Huibert A P Pols

Huibert A P Pols

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Huibert A P Pols

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A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.

J Med Genet 2014 Feb 16;51(2):122-31. Epub 2013 Dec 16.

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://jmg.bmj.com/cgi/doi/10.1136/jmedgenet-2013-102064
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http://dx.doi.org/10.1136/jmedgenet-2013-102064DOI Listing
February 2014

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Authors:
Karol Estrada Unnur Styrkarsdottir Evangelos Evangelou Yi-Hsiang Hsu Emma L Duncan Evangelia E Ntzani Ling Oei Omar M E Albagha Najaf Amin John P Kemp Daniel L Koller Guo Li Ching-Ti Liu Ryan L Minster Alireza Moayyeri Liesbeth Vandenput Dana Willner Su-Mei Xiao Laura M Yerges-Armstrong Hou-Feng Zheng Nerea Alonso Joel Eriksson Candace M Kammerer Stephen K Kaptoge Paul J Leo Gudmar Thorleifsson Scott G Wilson James F Wilson Ville Aalto Markku Alen Aaron K Aragaki Thor Aspelund Jacqueline R Center Zoe Dailiana David J Duggan Melissa Garcia Natàlia Garcia-Giralt Sylvie Giroux Göran Hallmans Lynne J Hocking Lise Bjerre Husted Karen A Jameson Rita Khusainova Ghi Su Kim Charles Kooperberg Theodora Koromila Marcin Kruk Marika Laaksonen Andrea Z Lacroix Seung Hun Lee Ping C Leung Joshua R Lewis Laura Masi Simona Mencej-Bedrac Tuan V Nguyen Xavier Nogues Millan S Patel Janez Prezelj Lynda M Rose Serena Scollen Kristin Siggeirsdottir Albert V Smith Olle Svensson Stella Trompet Olivia Trummer Natasja M van Schoor Jean Woo Kun Zhu Susana Balcells Maria Luisa Brandi Brendan M Buckley Sulin Cheng Claus Christiansen Cyrus Cooper George Dedoussis Ian Ford Morten Frost David Goltzman Jesús González-Macías Mika Kähönen Magnus Karlsson Elza Khusnutdinova Jung-Min Koh Panagoula Kollia Bente Lomholt Langdahl William D Leslie Paul Lips Östen Ljunggren Roman S Lorenc Janja Marc Dan Mellström Barbara Obermayer-Pietsch José M Olmos Ulrika Pettersson-Kymmer David M Reid José A Riancho Paul M Ridker François Rousseau P Eline Slagboom Nelson L S Tang Roser Urreizti Wim Van Hul Jorma Viikari María T Zarrabeitia Yurii S Aulchenko Martha Castano-Betancourt Elin Grundberg Lizbeth Herrera Thorvaldur Ingvarsson Hrefna Johannsdottir Tony Kwan Rui Li Robert Luben Carolina Medina-Gómez Stefan Th Palsson Sjur Reppe Jerome I Rotter Gunnar Sigurdsson Joyce B J van Meurs Dominique Verlaan Frances M K Williams Andrew R Wood Yanhua Zhou Kaare M Gautvik Tomi Pastinen Soumya Raychaudhuri Jane A Cauley Daniel I Chasman Graeme R Clark Steven R Cummings Patrick Danoy Elaine M Dennison Richard Eastell John A Eisman Vilmundur Gudnason Albert Hofman Rebecca D Jackson Graeme Jones J Wouter Jukema Kay-Tee Khaw Terho Lehtimäki Yongmei Liu Mattias Lorentzon Eugene McCloskey Braxton D Mitchell Kannabiran Nandakumar Geoffrey C Nicholson Ben A Oostra Munro Peacock Huibert A P Pols Richard L Prince Olli Raitakari Ian R Reid John Robbins Philip N Sambrook Pak Chung Sham Alan R Shuldiner Frances A Tylavsky Cornelia M van Duijn Nick J Wareham L Adrienne Cupples Michael J Econs David M Evans Tamara B Harris Annie Wai Chee Kung Bruce M Psaty Jonathan Reeve Timothy D Spector Elizabeth A Streeten M Carola Zillikens Unnur Thorsteinsdottir Claes Ohlsson David Karasik J Brent Richards Matthew A Brown Kari Stefansson André G Uitterlinden Stuart H Ralston John P A Ioannidis Douglas P Kiel Fernando Rivadeneira

Nat Genet 2012 Apr 15;44(5):491-501. Epub 2012 Apr 15.

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://kooperberg.fhcrc.org/papers/2012estrada.pdf
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http://www.nature.com/doifinder/10.1038/ng.2249
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http://dx.doi.org/10.1038/ng.2249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338864PMC
April 2012

Mild hyponatremia as a risk factor for fractures: the Rotterdam Study.

J Bone Miner Res 2011 Aug;26(8):1822-8

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/jbmr.380DOI Listing
August 2011

Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index.

Am J Clin Nutr 2010 May 24;91(5):1387-93. Epub 2010 Mar 24.

Department of Internal Medicine, Room D428, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.3945/ajcn.2009.28627DOI Listing
May 2010

Osmomediated natriuresis in humans: the role of vasopressin and tubular calcium sensing.

Nephrol Dial Transplant 2009 Nov 23;24(11):3326-33. Epub 2009 Jun 23.

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfp303DOI Listing
November 2009

Vitamin D binding protein genotype and osteoporosis.

Calcif Tissue Int 2009 Aug 2;85(2):85-93. Epub 2009 Jun 2.

Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00223-009-9251-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729412PMC
August 2009

Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: The Rotterdam Study.

J Clin Rheumatol 2009 Aug;15(5):230-7

Departments of Internal Medicine, Erasmus Medical Center, Rotterdam 3000 DR, The Netherlands.

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http://dx.doi.org/10.1097/RHU.0b013e3181b08f20DOI Listing
August 2009

Cost effectiveness of withdrawal of fall-risk-increasing drugs in geriatric outpatients.

Drugs Aging 2008 ;25(6):521-9

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://link.springer.com/content/pdf/10.2165/00002512-200825
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http://dx.doi.org/10.2165/00002512-200825060-00005DOI Listing
November 2008

Inappropriate benzodiazepine use in older adults and the risk of fracture.

Br J Clin Pharmacol 2008 Aug 6;66(2):276-82. Epub 2008 May 6.

Pharmaco-epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus University Medical Centre, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1111/j.1365-2125.2008.03185.x
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http://dx.doi.org/10.1111/j.1365-2125.2008.03185.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492915PMC
August 2008

Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study.

Clin Endocrinol (Oxf) 2008 Feb 4;68(2):175-81. Epub 2007 Sep 4.

Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1365-2265.2007.03016.xDOI Listing
February 2008

The RIZ Pro704 insertion-deletion polymorphism, bone mineral density and fracture risk: the Rotterdam study.

Bone 2008 Feb 23;42(2):286-93. Epub 2007 Oct 23.

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bone.2007.10.008DOI Listing
February 2008

Estrogen receptors alpha and beta and the risk of open-angle glaucoma: the Rotterdam Study.

Arch Ophthalmol 2008 Jan;126(1):110-4

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1001/archopht.126.1.110DOI Listing
January 2008

Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study.

Bone 2007 Dec 17;41(6):987-94. Epub 2007 Aug 17.

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bone.2007.08.021DOI Listing
December 2007

Withdrawal of fall-risk-increasing drugs in older persons: effect on mobility test outcomes.

Drugs Aging 2007 ;24(8):691-9

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.2165/00002512-200724080-00006DOI Listing
October 2007

Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer.

Mol Cell Endocrinol 2007 Sep 17;276(1-2):63-70. Epub 2007 Jul 17.

Department of Internal Medicine, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.mce.2007.06.007DOI Listing
September 2007

The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men.

J Clin Endocrinol Metab 2007 Aug 15;92(8):3206-12. Epub 2007 May 15.

Department of Internal Medicine, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2006-2136DOI Listing
August 2007

Withdrawal of fall-risk-increasing drugs in older persons: effect on tilt-table test outcomes.

J Am Geriatr Soc 2007 May;55(5):734-9

Department of Internal Medicine, Section of Geriatrics, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1532-5415.2007.01137.xDOI Listing
May 2007

Vitamin D receptor gene haplotype is associated with body height and bone size.

J Clin Endocrinol Metab 2007 Apr 9;92(4):1491-501. Epub 2007 Jan 9.

Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2006-1134DOI Listing
April 2007

Effect of monitoring bone turnover markers on persistence with risedronate treatment of postmenopausal osteoporosis.

J Clin Endocrinol Metab 2007 Apr 23;92(4):1296-304. Epub 2007 Jan 23.

Institut National de la Santé et de la Recherche Médicale Research Unit 403 and University Claude Bernard, Hôpital Edouard Herriot, Pavillon F, 69437 Lyon Cedex 03, France.

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http://dx.doi.org/10.1210/jc.2006-1526DOI Listing
April 2007

Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder.

Invest Ophthalmol Vis Sci 2007 Mar;48(3):1012-7

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1167/iovs.06-0577DOI Listing
March 2007

High-dose testosterone is associated with atherosclerosis in postmenopausal women.

Maturitas 2007 Feb 30;56(2):153-60. Epub 2006 Aug 30.

Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.maturitas.2006.07.004DOI Listing
February 2007

Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis. The Rotterdam Coronary Calcification Study.

Atherosclerosis 2006 Dec 8;189(2):464-9. Epub 2006 Feb 8.

Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2006.01.004DOI Listing
December 2006

TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study.

Stroke 2006 Nov 5;37(11):2667-71. Epub 2006 Oct 5.

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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https://www.ahajournals.org/doi/10.1161/01.STR.0000244779.30
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http://dx.doi.org/10.1161/01.STR.0000244779.30070.1aDOI Listing
November 2006

C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study.

J Clin Oncol 2006 Nov;24(33):5216-22

Department of Epidemiology & Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1200/JCO.2006.07.1381DOI Listing
November 2006

Calculation of bioavailable and free testosterone in men: a comparison of 5 published algorithms.

Clin Chem 2006 Sep 22;52(9):1777-84. Epub 2006 Jun 22.

Department of Endocrinology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1373/clinchem.2005.063354DOI Listing
September 2006

Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women.

Maturitas 2006 Aug 23;55(1):82-92. Epub 2006 Feb 23.

Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands; Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.maturitas.2006.01.008DOI Listing
August 2006

An igf-I gene polymorphism modifies the risk of diabetic retinopathy.

Diabetes 2006 Aug;55(8):2387-91

Department of Internal Medicine, Erasmus Medical Center, Room D-436, Dr. Molewaterplein 40, 3015 GD, Rotterdam, Netherlands.

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http://dx.doi.org/10.2337/db06-0021DOI Listing
August 2006

Glucocorticoid receptor polymorphism affects transrepression but not transactivation.

J Clin Endocrinol Metab 2006 Jul 9;91(7):2800-3. Epub 2006 May 9.

Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2005-2119DOI Listing
July 2006

A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients.

J Clin Endocrinol Metab 2006 Apr 7;91(4):1470-6. Epub 2006 Feb 7.

Department of Internal Medicine, Erasmus MC, Room Ee532, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2005-2156DOI Listing
April 2006

A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels.

J Clin Endocrinol Metab 2005 Sep 28;90(9):5313-6. Epub 2005 Jun 28.

Department of Internal Medicine, Room Ee585, Erasmus Medical Center, Dr. Molewaterplein 40, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2005-0307DOI Listing
September 2005

Endogenous oestrogens are related to cognition in healthy elderly women.

Clin Endocrinol (Oxf) 2005 Jul;63(1):50-5

Department of Internal Medicine, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/j.1365-2265.2005.02297.xDOI Listing
July 2005

A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women.

Eur J Endocrinol 2005 Feb;152(2):261-8

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1530/eje.1.01830DOI Listing
February 2005

Associations of sex-hormone-binding globulin (SHBG) with non-SHBG-bound levels of testosterone and estradiol in independently living men.

J Clin Endocrinol Metab 2005 Jan 27;90(1):157-62. Epub 2004 Oct 27.

Department of Internal Medicine, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2004-0422DOI Listing
January 2005

Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects.

Eur Heart J 2004 Dec;25(23):2143-8

Genetic Epidemiology Unit, Department of Epidemiology, Eramus Medical Centre Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ehj.2004.08.026DOI Listing
December 2004

ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the Rotterdam study.

J Bone Miner Res 2004 Sep 21;19(9):1490-6. Epub 2004 Jun 21.

Department of Internal Medicine, Erasmus Medical Center, Rotterdam 300 DR, The Netherlands.

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http://dx.doi.org/10.1359/JBMR.040605DOI Listing
September 2004

HMG-CoA reductase inhibitors and the risk of vertebral fracture.

J Bone Miner Res 2004 Sep 21;19(9):1525-30. Epub 2004 Jun 21.

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam 3000 DR, The Netherlands.

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http://dx.doi.org/10.1359/JBMR.040607DOI Listing
September 2004

Genetics and biology of vitamin D receptor polymorphisms.

Gene 2004 Sep;338(2):143-56

Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, PO Box 1738, NL-3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gene.2004.05.014DOI Listing
September 2004

Does bilirubin protect against hemochromatosis gene (HFE) related mortality?

Am J Med Genet A 2004 Aug;129A(1):39-43

Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.30163DOI Listing
August 2004

Risk factors for incident vertebral fractures in men and women: the Rotterdam Study.

J Bone Miner Res 2004 Jul 23;19(7):1172-80. Epub 2004 Feb 23.

Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1359/JBMR.040215DOI Listing
July 2004

The increase in cholesterol with menopause is associated with the apolipoprotein E genotype. A population-based longitudinal study.

Atherosclerosis 2004 Jul;175(1):169-76

Department of Internal Medicine, Room D429, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2004.04.001DOI Listing
July 2004

Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study.

J Clin Endocrinol Metab 2004 Jul;89(7):3261-9

Department of Internal Medicine, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2002-022041DOI Listing
July 2004

A meta-analysis of prior corticosteroid use and fracture risk.

J Bone Miner Res 2004 Jun 27;19(6):893-9. Epub 2004 Jan 27.

Centre for Metabolic Bone Diseases (WHO Collaborating Centre), University of Sheffield Medical School, Sheffield, United Kingdom.

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http://dx.doi.org/10.1359/JBMR.040134DOI Listing
June 2004

Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):187-93

Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, P.O. Box 1738, Genetic Laboratory, Room Ee575, NL-3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.083DOI Listing
May 2004

Paget's disease of bone in The Netherlands: a population-based radiological and biochemical survey--the Rotterdam Study.

J Bone Miner Res 2004 Apr 26;19(4):566-70. Epub 2004 Jan 26.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1359/jbmr.2004.19.4.566DOI Listing
April 2004

Obesity and hip osteoarthritis.

Am J Med 2003 Sep;115(4):329; author reply 329-30

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http://dx.doi.org/10.1016/s0002-9343(03)00365-6DOI Listing
September 2003