Publications by authors named "Huijuan Lin"

32 Publications

Dual activation of Hedgehog and Wnt/β-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer.

Aging (Albany NY) 2021 Apr 12;13(7):10749-10769. Epub 2021 Apr 12.

Guangdong Key Laboratory for Genome Stability and Disease Prevention, Department of Pathology, Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, P.R. China.

Mounting evidence has shown that miRNA-150 expression is upregulated in gastric cancer (GC) and is associated with gastric carcinogenesis, but the underlying oncogenic mechanism remains elusive. Here, we discovered that miRNA-150 targets the tumor suppressor SUFU to promote cell proliferation, migration, and the epithelial-mesenchymal transition (EMT) via the dual activation of Hedgehog (Hh) and Wnt signaling. MiRNA-150 was highly expressed in GC tissues and cell lines, and the level of this miRNA was negatively related to that of SUFU. In addition, both the miRNA-150 and SUFU levels were associated with tumor differentiation. Furthermore, miRNA-150 activated GC cell proliferation and migration . We found that miRNA-150 inhibitors repressed not only Wnt signaling by promoting cytoplasmic β-catenin localization, but also repressed Hh signaling and EMT. MiRNA-150 inhibition also resulted in significant tumor volume reductions , suggesting the potential application of miRNA-150 inhibitors in GC therapy. The expression of genes downstream of Hh and Wnt signaling was also reduced in tumors treated with miRNA-150 inhibitors. Notably, anti-SUFU siRNAs rescued the inhibitory effects of miRNA-150 inhibitors on Wnt signaling, Hh activation, EMT, cell proliferation, cell migration, and colony formation. Taken together, these findings indicate that miRNA-150 is oncogenic and promotes GC cell proliferation, migration, and EMT by activating Wnt and Hh signaling via the suppression of SUFU expression.
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http://dx.doi.org/10.18632/aging.202895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064165PMC
April 2021

Ultrafast Microwave Polarizing Electrons to Form Vertically Aligned Metal Hybrids as Lithiophilic Buffer for Lithium-Metal Batteries.

ACS Appl Mater Interfaces 2021 Apr 1;13(14):16594-16601. Epub 2021 Apr 1.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, P. R. China.

Lithium-metal batteries (LMBs) have attracted great attention because of their high theoretical capacity and low electrochemical potential. However, uncontrollable Li dendrite growth and significant volume expansion result in safety issues that largely limit their practical applications. Herein, we explore a microwave-assisted strategy for the rapid synthesis of vertically aligned metal hybrids on Cu foil (VAMH@CF). Such an elaborate architecture of VAMH provides a lithiophilic buffer layer after prelithiation, offering vast nucleation sites/seeds for Li deposition (Li@VAMH@CF) and lower nucleation overpotential. Consequently, Li@VAMH@CF exhibits an outstanding cyclability with a long lifespan (up to 5500 cycles) and a low voltage hysteresis (28 mV) in a symmetrical cell at 3 mA cm. LiFePO||Li@VAMH@CF full cells deliver a reversible capacity of about 140 mAh g for 200 cycles, further demonstrating opportunities of the microwave-involved strategy for optimizing Li-metal anodes.
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http://dx.doi.org/10.1021/acsami.1c03341DOI Listing
April 2021

3D Printed Flexible Strain Sensors: From Printing to Devices and Signals.

Adv Mater 2021 Feb 14;33(8):e2004782. Epub 2021 Jan 14.

Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE), Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, 710072, P. R. China.

The revolutionary and pioneering advancements of flexible electronics provide the boundless potential to become one of the leading trends in the exploitation of wearable devices and electronic skin. Working as substantial intermediates for the collection of external mechanical signals, flexible strain sensors that get intensive attention are regarded as indispensable components in flexible integrated electronic systems. Compared with conventional preparation methods including complicated lithography and transfer printing, 3D printing technology is utilized to manufacture various flexible strain sensors owing to the low processing cost, superior fabrication accuracy, and satisfactory production efficiency. Herein, up-to-date flexible strain sensors fabricated via 3D printing are highlighted, focusing on different printing methods based on photocuring and materials extrusion, including Digital Light Processing (DLP), fused deposition modeling (FDM), and direct ink writing (DIW). Sensing mechanisms of 3D printed strain sensors are also discussed. Furthermore, the existing bottlenecks and future prospects are provided for further progressing research.
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http://dx.doi.org/10.1002/adma.202004782DOI Listing
February 2021

Ultrafast Microwave Activating Polarized Electron for Scalable Porous Al toward High-Energy-Density Batteries.

Nano Lett 2020 Dec 24;20(12):8818-8824. Epub 2020 Nov 24.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China.

Chemical etching of metals generally brings about undesirable surface damage accompanied by deteriorated performance. However, new possibilities in view of structured interfaces and functional surfaces can be explored by wisely incorporating corrosion chemistry. Here, an ultrafast route to scalable Al foils with desired porous structures originating from Fe(III)-induced oxidation etching was presented. Coupling with efficient electron polarization involving microwave interaction, straightforward surface engineering is well established on various commercial Al foils within minutes, which can be successfully extended to bulk Al alloys. As a proof-of-concept demonstration, the well-defined porous Al foils featuring regulated surface energy, demonstrate great potential as current collectors in promoting cycling stability, for example, 85.2% reversible capacity sustained after 550 cycles (comparable to commercial Al/C foils), and energy density, that is, approximately 3 times of that by using pristine Al foils for LiFePO-Li half cells.
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http://dx.doi.org/10.1021/acs.nanolett.0c03762DOI Listing
December 2020

SUFU mediates EMT and Wnt/β-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer.

Cell Cycle 2020 Oct 5;19(20):2720-2733. Epub 2020 Oct 5.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathology, Shenzhen University School of Medicine , Shenzhen, Guangdong, China.

The poor prognosis of late gastric carcinomas (GC) underscores the necessity to identify novel biomarkers for earlier diagnosis and effective therapeutic targets. MiRNA-324-5p has been shown to be over-expressed in GC, however the biological function of miRNA-324-5p implicated in gastric cancer and its downstream targets were not well understood. Wnt/β-catenin signaling pathway is aberrantly regulated in GC. We sought to explore if miRNA-324-5p promotes oncogenesis through modulating Wnt signaling and EMT. MiRNA-324-5p is highly expressed in GC based on qRT-PCR and TCGA data. In addition, in vitro cell proliferation, cell migration assays and in vivo animal exenograft were executed to show that miRNA-324-5p is an oncogenic miRNA in GC. MiRNA-324-5p activates Wnt signaling and induces EMT in GC. Further, SUFU was identified as a target of miRNA-324-5p confirmed by western blotting and luciferase assays. Spearson analysis and TCGA data indicate that the expression of SUFU is negatively associated with the expression of miRNA-324-5p. Rescue experiments were performed to determine if SUFU mediates the Wnt activation, EMT and oncogenic function of miRNA-324-5p. MiRNA-324-5p inhibitors plus SUFU siRNAs rescue partially the inhibitory effect on Wnt signaling and EMT caused by miRNA-324-5p inhibitors. Finally, the suppression of cell proliferation, migration, and colony formation ability induced by miRNA-324-5p inhibitors is alleviated by addition of SUFU siRNAs. In summary, miRNA-324-5p is overexpressed and exerts cell growth and migration-promoting effects through activating Wnt signaling and EMT by targeting SUFU in GC. It represents a potential miRNA with an oncogenic role in human gastric cancer.
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http://dx.doi.org/10.1080/15384101.2020.1826632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644164PMC
October 2020

Stereoassembled VO@FeOOH Hollow Architectures with Lithiation Volumetric Strain Self-Reconstruction for Lithium-Ion Storage.

Research (Wash D C) 2020 8;2020:2360796. Epub 2020 Apr 8.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China.

Vanadium oxides have recently attracted widespread attention due to their unique advantages and have demonstrated promising chemical and physical properties for energy storage. This work develops a mild and efficient method to stereoassemble hollow VO@FeOOH heterostructured nanoflowers with thin nanosheets. These dual-phased architectures possess multiple lithiation voltage plateau and well-defined heterointerfaces facilitating efficient charge transfer, mass diffusion, and self-reconstruction with volumetric strain. As a proof of concept, the resulting VO@FeOOH hollow nanoflowers as an anode material for lithium-ion batteries (LIBs) realize high-specific capacities, long lifespans, and superior rate capabilities, e.g., maintaining a specific capacity as high as 985 mAh g at 200 mA g with good cyclability.
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http://dx.doi.org/10.34133/2020/2360796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168343PMC
April 2020

Selective Solid-Liquid Interface Sulfidation Growth of Hierarchical Copper Sulfide and Its Hybrid Nanoflakes for Superior Lithium-Ion Storage.

Chem Asian J 2020 Jun 30;15(11):1722-1727. Epub 2020 Apr 30.

Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, 710072, P. R. China.

Two-dimensional metal sulfides and their hybrids are emerging as promising candidates in various areas. Yet, it remains challenging to synthesize high-quality 2D metal sulfides and their hybrids, especially iso-component hybrids, in a simple and controllable way. In this work, a low-temperature selective solid-liquid sulfidation growth method has been developed for the synthesis of CuS nanoflakes and their hybrids. CuS nanoflakes of about 20 nm thickness and co-component hybrids CuO /CuS with variable composition ratios derived from different sulfidation time are obtained after the residual sulfur removal. Besides, benefiting from the mild low-temperature sulfidation conditions, selective sulfidation is realized between Cu and Fe to yield iso-component FeO /CuS 2D nanoflakes of about 10-20 nm thickness, whose composition ratio is readily tunable by controlling the precursor. The as-synthesized FeO /CuS nanoflakes demonstrate superior lithium storage performance (i. e., 707 mAh g at 500 mA g and 627 mAh g at 1000 mA g after 450 cycles) when tested as anode materials in LIBs owing to the advantages of the ultrathin 2D nanostructure as well as the lithiation volumetric strain self-reconstruction effect of the co-existing two phases during charging/discharging processes.
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http://dx.doi.org/10.1002/asia.202000304DOI Listing
June 2020

General Approach to Single and Hybrid Metal Oxide Fiber Structures for High-Performance Lithium-Ion Batteries.

Chem Asian J 2020 Apr 28;15(7):1105-1109. Epub 2020 Feb 28.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), 30 South Puzhu Road, Nanjing, 211816, P. R. China.

Owing to the high specific capacity and energy density, metal oxides have become very promising electrodes for lithium-ion batteries (LIBs). However, poor electrical conductivity accompanied with inferior cycling stability resulting from large volume changes are the main obstacles to achieve a high reversible capacity and stable cyclability. Herein, a facile and general approach to fabricate SnO , Fe O and Fe O /SnO fibers is proposed. The appealing structural features are favorable for offering a shortened lithium-ion diffusion length, easy access for the electrolyte and reduced volume variation when used as anodes in LIBs. As a consequence, both single and hybrid oxides show satisfactory reversible capacities (1206 mAh g for Fe O and 1481 mAh g for Fe O /SnO after 200 cycles at 200 mA g ) and long lifespans.
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http://dx.doi.org/10.1002/asia.201901690DOI Listing
April 2020

[Role of miRNA-340 in modulating gastric cancer cell proliferation and bioinformatic analysis].

Nan Fang Yi Ke Da Xue Xue Bao 2019 Jul;39(7):784-790

Department of Pathology, Guangdong Women and Children's Hospital Affiliated to Guangzhou Medical University, Guangzhou 510000, China.

Objective: To investigate the mechanism of miRNA-340 for regulating the proliferation of gastric cancer (GC) cells and predict its interacting circular RNAs (circRNAs), its downstream target genes and the involved signaling pathways.

Methods: The differentially expressed miRNAs in GC cell lines were analyzed and screened using miRNA microarrays. The expression level of miRNA-340 in 21 pairs of GC tissues and adjacent normal tissues was detected using real-time PCR. MTT and EdU assays were performed to examine the effect of miRNA-340 on the proliferation ability of HFE145 and BGC-823 cells. We also tested the effect of miRNA-340 inhibition on subcutaneous tumorigenesis of GC cells in a nude mouse model. The downstream target genes of miRNA-340 and the probable signal pathways were predicted online using Targetscan and DAVID database, respectively. The interacting circRNAs of miRNA-340 were analyzed using starBase platform.

Results: Among the differentially expressed miRNAs, miRNA-340 was significantly down-regulated in GC cell lines. Real-time PCR results showed that the expression of miRNA-340 was significantly lower in GC tissues than in the adjacent tissues ( < 0.05). MTT and EdU cell proliferation assays showed that miRNA-340 overexpression inhibited the proliferation of GC cells in vitro. In the nude mouse models, the proliferation of GC cells transfected with miRNA-340 inhibitor was obviously enhanced. Bioinformatics analysis suggested that miRNA-340 had 21 target genes with 3 or more conserved sites, and these genes were involved in tumorigenesis and invasion. The top 10 circRNAs were selected as the most powerful sponge circRNAs interacting with miRNA-340.

Conclusions: miRNA-340 may play the role of a tumor suppressor in tumorigenesis and progression. Overexpression of miRNA-340 suppress the proliferation of GC cells, suggesting its involvement in the development of GC along with multiple circRNAs.
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http://dx.doi.org/10.12122/j.issn.1673-4254.2019.07.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765559PMC
July 2019

Recent Advances in Metal-Organic Frameworks for Photo-/Electrocatalytic CO Reduction.

Chemistry 2019 Nov 3;25(62):14026-14035. Epub 2019 Sep 3.

Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, 710072, P.R. China.

Considerable attention has been paid to the utilization of CO , an abundant carbon source in nature. In this regard, porous catalysts have been eagerly explored with excellent performance for photo-/electrocatalytic reduction of CO to high valued products. Metal-organic frameworks (MOFs), featuring large surface area, high porosity, tunable composition and unique structural characteristics, have been widely exploited in catalytic CO reduction. This Minireview first reports the current progress of MOFs in CO reduction. Then, a specific interest is focused on MOFs in photo-/electrocatalytic reduction of CO by modifying their metal centers, organic linkers, and pores. Finally, the future directions of study are also highlighted to satisfy the requirement of practical applications.
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http://dx.doi.org/10.1002/chem.201902203DOI Listing
November 2019

Rational Design of a Flexible CNTs@PDMS Film Patterned by Bio-Inspired Templates as a Strain Sensor and Supercapacitor.

Small 2019 05 4;15(18):e1805493. Epub 2019 Apr 4.

Shaanxi Institute of Flexible Electronics, Northwestern Polytechnical University, Xi'an, 710072, China.

Flexible devices integrated with sensing and energy storage functions are highly desirable due to their potential application in wearable electronics and human motion detection. Here, a flexible film is designed in a facile and low-cost leaf templating process, comprising wrinkled carbon nanotubes (CNTs) as the conductive layer and patterned polydimethylsiloxane (PDMS) with bio-inspired microstructure as a soft substrate. Assembled from wrinkled CNTs on patterned PDMS film, a strain sensor is realized to possess sensitive resistance response against various deformations, producing a resistance response of 0.34%, 0.14%, and 9.1% under bending, pressing, and 20% strain, respectively. Besides, the strain sensor can reach a resistance response of 3.01 when stretched to 44%. Furthermore, through the electro-deposition of polyaniline, the CNTs film is developed into a supercapacitor, which exhibits a specific capacitance of 176 F g at 1 A g and a capacitance retention of 88% after 10 000 cycles. In addition, the fabricated supercapacitor shows super flexibility, delivering a capacitance retention of 98% after 180° bending for 100 cycles, 95% after 45° twisting for 100 cycles, and 98% after 100% stretching for 400 cycles. The superior capacitance stability demonstrates that the design of wrinkled CNTs-based electrodes fixed by microstructures is beneficial to the excellent electrochemical performance.
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http://dx.doi.org/10.1002/smll.201805493DOI Listing
May 2019

Organic Molecule-Driven Polymeric Actuators.

Macromol Rapid Commun 2019 Apr 27;40(7):e1800896. Epub 2019 Feb 27.

Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, 10691, Sweden.

Inspired by the motions of plant tissues in response to external stimuli, significant attention has been devoted to the development of actuating polymeric materials. In particular, polymeric actuators driven by organic molecules have been designed due to their combined superiorities of tunable functional monomers, designable chemical structures, and variable structural anisotropy. Here, the recent progress is summarized in terms of material synthesis, structure design, polymer-solvent interaction, and actuating performance. In addition, various possibilities for practical applications, including the ability to sense chemical vapors and solvent isomers, and future directions to satisfy the requirement of sensing and smart systems are also highlighted.
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http://dx.doi.org/10.1002/marc.201800896DOI Listing
April 2019

Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer.

Oncol Rep 2018 Dec 8;40(6):3323-3334. Epub 2018 Oct 8.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong 518060, P.R. China.

A mounting body of evidence has revealed that microRNAs (miRs) serve pivotal roles in various developmental processes, and in tumourigenesis, by binding to target genes and subsequently regulating gene expression. Continued activation of the Wnt/β‑catenin signalling is positively associated with human malignancy. In addition, miR‑194 dysregulation has been implicated in gastric cancer (GC); however, the molecular mechanisms underlying the effects of miR‑194 on GC carcinogenesis remain to be elucidated. The present study demonstrated that miR‑194 was upregulated in GC tissues and SUFU negative regulator of Ηedgehog signaling (SUFU) was downregulated in GC cell lines. Subsequently, inhibition of miR‑194 attenuated nuclear accumulation of β‑catenin, which consequently blocked Wnt/β‑catenin signalling. In addition, the cytoplasmic translocation of β‑catenin induced by miR‑194 inhibition was mediated by SUFU. Furthermore, genes associated with the Wnt/β‑catenin signalling pathway were revealed to be downregulated following inhibition of the Wnt signalling pathway by miR‑194 suppression. Finally, the results indicated that cell apoptosis was markedly increased in response to miR‑194 inhibition, strongly suggesting the carcinogenic effects of miR‑194 in GC. Taken together, these findings demonstrated that miR‑194 may promote gastric carcinogenesis through activation of the Wnt/β‑catenin signalling pathway, making it a potential therapeutic target for GC.
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http://dx.doi.org/10.3892/or.2018.6773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196585PMC
December 2018

Coaxial-cable hierarchical tubular MnO@FeO@C heterostructures as advanced anodes for lithium-ion batteries.

Nanotechnology 2019 Mar 11;30(9):094002. Epub 2018 Dec 11.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, People's Republic of China.

Nanostructured manganese oxides have been regarded as promising anodes for lithium-ion batteries (LIBs) due to their high specific capacity, environmental friendliness and low cost. However, as conversion-type electrodes, their scalable utilization is hindered by intrinsically low reaction kinetics, large volume variation and high polarization. Herein, a coaxial-cable tubular heterostructure composed of a hollow carbon skeleton, FeO nanoparticles and ultrathin MnO nanosheets from inside out, donated as MnO@FeO@C, is synthesized via a facile two-step hydrothermal process. The unique design integrates conductive carbon and nanostructured MnO and FeO into a one-dimensional (1D) hierarchically open architecture, which provides abundant electrode-electrolyte contact areas, favorable heterointerfaces and ultrafast electron/ion pathways. Benefiting from these features, the MnO@FeO@C anode exhibits a high reversible capacity of 946 mAh g at 200 mA g after 160 cycles, and excellent cyclability with a specific capacity of 845 mAh g at 500 mA g after 600 cycles. This work might provide an insightful guideline for the design of novel electrode materials.
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http://dx.doi.org/10.1088/1361-6528/aaf7c5DOI Listing
March 2019

Topochemical pyrolytic synthesis of quasi-Mxene hybrids via ionic liquid-iron phthalocyanine as a self-template.

Chem Commun (Camb) 2019 Jan;55(6):771-774

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China.

A quasi-Mxene architecture was synthesized by 1-ethyl-3-methylimidazolium dicyanamide-iron phthalocyanine via self-template pyrolysis. The unique quasi-Mxene structure results in a rich contact area and good electronic conductivity, showing excellent rate capacity and cycling stability for lithium storage.
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http://dx.doi.org/10.1039/c8cc08997cDOI Listing
January 2019

Topochemical Synthesis of 2D Carbon Hybrids through Self-Boosting Catalytic Carbonization of a Metal-Polymer Framework.

Angew Chem Int Ed Engl 2018 Dec 15;57(50):16436-16441. Epub 2018 Nov 15.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211800, China.

Two-dimensional (2D) carbon hybrids have promise in various areas such as energy storage and catalysis. Simple methods for controllable fabrication of 2D graphitic carbon hybrids in a scalable manner remains challenging. Now, a microwave-assisted strategy for mass production of 2D carbon hybrids based on self-boosting catalytic carbonization of a metal-agarose framework is demonstrated. Hybrids including hollow Fe C nanoparticles, Ni/Co nanoparticles, and hollow FeO nanoparticles uniformly embedded in 2D graphitic carbon nanosheets (GCNs) are obtained, demonstrating the generality of the approach. Metal-polymer coordination and microwave-enabled fast catalytic decomposition of precursors play vital roles in facilitating the formation of the nanosheet structure. The resulting FeO -GCNs hybrid exhibits superior lithium-storage performance (1118 mAh g at 500 mA g and 818 mAh g at 2000 mA g after 1200 cycles).
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http://dx.doi.org/10.1002/anie.201810434DOI Listing
December 2018

Inhibition of the miR-192/215-Rab11-FIP2 axis suppresses human gastric cancer progression.

Cell Death Dis 2018 07 13;9(7):778. Epub 2018 Jul 13.

Department of Pathology, School of Basic Medical Sciences, Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen Key Laboratory of Micromolecule Innovatal Drugs, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China.

Less than a century ago, gastric cancer (GC) was the most common cancer throughout the world. Despite advances in surgical, chemotherapeutic, and radiotherapeutic treatment, GC remains the number 3 cancer killer worldwide. This fact highlights the need for better diagnostic biomarkers and more effective therapeutic targets. RAB11-FIP2, a member of the Rab11 family of interacting proteins, exhibits potential tumor suppressor function. However, involvement of RAB11-FIP2 in gastric carcinogenesis is yet to be elucidated. In this study, we demonstrated that RAB11-FIP2 was downregulated in GC tissues and constituted a target of the known onco-miRs, miR-192/215. We also showed that functionally, Rab11-FIP2 regulation by miR-192/215 is involved in GC-related biological activities. Finally, RAB11-FIP2 inhibition by miR-192/215 affected the establishment of cell polarity and tight junction formation in GC cells. In summary, this miR-192/215-Rab11-FIP2 axis appears to represent a new molecular mechanism underlying GC progression, while supplying a promising avenue of further research into diagnosis and therapy of GC.
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http://dx.doi.org/10.1038/s41419-018-0785-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045576PMC
July 2018

SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling.

Cancer Med 2018 01 13;7(1):146-156. Epub 2017 Dec 13.

Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, 518060, China.

SMG-1,a member of the phosphoinositide kinase-like kinase family, functioned as a tumor suppressor gene. However, the role of SMG-1 in GC remain uncharacterized. In this study, regulation of SMG-1 by miR-192 and-215, along with the biological effects of this modulation, were studied in GC. We used gene microarrays to screening and luciferase reporter assays were to verify the potential targets of miR-192 and-215. Tissue microarrays analyses were applied to measure the levels of SMG-1 in GC tissues. Western blot assays were used to assess the signaling pathway of SMG-1 regulated by miR-192 and-215 in GC. SMG-1 was significantly downregulated in GC tissues.The proliferative and invasive properties of GC cells were decreased by inhibition of miR-192 and-215, whereas an SMG-1siRNA rescued the inhibitory effects. Finally, SMG-1 inhibition by miR-192 and-215 primed Wnt signaling and induced EMT. Wnt signaling pathway proteins were decreased markedly by inhibitors of miR-192 and-215, while SMG-1 siRNA reversed the inhibition apparently. Meanwhile, miR-192 and-215 inhitibtors increased E-cadherin expression and decreased N-cadherin and cotransfection of SMG-1 siRNA reversed these effects. In summary, these findings illustrate that SMG-1 is suppressed by miR-192 and-215 and functions as a tumor suppressor in GC by inactivating Wnt signaling and suppressing EMT.
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http://dx.doi.org/10.1002/cam4.1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773975PMC
January 2018

Flexible and Actuating Nanoporous Poly(Ionic Liquid)-Paper-Based Hybrid Membranes.

ACS Appl Mater Interfaces 2017 May 24;9(17):15148-15155. Epub 2017 Apr 24.

Department of Chemistry and Biomolecular Science & Center for Advanced Materials Processing, Clarkson University , 8 Clarkson Avenue, Potsdam, New York 13699, United States.

Porous and flexible actuating materials are important for the development of smart systems. We report here a facile method to prepare scalable, flexible actuating porous membranes based on a poly(ionic liquid)-modified tissue paper. The targeted membrane property profile was based on synergy of the gradient porous structure of a poly(ionic liquid) network and flexibility of a tissue paper. The gradient porous structure was built through an ammonia-triggered electrostatic complexation of a poly(ionic liquid) with poly(acrylic acid), which were previously impregnated inside the tissue paper. As a result, these porous membranes undergo deformation by bending in response to organic solvents in the vapor or liquid phase and can recover their shape in air, which demonstrates their ability to serve as solvent sensors. Besides, they show enhanced mechanical properties due to the introduction of mechanically flexible tissue paper that allows the membranes to be designed as new responsive textiles and contractile actuators.
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http://dx.doi.org/10.1021/acsami.7b02920DOI Listing
May 2017

Dynamics of 8G12 competitive antibody in "prime-boost" vaccination of Hepatitis E vaccine.

Hum Vaccin Immunother 2017 06 8;13(6):1-6. Epub 2017 Mar 8.

a National Institutes for Food and Drug Control , Beijing , China.

Hepatitis E virus still poses a great threat to public health worldwide. To date, Hecolin® is the only licensed HEV vaccine in China. Total anti-HEV antibody has been used to reflect vaccine induced immune response in clinical trials for the lack of robust HEV neutralizing antibody detection methods. In this study, we applied a broad neutralizing mouse monoclonal antibody 8G12 to develop a competitive ELSIA assay and quantified 8G12 competitive antibody (8G12-like antibody) in serum samples. The presence of 8G12-like antibody was detected both from participants from HEV vaccine clinical trial and mice immunized with HEV vaccine. Furthermore, 8G12-like antibody was found to have a similar dynamic pattern as anti-HEV antibody during "prime-boost" vaccination, and the proportion of 8G12-like antibody in anti-HEV antibody increased along boost vaccination. Together with previously reported finding that 8G12 could block the most binding of HEV vaccine induced serum antibody to vaccine antigen, we proposed that 8G12-like antibody might be a promising surrogate for vaccine induced HEV neutralizing antibody and had potential to be used as a convenient indicator for HEV vaccine potency evaluation.
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http://dx.doi.org/10.1080/21645515.2017.1291105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489301PMC
June 2017

Hierarchically Arranged Helical Fiber Actuators Derived from Commercial Cloth.

Adv Mater 2017 Apr 20;29(16). Epub 2017 Feb 20.

Department of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, D-14476, Potsdam, Germany.

The first hygroscopically tunable cloth actuator is realized via impregnation of a commercial cloth template by a three dimensionally (3D) nanoporous polymer/carbon nanotube hybrid network. The nanoporous hybrid guarantees diffusion of water into the cloth actuator and amplifies the deformation scale. The cloth actuators are mechanically stable with high tensile strength. Because the commercial cotton cloth is inexpensive, such actuators capable of complex motions can be produced in a large size and scale for a wide variety of utilities (e.g. electric generators and "smart" materials).
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http://dx.doi.org/10.1002/adma.201605103DOI Listing
April 2017

Hepatitis E virus: Current epidemiology and vaccine.

Hum Vaccin Immunother 2016 10 16;12(10):2603-2610. Epub 2016 May 16.

a National Institutes for Food and Drug Control , Beijing , PR China.

Hepatitis E virus infections have been continuously reported in Indian subcontinent, Africa, southeast and central Asia, posing great health threats to the public, especially to pregnant women. Hecolin® is the only licensed HEV vaccine developed by Xiamen Innovax Biotech Co., Ltd. Extensive characterizations on antigenicity, physicochemical properties, efficacy in clinical trials, and manufacturing capability have made Hecolin® a promising vaccine for HEV control. However, there are many obstacles in large scale application of Hecolin®. Efforts are needed to further evaluate safety and efficacy in HEV risk populations, and to complement HEV standards for quality control. Passing World Health Organization prequalification and licensing outside China are priorities as these are also hindering Hecolin® promotion. Multilateral cooperation among Chinese vaccine manufacturers, Chinese National Regulatory Authorization (NRA) and WHO will expedite the entrance of Hecolin® into international market, so that Hecolin® could play its due role in global hepatitis E control.
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http://dx.doi.org/10.1080/21645515.2016.1184806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085000PMC
October 2016

Electrochromic fiber-shaped supercapacitors.

Adv Mater 2014 Dec 22;26(48):8126-32. Epub 2014 Oct 22.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200438, PR China.

An electrochromic fiber-shaped super-capacitor is developed by winding aligned carbon nanotube/polyaniline composite sheets on an elastic fiber. The fiber-shaped supercapacitors demonstrate rapid and reversible chromatic transitions under different working states, which can be directly observed by the naked eye. They are also stretchable and flexible, and are woven into textiles to display designed signals in addition to storing energy.
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http://dx.doi.org/10.1002/adma.201403243DOI Listing
December 2014

Winding aligned carbon nanotube composite yarns into coaxial fiber full batteries with high performances.

Nano Lett 2014 Jun 15;14(6):3432-8. Epub 2014 May 15.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University , Shanghai 200438, China.

Inspired by the fantastic and fast-growing wearable electronics such as Google Glass and Apple iWatch, matchable lightweight and weaveable energy storage systems are urgently demanded while remaining as a bottleneck in the whole technology. Fiber-shaped energy storage devices that can be woven into electronic textiles may represent a general and effective strategy to overcome the above difficulty. Here a coaxial fiber lithium-ion battery has been achieved by sequentially winding aligned carbon nanotube composite yarn cathode and anode onto a cotton fiber. Novel yarn structures are designed to enable a high performance with a linear energy density of 0.75 mWh cm(-1). A wearable energy storage textile is also produced with an areal energy density of 4.5 mWh cm(-2).
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http://dx.doi.org/10.1021/nl5009647DOI Listing
June 2014

Smart, stretchable supercapacitors.

Adv Mater 2014 Jul 2;26(26):4444-9. Epub 2014 May 2.

State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai, 200438, China.

Smart supercapacitors are developed by depositing conducting polymers onto aligned carbon-nanotube sheets. These supercapacitors rapidly and reversibly demonstrate color changes in response to a variation in the level of stored energy and the chromatic transitions can be directly observed by the naked eye.
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http://dx.doi.org/10.1002/adma.201400842DOI Listing
July 2014

Twisted aligned carbon nanotube/silicon composite fiber anode for flexible wire-shaped lithium-ion battery.

Adv Mater 2014 Feb 27;26(8):1217-22. Epub 2013 Nov 27.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai, 200438, China.

Twisted, aligned carbon nanotube/silicon composite fibers with remarkable mechanical and electronic properties are designed to develop novel flexible lithium-ion batteries with a high cyclic stability. The core-sheath architecture and the aligned structure of the composite nanotube offer excellent combined properties.
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http://dx.doi.org/10.1002/adma.201304319DOI Listing
February 2014

Integrated polymer solar cell and electrochemical supercapacitor in a flexible and stable fiber format.

Adv Mater 2014 Jan 31;26(3):466-70. Epub 2013 Oct 31.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai, 200438, China.

An all-solid-state, coaxial and self-powered "energy fiber" is demonstrated that simultaneously converts solar energy to electric energy and further stores it. The "energy fiber" is flexible and can be scaled up for the practical application by the well-developed textile technology, and may open a new avenue to future photoelectronics and electronics.
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http://dx.doi.org/10.1002/adma.201302951DOI Listing
January 2014

Novel electric double-layer capacitor with a coaxial fiber structure.

Adv Mater 2013 Nov 16;25(44):6436-41. Epub 2013 Aug 16.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai, 200438, China.

A coaxial electric double-layer capacitor fiber is developed from the aligned carbon nanotube fiber and sheet, which functions as two electrodes with a polymer gel sandwiched between them. The unique coaxial structure enables a rapid transportation of ions between the two electrodes with a high electrochemical performance. These energy storage fibers are also flexible and stretchable, and can be woven into and widely used for electronic textiles.
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http://dx.doi.org/10.1002/adma.201301519DOI Listing
November 2013

Conducting polymer composite film incorporated with aligned carbon nanotubes for transparent, flexible and efficient supercapacitor.

Sci Rep 2013 ;3:1353

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.

Polyaniline composite films incorporated with aligned multi-walled carbon nanotubes (MWCNTs) are synthesized through an easy electrodeposition process. These robust and electrically conductive films are found to function as effective electrodes to fabricate transparent and flexible supercapacitors with a maximum specific capacitance of 233 F/g at a current density of 1 A/g. It is 36 times of bare MWCNT sheet, 23 times of pure polyaniline and 3 times of randomly dispersed MWCNT/polyaniline film under the same conditions. The novel supercapacitors also show a high cyclic stability.
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http://dx.doi.org/10.1038/srep01353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582998PMC
August 2013

An Integrated "energy wire" for both photoelectric conversion and energy storage.

Angew Chem Int Ed Engl 2012 Nov 29;51(48):11977-80. Epub 2012 Oct 29.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, China.

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http://dx.doi.org/10.1002/anie.201207023DOI Listing
November 2012