Huichun Xu

Huichun Xu

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Huichun Xu

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Brain-derived neurotrophic factor, epigenetics in stroke skeletal muscle, and exercise training.

Neurol Genet 2019 Jun 1;5(3):e331. Epub 2019 May 1.

VA Maryland Health Care System, Research Service, Department of Medicine, Division of Gerontology and Geriatric Medicine, Department of Neurology, at the University of Maryland School of Medicine, and the Baltimore Geriatric Research, Education and Clinical Center (GRECC), MD.

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http://dx.doi.org/10.1212/NXG.0000000000000331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515940PMC
June 2019

Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.

PLoS One 2018 1;13(11):e0206554. Epub 2018 Nov 1.

University of Maryland School of Medicine, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206554PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211695PMC
April 2019

Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal.

J Clin Lipidol 2019 Jan - Feb;13(1):109-114. Epub 2018 Nov 20.

Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1016/j.jacl.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379118PMC
November 2018

Polygenic Risk for Depression Increases Risk of Ischemic Stroke: From the Stroke Genetics Network Study.

Stroke 2018 03 8;49(3):543-548. Epub 2018 Feb 8.

From the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (S.W.-S., Q.Q.); University of Maryland School of Medicine, Baltimore (T.D., B.D.M., H.X., K.R.); Department of Medicine, Ohio State University, Columbus (R.D.J.); Department of Epidemiology (S.L.) and Department of Medicine (S.L.), Brown School of Public Health and Alpert Medical School, Providence, RI; Division of Cardiology, University of Florida, Gainesville (K.P.); Department of Neurology (J.S.) and Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Genomic Medicine (E.C.D., J.W.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology, Carver College of Medicine (E.C.L.) and Department of Epidemiology, College of Public Health (E.C.L.), University of Iowa, Iowa City.

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http://dx.doi.org/10.1161/STROKEAHA.117.018857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909718PMC
March 2018

A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans.

J Pers Med 2018 02 26;8(1). Epub 2018 Feb 26.

Department of Internal Medicine and Molecular Pharmacology and Physiology, and the Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/jpm8010011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872085PMC
February 2018

and Loci Associate with Plasma Osmolality.

Authors:
Carsten A Böger Mathias Gorski Gearoid M McMahon Huichun Xu Yen-Pei C Chang Peter J van der Most Gerjan Navis Ilja M Nolte Martin H de Borst Weihua Zhang Benjamin Lehne Marie Loh Sian-Tsung Tan Eric Boerwinkle Morgan E Grams Peggy Sekula Man Li Beth Wilmot James G Moon Paul Scheet Francesco Cucca Xiangjun Xiao Leo-Pekka Lyytikäinen Graciela Delgado Tanja B Grammer Marcus E Kleber Sanaz Sedaghat Fernando Rivadeneira Tanguy Corre Zoltan Kutalik Sven Bergmann Carrie M Nielson Priya Srikanth Alexander Teumer Martina Müller-Nurasyid Anne Catharina Brockhaus Arne Pfeufer Wolfgang Rathmann Annette Peters Martha Matsumoto Mariza de Andrade Elizabeth J Atkinson Cassianne Robinson-Cohen Ian H de Boer Shih-Jen Hwang Iris M Heid Martin Gögele Maria Pina Concas Toshiko Tanaka Stefania Bandinelli Mike A Nalls Andrew Singleton Salman M Tajuddin Adebowale Adeyemo Jie Zhou Ayo Doumatey Shannon McWeeney Joanne Murabito Nora Franceschini Michael Flessner Michael Shlipak James G Wilson Guanjie Chen Charles N Rotimi Alan B Zonderman Michele K Evans Luigi Ferrucci Olivier Devuyst Mario Pirastu Alan Shuldiner Andrew A Hicks Peter Paul Pramstaller Bryan Kestenbaum Sharon L R Kardia Stephen T Turner LifeLines Cohort Study Tamara Ellefson Briske Christian Gieger Konstantin Strauch Christa Meisinger Thomas Meitinger Uwe Völker Matthias Nauck Henry Völzke Peter Vollenweider Murielle Bochud Gerard Waeber Mika Kähönen Terho Lehtimäki Winfried März Abbas Dehghan Oscar H Franco Andre G Uitterlinden Albert Hofman Herman A Taylor John C Chambers Jaspal S Kooner Caroline S Fox Robert Hitzemann Eric S Orwoll Cristian Pattaro David Schlessinger Anna Köttgen Harold Snieder Afshin Parsa David M Cohen

J Am Soc Nephrol 2017 Aug 30;28(8):2311-2321. Epub 2017 Mar 30.

Due to the number of contributing authors, the affiliations are listed in the supplemental material.

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http://dx.doi.org/10.1681/ASN.2016080892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533231PMC
August 2017

Familial Hypercholesterolemia and Type 2 Diabetes in the Old Order Amish.

Diabetes 2017 07 20;66(7):2054-2058. Epub 2017 Apr 20.

Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes & Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD

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http://dx.doi.org/10.2337/db17-0173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482078PMC
July 2017

The Importance of Conducting Stroke Genomics Research in African Ancestry Populations.

Glob Heart 2017 06 20;12(2):163-168. Epub 2017 Mar 20.

Department of Neurology, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.gheart.2017.01.004DOI Listing
June 2017

A Deep Proteome Analysis Identifies the Complete Secretome as the Functional Unit of Human Cardiac Progenitor Cells.

Circ Res 2017 Mar 1;120(5):816-834. Epub 2016 Dec 1.

From the Division of Cardiac Surgery, School of Medicine (S.S., R.M., G.E.B., B.W., P.S., S.R.D., B.S.T., S.K.), Department of Pharmaceutical Sciences, School of Pharmacy (M.M.K., Y.A.G., D.R.G.), Division of Endocrinology, Diabetes and Nutrition, Department of Medicine (H.X.), Department of Physiology and Medicine, School of Medicine (L.C.), Department of OB/GYN & Reproductive Science, Department of Biochemistry and Molecular Biology, School of Medicine (P.Y.), and Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine (M.E.T.), University of Maryland, Baltimore; and Cardiovascular and Metabolic Diseases, Innovative Medicines Biotech Unit MedImmune, Inc., Gaithersburg, MD (S.K.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834230PMC
March 2017

Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

Stroke 2016 Feb 5;47(2):307-16. Epub 2016 Jan 5.

From the Veterans Affairs Maryland Health Care System, Baltimore, MD (Y.-C.C., S.J.K., J.W.C., B.D.M.); University of Maryland School of Medicine, Baltimore (Y.-C.C., H.X., S.J.K., J.W.C., J.R.O., B.D.M.); The University of Gothenburg, Gothenburg, Sweden (T.M.S., C.J.); University of Rostock, Rostock, Germany (A.-K.G., A. Rolfs); University of Nottingham Malaysia Campus, Selangor Darul Ehsa, Malaysia (W.K.H.); University of Cambridge, Cambridge, UK (M.T., J.D., S.B., H.S.M., S.D., D.S.); Institut Pasteur de Lille, F-59000 Lille, France (P.A.); University of Newcastle, Australia (E.G.H.); Ludwig-Maximilians-Universität, Munich, Germany (R.M., K.S., M.D.); Wellcome Trust Sanger Institute, Cambridge, UK (J.D.); Center for Non-Communicable Diseases, Karachi, Pakistan (A. Rasheed, D.S.); University of Pennsylvania (W.Z., D.S.); Basel University Hospital, Switzerland (S.E.); Heidelberg University Hospital, Germany (C.G.-G.); Centre d'Étude du Polymorphisme Humain, Paris, France (Y.K.); RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (Y.K.); National Genotyping Center, Evry, France (M.L.); Genome Quebec, McGill University, Montreal, Canada (M.L.); Lille University Hospital, France (D.L., S.D.); KU Leuven - University of Leuven, Leuven, Belgium (V.T.); Vesalius Research Center, VIB, Leuven, Belgium (V.T.); University Hospitals Leuven, Leuven, Belgium (V.T.); Helsinki University Central Hospital, Helsinki, Finland (T.M.M., T.T.); Università degli Studi di Brescia, Brescia, Italy (A. Pezzini); Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (E.A.P., G.B.B.); University of Lund, Sweden (B.N.); University of Oxford, John Radcliffe Hospital (P.M.R.); University of Edinburgh, Edinburgh, UK (C.S.); Jagiellonian University Medical College, Krakow, Poland (A.S.); Lund University, Lund, Sweden (A.L.); Skåne University Hospital, Lund, Sweden (A.L.); University of Glasgow, Glasgow, UK (M.R.W.); University of Adelaide, Australia (J.J.); Mount Sinai Hos

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http://dx.doi.org/10.1161/STROKEAHA.115.011328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729659PMC
February 2016

Aryl Hydrocarbon Receptor Repressor Methylation: A Link Between Smoking and Atherosclerosis.

Circ Cardiovasc Genet 2015 Oct;8(5):640-2

From the Department of Neurology, Maryland Stroke Center, University of Maryland School of Medicine, Baltimore (J.W.C.); Department of Neurology, Baltimore VA Medical Center, Baltimore (J.W.C.); and Division of Endocrinology, Department of Medicine, University of Maryland School of Medicine, Baltimore (H.X.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620580PMC
October 2015

Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans.

J Endocrinol Metab 2015 Jun;5(3):199-210

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.14740/jem286wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618674PMC
June 2015

Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities.

Alzheimer Dis Assoc Disord 2014 Jul-Sep;28(3):226-33

*CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences †CAS Key Laboratory of Genome Sciences and Information, University of Chinese Academy of Sciences, Beijing, China ‡Department of Neurology and MIND Institute, School of Medicine ∥Alzheimer's Disease Center, School of Medicine, University of California at Davis, Sacramento, CA §Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.

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https://insights.ovid.com/crossref?an=00002093-201407000-000
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http://dx.doi.org/10.1097/WAD.0000000000000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139468PMC
April 2015

DNA repair/replication transcripts are down regulated in patients with Fragile X Syndrome.

BMC Res Notes 2013 Mar 11;6:90. Epub 2013 Mar 11.

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Dr. MSC 5635, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1756-0500-6-90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637561PMC
March 2013

MeCP2 modulates gene expression pathways in astrocytes.

Mol Autism 2013 Jan 25;4(1). Epub 2013 Jan 25.

Department of Medical Microbiology and Immunology, UC Davis Genome Center, University of California Davis, 1 Shields Avenue, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1186/2040-2392-4-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561260PMC
January 2013

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

Eur J Hum Genet 2012 Apr 16;20(4):463-8. Epub 2011 Nov 16.

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/ejhg.2011.206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306855PMC
April 2012

Regional genome transcriptional response of adult mouse brain to hypoxia.

BMC Genomics 2011 Oct 11;12:499. Epub 2011 Oct 11.

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Bethesda, MD 20892-5635, USA.

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http://dx.doi.org/10.1186/1471-2164-12-499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218040PMC
October 2011

Profiles of lacunar and nonlacunar stroke.

Ann Neurol 2011 Sep 27;70(3):477-85. Epub 2011 Jul 27.

Department of Neurology and the MIND Institute, University of California at Davis, Sacramento, CA 95817, USA.

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http://doi.wiley.com/10.1002/ana.22497
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http://dx.doi.org/10.1002/ana.22497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201749PMC
September 2011

Genome response to tissue plasminogen activator in experimental ischemic stroke.

BMC Genomics 2010 Apr 21;11:254. Epub 2010 Apr 21.

Department of Neurology and M,I,N,D, Institute, University of California at Davis, Sacramento, California 95817, USA.

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http://dx.doi.org/10.1186/1471-2164-11-254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875237PMC
April 2010

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury.

Ann Neurol 2010 Apr;67(4):526-33

Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA.

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http://dx.doi.org/10.1002/ana.21924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919346PMC
April 2010

Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures.

J Cereb Blood Flow Metab 2010 Jan 2;30(1):92-101. Epub 2009 Sep 2.

Department of Neurology and the M.I.N.D. Institute, University of California at Davis Medical Center, Sacramento, California 95817, USA.

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http://journals.sagepub.com/doi/10.1038/jcbfm.2009.186
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http://dx.doi.org/10.1038/jcbfm.2009.186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949089PMC
January 2010

Brief focal cerebral ischemia that simulates transient ischemic attacks in humans regulates gene expression in rat peripheral blood.

J Cereb Blood Flow Metab 2010 Jan 9;30(1):110-8. Epub 2009 Sep 9.

Department of Neurology and M.I.N.D. Institute, University of California at Davis, Sacramento, California 95817, USA.

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http://journals.sagepub.com/doi/10.1038/jcbfm.2009.189
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http://dx.doi.org/10.1038/jcbfm.2009.189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949112PMC
January 2010

Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons.

Neurobiol Dis 2008 May 9;30(2):201-11. Epub 2008 Feb 9.

Department of Neurology, MIND Institute, Neuroscience and Genetics Graduate Programs, University of California at Davis, Sacramento, California 95817, USA.

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http://dx.doi.org/10.1016/j.nbd.2008.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413433PMC
May 2008

A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis.

Mol Cell Neurosci 2007 Nov 9;36(3):392-407. Epub 2007 Aug 9.

M.I.N.D. Institute and Department of Neurology, University of California at Davis Medical Center, University of California at Davis, Sacramento, CA 95817, USA.

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http://dx.doi.org/10.1016/j.mcn.2007.07.014DOI Listing
November 2007

Genomic profiles of stroke in blood.

Stroke 2007 Feb;38(2 Suppl):691-3

Department of Neurology, University of California at Davis, Davis, CA, USA.

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http://dx.doi.org/10.1161/01.STR.0000247940.27518.38DOI Listing
February 2007

The future of genomic profiling of neurological diseases using blood.

Arch Neurol 2006 Nov;63(11):1529-36

Department of Neurology and Medical Investigation of Neurodevelopmental Disorders Institute, University of California-Davis Medical Center, Sacramento, CA 95817, USA.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/arc
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http://dx.doi.org/10.1001/archneur.63.11.1529DOI Listing
November 2006

Genomics of brain and blood: progress and pitfalls.

Epilepsia 2006 Oct;47(10):1603-7

Department of Neurology and the M.I.N.D. Institute, University of California at Davis, Sacramento, California 95817, USA.

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http://doi.wiley.com/10.1111/j.1528-1167.2006.00809.x
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http://dx.doi.org/10.1111/j.1528-1167.2006.00809.xDOI Listing
October 2006

Hypoxia preconditioning in the brain.

Dev Neurosci 2005 Mar-Aug;27(2-4):87-92

Department of Neurology, M.I.N.D. Institute, University of California at Davis, Davis, CA 95817, USA.

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http://dx.doi.org/10.1159/000085979DOI Listing
August 2005