Publications by authors named "Hui Sun"

1,830 Publications

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Rapid identification of chemical components in Zhizi Baipi decoction by ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry coupled with a novel informatics UNIFI platform.

J Sep Sci 2022 Aug 9. Epub 2022 Aug 9.

National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China.

Zhizi Baipi Decoction is a classic traditional Chinese medicine formula for the treatment of jaundice and various liver diseases. The chemical components of Zhizi baipi decoction were not clear resulting from the paucity of relevant studies, which hindered the elucidation of the pharmacological mechanism, the comprehensive development and utilization of Zhizi baipi decoction in clinical. In this study, ultra performance liquid chromatography-quadrupole-time of flight mass spectrometry combined with UNIFI natural product information analysis platform was used to rapidly analyze and identify the chemical components in Zhizi baipi decoction. A total of 122 chemical components, including 53 flavonoids, 16 alkaloids, 25 terpenoids, 5 phenylpropanoids, 14 organic acids, and 7 others, were identified from Zhizi baipi decoction. These compounds may be the active components of Zhizi baipi decoction. The method established in this study can systematically, rapidly, and accurately resolve the chemical components in Zhizi baipi decoction, which lays the foundation for further establishment of the pharmacodynamic substance basis and quality control of Zhizi baipi decoction. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jssc.202200306DOI Listing
August 2022

A panel of lipid markers for rice discrimination of Wuchang Daohuaxiang in China.

Food Res Int 2022 Sep 14;159:111511. Epub 2022 Jun 14.

Academy of National Food and Strategic Reserves Administration, Beijing 100037, PR China.

Wuchang Daohuaxiang (DHX) rice is a famous product in China, while identification and authentication method is limited. Due to the special taste and flavor of DHX, lipidomics was conducted to discriminate it from faked rice. First, lipid profiles of DHX and other nine rice varieties were required from the established UPLC-Q/TOF-MS/MS method. The compositions and contents of lipids significantly varied among different rice. Then, twenty-six potential biomarkers containing 6 DGs, 5 PAs, 4 PCs, 1 PE, 3 PGs, 2 PIs, 2 PSs, 2 SMs, and 1 Cer were characterized and verified for identifying DHX from all faked rice. The accuracy of developed methods for DHX discrimination was 97.14%. In addition, OPLS-DA models were established for DHX distinction between each of the nine rice cultivars. Our results would supply as supplementary tools for discrimination of DHX rice for supervision departments and industries.
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http://dx.doi.org/10.1016/j.foodres.2022.111511DOI Listing
September 2022

Duck CD8 T Cell Response to H5N1 Highly Pathogenic Avian Influenza Virus Infection In Vivo and In Vitro.

J Immunol 2022 Aug 8. Epub 2022 Aug 8.

National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China;

Domestic ducks are the important host for H5N1 highly pathogenic avian influenza virus (HPAIV) infection and epidemiology, but little is known about the duck T cell response to H5N1 AIV infection. In infection experiments of mallard ducks, we detected significantly increased CD8 cells and augmented expression of cytotoxicity-associated genes, including granzyme A and IFN-γ, in PBMCs from 5 to 9 d postinfection when the virus shedding was clearly decreased, which suggested the importance of the duck cytotoxic T cell response in eliminating H5N1 infection in vivo. Intriguingly, we found that a CD8 population of PBMCs was clearly upregulated in infected ducks from 7 to 9 d postinfection compared with uninfected ducks. Next, we used Smart-Seq2 technology to investigate the heterogeneity and transcriptional differences of the duck CD8 cells. Thus, CD8 cells were likely to be more responsive to H5N1 AIV infection, based on the high level of expression of genes involved in T cell responses, activation, and proliferation, including MALT1, ITK, LCK, CD3E, CD247, CFLAR, IL-18R1, and IL-18RAP. More importantly, we have also successfully cultured H5N1 AIV-specific duck T cells in vitro, to our knowledge, for the first time, and demonstrated that the CD8 population was increased with the duck T cell activation and response in vitro, which was consistent with results in vivo. Thus, the duck CD8 cells represent a potentially effective immune response to H5N1 AIV infection in vivo and in vitro. These findings provide novel insights and direction for developing effective H5N1 AIV vaccines.
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http://dx.doi.org/10.4049/jimmunol.2101147DOI Listing
August 2022

The Central Circadian Clock Protein TaCCA1 Regulates Seedling Growth and Spike Development in Wheat ( L.).

Front Plant Sci 2022 18;13:946213. Epub 2022 Jul 18.

The Municipal Key Laboratory of the Molecular Genetics of Hybrid Wheat, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.

The biological functions of the circadian clock on growth and development have been well elucidated in model plants, while its regulatory roles in crop species, especially the roles on yield-related traits, are poorly understood. In this study, we characterized the core clock gene homoeologs in wheat and studied their biological functions in seedling growth and spike development. homoeologs exhibit typical diurnal expression patterns, which are positively regulated by rhythmic histone modifications including histone H3 lysine 4 trimethylation (H3K4me3), histone H3 lysine 9 acetylation (H3K9Ac), and histone H3 lysine 36 trimethylation (H3K36me3). TaCCA1s are preferentially located in the nucleus and tend to form both homo- and heterodimers. overexpression (OE) transgenic wheat plants show disrupted circadian rhythmicity coupling with reduced chlorophyll and starch content, as well as biomass at seedling stage, also decreased spike length, grain number per spike, and grain size at the ripening stage. Further studies using DNA affinity purification followed by deep sequencing [DNA affinity purification and sequencing (DAP-seq)] indicated that TaCCA1 preferentially binds to sequences similarly to "evening elements" (EE) motif in the wheat genome, particularly genes associated with photosynthesis, carbon utilization, and auxin homeostasis, and decreased transcriptional levels of these target genes are observed in OE transgenic wheat plants. Collectively, our study provides novel insights into a circadian-mediated mechanism of gene regulation to coordinate photosynthetic and metabolic activities in wheat, which is important for optimal plant growth and crop yield formation.
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http://dx.doi.org/10.3389/fpls.2022.946213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340162PMC
July 2022

Research on the Mechanism of HRP Relieving IPEC-J2 Cells Immunological Stress Based on Transcriptome Sequencing Analysis.

Front Nutr 2022 15;9:944390. Epub 2022 Jul 15.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.

Early weaning increased the economic benefits of piglets. However, early weaning damages the intestinal barrier of piglets and causes immunological stress. The mechanism by which polysaccharide (HRP) alleviates lipopolysaccharide (LPS)-induced intestinal porcine epithelial cells (IPEC-J2) inflammatory damage was investigated using proteomics in our previous studies. In this study we employed RNA-sequencing (RNA-seq) to determine the level and function of differentially expressed genes (DEGs) and further explore the mechanism of the HRP anti-inflammatory and immune process. The differential expression analysis indicated that 3622, 1216, and 2100 DEGs in the IPEC-J2 cells were identified in C vs. L, L vs. H6-L, and C vs. H6-L, respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis foundsix identified pathways related to the immune system. Additionally, we used the Science, Technology, Engineering, and Math (STEM) program to categorize the 3,134 DEGs that were differentially expressed in H2-L, H4-L and H6-L into eight possible expression profiles, in which 612 were clustered into two profiles. The accuracy and consistency of RNA-seq data were validated by the results of qRT-PCR of the nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (NFKB2), MAP kinase interacting serine/threonine kinase 2 (MKNK2), mitogen-activated protein kinase kinase 1 (MAP2K1), mitogen-activated protein kinase kinase kinase 8 (MAP3K8), Ras-related protein R-Ras (RRAS), TNF receptor-associated factor 1 (TRAF1), NF-kappa-B inhibitor alpha (NFKBIA), interleukin 8 (IL8), tumor necrosis factor, alpha-induced protein 3 (TNFAIP3), and transforming growth factor beta-1 (TGFB1). Transcriptome sequencing also indicated that HRP reduced the expression levels of related DEGs and inhibited the activation of the mitogen-activated protein kinase (MAPK)/nuclear factor kappa-B (NF-κB) signaling pathway. Our findings indicate that the application of HRP in piglet diets during the early weaning period can improve intestinal epithelial function and integrity, and relieve intestinal damage, and improve piglet health.
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http://dx.doi.org/10.3389/fnut.2022.944390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336541PMC
July 2022

Unilateral Surgery for Medullary Thyroid Carcinoma: Seeking for Clinical Practice Guidelines.

Front Endocrinol (Lausanne) 2022 11;13:875875. Epub 2022 Jul 11.

Division of Endocrine and Metabolic Diseases, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Auxologico Italiano, Milan, Italy.

Optimized preoperative diagnostic tools with calcitonin tests, ultrasound features, functional imaging modalities, and genetic testing to detect hereditary forms have led to an increased rate of earlier diagnosis and surgery for medullary thyroid cancer (MTC). This helps to adapt the primary surgery to the tumor stage and avoid surgical overtreatment for localized tumor growth, i.e., deviating from the regularly recommended thyroidectomy with bilateral central lymph node dissection in favor of a limited unilateral approach. To limit primary surgical therapy, it is crucial that the MTC is clinically unifocal, sporadic, and confined to the thyroid, and that calcitonin levels indicate biochemical recovery after surgery. The main requirement for such a limited approach is the availability of frozen section studies that reliably indicate (i) R0 resection of the MTC, (ii) absence of infiltration of the organ capsule, (iii) lack of desmoplasia (i.e., evidence of the metastatic potential of the MTC), (iiii) absence of contralateral disease or precancerous lesions. Informed consent is mandatory from the patient, who has been fully informed of the advantages, disadvantages, and potential risks of not undergoing the "classic" surgical procedure. The aim of this article is to review the guidelines for the management of early-stage MTC.
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http://dx.doi.org/10.3389/fendo.2022.875875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309363PMC
July 2022

Multidirectional insights into the phytochemical, biological, and multivariate analysis of extracts from the aerial part of Linnaeus.

Nat Prod Res 2022 Jul 27:1-5. Epub 2022 Jul 27.

College of Medicine, Yanbian University, Yanji, China.

Linnaeus (SP) has been utilised to treat gastritis. We report the qualitative and quantitative phytochemical analysis, antioxidant and enzyme inhibitory activities of SP. The correlation between the biological activities and total bioactive contents of the extracts was also studied via multivariate analysis. Methanol extract contained many active compounds and exhibited good antioxidant activity. Therefore, this was selected for further phytochemical profiling and stability studies. Fourteen compounds were identified by ultra-performance liquid chromatography-electrospray ionisation-orbitrap-mass spectrometry for the first time from this plant. Iridoids, xanthones, and flavonoids were the main components. Methanol extract exhibited good stability and antioxidant capacity in stability studies, with low toxicity, and showed a protective effect on the oxidation of olive and sunflower oils. SP has the potential to be developed and used as an antioxidant, or as urease and XO inhibitors, and its methanol extract could be used as a natural oil stabiliser.
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http://dx.doi.org/10.1080/14786419.2022.2103812DOI Listing
July 2022

Research Progress of p-Type Oxide Thin-Film Transistors.

Materials (Basel) 2022 Jul 8;15(14). Epub 2022 Jul 8.

School of Space Science and Physics, Shandong University, Weihai 264209, China.

The development of transparent electronics has advanced metal-oxide-semiconductor Thin-Film transistor (TFT) technology. In the field of flat-panel displays, as basic units, TFTs play an important role in achieving high speed, brightness, and screen contrast ratio to display information by controlling liquid crystal pixel dots. Oxide TFTs have gradually replaced silicon-based TFTs owing to their field-effect mobility, stability, and responsiveness. In the market, n-type oxide TFTs have been widely used, and their preparation methods have been gradually refined; however, p-Type oxide TFTs with the same properties are difficult to obtain. Fabricating p-Type oxide TFTs with the same performance as n-type oxide TFTs can ensure more energy-efficient complementary electronics and better transparent display applications. This paper summarizes the basic understanding of the structure and performance of the p-Type oxide TFTs, expounding the research progress and challenges of oxide transistors. The microstructures of the three types of p-Type oxides and significant efforts to improve the performance of oxide TFTs are highlighted. Finally, the latest progress and prospects of oxide TFTs based on p-Type oxide semiconductors and other p-Type semiconductor electronic devices are discussed.
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http://dx.doi.org/10.3390/ma15144781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323180PMC
July 2022

Growth, Yield and Photosynthetic Performance of Winter Wheat as Affected by Co-Application of Nitrogen Fertilizer and Organic Manures.

Life (Basel) 2022 Jul 6;12(7). Epub 2022 Jul 6.

Agricultural Institute, Centre for Agricultural Research, ELKH, 2462 Martonvásár, Hungary.

The application of organic manures was found to be beneficial, however, the integrated use of organic manures with chemical nitrogen fertilizers has proven more sustainable in increasing the photosynthetic attributes and grain yield of the winter-wheat crop. A multi-factor split-plot design was adopted, nitrogen and manure fertilizer treatments were set in the sub-plots, including nitrogen-gradient treatment of T1:0 kg N ha, T2:100 kg N ha, T3:200 kg N ha, and T4:300 kg N ha (pure nitrogen -fertilizer application) The 25% reduction in nitrogen combined with the manure-fertilizer application includes T5:75 kg N ha nitrogen and 25 kg N ha manure, T6:150 kg N ha nitrogen and 50 kg N ha manure, and T7:225 kg N ha nitrogen and 75 kg N ha manure. The maximum results of the total chlorophyll content and photosynthetic rate were 5.73 mg/g FW and 68.13 m mol m s, observed under T4 in Zhongmai 175, as compared to Jindong 22 at the heading stage. However, the maximum results of intercellular CO concentration were 1998.47 μmol mol, observed under T3 in Jindong 22, as compared to Zhongmai 175 at the tillering stage. The maximum results of LAI were 5.35 (cm), observed under T7 in Jindong 22, as compared to Zhongmai 175 at the booting stage. However, the maximum results of Tr and Gs were 6.31 mmol HO m s and 0.90 HO mol m s, respectively, observed under T7 in Zhongmai 175 as compared to Jindong 22 at the flowering stage. The results revealed that grain yield 8696.93 kg ha, grains spike 51.33 (g), and 1000-grain weight 39.27 (g) were significantly higher, under T3 in Zhongmai 175, as compared to Jindong 22. Moreover, the spike number plot of 656.67 m was significantly higher in Jindong 22, as compared to Zhongmai 175. It was concluded from the study that the combined application of nitrogen and manure fertilizers in winter wheat is significant for enhancing seed at the jointing and flowering stages. For increased grain yield and higher economic return, Zhongmai 175 outperformed the other cultivars examined. This research brings awareness toward the nitrogen-fertilizer-management approach established for farmers' practice, which might be observed as an instruction to increase agricultural management for the winter-wheat-growth season.
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http://dx.doi.org/10.3390/life12071000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319553PMC
July 2022

Cadmium (Cd) accumulation in traditional Chinese medicine materials (TCMMs): A critical review.

Ecotoxicol Environ Saf 2022 Jul 23;242:113904. Epub 2022 Jul 23.

Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China. Electronic address:

Traditional Chinese medicine (TCM) has accumulated a wealth of ecological wisdom and is regarded as an outstanding cultural and medical resource in China. However, in the context of serious environmental pollution, the potential harm caused by TCM materials (TCMMs) due to toxic heavy metals has seriously affected the sustainable development of TCM. Cadmium (Cd) is an internationally recognized heavy metal contaminant. In this paper, 270 reports on Cd in TCMMs were screened from 1969 publications covering 243 species in 81 families. According to the source of the TCMMs, the data were divided into the following categories: aboveground part, bark, flower and fruit, herb, leaf and rhizome. The temporal dynamics of the Cd content and its correlations with the habitats and categories (parts) of TCMMs were also studied. The results show that 22.05 % of the investigated TCMM samples exceeded the relevant domestic standards (Cd≤0.3 mg/kg), among which the maximum Cd content was 17.75 mg/kg. Myrtaceae and Syzygium aromaticum were the family and species with the highest mean Cd content, respectively. Regarding the source of TCMMs of great concern, the mean Cd content of TCMMs decreased in the order of herb > aboveground part > flower and fruit > leaf > rhizome > bark. In addition, in terms of the spatiotemporal distribution, the spatial distribution of the mean Cd content of TCMMs was significantly higher on the Qinghai-Tibet Plateau, followed by Southwest China. When comparing different times, more serious Cd pollution of TCMMs existed after 2000, and the highest mean Cd content was observed in 2000-2004. In summary, soil acidity must be decreased and the cultivation conditions of Cd-hyperaccumulators such as Ligusticum chuanxiong and Lonicera japonica must be modified, in conjunction with a scientific health risk assessment, to ensure the sustainable development of TCMMs.
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http://dx.doi.org/10.1016/j.ecoenv.2022.113904DOI Listing
July 2022

ITGB1 as a prognostic biomarker correlated with immune suppression in gastric cancer.

Cancer Med 2022 Jul 21. Epub 2022 Jul 21.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.

Introduction: Gastric cancer is one of the common malignant tumors with a high incidence and mortality in China. Prognostic biomarkers and potential predictors of the treatment efficacy of gastric cancer urgently need to be identified. Integrin-β (ITGB) is a superfamily of integrins and is involved in cell adhesion, tissue repair, immune response, and tumor metastasis.

Methods: We analyzed ITGB1 expression in our hospital samples of the gastric cancer cohort. And the public data of The Cancer Genome Atlas stomach adenocarcinoma (TCGA-STAD), The Asian Cancer Research Group (ACRG)/GSE62254, and GSE15459 data sets were analyzed by using the bioinformatic methods. The relationships between ITGB1 expression and clinicopathological features, patient prognosis, activation of the Wnt/β-catenin signaling pathway, and tumor immunosuppressive factors were also explored.

Results: The positive rate of ITGB1 expression in the Fudan University Shanghai Cancer Center gastric cancer tumor tissues was 61.4% (258/420) and correlated with deep invasion (p = 0.017), an advanced clinical stage (p = 0.011), and a poor prognosis (p < 0.05). The TCGA-STAD/ACRG/GSE15459 cohorts also showed similar results. ITGB1 is one of the upstream molecules of the Wnt/β-catenin signaling pathway and is correlated with tumor immune suppression. In gastric cancer, we found a correlation between ITGB1 expression and Wnt/β-catenin signaling pathway activity. In the TCGA-STAD/ACRG/GSE15459 cohorts, ITGB1 expression was positively associated with immunosuppressive factors and negatively associated with immunoactive factors. Patients with low ITGB1 expression exhibited a significantly high immunotherapy response ratio according to an analysis of tumor immune dysfunction and exclusion (TIDE), which may indicate that ITGB1 is a potential predictor of immunotherapy efficacy.

Conclusions: ITGB1 affects the prognosis in gastric cancer patients and plays a core role in immune suppression in gastric cancer.
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http://dx.doi.org/10.1002/cam4.5042DOI Listing
July 2022

Thermalization dynamics of a gauge theory on a quantum simulator.

Science 2022 07 14;377(6603):311-314. Epub 2022 Jul 14.

Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences, University of Science and Technology of China, Hefei 230026, China.

Gauge theories form the foundation of modern physics, with applications ranging from elementary particle physics and early-universe cosmology to condensed matter systems. We perform quantum simulations of the unitary dynamics of a U(1) symmetric gauge field theory and demonstrate emergent irreversible behavior. The highly constrained gauge theory dynamics are encoded in a one-dimensional Bose-Hubbard simulator, which couples fermionic matter fields through dynamical gauge fields. We investigated global quantum quenches and the equilibration to a steady state well approximated by a thermal ensemble. Our work may enable the investigation of elusive phenomena, such as Schwinger pair production and string breaking, and paves the way for simulating more complex, higher-dimensional gauge theories on quantum synthetic matter devices.
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http://dx.doi.org/10.1126/science.abl6277DOI Listing
July 2022

Rapid characterization of chemical constituents in Naoling Pian by LC-MS combined with data processing techniques.

J Sep Sci 2022 Jul 20. Epub 2022 Jul 20.

National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Functional Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, China.

Naoling Pian is a prescription composed of 15 herbs, which is mainly used for the treatment of insomnia in clinical practice. However, the chemical constituents in Naoling Pian are numerous and unclear, which hinders the interpretation of its bioactive constituents and the subsequent research on the material basis for pharmacodynamics. The purpose of this study is to develop a rapid method for identifying the chemical constituents of Naoling Pian using high-throughput ultra-performance liquid chromatography quadrupole time of flight coupled with mass spectrometry combined with a software platform for data processing. The whole composition of Naoling Pian was characterized in positive and negative ion modes. In this experiment, an overall total of 201 constituents were identified by using reference standards, online and self-built databases matching, fragmentation rules analysis of mass spectrometry peaks with a software platform. Meanwhile, Naoling Pian was analyzed for the first time using LC-MS method, the constituents could be identified in a quick and accurate manner, and the results could provide a scientific basis for the follow-up research on the pharmacodynamic material basis and quality control of Naoling Pian. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jssc.202200244DOI Listing
July 2022

Recent Studies on the Preparation and Application of Ionic Amphiphilic Lignin: A Comprehensive Review.

J Agric Food Chem 2022 Jul 18;70(29):8871-8891. Epub 2022 Jul 18.

State Key Laboratory of Biobased Material and Green Papermaking, Key Laboratory of Pulp & Paper Science and Technology of Shandong Province/Ministry of Education, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.

As the second most abundant natural polymer after cellulose, lignin has received considerable attention recently due to its reproducibility, safety, and biodegradability. Studies are now focusing on the development of new lignin applications to replace petroleum-based chemicals. Unfortunately, lignin has several inherent problems, such as poor water solubility and a tendency to agglomerate. However, after chemical modification, lignin can gain new functions through the introduction of new functional groups. For example, amphiphilic lignin is a polymer that is soluble in both water and organic solvents. Amphiphilic lignin polymers can be divided into anionic, cationic, and anionic-cationic amphoteric lignin-based polymers, according to the ions contained in their molecular structure. Amphiphilic lignin polymers also have a wide range of applications in various industrial fields and can be used as wetting agents, detergents, controlled release fertilizers, adsorbents, and emulsifiers. Thus, this article reviews research progress on the synthesis and applications of amphiphilic lignin-derived polymers over the past 10 years, providing a theoretical reference for the utilization of high-added-value and high-performance lignin.
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http://dx.doi.org/10.1021/acs.jafc.2c02798DOI Listing
July 2022

Does pretreatment elevated calcitonin level cause the poor prognosis in patients with medullary thyroid cancer?

Ann Transl Med 2022 Jun;10(12):709

Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun, China.

Background: Medullary thyroid carcinoma (MTC) patients have poor survival, tumor/node/metastasis (TNM) stage and biochemical prognosis are the most important factors. We investigated the clinical significance of calcitonin (Ctn) to assess the biochemical prognosis of MTC.

Methods: This retrospective observational study enrolled 77 MTC patients with complete information and primary surgery at the Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University between 2009 and 2020. Patient and MTC characteristics were recorded. All patients were divided into remission, stable, and progression according to biochemical prognosis. We analyzed the correlation between preoperative serum Ctn, TNM stage and biochemical prognosis.

Results: Elevated preoperative serum Ctn was positively correlated with TNM stage. Patients with higher Ctn, multifocality, and bilateral tumors were associated with a higher TNM stage. Multivariate logistic regression analysis showed that preoperative serum Ctn level was an independent risk factor for TNM stage. Receiver operating characteristic (ROC) analysis found the best Ctn cut-off value for predicting TNM III was 45.88 pg/mL, which had a sensitivity of 87.2% and a specificity of 65.8%. The best Ctn cut-off value for predicting TNM IV was 167.00 pg/mL, with a sensitivity of 92.9% and a specificity of 77.6%. In univariate analysis, patients with higher preoperative serum Ctn, multifocality, bilateral tumors, and higher TNM stage were more likely to progress. The optimal cut-off value for progression was 195.5 pg/mL, which had a sensitivity of 80.0% and a specificity of 70.2%. For every 1-unit increase in preoperative serum Ctn levels, the risk of progression increased by 1.004 times (P=0.008), and patients with TNM stage III [hazard ratio (HR) =9.663; 95% confidence interval (CI): 1.411, 66.156] were nearly 9.7-fold more likely to progress than those in TNM stage I/II.

Conclusions: Elevated preoperative serum Ctn predicted poor clinical outcomes in MTC.
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http://dx.doi.org/10.21037/atm-22-2737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279776PMC
June 2022

Decreased expression of claudin-18.2 in alpha-fetoprotein-producing gastric cancer compared to conventional gastric cancer.

J Gastrointest Oncol 2022 Jun;13(3):1035-1045

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Alpha-fetoprotein-producing gastric cancer (AFPGC) is a subtype of gastric cancer (GC) with more aggressive biological behavior. As a highly specific tight junction component exclusively present in gastric mucosa and gastric adenocarcinomas, claudin-18.2 (CLDN18.2) has become an emerging target in GC. In this study, we aimed to provide insight into AFPGC and investigate the expression and the clinical implications of CLDN18.2 in AFPGC.

Methods: We retrospectively collected 98 cases of AFPGC and reviewed their clinical, morphological, and immunohistochemical features. Another 356 patients with stage-matched conventional GC (cGC) were enrolled as a control group. We further surveyed CLDN18.2 expression by immunohistochemistry (IHC) in 51 AFPGC tissues and explained its association with the clinicopathological parameters of AFPGC.

Results: Our results showed that AFPGC was a unique GC type with elevated serum alpha-fetoprotein (AFP), which was a predictor of a worse prognosis. AFPGC showed typical morphological features and positive staining of at least 1 hepatocytic or enteroblastic marker. The expression rate of CLDN18.2 was low, with a positivity rate of 21.6%, which was much lower than that observed in cGC tissues (38.5%). A significant correlation was found between CLDN18.2 expression and the differentiation of AFPGC. CLDN18.2 expression was negatively correlated with the serum AFP level of AFPGC. We also found that AFPGC with a hepatoid type (HPT) component showed a significantly lower CLDN18.2 expression than those without.

Conclusions: This study demonstrated that CLDN18.2 was significantly decreased in AFPGC and was negatively correlated with the patient's preoperative serum AFP level. The negative correlation between AFP and CLDN18.2 could be explained by retro-differentiation of AFPGC. Special treatment strategies might be needed for this unique tumor type.
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http://dx.doi.org/10.21037/jgo-22-462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274048PMC
June 2022

A trial of arbidol hydrochloride in adults with COVID-19.

Chin Med J (Engl) 2022 Jul 14. Epub 2022 Jul 14.

Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.

Background: To date, there is no effective medicine to treat coronavirus disease 2019 (COVID-19), and the antiviral efficacy of arbidol in the treatment for COVID-19 remained equivocal and controversial. The purpose of this study was to evaluate the efficacy and safety of arbidol tablets in the treatment of COVID-19.

Methods: This was a prospective, open-label, controlled and multicenter investigator-initiated trial involving adult patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients were stratified 1:2 to either standard-of-care (SOC) or SOC plus arbidol tablets (oral administration of 200 mg per time, three times a day for 14 days). The primary endpoint was negative conversion of SARS-CoV-2 within the first week. The rates and 95% confidential intervals were calculated for each variable.

Results: A total of 99 patients with laboratory-confirmed SARS-CoV-2 infection were enrolled; 66 were assigned to the SOC plus arbidol tablets group, and 33 to the SOC group. The negative conversion rate of SARS-CoV-2 within the first week in patients receiving arbidol tablets was significantly higher than that of the SOC group (70.3% [45/64] vs. 42.4% [14/33]; difference of conversion rate 27.9%; 95% confidence interval [CI], 7.7%-48.1%; P  = 0.008). Compared to those in the SOC group, patients receiving arbidol tablets had a shorter duration of clinical recovery (median 7.0 days vs. 12.0 days; hazard ratio [HR]: 1.877, 95% CI: 1.151-3.060, P = 0.006), symptom of fever (median 3.0 days vs. 12.0 days; HR: 18.990, 95% CI: 5.350-67.410, P < 0.001), as well as hospitalization (median 12.5 days vs. 20.0 days; P < 0.001). Moreover, the addition of arbidol tablets to SOC led to more rapid normalization of declined blood lymphocytes (median 10.0 days vs. 14.5 days; P > 0.05). The most common adverse event in the arbidol tablets group was the elevation of transaminase (5/200, 2.5%), and no one withdrew from the study due to adverse events or disease progression.

Conclusions: SOC plus arbidol tablets significantly increase the negative conversion rate of SARS-CoV-2 within the first week anas, accelerate the recovery of COVID-19 patients. During the treatment with arbidol tablets, we find no significant serious adverse events.

Trial Registration: Chinese Clinical Trial Registry, NCT04260594, www.clinicaltrials.gov/ct2/show/NCT04260594?term=NCT04260594&draw=2&rank=1.
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http://dx.doi.org/10.1097/CM9.0000000000002104DOI Listing
July 2022

Advances in Barrier Membranes for Guided Bone Regeneration Techniques.

Front Bioeng Biotechnol 2022 22;10:921576. Epub 2022 Jun 22.

Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, China.

Guided bone regeneration (GBR) is a widely used technique for alveolar bone augmentation. Among all the principal elements, barrier membrane is recognized as the key to the success of GBR. Ideal barrier membrane should have satisfactory biological and mechanical properties. According to their composition, barrier membranes can be divided into polymer membranes and non-polymer membranes. Polymer barrier membranes have become a research hotspot not only because they can control the physical and chemical characteristics of the membranes by regulating the synthesis conditions but also because their prices are relatively low. Still now the bone augment effect of barrier membrane used in clinical practice is more dependent on the body's own growth potential and the osteogenic effect is difficult to predict. Therefore, scholars have carried out many researches to explore new barrier membranes in order to improve the success rate of bone enhancement. The aim of this study is to collect and compare recent studies on optimizing barrier membranes. The characteristics and research progress of different types of barrier membranes were also discussed in detail.
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http://dx.doi.org/10.3389/fbioe.2022.921576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257033PMC
June 2022

ARID2, a Rare Cause of Coffin-Siris Syndrome: A Clinical Description of Two Cases.

Front Pediatr 2022 23;10:911954. Epub 2022 Jun 23.

Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, China.

Background: Coffin-Siris syndrome (CSS) is a multiple congenital anomaly syndrome characterized by coarse facial features, sparse scalp hair, hypertrichosis, and hypo/aplastic digital nails and phalanges. Mutations in the BAF (SWI/SNF)-complex subunits (SMARCE1, SMARCB1, SMARCA4, SMARCA2, ARID1B, and ARID1A) have been shown to cause CSS. People diagnosed with BAF pathway related diseases are increasing, and (NM_152641.4) is the least common of these genes. Mutations in the ARID2 gene is the cause for Coffin-Siris syndrome 6 (CSS6). By now only 16 individuals with CSS have been reported to have pathogenic variants in .

Case Presentation: In this article, we introduced two individuals with clinical features consistent with CSS6 (Coffin-Siris syndrome 6). This article increases the number of reported cases, provides better phenotypic information for this rare syndrome, and allows everyone to better understand the disease.

Conclusion: Our observations indicate that mutations could have variable phenotypes, even in patients from the same family.
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http://dx.doi.org/10.3389/fped.2022.911954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265212PMC
June 2022

Isothermal and Non-Isothermal Crystallization Kinetics of Poly(ethylene chlorotrifluoroethylene).

Polymers (Basel) 2022 Jun 28;14(13). Epub 2022 Jun 28.

Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology, College of Textiles Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.

The isothermal (IT) and non-isothermal (NIT) crystallization kinetics, morphology, and structure of poly(ethylene chlorotrifluoroethylene) (ECTFE) were investigated via differential scanning calorimetry (DSC), polarized optical microscopy (POM), and wide-angle X-ray diffraction (XRD). The Avrami equation could well describe the overall IT crystallization process of ECTFE, and, furthermore, the overall crystallization rate decreased at higher crystallization temperatures (). The equilibrium melting point for ECTFE was found to be 238.66 °C. The activation energies for IT and NIT crystallization were determined as -137.68 and -120.54 kJ/mol, respectively. The Jeziorny model fitted well with the initial stages of NIT melt crystallization, while deviations from linearity in the later stages of the process were due to the collisions of spherulites. Spherulites of ECTFE organized in a hexagonal crystal system were found. The relative crystalline degree of ECTFE under NIT conditions was about 54.55%, and this decreased with the increase in cooling rate. Moreover, the Ozawa and Mo models were suitable for modeling the overall NIT crystallization process of ECTFE.
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http://dx.doi.org/10.3390/polym14132630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269497PMC
June 2022

Preparation of the Carbonized [email protected] Nanofiber Membrane for Cadmium Ion Adsorption.

Polymers (Basel) 2022 Jun 21;14(13). Epub 2022 Jun 21.

College of Textiles Science and Engineering, Zhejiang Sci-Tech University, 928 Second Avenue, Xiasha Higher Education Zone, Hangzhou 310018, China.

The zeolitic imidazolate framework (ZIF-8)@polyacrylonitrile (PAN) nanofiber membrane was prepared and carbonized for heavy metal cadmium ion (Cd) adsorption in aqueous medium. Zinc oxide (ZnO) was first sputtered onto the surface of the PAN electrospun nanofiber membrane to provide a metal ion source. Then, the [email protected] nanofiber membrane was prepared via in situ solvothermal reaction and carbonized in a tube furnace at 900 °C under a N atmosphere to enhance adsorption performance. The synthesized ZIF-8 particles with polyhedral structure were uniformly immobilized on the surface of the PAN electrospun nanofiber membrane. After being heated at 900 °C, the polygonal ZIF-8 shrank, and the carbonized [email protected] nanofiber membrane was obtained. Compared with the nanofiber membrane without being carbonized, the adsorption capacity of the carbonized [email protected] nanofiber membrane reached 102 mg L, and its Cd adsorption efficiency could be more than 90% under the adsorption temperature of 35 °C and solution of pH = 7.5 conditions. According to the adsorption thermodynamics analysis, the Cd adsorption process of the carbonized [email protected] nanofiber membrane was spontaneous. The whole Cd adsorption process was more suitably described by the pseudo second-order adsorption kinetics model, indicating that there exists a chemical adsorption mechanism besides physical adsorption.
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http://dx.doi.org/10.3390/polym14132523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268802PMC
June 2022

Utilizing the Transverse Thermoelectric Effect of Thin Films for Pulse Laser Detection.

Sensors (Basel) 2022 Jun 28;22(13). Epub 2022 Jun 28.

School of Space Science and Physics, Shandong University, Weihai 264209, China.

In this work, pulse laser detectors based on the transverse thermoelectric effect of YBaCuO thin films on vicinal cut LaAlO (001) substrates have been fabricated. The anisotropic Seebeck coefficients between -plane () and -axis () of thin films are utilized to generate the output voltage signal in such kind of detectors. Fast response has been determined in these sensors, including both the rise time and the decay time. Under the irradiation of pulse laser with the pulse duration of 5-7 ns, the output voltage of these detectors shows the rise time and the decay time of 6 and 42 ns, respectively, which are much smaller than those from other materials. The small rise time in YBaCuO-based detectors may be due to its low resistivity. While the high thermal conductivity and the large contribution of electronic thermal conductivity to the thermal conductivity of YBaCuO are thought to be responsible for the small decay time. In addition, these detectors show good response under the irradiation of pulse lasers with a repetition rate of 4 kHz, including the precise determinations of amplitude and time. These results may pave a simple and convenient approach to manufacture the pulse laser detectors with a fast response.
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http://dx.doi.org/10.3390/s22134867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268995PMC
June 2022

The association between common serum adipokines levels and postmenopausal osteoporosis: A meta-analysis.

J Cell Mol Med 2022 Aug 5;26(15):4333-4342. Epub 2022 Jul 5.

Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

The clinical relevance of blood levels of adipokines in individuals with postmenopausal osteoporosis (PMOP) has not been previously clarified. We performed this meta-analysis to clarify the association between three common adipokines levels and the occurrence of PMOP. PubMed, Embase, Cochrane library, and China National Knowledgement Infrastructure (CNKI) were searched for collecting articles published before 31 October 2021, without language and status restrictions. Fourteen studies met the selection criteria. Meta-analysis revealed that blood leptin level was remarkably lower (mean difference [MD], -1.94; 95% confidence interval [CI], -3.83 to -0.06; I  = 96%) and adiponectin level was remarkably higher (MD, 3.48; 95% CI, 2.36 to 4.60; I  = 90%) in individuals with PMOP than healthy individuals with normal bone mineral density (BMD). However, the statistical difference in leptin level was changed after eliminating the confounding influence of leptin sources and assay approaches. Furthermore, a positive association (r = 0.28) between leptin level and body mass index (BMI) as well as a negative association (r = -0.33) between adiponectin level and BMD was found. Moreover, adiponectin had the highest probability of predicting PMOP (84%). Current evidence suggests that leptin positively affects BMI and adiponectin negatively affects BMD, and adiponectin is the most relevant adipokine negatively associated with PMOP.
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http://dx.doi.org/10.1111/jcmm.17457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344814PMC
August 2022

Number of standard modifiable risk factors and mortality in patients with first-presentation ST-segment elevation myocardial infarction: insights from China Acute Myocardial Infarction registry.

BMC Med 2022 07 6;20(1):217. Epub 2022 Jul 6.

Coronary Heart Disease Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, 167 Beilishi Rd, Beijing, 100037, China.

Background: Recent publications reported a paradoxical finding that there was an inverse association between the number of standard modifiable risk factors (SMuRFs; smoking, hypertension, diabetes, and hyperlipidemia) and mortality in patients with myocardial infarction. However, the current evidence is only limited to those highly developed countries with advanced medical management systems.

Methods: The China Acute Myocardial Infarction registry is a prospective observational study including patients with acute myocardial infarction from three-level hospitals across 31 administrative regions throughout mainland China. A total of 16,228 patients with first-presentation ST-elevation myocardial infarction (STEMI) admitted to hospitals from January 2013 to September 2014 were enrolled in the current analysis. Cox proportional hazard models adjusting for baseline characteristics, clinical profiles at presentation, and in-hospital treatments were used to assess the association of the number of SMuRFs with all-cause mortality at 30 days after STEMI presentation.

Results: A total of 1918 (11.8%), 11,503 (70.9%), and 2807 (17.3%) patients had 0, 1-2, and 3-4 SMuRFs at presentation, respectively. Patients with fewer SMuRFs were older and more likely to be females, experienced longer pre-hospital delays, and were less likely to receive primary percutaneous coronary intervention and evidence-based medications. Compared with those without any SMuRF, patients with 1-2 SMuRFs and 3-4 SMuRFs were associated with an HR of 0.74 (95% CI, 0.63-0.87) and 0.63 (0.51-0.77) for all-cause mortality up to 30 days in the unadjusted model (P < 0.0001). However, after multivariate adjustment, the number of SMuRFs was positively associated with increased mortality risk (HR for 1-2 SMuRFs, 1.15 [0.95-1.39]; HR for 3-4 SMuRFs, 1.31 [1.02-1.68]; P = 0.03), and the association was only significant among patients admitted to hospitals beyond 12 h from onset (HR for 1-2 SMuRFs, 1.39 [1.03-1.87]; HR for 3-4 SMuRFs, 2.06 [1.41-3.01]) but not their counterparts (P = 0.01).

Conclusions: The increased crude mortality risk among patients without SMuRFs is explained by confounding factors related to their poor risk profiles (old age, longer pre-hospital delays, and poor clinical management). After multivariate adjustment, a higher risk-factor burden was associated with poor prognosis among patients with STEMI.
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http://dx.doi.org/10.1186/s12916-022-02418-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258075PMC
July 2022

Skin substitutes comprised of recombinant human collagen hydrogel promote full-thickness skin defect reconstruction.

Burns 2022 Jun 18. Epub 2022 Jun 18.

Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China; Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212001, China. Electronic address:

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http://dx.doi.org/10.1016/j.burns.2022.06.005DOI Listing
June 2022

[miR-27a induces ferroptosis by inhibiting solute carrier family 7 member-11 (SLC7A11) and causes cerebral ischemia-reperfusion injury in rats].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jul;38(7):617-624

North China University of Science and Technology Affiliated Hospital, Key Laboratory of Medical Molecular Testing and Diagnosis in Tangshan, Tangshan 063000, China. *Corresponding author, E-mail:

Objective To investigate the role and molecular mechanism of miR-27a in cerebral ischemia reperfusion injury model in rats. Methods The male Sprague Dawley rats were randomly divided into control group, sham group, middle cerebral artery occlusion/reperfusion model group(MCAO/R group)( according to different ischemia reperfusion time, the model group was divided into the 3, 6, 12 and 24 hours reperfusion groups after 2 hour-ischemia), and vehicle group, agomir-27a group, antagomir-27a group. The Zea-Longa method was used to establish rat MCAO model. The levels of miR-27a and solute carrier family 7 member-11 (SLC7A11) in brain tissues were detected by real-time fluorescence quantitative PCR. Zea-Longa score was used to evaluate neuro score. 2, 3, 5 triphenyl tetrazolium chloride(TTC) staining was used to test the infarct volume. The relative expression levels of glutathione peroxidase 4(GPx4) and SLC7A11 proteins were detected by Western blot analysis. The contents of GSH, Fe and MDA were detected by GSH, Fe and MDA detection kits. The target gene of miR-27a was confirmed by dual luciferase reporter gene technique. Results After cerebral ischemia reperfusion, the level of miR-27a was up-regulated and the level of SLC7A11 was down-regulated. Inhibition of miR-27a expression reduced neurological score and cerebral infarct volume, and inhibited ferroptosis after cerebral ischemia reperfusion. Conclusion In the process of cerebral ischemia and reperfusion, the up-regulated miR-27a may induce ferroptosis through inhibiting SLC7A11, thus causing brain tissue damage.
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July 2022

Monitoring Leaf Nitrogen Accumulation With Optimized Spectral Index in Winter Wheat Under Different Irrigation Regimes.

Front Plant Sci 2022 17;13:913240. Epub 2022 Jun 17.

College of Resource and Environment, Shanxi Agricultural University, Jinzhong, China.

Rapid and non-destructive estimation of leaf nitrogen accumulation (LNA) is essential to field nitrogen management. Currently, many vegetation indices have been used for indicating nitrogen status. Few studies systematically analyzed the performance of vegetation indices of winter wheat in estimating LNA under different irrigation regimes. This study aimed to develop a new spectral index for LNA estimation. In this study, 2 years of field experiments with different irrigation regimes were conducted from 2015 to 2017. The original reflectance (OR) and three transformed spectra [e.g., the first derivative reflectance (FDR), logarithm of the reciprocal of the spectra (Log(1/)), and continuum removal (CR)] were used to calculate two- and three-band spectral indices. Correlation analyses and univariate linear and non-linear regression between transformed-based spectral indices and LNA were performed. The performance of the optimal spectral index was evaluated with classical vegetation index. The results showed that FDR was the most stable transformation method, which can effectively enhance the relationships to LNA and improve prediction performance. With a linear relationship with LNA, FDR-based three-band spectral index 1 (FDR-TBI1) (451, 706, 688) generated the best performance with coefficient of determination ( ) of 0.73 and 0.79, the root mean square error (RMSE) of 1.267 and 1.266 g/m, and the ratio of performance to interquartile distance (RPIQ) of 2.84 and 2.71 in calibration and validation datasets, respectively. The optimized spectral index [FDR-TBI1 (451, 706, 688)] is more effective and might be recommended as an indicator for estimating winter wheat LNA under different irrigation regimes.
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http://dx.doi.org/10.3389/fpls.2022.913240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247552PMC
June 2022

Long-term conservative management of symptomatic bladder endometriosis: A case series of 17 patients.

Taiwan J Obstet Gynecol 2022 Jul;61(4):606-611

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.

Objectives: This study aimed to evaluate the course of long-term conservative management of bladder endometriosis (BE).

Materials And Methods: We retrospectively reviewed 17 cases of BE conservatively managed without surgery in our facility. The following factors were analyzed: age, medical history, lesion size, symptoms, hormonal treatment, and follow-up outcomes.

Results: In this study, 15 patients received hormonal therapy and 2 did not. Oral contraceptive (OC), dienogest (DNG), and gonadotropin-releasing hormone agonist (GnRHa) were administered as the first regimen in 7, 5, and 3 patients, respectively. Of the 7 patients, OC administration was effective in alleviating urinary symptoms in all but 2 patients. Of 3 patients who received GnRHa, 2 switched to OC and then DNG, and 1 patient discontinued the treatment because of adverse effects. Of 5 patients who received DNG, all experienced symptom relief. DNG, OC, and GnRHa administration were effective and tolerable in 9 of 10 patients (90.0%), in 5 of 9 patients (55.6%), and in 2 of 3 patients (66.7%), respectively. In particular, 3 patients completed DNG treatment until menopause. The size of the BE lesion significantly decreased after 3 months of DNG administration, and the reduction effect was maintained until 48 months thereafter.

Conclusion: This study proposed that hormonal therapy for BE is an effective option for those who are not planning to conceive or to undergo surgery. Specifically, DNG may be suitable for patients refusing surgery, considering the effectiveness and tolerance for long-term use.
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http://dx.doi.org/10.1016/j.tjog.2022.02.044DOI Listing
July 2022

Differential diagnosis of diffuse sclerotic thyroid papillary carcinoma and Hashimoto's thyroiditis using fine-needle aspiration cytology, BRAF , and ultrasound elastography.

J Clin Ultrasound 2022 Jul 2. Epub 2022 Jul 2.

Department of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.

Background: The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) has ultrasound findings that are similar to Hashimoto's thyroiditis (HT), resulting in under-diagnosis. DSV-PTC combined with HT is also common, so early and accurate diagnosis of DSV-PTC using a variety of diagnostic techniques, including FNAC, BRAF mutation detection, and ultrasound elastography, is critical.

Objective: To assess the diagnostic value of fine-needle aspiration cytology (FNAC) and BRAF detection in combination with ultrasound elastography in the diagnosis of DSV-PTC.

Methods: We performed a retrospective analysis of 40 patients with pathologically confirmed DSV-PTC and 43 patients with HT admitted to our hospital's ultrasound department between January 2015 and December 2020. Preoperative FNAC, BRAF mutation detection, and ultrasound elastography imaging were all performed on all patients. For a definitive diagnosis, the results of these tests were compared to postoperative pathological findings. The diagnostic value of FNAC, BRAF mutation detection, ultrasound elasticity imaging, and their combination for DSV-PTC diagnosis was assessed.

Results: The mean elastic strain rate ratio (E1/E2) of the 40 DSV-PTC cases was 5.75 ± 2.14, while that of the 43 HT cases was 2.81 ± 1.20. The receiver operating characteristic (ROC) curve was generated using the average value of E2/E1. The area under the ROC curve was 0.910, and the optimal E2/E1 cut-off value was 4.500. When FNAC, BRAF mutation detection, and ultrasound elasticity imaging detection were combined, the diagnostic sensitivity, specificity, negative predictive value, positive predictive value, and accuracy of DSV-PTC diagnosis were 92.5%, 95.3%, 93.2%, 94.9%, and 94.0%, respectively, which were significantly higher than the single technique (p < 0.05).

Conclusions: The use of FNAC, BRAF mutation detection, and ultrasound elastography in combination is more helpful in establishing an accurate diagnosis of DSV-PTC than using a single diagnostic technique alone.
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http://dx.doi.org/10.1002/jcu.23260DOI Listing
July 2022

Case fatality rate of the adult in-patients with COVID-19 and digestive system tumors: A systematic review and meta-analysis.

Medicine (Baltimore) 2022 Jun 24;101(25):e29364. Epub 2022 Jun 24.

Department of Oncology, Pukou Branch Hospital of Jiangsu Province Hospital (Nanjing Pukou Central Hospital), Nanjing, China.

Background: During the coronavirus disease 2019 (COVID-19) pandemic, endoscopic screening for gastrointestinal tumors was suspended or delayed in most countries. Thus, our study aimed to quantify the impact of COVID-19 on the clinical outcomes of patients with digestive system tumors through a systematic review and meta-analysis.

Methods: We systematically searched the PubMed, Web of Science, Cochrane Library, and Embase databases as of March 7, 2021 to identify the case fatality rate (CFR) of COVID-19 patients diagnosed with digestive system tumors. A random-effects model was used for meta-analysis, I2 was used to assess heterogeneity, and funnel plot was used to assess publication bias.

Results: A total of 13 studies were included, involving 2943 tumor patients with COVID-19, of which 871 were digestive system tumors, and the CFR was 24% (95% CI, 18%-30%; I2 = 55.7%). The mortality rate of colorectal cancer was 21% (95% CI, 14%-27%; I2 = 0.0%), gastric cancer was 25% (95% CI, 6%-45%; I2 = 0.0%), and hepatobiliary cancer was 29%. In general, there was no significant difference in the CFR of digestive system tumors.

Conclusion: The combined CFR of digestive system tumors and COVID-19 patients was 24%, which is much higher than that of the general population. Under the premise of fully complying with the international guidelines to limit the spread of COVID-19, we call for the resumption of endoscopic screening programs and selective surgery as soon as possible.

Registration Information: PROSPERO registration no. CRD42021248194.
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http://dx.doi.org/10.1097/MD.0000000000029364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276255PMC
June 2022
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