignancy treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/10717544.2021.1921080DOI Listing
December 2021

A smartphone-integrated optosensing platform based on red-emission carbon dots for real-time detection of pyrethroids.

Biosens Bioelectron 2021 Jun 23;191:113460. Epub 2021 Jun 23.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, 11 Fucheng Road, Beijing, 100048, China.

This report described the development of an optosensing platform based on red-emission carbon dots (RCDs) integrated with a smartphone application that, together, can detect pyrethroids in real time. Based on the high stability and selectivity of molecular imprinting technology, RCDs-based optosensing imprinted polymers was obtained by using a one-pot inverse microemulsion surface imprinting method. Lambda-cyhalothrin (LC), which is a pyrethroid pesticide, can interact with the widely distributed -NH groups on the surface of the RCD-based optosensing nanomaterials to achieve fixed-point adsorption. The quantitative detection of pyrethroids in a wide concentration range (1-120 μg/L) could be achieved, and the limit of detection (LOD) was 0.89 μg/L. Furthermore, a portable UV light box combined with a smartphone was used to convert the change in fluorescence of the RCDs-based optosensing nanomaterials into specific values upon adding pyrethroids, and the LOD by using smartphone was 6.66 μg/L. The developed platform has numerous advantages, including low cost, simple operation, high sensitivity, and good specificity, among others, and it achieves on-site visualization and rapid detection.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bios.2021.113460DOI Listing
June 2021

Natural and Artificial Chiral-Based Systems for Separation Applications.

Crit Rev Anal Chem 2021 Jun 21:1-19. Epub 2021 Jun 21.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, China.

Chiral separation has attracted much attention for basic research and industrial applications in analytical chemistry. Generally, chiral separations use natural or artificial chiral-based materials as adsorbents. To improve the precision and efficiency of chiral separation, focus has shifted from natural and synthetic adsorbents to binary combinations of materials. This review specifically summarizes the significant advancements made in natural and artificial chiral adsorbents as promising candidates for diverse drug and biomolecule separation applications as well as the remaining drawbacks and challenges for research on chiral separations. The mechanisms of chiral-based recognition and separation and history and development of natural and artificial chiral-based systems are the focus of this review. Future directions in natural and artificial chiral-based systems for practical separations and other applications are also presented.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/10408347.2021.1932408DOI Listing
June 2021

Associations of toothbrushing behaviour with risks of vascular and nonvascular diseases in Chinese adults.

Eur J Clin Invest 2021 Jun 21:e13634. Epub 2021 Jun 21.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.

Accumulating evidence has shown that poor oral hygiene is associated with increased risk of cardiometabolic diseases in Western populations. However, its relevance about the relationships in Chinese adults remains unclear. The China Kadoorie Biobank enrolled 512 715 adults aged 30-79 years in China during 2004-2008. Cox regression was used to estimate adjusted hazard ratios (HRs) for each disease associated with measures of oral hygiene. Overall 9.3% of the participants reported rarely or never brushing teeth at baseline. Participants who rarely or never brushed teeth had adjusted HR of 1.12 (95% CI: 1.09, 1.15) for MVE, with similar HRs for stroke (1.08, 1.05-1.12), intracerebral haemorrhage (1.18, 1.11-1.26) and pulmonary heart disease (1.22, 1.13-1.32) compared with those who brushed teeth regularly. Those who did not brush teeth also had increased risk of cancer (1.09, 1.04-1.14), chronic obstructive pulmonary disease (COPD) (1.12, 1.05-1.20), liver cirrhosis (1.25, 1.09-1.44) and all-cause death (1.25, 1.21-1.28) but not type 2 diabetes (0.94, 0.86-1.03) and chronic kidney disease (0.98, 0.81-1.18). Among Chinese adults, we found that poor oral hygiene is associated with higher risks of major vascular disease, cancer, COPD, liver cirrhosis and all-cause deaths, but not type 2 diabetes and chronic kidney disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/eci.13634DOI Listing
June 2021

Identification of Differentially Expressed Plasma lncRNAs As Potential Biomarkers for Breast Cancer.

Clin Breast Cancer 2021 May 18. Epub 2021 May 18.

Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. Electronic address:

Background: Breast cancer is the most common malignant tumor in women and is not easy to diagnose. Increasing evidence has underscored that long non-coding RNAs (lncRNAs) play important regulatory roles in the occurrence and progression of many cancers, including breast cancer. We aimed to identify lncRNAs in plasma as potential biomarkers for breast cancer.

Patients And Methods: We analyzed the Gene Expression Omnibus (GEO) datasets GSE22820, GSE42568, and GSE65194 to identify the common differential genes between cancer tissues and adjacent tissues. Then 14 lncRNAs were identified among the common differential genes and validated by using real-time quantitative polymerase chain reaction in 92 patients with breast cancer and 100 healthy controls. Receiver operating characteristic (ROC) curves were constructed to evaluate their diagnostic value for breast cancer.

Results: Integrated analysis of the GEO datasets identified three significantly upregulated and 11 downregulated lncRNAs in breast cancer tissues. Compared with healthy controls, MIAT was significantly upregulated in breast cancer patient plasma, and LINC00968 and LINC01140 were significantly downregulated. ROC curve analysis suggested that these three lncRNAs can discriminate breast cancer from healthy individual with high specificity and sensitivity.

Conclusion: This research identified three differentially expressed lncRNAs in breast cancer patient plasma. Our data suggest that these three lncRNAs can be used as potential diagnostic biomarkers of breast cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clbc.2021.05.003DOI Listing
May 2021

Highland Barley and Its By-Products Enriched with Phenolic Compounds for Inhibition of Pyrraline Formation by Scavenging α-Dicarbonyl Compounds.

Foods 2021 May 17;10(5). Epub 2021 May 17.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China.

Pyrraline, a typical kind of advanced glycation end product, has been found to contribute to the development of pathologies associated with ageing and diabetes mellitus. In the study, phenolic compounds extracted from highland barley whole grain (HBWG) and vinasse (HBVN) were used to inhibit pyrraline formation in a simulated food. The optimal extraction condition for HBWG and HBVN was using 8 mL of 50% acetone solution at 50 °C for 60 min. The extraction and identification of phenolic compounds from HBWG and HBVN were performed by UPLC-PAD-MS/MS. The inhibitory effects of pyrraline in the simulated food were 52.03% and 49.22% by HBVN and HBWG, respectively. The diphenyl picrylhydrazyl radical- and ferric-reducing ability of plasma assays was used to evaluate the antioxidant activity of the extracts. The main inhibition pathways and molecular mechanism of phenolic compounds on pyrraline regulation were explored by scavenging α-dicarbonyl compounds. The study demonstrated that highland barley and its by-products can potentially be used as a functional food to regulate pyrraline formation during food processing.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/foods10051109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156036PMC
May 2021

Cause analysis of PM pollution during the COVID-19 lockdown in Nanning, China.

Sci Rep 2021 05 27;11(1):11119. Epub 2021 May 27.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Fudan University, No. 220 Handan Road, Shanghai, 200433, China.

To analyse the cause of the atmospheric PM pollution that occurred during the COVID-19 lockdown in Nanning, Guangxi, China, a single particulate aerosol mass spectrometer, aethalometer, and particulate Lidar coupled with monitoring near-surface gaseous pollutants, meteorological conditions, remote fire spot sensing by satellite and backward trajectory models were utilized during 18-24 February 2020. Three haze stages were identified: the pre-pollution period (PPP), pollution accumulation period (PAP) and pollution dissipation period (PDP). The dominant source of PM in the PPP was biomass burning (BB) (40.4%), followed by secondary inorganic sources (28.1%) and motor vehicle exhaust (11.7%). The PAP was characterized by a large abundance of secondary inorganic sources, which contributed 56.1% of the total PM concentration, followed by BB (17.4%). The absorption Ångström exponent (2.2) in the PPP was higher than that in the other two periods. Analysis of fire spots monitored by remote satellite sensing indicated that open BB in regions around Nanning City could be one of the main factors. A planetary boundary layer-relative humidity-secondary particle matter-particulate matter positive feedback mechanism was employed to elucidate the atmospheric processes in this study. This study highlights the importance of understanding the role of BB, secondary inorganic sources and meteorology in air pollution formation and calls for policies for emission control strategies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-021-90617-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160135PMC
May 2021

Novel GLP-1/anti-apolipoprotein B bifunctional fusion protein alleviates diabetes and diabetic complications in combination with low-intensity ultrasound.

Life Sci 2021 Aug 29;278:119549. Epub 2021 Apr 29.

Ultrasound Department of The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang Province, China. Electronic address:

Aims: To engineer and screen a novel GLP-1/anti-apolipoprotein B (apoB) bifunctional fusion protein with therapeutic potential on alleviating diabetes and diabetic complication in combination with low-intensity ultrasound.

Main Methods: Anti-apoB antibodies were screened by phage display technology and further fused to mutated GLP-1 (7-37) via light or heavy fusion to generate bifunctional fusion protein (termed aBG). The optimal design of aBG fusion protein was further confirmed by in vitro epitope competition assay and cAMP accumulation assay. Subsequently, chronic study in DIO mice were subjected to assess the long-term efficacy of screened fusion protein.

Key Findings: The selected GLP-1/anti-apoB fusion protein, aBG-8, exerted either the highest binding affinities for GLP-1R and apoB, or the greatest LDL-C uptake capacity and GLP-1R activation activity. After 60-day treatment in DIO mice, aBG-8 was proved to exert the promising improvement on hyperglycemia, hyperlipidemia, and obesity in DIO mice. Furthermore, combined therapy of aBG-8 and low-intensity ultrasound could accelerate skin wound closure in diabetic mice.

Significance: A novel long-lasting bifunctional fusion molecule, aBG-8, was designed with the enormous potential on alleviating diabetes and diabetic complications in combination with low-intensity ultrasound.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2021.119549DOI Listing
August 2021

Gut microbiota regulation and anti-inflammatory effect of β-carotene in dextran sulfate sodium-stimulated ulcerative colitis in rats.

J Food Sci 2021 May 21;86(5):2118-2130. Epub 2021 Apr 21.

College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.

β-Carotene displays antioxidant and anti-inflammatory activities and prevents the development of cancer. Ulcerative colitis (UC) is a kind of inflammatory bowel disease that is accompanied by a certain risk of colon cancer. However, the role of β-carotene in the modulation of gut microbiota and UC improvement is unclear. In this research, the properties of β-carotene on anti-inflammatory and the composition of gut microbiota were evaluated in a rat model of UC induced by dextran sulfate sodium (DSS). The results revealed that β-carotene significantly (p < 0.05) decreased the severity of colitis in rats, as assessed using body weight (6.00 ± 1.73%), colon length (22.23 ± 0.53%), and disease activity index, and improved the structure of the colon damaged. Moreover, colonic levels of proinflammatory cytokines were significantly lower following β-carotene supplementation. β-Carotene intervention also lowered the expression levels of phosphorylated p65 (0.60 ± 0.02), p38 (0.57 ± 0.00), Erk (0.63 ± 0.04), and JNK (0.70 ± 0.00). The result of the relative abundance of gut microbiota showed that DSS administration significantly changed the microbial structure at the phylum and genus levels of rats. Furthermore, β-carotene treatment significantly increased the abundance of Faecalibacterium, the levels of which negatively correlated with the levels of inflammatory cytokines. Faecalibacterium may be a potential target in the alleviation of DSS-induced UC. β-Carotene can alleviate DSS-induced UC through the regulation of gut microbiota. This study provides a reference for the rational use of β-carotene in the treatment of UC. PRACTICAL APPLICATION: β-Carotene can relieve ulcerative colitis and regulate the gut microbiota; the nutritional intervention of β-carotene enhancing animal health.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1750-3841.15684DOI Listing
May 2021

Development of hydrophilic magnetic molecularly imprinted polymers for the dispersive solid-phase extraction of sulfonamides from animal-derived samples before HPLC detection.

J Sep Sci 2021 Jun 7;44(12):2399-2407. Epub 2021 May 7.

School of Light Industry, Beijing Technology and Business University, Beijing, P.R. China.

Highly hydrophilic magnetic molecularly imprinted polymers were prepared through a surface imprinting technique for dispersive solid-phase extraction coupled with high-performance liquid chromatography to detect trace levels of ten sulfonamides in animal-derived samples. The obtained imprinted polymers were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and adsorption experiments, which exhibited excellent specific adsorption for template sulfamethazine in aqueous solution. Moreover, the adsorption process could be completed within 25 min. Under the optimum conditions, the method exhibits good linear performance in the range of 5-to 10 mg/L, limits of detection ranging from 0.57 to 1.50 μg/L, and good recoveries of 85.09-110.93% in the spiked samples (chicken, cow milk, and goat milk). The proposed detection method not only avoids the use of organic solvents but also simplifies the pretreatment procedure via excellent magnetic properties. Furthermore, the method shows great potential for the rapid detection of drug residues.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.202001244DOI Listing
June 2021

Microstructural changes in the cingulate gyrus of patients with mild cognitive impairment induced by cerebral small vessel disease.

Neurol Res 2021 Apr 7:1-9. Epub 2021 Apr 7.

Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

: The purpose of our study was to distinguish the changes in the microstructure of the cingulate cortex in patients with mild cognitive impairment (MCI) induced by cerebral small vessel disease (CSVD). 80 patients were diagnosed with CSVD in this study, including 55 patients with MCI and 25 patients without MCI. Diffusion kurtosis imaging (DKI) and Montreal cognitive assessment (MoCA) were performed in all patients. The anterior cingulate gyrus, posterior cingulate gyrus and middle cingulate gyrus were selected as the regions of interest, and some parameters were recorded. Compared with the non-MCI group, the MCI group mainly showed obviously higher mean diffusion (MD) and radial diffusion (RD) values ( = 0.022 and = 0.029) but lower fractional anisotropy (FA), axial kurtosis (AK), mean kurtosis (MK) and radial kurtosis (RK) values ( = 0.047, = 0.001, < 0.01, and = 0.001, respectively) in the right anterior cingulate gyrus. Meanwhile, in the right posterior cingulate gyrus, the MCI group also showed higher axial diffusion (AD) and MD ( = 0.027 and = 0.030) and lower AK ( = 0.014). Additionally, negative correlations of AD, MD, and RD with MoCA scores and positive correlations of FA, AK, MK and RK with MoCA scores were observed in some regions of the cingulate gyrus. DKI is a good method to examine microstructural damage in the cingulate cortex, and some parameters of DKI may be used as imaging biomarkers to detect early MCI in patients with CSVD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2021.1910903DOI Listing
April 2021

Research on multi-path dense networks for MRI spinal segmentation.

PLoS One 2021 12;16(3):e0248303. Epub 2021 Mar 12.

Faculty of Intelligent Manufacturing, Wuyi University, Jiangmen, Guangdong, China.

Accurate and robust segmentation of anatomical structures from magnetic resonance images is valuable in many computer-aided clinical tasks. Traditional codec networks are not satisfactory because of their low accuracy of edge segmentation, the low recognition rate of the target, and loss of detailed information. To address these problems, this study proposes a series of improved models for semantic segmentation and progressively optimizes them from the three aspects of convolution module, codec unit, and feature fusion. Instead of the standard convolution structure, we apply a new type of convolution module for the feature extraction. The networks integrate a multi-path method to obtain richer-detail edge information. Finally, a dense network is utilized to strengthen the ability of the feature fusion and integrate more different-level information. The evaluation of the Accuracy, Dice coefficient, and Jaccard index led to values of 0.9855, 0.9185, and 0.8507, respectively. These metrics of the best network increased by 1.0%, 4.0%, and 6.1%, respectively. Boundary F1-Score reached 0.9124 indicating that the proposed networks can segment smaller targets to obtain smoother edges. Our methods obtain more key information than traditional methods and achieve superiority in segmentation performance.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248303PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954354PMC
March 2021

Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects.

Molecules 2021 Feb 21;26(4). Epub 2021 Feb 21.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.

With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules26041145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924630PMC
February 2021

Triple-dimensional spectroscopy combined with chemometrics for the discrimination of pesticide residues based on ionic liquid-stabilized Mn-ZnS quantum dots and covalent organic frameworks.

Food Chem 2021 Apr 16;342:128299. Epub 2020 Oct 16.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, No. 11 Fucheng Road, Beijing 100048, China.

Manganese-doped zinc sulfide quantum dots (Mn-ZnS QDs) are promising candidates for multi-channel sensing analysis due to their multi-dimensional optical properties. In this study, we integrated amino-silane and ionic liquid co-modified Mn-ZnS QDs and covalent organic frameworks (COFs) into optosensing nanoparticles to provide triple-dimensional optical response signals and combined them with chemometrics for the analysis of multiple pesticide residues. Through the exploration and optimization of a series of conditions, fluorescence, room temperature phosphorescence, and ultraviolet-visible combined with chemometrics were used for the discrimination and recognition of multiple pesticide residues in fruits and vegetables. The ionic liquid of 1-vinyl-3-ethylimidazolium tetrafluoroborate was used to modify Mn-ZnS QDs to improve the optical response and enrichment of pesticide adsorption sites, which were also synergistically enhanced by the COF support. This is a potential method to discriminate pesticides efficiently and enables fast and reliable analysis of pesticides in the agricultural and food industries.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.128299DOI Listing
April 2021

β-Arrestin-2 attenuates hepatic ischemia-reperfusion injury by activating PI3K/Akt signaling.

Aging (Albany NY) 2020 12 11;13(2):2251-2263. Epub 2020 Dec 11.

Department of Hepatic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, P. R. China.

Hepatic ischemia-reperfusion injury (IRI) remains a common complication during liver transplantation (LT), partial hepatectomy and hemorrhagic shock in patients. As a member of the G protein-coupled receptors adaptors, ARRB2 has been reported to be involved in a variety of physiological and pathological processes. However, whether β-arrestin-2 affects the pathogenesis of hepatic IRI remains unknown. The goal of the present study was to determine whether ARRB2 protects against hepatic IR injury and elucidate the underlying mechanisms. To this end, 70% hepatic IR models were established in knockdown mice and wild-type littermates, with blood and liver samples collected at 1, 6 and 12 h after reperfusion to evaluate liver injury. The effect of ARBB2 on PI3K/Akt signaling during IR injury was evaluated in vivo, and PI3K/Akt pathway regulation by ARRB2 was further assessed in vitro. Our results showed that ARRB2 knockdown aggravates hepatic IR injury by promoting the apoptosis of hepatocytes and inhibiting their proliferation. In addition, ARRB2 deficiency inhibited PI3K/Akt pathway activation, while the administration of the PI3K/Akt inhibitor PX866 resulted in severe IR injury in mice. Furthermore, the liver-protecting effect of ARRB2 was shown to depend on PI3K/Akt pathway activation. In summary, our results suggest that β-Arrestin-2 protects against hepatic IRI by activating PI3K/Akt signaling, which may provide a novel therapeutic strategy for treating liver ischemia-reperfusion injury.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.202246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880335PMC
December 2020

Evaluation of the efficacy and safety of fire needle compared to filiform needle on knee osteoarthritis: study protocol for a randomized controlled trial.

Trials 2020 Nov 4;21(1):911. Epub 2020 Nov 4.

Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, China.

Background: Knee osteoarthritis is a common clinical chronic degenerative disease associated with high morbidity and long-term disability. Previous studies have confirmed the efficacy of acupuncture on knee osteoarthritis. Fire needle acupuncture is a combination of heat and acupuncture, which may be more effective than the commonly used filiform needle acupuncture. This study is designed as a randomized controlled trial to evaluate the efficacy and safety of fire needle acupuncture compared to filiform needle acupuncture in knee osteoarthritis patients.

Methods And Analysis: This is a prospective randomized controlled superiority clinical trial to evaluate the efficacy and safety of fire needle acupuncture compared to filiform needle acupuncture for knee osteoarthritis. A total of 100 participants will be randomly assigned to two different groups. Participants will receive fire needle acupuncture treatment in the fire needle group, while participants in the filiform needle group will be treated with a filiform needle at the same acupuncture points as the fire needle group. All participants will receive 6 weeks of treatment (2 times per week). The primary outcome is the change of the Western Ontario and McMaster Universities Osteoarthritis Index, and the secondary outcomes include the change of the visual analog scale and 12-item Short Form Health Survey from baseline to endpoint.

Ethics And Dissemination: Ethical approval of this study was granted by the Research Ethical Committee of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University (2018SB-066). Written informed consent will be obtained from all participants. Outcomes of the trial will be disseminated through peer-reviewed publications.

Trial Registration: Chinese Clinical Trial Registry ChiCTR1800019579 . Registered on November 18, 2018.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-020-04827-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640691PMC
November 2020

Ionic liquid-sensitized molecularly imprinted polymers based on heteroatom co-doped quantum dots functionalized graphene for sensitive detection of λ-cyhalothrin.

Anal Chim Acta 2020 Nov 29;1136:9-18. Epub 2020 Aug 29.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing, 100048, China.

Ionic liquid-sensitized molecularly imprinted polymers (MIPs) based on Mn and Cu co-doped ZnInS quantum dots functionalized graphene ([email protected]) were prepared by a one-pot facile polymerization at room temperature. Here, the ionic liquid was used as functional monomers to provide chemical bonds for the recognition sites of target molecules. The ionic liquid was also used to improve the selectivity and adsorption capacity, and enhance the fluorescence stability and sensitivity of the MIPs for surface modification. Additionally, the Mn/Cu co-doped ZnInS quantum dots could play a synergistic role in avoiding the toxicity of the heavy metals, and enhance the fluorescence performance. An increased efficiency and sensitivity of [email protected] was obtained owing to the use of graphene with its large specific surface area, which effectively increased the number of binding sites to facilitate the electron transfer process. The turn-off fluorescence spectra of [email protected] decreased sharply with an increasing concentration of the λ-cyhalothrin standards within the range from 1 to 350 μg g. The detection limit of [email protected] was 0.246 μg g. Furthermore, the [email protected] toward λ-cyhalothrin detection in real samples, as well as its recovery, reproducibility and stability, proved that the [email protected] could be extensively applied for the accurate detection of pesticide residues in food samples.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aca.2020.08.041DOI Listing
November 2020

Contribution of T-Type Calcium Channels to Spinal Cord Injury-Induced Hyperexcitability of Nociceptors.

J Neurosci 2020 09 24;40(38):7229-7240. Epub 2020 Aug 24.

Department of Anesthesiology, HSC L4-076, Stony Brook Medicine, Stony Brook, NY 11794

A hyperexcitable state and spontaneous activity of nociceptors have been suggested to play a critical role in the development of chronic neuropathic pain following spinal cord injury (SCI). In male rats, we employed the action potential-clamp technique to determine the underlying ionic mechanisms responsible for driving SCI-nociceptors to a hyperexcitable state and for triggering their spontaneous activity. We found that the increased activity of low voltage activated T-type calcium channels induced by the injury sustains the bulk (∼60-70%) of the inward current active at subthreshold voltages during the interspike interval in SCI-nociceptors, with a modest contribution (∼10-15%) from tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. In current-clamp recordings, inhibition of T-type calcium channels with 1 μm TTA-P2 reduced both the spontaneous and the evoked firing in response to current injections in SCI-nociceptors to a level similar to sham-nociceptors. Electrophysiology was then combined with the conditioned place preference (CPP) paradigm to determine the relationship between the increased activity of T-type channels in SCI-nociceptors and chronic neuropathic pain following SCI. The size of the interspike T-type calcium current recorded from nociceptors isolated from SCI rats showing TTA-P2-induced CPP (responders) was ∼6 fold greater than the interspike T-type calcium current recorded from nociceptors isolated from SCI rats without TTA-P2-induced CPP (non-responders). Taken together, our data suggest that the increased activity of T-type calcium channels induced by the injury plays a primary role in driving SCI-nociceptors to a hyperexcitable state and contributes to chronic neuropathic pain following SCI. Chronic neuropathic pain is a major comorbidity of spinal cord injury (SCI), affecting up to 70-80% of patients. Anticonvulsant and tricyclic antidepressant drugs are first line analgesics used to treat SCI-induced neuropathic pain, but their efficacy is very limited. A hyperexcitable state and spontaneous activity of SCI-nociceptors have been proposed as a possible underlying cause for the development of chronic neuropathic pain following SCI. Here, we show that the increased activity of T-type calcium channels induced by the injury plays a major role in driving SCI-nociceptors to a hyperexcitable state and for promoting their spontaneous activity, suggesting that T-type calcium channels may represent a pharmacological target to treat SCI-induced neuropathic pain.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0517-20.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534916PMC
September 2020

Determination of nereistoxin-related insecticide via quantum-dots-doped covalent organic frameworks in a molecularly imprinted network.

Mikrochim Acta 2020 07 20;187(8):464. Epub 2020 Jul 20.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), No. 11 Fucheng Road, Beijing, 100048, People's Republic of China.

Quantum-dots-doped covalent organic frameworks in a molecularly imprinted network (QDs-doped [email protected]) were developed for detection of nereistoxin (NRT)-related insecticide in tap water. The preparation of QDs-doped [email protected] was easy to accomplish via one-pot synthesis at room temperature. QDs-doped [email protected] quenched by targeting thiosultap due to the photoinduced charge transfer. A Brunauer-Emmett-Teller surface area of 186.20 m g and a maximum adsorption capacity of 771 mg g of the QDs-doped [email protected] exhibited good selectivity and adsorption capacity. Direct fluorescence determination was established over the range 5-100 μg L (R = 0.9959) with a detection limit of 1.60 μg L. Furthermore, 86.5-106.5% recoveries of spiked tap water were achieved. The determination system was feasible for tracing the NRT-related insecticide with high accuracy and good repeatability and reproducibility. Graphical abstract .
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-020-04435-zDOI Listing
July 2020

High-Performance Multiporous Imprinted Microspheres Based on N-Doped Carbon Dots Exfoliated from Covalent Organic Framework for Flonicamid Optosensing.

ACS Appl Mater Interfaces 2020 Jun 26;12(22):25150-25158. Epub 2020 May 26.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.

High-performance, multiporous imprinted microspheres were prepared from nitrogen-doped carbon dots (N-CDs) using a one-pot reverse microemulsion surface-imprinting method. Here, the N-CDs were exfoliated from a common layer covalent organic framework in a top-down preparation, and an ionic liquid was added to improve the sensitivity and the fluorescence stability. The multiporous imprinted microspheres were successfully applied to flonicamid optosensing in fruits and vegetables with simultaneous analysis of 96 samples by multifunctional enzyme labeling. The fluorescence sensing procedure was performed on recyclable multiporous imprinted microspheres coupling with the interface of N-CDs by taking advantage of the fluorescence-resonance charge-transfer strategy between the N-doped carbon dots and flonicamid molecules, quenching the fluorescence intensity. The multiporous imprinted microspheres exhibited purple fluorescence, which decreased sharply in intensity as the concentration of flonicamid increased. The fluorescence quenching correlation with the concentration of flonicamid showed good linearity in the range of 0.02-0.2 μg g with a detection limit of 0.0059 μg g. This research not only enriches the foundational study of flonicamid residues but also greatly expands the potential applications of multiporous imprinted microspheres for analysis of pesticide residues in agricultural, food, and environmental monitoring.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c04766DOI Listing
June 2020

Inhibitory effect of phenolic compounds and plant extracts on the formation of advance glycation end products: A comprehensive review.

Food Res Int 2020 04 23;130:108933. Epub 2019 Dec 23.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.

Advance glycation end products (AGEs) are a diverse group of compounds formed through the non-enzymatic maillard reaction of reducing sugars with the free amino groups in proteins, lipids or nucleic acids. Accumulation of AGEs has been suggested to be a pathogenic mechanism of oxidative stress, inflammation and structural tissue damage leading to chronic vascular problems in many ailments including diabetes, atherosclerosis, neuropathy, retinopathy, nephropathy, aging, and chronic renal disease. Treatment with AGEs inhibitors is believed to be a potential strategy for preventing lifestyle-related diseases. To inhibit the AGEs development is supposed to show part in the inhibition of diabetic problems. Study of dietary bioactive combinations with antiglycation properties delivers future views for inhibition or mediation associated to AGEs complications. Many study show the possibility of dietary constituents to stop AGE development. Therefore, search for natural compounds able to prevent glycation and have the potential therapeutic ability to inhibit diabetes and age associated diseases. The purpose of this review is to critically evaluate the existing literature on different phenolics on AGEs inhibition.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodres.2019.108933DOI Listing
April 2020

Ionic-liquid-stabilized fluorescent probe based on S-doped carbon dot-embedded covalent-organic frameworks for determination of histamine.

Mikrochim Acta 2019 12 6;187(1):28. Epub 2019 Dec 6.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, 11 Fucheng Road, Beijing, 100048, China.

An ionic-liquid-stabilized fluorescent probe for histamine is described. Sulfur-doped carbon dots (S-CDs) were incorporated into a covalent organic framework (COF) that was prepared from 1,3,5-triformylphloroglucinol and 2,5-dimethyl-p-phenylenediamine by one-pot hydrothermal polymerization in the dark. The blue fluorescence of the S-CDs (with excitation/emission maxima at 350/440 nm) is enhanced (compared to undoped CDs) due to element doping by ionic-liquid modification. The COF is resistant to acids, bases, and boiling water. The fluorescence of the probe is statically quenched by histamine, and quenching follows the Stern-Volmer equation. The normalized fluorescence of the probe drops in the 10 to 1000 μg kg histamine concentration range, and the limit of detection is 5.3 μg kg. The probe was successfully applied to the analysis of wine and fermented meat products. The recoveries from spiked samples range between 84.6 and 115.3%. The method is selective, sensitive, stable and repeatable. The mechanisms of the fluorometric response and molecular recognition were explored. Graphical abstractSchematic presentation of ionic-liquid-stabilized fluorescent probe based on S-doped carbon dot-embedded covalent organic framework for determination of histamine. The ionic liquid [VBIm][BF] reacts with MPTS-modified carbon dots to enhance the fluorescence signal for analyte recognition.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3833-7DOI Listing
December 2019

Corn silk extract inhibit the formation of N-carboxymethyllysine by scavenging glyoxal/methyl glyoxal in a casein glucose-fatty acid model system.

Food Chem 2020 Mar 22;309:125708. Epub 2019 Oct 22.

Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China. Electronic address:

Herein, corn silk extract and its flavonoids were used to inhibit the formation of N-carboxymethyllysine (CML) in a casein glucose-fatty acid model system. Under these optimum extraction conditions, nine major flavonoids were identified and quantified by HPLC-MS/MS. The percent inhibition of CML formation by corn silk extract was 76.57%. The inhibitory mechanism of corn silk extract toward CML formation was further investigated by examining the trapping of glyoxal/methyl glyoxal by the major flavonoids (5 mM) using HPLC-ESI-MS, and mono-, di-, and tri-adducts were found for some flavonoid compounds. The antioxidant activity of the corn silk extract was evaluated by the DPPH and ABTS assays. The scavenging activity of the corn silk extract for DPPH and ABTS was 84.38% and 89.11%, respectively. The results suggested that corn silk extract inhibited CML formation through glyoxal/methyl glyoxal scavenging or by its antioxidant activity attributed to its flavonoid content.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2019.125708DOI Listing
March 2020

Carbon-Based Nanomaterials in Sensors for Food Safety.

Nanomaterials (Basel) 2019 Sep 17;9(9). Epub 2019 Sep 17.

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China.

Food safety is one of the most important and widespread research topics worldwide. The development of relevant analytical methods or devices for detection of unsafe factors in foods is necessary to ensure food safety and an important aspect of the studies of food safety. In recent years, developing high-performance sensors used for food safety analysis has made remarkable progress. The combination of carbon-based nanomaterials with excellent properties is a specific type of sensor for enhancing the signal conversion and thus improving detection accuracy and sensitivity, thus reaching unprecedented levels and having good application potential. This review describes the roles and contributions of typical carbon-based nanomaterials, such as mesoporous carbon, single- or multi-walled carbon nanotubes, graphene and carbon quantum dots, in the construction and performance improvement of various chemo- and biosensors for various signals. Additionally, this review focuses on the progress of applications of this type of sensor in food safety inspection, especially for the analysis and detection of all types of toxic and harmful substances in foods.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nano9091330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781043PMC
September 2019

Synthesis of magnetic nanoparticles to detect Sudan dye adulteration in chilli powders.

Food Chem 2019 Nov 8;299:125144. Epub 2019 Jul 8.

Food Science and Technology Programme, c/o Department of Chemistry, National University of Singapore, Singapore 117543, Singapore; National University of Singapore (Suzhou) Research Institute, 377 Lin Quan Street, Suzhou Industrial Park, Suzhou, Jiangsu 215123, PR China. Electronic address:

Magnetic nanoparticles were synthesised to extract Sudan dyes from chilli powders. The adsorbents used were magnetic ferroferric oxide nanoparticles coated with polystyrene. The extraction procedures for Sudan dyes comprised liquid-solid extraction and magnetic solid phase extraction. The conditions were optimised to achieve efficient magnetic solid phase extraction, including extraction and desorption time, type and volume of the desorption solvent, and the mass of the adsorbents. Repeatability tests showed satisfactory recovery rates of 80.2-115.8%, with a relative standard deviation <3.8%. The results suggested that the proposed extraction method was effective and efficient to extract Sudan dyes from chilli powders. The extraction process was simpler compared with traditional approaches because the adsorbents can be rapidly removed from the sample matrix using a permanent magnet. The use of recyclable adsorbents decreased the cost greatly. Chilli powder samples collected from local markets in Singapore were tested using the proposed method under optimum conditions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2019.125144DOI Listing
November 2019

A clinical study to assess the influence of acupuncture at "Wang's Jiaji" acupoints on limb spasticity in patients in convalescent stage of ischemic stroke: study protocol for a randomized controlled trial.

Trials 2019 Jul 10;20(1):419. Epub 2019 Jul 10.

Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No.23 Meishuguanhou Street, Dongcheng District, Beijing, 100010, China.

Background: Stroke is characterized by high morbidity, high mortality, and high disability. Spasticity, one of the most common complications after stroke, may reduce the potential success of rehabilitation and has a detrimental effect on stroke patients' daily function and quality of life. Moreover, the long-term management of spasticity is a financial burden to patients and increases societal costs. The current treatments, mainly including physical therapy, oral drugs, drug injection therapy, and surgical interventions, have been used to reduce spasticity. However, every conventional approach has its limitations. Acupuncture at the "Wang's Jiaji" acupoints, based on the experience of the famous old doctor of traditional Chinese medicine (TCM) Le Ting Wang in treating post-stroke limb spasm, has been widely practiced in our department. This intervention has effectively avoided the controversy around acupuncture at local acupoints on the limbs, and is easy to apply without side effects. Our previous studies had found that acupuncture at the "Wang's Jiaji-points" can reduce the occurrence and severity of spasticity occurring after stroke in the early stage (the first 21 days). In this study, we chose patients in the convalescent stage, 1-6 months after stroke, so as to study the efficacy and the specific intervention time of "Wang's jiaji" in the convalescent stage after stroke.

Methods: This is a randomized, controlled, and single-blind study. Patients in the convalescent stage within 1-6 months of ischemic stroke will be selected as subjects. A total of 100 subjects will be randomly assigned to two groups. The acupuncture group will be given acupuncture treatment five times a week; the medicine group will be given 10mg baclofen three times a day. These two groups will continue to receive current usual care for the prevention and treatment of cerebrovascular diseases, but drugs that affect muscle tone will not be allowed. The treatment will last for 2 weeks. The primary outcome measurement is the simplified Fugl-Meyer Assessment. The secondary outcome measurements are the Modified Ashworth Scale, Modified Barthel Scale, and the H-reflex, F response, and H/M ratios of electromyography. All outcome measurements are assessed at baseline, 2 weeks, 4 weeks, and 12 weeks after first treatment except the electromyography, which is assessed at baseline and 2 weeks after first acupuncture.

Discussion: This trial aims to evaluate the effects and the specific intervention time of "Wang's Jiaji" acupoints on spasticity after stroke.

Trial Registration: ISRCTN registry, ISRCTN31511176 . Registered on 29 August 2017. Version number of protocol 2016-2-1161 Version date of protocol: 2016-1.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3464-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621988PMC
July 2019

Rapid determination of lambda-cyhalothrin using a fluorescent probe based on ionic-liquid-sensitized carbon dots coated with molecularly imprinted polymers.

Anal Bioanal Chem 2019 Aug 28;411(20):5309-5316. Epub 2019 Jun 28.

Beijing Technology and Business University, No. 11 Fucheng Road, Beijing, 100048, China.

A highly selective and sensitive fluorescent probe for optosensing lambda-cyhalothrin (LC) was prepared. The probe was based on sulfur-doped carbon dots (CDs) coated with molecularly imprinted polymers (MIPs). Doping the CDs with sulfur and modifying the surfaces of the CDs with an ionic liquid enhanced the performance of the fluorescent probe. The selectivity of the probe was improved through the application of molecular imprinting technology utilizing acrylamide and 1-vinyl-3-butylimidazolium tetrafluoroborate [VBIm][BF] as functional monomers. The resulting probe was used to detect LC, which is a pesticide residue, in vegetables and tea. Under optimal detection conditions, the linear range of the probe was found to be 1-150 μg kg and the limit of detection to be 0.5 μg kg by analyzing excitation/emission maxima at 350/450 nm. The developed method was successfully used to determine LC in vegetables and tea, yielding recoveries of 98.90-116.93%. These results suggest that this fluorescent probe based on MIP-coated, room-temperature ionic-liquid-sensitized, sulfur-doped carbon dots has great potential to be utilized for the precise detection of LC in complex samples. Graphical abstract.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00216-019-01912-0DOI Listing
August 2019

Pyridine nucleotide-disulphide oxidoreductase domain 2 (PYROXD2): Role in mitochondrial function.

Mitochondrion 2019 07 3;47:114-124. Epub 2019 Jun 3.

Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou 310036, China. Electronic address:

Pyridine Nucleotide-Disulphide Oxidoreductase Domain 2 (PYROXD2), a Hepatitis B virus X protein (HBx)-interacting protein, is significantly down-regulated in hepatocellular carcinoma (HCC), however its exact biological function remains unclear. The aim of this study is to investigate the subcellular localization and biological function of PYROXD2 in hepatic cells. The results showed that PYROXD2 was imported to the mitochondrial inner membrane/matrix by Tom40 and Tim23, but not Mia40. PYROXD2 151-230aa might be the mitochondrial targeting sequence. PYROXD2 interacted with complex IV subunit COX5B. Knockout of PYROXD2 decreased MMP, intracellular ROS, complex IV activity, cell proliferation, ATP content and mtDNA copy number, but increased mtROS levels and the number of immature mitochondria. In summary, our data illustrated that PYROXD2 localizes to the mitochondrial inner membrane/matrix, and it plays important roles in regulating mitochondrial function.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mito.2019.05.007DOI Listing
July 2019

Baijiu Vinasse Extract Scavenges Glyoxal and Inhibits the Formation of -Carboxymethyllysine in Dairy Food.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.

The inhibitory effects of baijiu vinasse extract and its phenolic acid compounds on the -carboxymethyllysine (CML) formation from dairy food were investigated. The inhibitory effect of the baijiu vinasse extract against CML formation was 43.2% in the casein and D-glucose model, which used 6 mL of the 70% acetone extract at 60 °C for 40 min. The HPLC-MS/MS profiles of the vinasse extract indicated that vanillic, chlorogenic, -coumaric, sinapic, caffeic, ferulic, and syringic acids were seven major phenolic acid compounds. Furthermore, the inhibitory mechanism of the phenolic acid compounds in the model of dairy food was discussed by the trapping and scavenging of glyoxal. The results of this study exhibit that seven major antioxidant phenolic acid compounds may play important roles in the antioxidant activity and CML inhibition of the vinasse extract in a model of dairy foods.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24081526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514854PMC
April 2019
-->