Publications by authors named "Hui Peng"

820 Publications

Dielectric polarization effect and transient relaxation in FAPbBr films before and after PMMA passivation.

Phys Chem Chem Phys 2021 May;23(17):10153-10163

Beijing National Laboratory for Molecular Sciences, Molecular Reaction Dynamics Laboratory, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China. and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.

In organic-inorganic hybrid ionic lead halide perovskites with a naturally arranged layered structure, the dielectric polarization effect caused by the dielectric mismatch between the organic and inorganic layers takes effect in their optical responses. But this effect has received little attention. Here we used infrared transient spectroscopy to study FAPbBr3 perovskite polycrystalline films before and after PMMA film passivation and found that there is a dielectric polarization effect at the interface between the organic cation layer and the inorganic lattice layer inside the perovskite lattice, and also at the interface between the PMMA film and perovskite film. Due to the dielectric polarization effect and the spatial confinement of the surface electronic (or polaron) state, the luminescence intensity of the passivated perovskite film is significantly enhanced, and the exciton lifetime is greatly increased. Dielectric polarization enhances their efficient transient absorption (TA) and leads to the intramolecular vibration frequency red-shifts, which exhibited the combined relaxation kinetics of the large polaron with dielectric polarization in the perovskite film. Dielectric polarization between the internal lattice and the nanocrystal surface of the perovskite film shows different relaxation processes. The polarization-dependent TA spectrum reveals that the dielectric polarization field causes light-induced anisotropy by changing the chemical bond configurations. These direct TA experimental observations help us to understand the influence of the dielectric polarization effect on the electronic state in various organic-inorganic nanocomposite perovskites.
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http://dx.doi.org/10.1039/d1cp01136gDOI Listing
May 2021

Highly Stable Waterborne Luminescent Inks Based on MAPbBr@PbBr(OH) Nanocrystals for LEDs and Anticounterfeit Applications.

ACS Appl Mater Interfaces 2021 May 22;13(17):20622-20632. Epub 2021 Apr 22.

Key Laboratory of Polar Materials and Devices, Ministry of Education, Department of Electronics, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China.

Waterborne polymers are advantageous in terms of cost, convenience, sustainability, and environmental friendliness. As lead halide perovskite (LHP) nanocrystals suffer from fast degradation in the presence of water, it is challenging to encapsulate LHP nanocrystals in waterborne polymers. In this work, luminescent MAPbBr@PbBr(OH) nanocrystals were synthesized via the aqueous grinding process in the presence of 2-methyl-imidazole (2-MIM) and oleylamime (OAm). 2-MIM triggers the formation of the PbBr(OH) matrix, and OAm acts as a size-control ligand to control the size of MAPbBr@PbBrOH particles in the nanoscale range. Highly stable waterborne luminescent inks were successfully prepared by blending MAPbBr@PbBr(OH) nanocrystals with waterborne polymers, including poly(vinylpyrrolidone), poly(vinyl acetate), and acrylate resins. Owning to the dual protection of the polymer matrix and PbBr(OH) to LHP quantum dots (QDs), the luminescent films exhibit excellent stability to the environment under thermal and light irradiation. The ink can be used as a phosphor to fabricate down-converting green and white light-emitting diodes (LEDs). Waterborne anticounterfeiting inks suitable for screen printing were prepared via formula tuning for the anticounterfeit purpose. The anticounterfeiting luminescent patterns can be screen printed on paper, cloth, and poly(ethylene terephthalate) (PET), with encryption and decryption of information being accurately and conveniently realized by switching UV irradiation.
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http://dx.doi.org/10.1021/acsami.1c01905DOI Listing
May 2021

Gases emission during the continuous thermophilic composting of dairy manure amended with activated oil shale semicoke.

J Environ Manage 2021 Apr 13;290:112519. Epub 2021 Apr 13.

Shandong Industrial Engineering Laboratory of Biogas Production & Utilization, Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong Province, 266101, PR China; Dalian National Laboratory for Clean Energy, Dalian, 116023, PR China. Electronic address:

NH and greenhouse gases emission are big problems during composting, which can cause great nitrogen nutrient loss and environmental pollution. This study investigated effects of the porous bulking agent of oil shale semicoke and its activated material on the gases emission during the continuous thermophilic composting. Results showed addition of semicoke could significantly reduce the NH emission by 74.65% due to its great adsorption capacity to NH-N and NH, further the effect could be enhanced to 85.92% when utilizing the activated semicoke with larger pore volume and specific surface area. In addition, the CH emission in the semicoke and activated semicoke group was also greatly mitigated, with a reduction of 67.23% and 87.62% respectively, while the NO emission was significantly increased by 93.14% and 100.82%. Quantification analysis of the functional genes found the abundance of mcrA was high at the massive CH-producing stage and the archaeal amoA was dominant at the NO-producing stage in all the composting groups. Correlation and redundancy analysis suggested there was a positive correlation between the CH emission and mcrA. Addition of semicoke especially activated semicoke could reduce the CH production by inhibiting the methanogens. For the NH and NO, it was closely related with the nitrification process conducted by archaeal amoA. Addition of semicoke especially activated semicoke was beneficial for the growth of ammonia-oxidizing archaea, causing the less NH-N transformation to NH but more NO emission.
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http://dx.doi.org/10.1016/j.jenvman.2021.112519DOI Listing
April 2021

Effect of a three-piece inflatable penile prosthesis combined with a phosphodiesterase-5 inhibitor on erectile dysfunction.

J Int Med Res 2021 Apr;49(4):300060520985365

Department of Urology, the Second People's Hospital of Nantong City, Nantong City, Jiangsu Province, China.

Objective: To investigate the therapeutic effect of implanting a three-piece inflatable penile prosthesis (IPP) combined with the phosphodiesterase-5 inhibitor sildenafil in severe erectile dysfunction (ED) patients.

Methods: This randomized controlled study included 123 ED patients. Sixty-two patients received the IPP implantation and 61 patients received the IPP implantation and the phosphodiesterase-5 inhibitor sildenafil. Erectile function and sexual life quality were evaluated using the five-item International Index of Erectile Function (IIEF) and modified Sexual Life Quality Questionnaire-Quality of Life domain (mSLQQ-QoL), respectively. Serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, vascular cell adhesion molecule (VCAM)-1, and intercellular adhesion molecule (ICAM)-1 levels were assessed. Kaplan-Meier curves were used to assess the overall IPP survival.

Results: Implantation of the three-piece IPP with sildenafil improved erectile function and sexual life quality, alleviated the inflammatory response, reduced the complication rate, and improved overall IPP survival.

Conclusion: Implantation of the three-piece IPP combined with a phosphodiesterase-5 inhibitor significantly improved clinical outcomes and the prognosis in ED patients.
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http://dx.doi.org/10.1177/0300060520985365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047857PMC
April 2021

Artisan versus Artiflex phakic intraocular lens implantation in the treatment of moderate to high myopia: meta-analysis.

BMC Ophthalmol 2021 Apr 10;21(1):171. Epub 2021 Apr 10.

Department of Ophthalmology, the Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266000, Shandong Province, China.

Background: To compare the postoperative safety, efficacy, predictability, visual quality and biomechanics after implantation of Artisan vs. Artiflex phakic intraocular lenses (PIOLs).

Methods: Pubmed, Embase, Cochrane Library were conducted up from January 2000 to February 2020. Comparative clinical studies reporting in accordance with the eligibility criteria were included in this meta-analysis. The pooled weighted mean differences (WMDs) and odds ratios (ORs) with corresponding 95% confidence intervals were calculated.

Results: Comparative trials with myopia patients were selected in this review. The pooled WMD and OR estimates statistical significance in terms of postoperative best corrected visual acuity (BCVA), efficacy, postoperative spherical equivalence (SE), predictability, contrast sensitivity and mean intraocular higher-order aberrations (HOA) (mm) for a 6-mm pupil, manifesting that Artiflex PIOL showed evident beneficial effect for correcting myopia compared to Artisan PIOL. There was no significant difference in the incidence of complications between the two groups.

Conclusion: Both of two techniques were safe and effective for myopia and compared to Artisan PIOL, Artiflex PIOL had significant improvement in efficacy, predictability, contrast sensitivityand HOA, except safety and complications in the treatment of moderate to high myopia.
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http://dx.doi.org/10.1186/s12886-021-01930-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035774PMC
April 2021

The Effects of Hemodialysis and Peritoneal Dialysis on the Gut Microbiota of End-Stage Renal Disease Patients, and the Relationship Between Gut Microbiota and Patient Prognoses.

Front Cell Infect Microbiol 2021 23;11:579386. Epub 2021 Mar 23.

Department of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Gut microbiota alterations occur in end-stage renal disease (ESRD) patients with or without dialysis. However, it remains unclear whether changes in gut microbiota of dialysis ESRD patients result from dialysis or ESRD, or both. Similarly, there is a dearth of information on the relationship between gut microbiota and ESRD prognoses. We collected fecal samples and tracked clinical outcomes from 73 ESRD patients, including 33 pre-dialysis ESRD patients, 19 peritoneal dialysis (PD) patients, and 21 hemodialysis (HD) patients. 16S rRNA sequencing and bioinformatics tools were used to analyze the gut microbiota of ESRD patients and healthy controls. Gut microbiota diversity was different before and after dialysis. Bacteroidetes were significantly deceased in HD patients. Twelve bacterial genera exhibited statistically significant differences, due to dialysis (all < 0.05, FDR corrected). HD reversed abnormal changes in and in pre-dialysis patients. Functional predictions of microbial communities showed that PD and HD altered signal transduction and metabolic pathways in ESRD patients. Furthermore, and were associated with cardiovascular mortality. , , and were related to peritonitis in PD patients. This study not only demonstrated differences in gut microbiota between pre-dialysis and dialysis ESRD patients, but also firstly proposed gut bacteria may exert an impact on patient prognosis.
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http://dx.doi.org/10.3389/fcimb.2021.579386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021868PMC
March 2021

FGFR leads to sustained activation of STAT3 to mediate resistance to EGFR-TKIs treatment.

Invest New Drugs 2021 Apr 7. Epub 2021 Apr 7.

Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Chinese Ministry of Education, Ocean University of China, Qingdao, 266100, People's Republic of China.

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have led to great advances in the treatment of non-small cell lung cancer (NSCLC), but the emergence of drug resistance severely limits their clinical use. Thus, elucidation of the mechanism underlying resistance to EGFR-TKIs is of great importance. In our study, sustained activation of STAT3 was confirmed to be involved in resistance to EGFR-TKIs, and this resistance occurred regardless of exposure time, EGFR-TKIs type, and even cancer cell type. Mechanistically, the sustained activation of STAT3 was not related to gp130/JAK signalling pathway or HER2/EGFR heterodimer formation, while related to the expression and activation levels of STAT3. Furthermore, FGFR was shown to bind more strongly to STAT3 after gefitinib treatment, and the inhibition of FGFR reduced the phosphorylation of STAT3, thereby counteracting the effects of EGFR-TKIs and resulting in the synergistic inhibition of cancer cell proliferation. Taken together, the FGFR/STAT3 axis mediates the sustained activation of STAT3 upon EGFR-TKI treatment. This finding elucidates a new mechanism underlying drug resistance to EGFR-TKIs that the FGFR/STAT3 axis mediates the sustained activation of STAT3, providing theoretical support for considering the combination of TKIs and FGFR inhibitors in clinical cancer treatment.
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http://dx.doi.org/10.1007/s10637-021-01061-1DOI Listing
April 2021

Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop.

Science 2021 03;371(6536)

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains LinSca-1Mac-1 hematopoietic stem cells derived from the fetal liver. This population includes LinCD122CD49a progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon-γ (IFN-γ) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-γR liver progenitors. Thus, an IFN-γ-dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver.
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http://dx.doi.org/10.1126/science.aba4177DOI Listing
March 2021

Enhanced Nontarget Screening Algorithm Reveals Highly Abundant Chlorinated Azo Dye Compounds in House Dust.

Environ Sci Technol 2021 04 15;55(8):4729-4739. Epub 2021 Mar 15.

Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada.

Humans spend 90% of their time indoors, but the majority of indoor pollutants remain unknown. In this study, a nontarget screening algorithm with reduced false discovery rates was developed to screen indoor pollutants using the Toxic Substances Control Act (TSCA) database. First, a putative lock mass algorithm was developed for post-acquisition calibration of Orbitrap mass spectra to sub-ppm mass accuracy. Then, a one-stop screening algorithm was developed by combining MS spectra, isotopic peaks, retention time prediction, and MS spectra. A sufficient true positive rate (73%) and false discovery rate (5%) were achieved for the screening of halogenated compounds at a score cutoff of 0.28. Above this cutoff, 427 chemicals were detected from 24 house dust samples, including 39 chlorinated compounds. While some identified halogenated compounds (, triclosan) are well known, 18 previously unrecognized chlorinated azo dyes were detected with high abundance as the largest class of chlorinated compounds. Two chlorinated azo dyes were confirmed with authentic standards, but the two most abundant chlorinated azo dyes were missed by the algorithm due to the limited breadth of the TSCA database. These compounds were annotated as chlorinated analogues of Disperse Blue 373 and Disperse Violet 93 using the DIPIC-Frag method. This study revealed the presence of highly abundant chlorinated azo dyes in house dusts, highlighting their potential health risks in the indoor environment.
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http://dx.doi.org/10.1021/acs.est.0c06382DOI Listing
April 2021

Highly Efficient Cool-White Photoluminescence of (Gua)CuI Single Crystals: Formation and Optical Properties.

ACS Appl Mater Interfaces 2021 Mar 14;13(11):13443-13451. Epub 2021 Mar 14.

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Zero-dimensional lead-free organic-inorganic hybrid metal halides have drawn attention as a result of their local metal ion confinement structure and photoelectric properties. Herein, a lead-free compound of (Gua)CuI (Gua = guanidine) with a different metal ion confinement has been discovered, which possesses a unique [CuI] face-sharing tetrahedral dimer structure. First-principles calculation demonstrates the inherent nature of a direct band gap for (Gua)CuI, and its band gap of ∼2.98 eV was determined by experiments. Worthy of note is that (Gua)CuI exhibits a highly efficient cool-white emission peaking at 481 nm, a full-width at half-maximum of 125 nm, a large Stokes shift, and a photoluminescence quantum efficiency of 96%, originating from self-trapped exciton emission. More importantly, (Gua)CuI single crystals have a reversible thermoinduced luminescence characteristic due to a structural transition scaled by the electron-phonon coupling coefficients, which can be converted back and forth between cool-white and yellow color emission by heating or cooling treatment within a short time. In brief, as-synthesized (Gua)CuI shows great potential for application both in single-component white solid-state lighting and sensitive temperature scaling.
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http://dx.doi.org/10.1021/acsami.1c02503DOI Listing
March 2021

Different effects of morning and nocturnal hypertension on target organ damage in chronic kidney disease.

J Clin Hypertens (Greenwich) 2021 May 7;23(5):1051-1059. Epub 2021 Mar 7.

Division of Nephrology, Department of Medicine, The Fifth Affiliated Hospital Sun Yat-sen University, Zhuhai, China.

Both morning hypertension (MH) and nocturnal hypertension (NH) are associated with severe target organ damage in patients with chronic kidney disease (CKD). However, the isolated or combined effects of MH and NH on target organ damage are less well-defined. A cross-sectional study was conducted among 2386 non-dialysis CKD patients with ambulatory blood pressure monitoring. The authors categorized patients into four groups based on the presence or absence of MH and NH. Multivariate logistic analyses were used to evaluate the correlation between hypertension subtypes and target organ damage, including left ventricular hypertrophy (LVH), abnormal carotid intima-media thickness (CIMT), low estimated glomerular filtration rate (eGFR), and albuminuria. The percentages of isolated MH, isolated NH, and combined MH and NH were 2.3%, 24.0%, and 49.3%, respectively. Compared to patients without MH and NH, isolated MH was only related to low eGFR (2.26 [95% confidence interval: 1.00-5.09]) and albuminuria (2.17 [95% CI: 1.03-4.54]). Meanwhile, combined MH and NH group compared to the group without MH and NH had a higher risk of LVH (2.87 [95% CI: 2.01-4.09]), abnormal CIMT (2.01 [95% CI: 1.47-2.75]), low eGFR (3.18 [95% CI: 2.23-4.54]), and albuminuria (1.79 [95% CI: 1.33-2.40]), even in patients without daytime hypertension. The risk of cardiovascular and renal damage was also observed in the isolated NH group. In conclusion, morning hypertension is associated with kidney dysfunction and has combined effects with nocturnal hypertension on cardiovascular damage in chronic kidney disease patients.
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http://dx.doi.org/10.1111/jch.14234DOI Listing
May 2021

Atomic Insights into Ti Doping on the Stability Enhancement of Truncated Octahedron LiMnO Nanoparticles.

Nanomaterials (Basel) 2021 Feb 17;11(2). Epub 2021 Feb 17.

Key Laboratory of Polar Materials and Devices (MOE) and Department of Electronics, East China Normal University, Shanghai 200062, China.

Ti-doped truncated octahedron LiTiMnO nanocomposites were synthesized through a facile hydrothermal treatment and calcination process. By using spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM), the effects of Ti-doping on the structure evolution and stability enhancement of LiMnO are revealed. It is found that truncated octahedrons are easily formed in Ti doping LiMnO material. Structural characterizations reveal that most of the Ti ions are composed into the spinel to form a more stable spinel LiTiMnO phase framework in bulk. However, a portion of Ti ions occupy 8a sites around the {001} plane surface to form a new TiMnO-like structure. The combination of LiTiMnO frameworks in bulk and the TiMnO-like structure at the surface may enhance the stability of the spinel LiMnO. Our findings demonstrate the critical role of Ti doping in the surface chemical and structural evolution of LiMnO and may guide the design principle for viable electrode materials.
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http://dx.doi.org/10.3390/nano11020508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922770PMC
February 2021

Uric acid metabolism in polycystic ovary syndrome.

Clin Chim Acta 2021 Jun 28;517:74-80. Epub 2021 Feb 28.

Department of Emergency, The Central Hospital of Shaoyang, Shaoyang 422000, China. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2021.02.009DOI Listing
June 2021

YAP promotes sorafenib resistance in hepatocellular carcinoma by upregulating survivin.

Cell Oncol (Dordr) 2021 Mar 3. Epub 2021 Mar 3.

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.

Background: Sorafenib is the standard first-line treatment for advanced hepatocellular carcinoma (HCC), but its use is hampered by secondary drug resistance. Yes-associated protein (YAP) is a downstream effector of the Hippo signaling pathway, which is crucial for liver tumorigenesis. As yet, however, the mechanism underlying sorafenib resistance and the role of YAP therein is not fully understood and needs to be explored further.

Methods: Western blotting, flow cytometry and CCK-8 assays were used to assess the role of YAP in HCC sorafenib resistance. Next, qRT-PCR and Western blotting were performed to identify survivin as a YAP downstream effector, and rescue experiments were performed to confirm that YAP induces sorafenib resistance via survivin. Additionally, Western blotting, flow cytometry and in vivo xenograft models were used to evaluate the effect of verteporfin in combination with sorafenib on HCC.

Results: We found that sorafenib enhances YAP nuclear accumulation and activation, thereby promoting sorafenib resistance through inhibiting apoptosis in HCC cells. In addition, we found that survivin acts as a downstream mediator of YAP to resist sorafenib-induced apoptosis. Pharmacological inhibition of YAP by verteporfin increased the sensitivity of HCC cells to sorafenib and reversed sorafenib resistance. Moreover, verteporfin in combination with sorafenib significantly suppressed in vivo HCC tumor growth.

Conclusions: Our data indicate that YAP promotes sorafenib resistance through upregulation of survivin expression in HCC cells. Targeting YAP may be a therapeutic strategy to improve the antitumor effects of sorafenib in HCC.
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http://dx.doi.org/10.1007/s13402-021-00595-zDOI Listing
March 2021

VEGFR2-targeted antibody fused with IFN mut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity.

Acta Pharm Sin B 2021 Feb 19;11(2):420-433. Epub 2020 Sep 19.

Antibody Engineering Laboratory, School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, China.

Although interferon (IFN) and anti-angiogenesis antibodies have shown appropriate clinical benefit in the treatment of malignant cancer, they are deficient in clinical applications. Previously, we described an anti-vascular endothelial growth factor receptor 2 (VEGFR2)-IFN fusion protein named JZA01, which showed increased half-life and reduced side effects compared with IFN, and it was more effective than the anti-VEGFR2 antibody against tumors. However, the affinity of the IFN component of the fusion protein for its receptor-IFNAR1 was decreased. To address this problem, an IFN-mutant fused with anti-VEGFR2 was designed to produce anti-VEGFR2-IFNmut, which was used to target VEGFR2 with enhanced anti-tumor and anti-metastasis efficacy. Anti-VEGFR2-IFNmut specifically inhibited proliferation of tumor cells and promoted apoptosis. In addition, anti-VEGFR2-IFNmut inhibited migration of colorectal cancer cells and invasion by regulating the PI3K-AKT-GSK3-snail signal pathway. Anti-VEGFR2-IFNmut showed superior anti-tumor efficacy with improved tumor microenvironment (TME) by enhancing dendritic cell maturation, dendritic cell activity, and increasing tumor-infiltrating CD8 T cells. Thus, this study provides a novel approach for the treatment of metastatic colorectal cancer, and this design may become a new approach to cancer immunotherapy.
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http://dx.doi.org/10.1016/j.apsb.2020.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893194PMC
February 2021

Computational pharmacology and bioinformatics to explore the potential mechanism of Schisandra against atherosclerosis.

Food Chem Toxicol 2021 Apr 11;150:112058. Epub 2021 Feb 11.

Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, PR China; Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Guilin, 541004, PR China. Electronic address:

The present study uses network pharmacology to study the potential mechanism of Schisandra against atherosclerosis. Drug-disease targets were explored through the traditional Chinese medicine systemic pharmacology network. STRING database and Cytoscape software were employed to construct a component/pathway-target interaction network to screen the key regulatory factors from Schisandra. For cellular, biological and molecular pathways, Gene Ontology (GO) and KEGG pathway analyses were used while the interceptive acquaintances of the pathways was obtained through Metascape database. Initial molecular docking analyses of components from Schisandra pointed the possible interaction of non-muscle myosin ⅡA (NM ⅡA) against atherosclerosis. The screening results from GO and KEGG identified 525 possible targets of 18 active ingredients from Schisandra that further pointed 1451 possible pathways against the pathogenesis of disease whereas 167 targets were further refined based on common/interesting signaling target pathways. Further results of molecular signaling by docking identified very compatible binding between NM IIA and the constituents of Schisandra. Schisandra has a possible target of the serotonergic synapse, neuroactive ligand-receptor interaction and also has close interference in tumor pathways through PTGS2, NOS3, HMOX1 and ESR1. Moreover, it is also concluded that Schisandra has a close association with neuroendocrine, immune-inflammation and oxidative stress. Therefore, it may have the potential of therapeutic utility against atherosclerosis.
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http://dx.doi.org/10.1016/j.fct.2021.112058DOI Listing
April 2021

INF2 p.Arg214Cys mutation in a Chinese family with rapidly progressive renal failure and follow-up of renal transplantation: case report and literature review.

BMC Nephrol 2021 Feb 4;22(1):51. Epub 2021 Feb 4.

Division of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Ave #600, Guangzhou, 510630, China.

Background: Heterozygous mutations in the inverted formin 2 (INF2) gene are related to secondary focal segmental glomerulosclerosis (FSGS), a rare secondary disease associated with rapidly progressive renal failure.

Case Presentation: We report a patient with familial autosomal INF2 mutation manifesting nephritic syndromes and elevated serum creatinine levels. Mutational analysis revealed an autosomal dominant (AD) inheritance pattern and a mutation in exon 4 (p.Arg214Cys) of INF2 as the likely cause, which has not been previously described in an Asian family. The patient progressed to end-stage renal disease (ESRD) and received hemodialysis. His mother had undergone renal transplant 3 years earlier, and his grandmother had carried the p.Arg214Cys mutation for more than 80 years without any sign of renal dysfunction.

Conclusions: This is the first report to identify an association between a familial autosomal dominant INF2 p.Arg214Cys mutation and rapidly progressive renal disease in an Asian family. INF2 mutation analysis should not be restricted to individuals without family history of FSGS, rather it should also be performed on individuals for whom drug-based therapies are not effective. In this case, kidney transplant is an effective alternative.
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http://dx.doi.org/10.1186/s12882-021-02254-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863463PMC
February 2021

Maternal high-fat diet disrupted one-carbon metabolism in offspring, contributing to nonalcoholic fatty liver disease.

Liver Int 2021 Feb 2. Epub 2021 Feb 2.

Department of Nutrition, Texas A&M University, College Station, TX, USA.

Background & Aims: Pregnant women may transmit their metabolic phenotypes to their offspring, enhancing the risk for nonalcoholic fatty liver disease (NAFLD); however, the molecular mechanisms remain unclear.

Methods: Prior to pregnancy female mice were fed either a maternal normal-fat diet (NF-group, "no effectors"), or a maternal high-fat diet (HF-group, "persistent effectors"), or were transitioned from a HF to a NF diet before pregnancy (H9N-group, "effectors removal"), followed by pregnancy and lactation, and then offspring were fed high-fat diets after weaning. Offspring livers were analysed by functional studies, as well as next-generation sequencing for gene expression profiles and DNA methylation changes.

Results: The HF, but not the H9N offspring, displayed glucose intolerance and hepatic steatosis. The HF offspring also displayed a disruption of lipid homeostasis associated with an altered methionine cycle and abnormal one-carbon metabolism that caused DNA hypermethylation and L-carnitine depletion associated with deactivated AMPK signalling and decreased expression of PPAR-α and genes for fatty acid oxidation. These changes were not present in H9N offspring. In addition, we identified maternal HF diet-induced genes involved in one-carbon metabolism that were associated with DNA methylation modifications in HF offspring. Importantly, the DNA methylation modifications and their associated gene expression changes were reversed in H9N offspring livers.

Conclusions: Our results demonstrate for the first time that maternal HF diet disrupted the methionine cycle and one-carbon metabolism in offspring livers which further altered lipid homeostasis. CpG islands of specific genes involved in one-carbon metabolism modified by different maternal diets were identified.
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http://dx.doi.org/10.1111/liv.14811DOI Listing
February 2021

Ion adsorption-induced reversible polarization switching of a van der Waals layered ferroelectric.

Nat Commun 2021 Jan 28;12(1):655. Epub 2021 Jan 28.

Key Laboratory of Polar Materials and Devices (MOE) and Department of Electronics, East China Normal University, Shanghai, 200241, China.

Solid-liquid interface is a key concept of many research fields, enabling numerous physical phenomena and practical applications. For example, electrode-electrolyte interfaces with electric double layers have been widely used in energy storage and regulating physical properties of functional materials. Creating a specific interface allows emergent functionalities and effects. Here, we show the artificial control of ferroelectric-liquid interfacial structures to switch polarization states reversibly in a van der Waals layered ferroelectric CuInPS (CIPS). We discover that upward and downward polarization states can be induced by spontaneous physical adsorption of dodecylbenzenesulphonate anions and N,N-diethyl-N-methyl-N-(2-methoxyethyl)-ammonium cations, respectively, at the ferroelectric-liquid interface. This distinctive approach circumvents the structural damage of CIPS caused by Cu-ion conductivity during electrical switching process. Moreover, the polarized state features super-long retention time (>1 year). The interplay between ferroelectric dipoles and adsorbed organic ions has been studied systematically by comparative experiments and first-principles calculations. Such ion adsorption-induced reversible polarization switching in a van der Waals ferroelectric enriches the functionalities of solid-liquid interfaces, offering opportunities for liquid-controlled two-dimensional ferroelectric-based devices.
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http://dx.doi.org/10.1038/s41467-021-20945-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844287PMC
January 2021

Effect of Diethylene Glycol on the Inkjet Printability of Reactive Dye Solution for Cotton Fabrics.

Langmuir 2021 Feb 19;37(4):1493-1500. Epub 2021 Jan 19.

College of Textiles & Clothing, State Key Laboratory for Bio-fibers and Eco-textiles, Collaborative Innovation Center for Eco-textiles of Shandong Province, 308 Ningxia Road, Qingdao 266071, China.

Digital inkjet printing technology plays an increasingly important role in textile printing. The printing printability of reactive dye inks is the key to improving the quality of printed fabrics. In this study, an eco-friendly and simple method to improve the inkjet printability of reactive dye solutions was proposed. The influence of diethylene glycol on the surface tension, rheology, and dye molecule aggregation properties for three reactive dye solutions was investigated. The jetting performance of dye solutions was explored by observing droplet formation. Moreover, the color performance of printed cotton fabrics, including reactive dye solution penetration, colorimetric values, and color strength, was evaluated. Addition of diethylene glycol could change the aggregation of dye molecules by hydrophobic forces and hydrogen bonds. Diethylene glycol could inhibit formation of satellite droplets by changing the viscosity and surface tension of solutions, which made the pattern printed on cotton fabrics show regular edge sharpness. Furthermore, the dye solutions containing 10% DEG not only satisfied various properties of reactive dye inks but also had the highest color strength and the deepest and brightest colors.
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http://dx.doi.org/10.1021/acs.langmuir.0c03016DOI Listing
February 2021

Suspect and Nontarget Screening Revealed Class-Specific Temporal Trends (2000-2017) of Poly- and Perfluoroalkyl Substances in St. Lawrence Beluga Whales.

Environ Sci Technol 2021 02 14;55(3):1659-1671. Epub 2021 Jan 14.

Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.

The global use of >3000 per- and polyfluoroalkyl substances (PFASs) has given rise to chemical regulatory action. However, limited information exists regarding current and historical emissions for the majority of PFASs under currently implemented regulations. This study employed suspect and nontarget screening to examine the temporal trends of legacy and unregulated PFASs in liver of the endangered beluga whale () population from the St. Lawrence Estuary in Canada collected from 2000 to 2017. A suite of 54 PFASs were tentatively identified, and were grouped into nine structurally distinct classes. Single-hydrogenated perfluoro carboxylic acids (H-PFCAs), single-hydrogenated sulfonamides (H-Sulfonamides), as well as other select sulfonamides were detected for the first time in wildlife. Greater concentrations of the majority of PFASs were determined in newborns and juveniles than in adults, suggesting effective placental and lactational transfer of PFASs. Legacy per- and polyfluoroalkyl acids and perfluorooctane sulfonamide in beluga whale liver were found to significantly decrease in concentration between 2000 and 2017, while unregulated short-chain PFAS alternatives, H-PFCAs, and odd-chain FTCAs were found to increase over time. The implementation of suspect and nontarget screening revealed class-specific temporal trends of PFASs in SLE beluga whales, and supported continuous emissions of unregulated PFASs into the environment.
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http://dx.doi.org/10.1021/acs.est.0c05957DOI Listing
February 2021

Multigene editing: current approaches and beyond.

Brief Bioinform 2021 Jan 11. Epub 2021 Jan 11.

Data Science Institute, University of Technology Sydney, PO Box 123, Ultimo, NSW 2007, Australia.

CRISPR/Cas9 multigene editing is an active and widely studied topic in the fields of biomedicine and biology. It involves a simultaneous participation of multiple single-guide RNAs (sgRNAs) to edit multiple target genes in a way that each gene is edited by one of these sgRNAs. There are possibly numerous sgRNA candidates capable of on-target editing on each of these genes with various efficiencies. Meanwhile, each of these sgRNA candidates may cause unwanted off-target editing at many other genes. Therefore, selection optimization of these multiple sgRNAs is demanded so as to minimize the number of sgRNAs and thus reduce the collective negative effects caused by the off-target editing. This survey reviews wet-laboratory approaches to the implementation of multigene editing and their needs of computational tools for better design. We found that though off-target editing is unavoidable during the gene editing, those disfavored cuttings by some target genes' sgRNAs can potentially become on-target editing sites for some other genes of interests. This off-to-on role conversion is beneficial to optimize the sgRNA selection in multigene editing. We present a preference cutting score to assess those beneficial off-target cutting sites, which have a few mismatches with their host genes' on-target editing sites. These potential sgRNAs can be prioritized for recommendation via ranking their on-target average cutting efficiency, the total off-target site number and their average preference cutting score. We also present case studies on cancer-associated genes to demonstrate tremendous usefulness of the new method.
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http://dx.doi.org/10.1093/bib/bbaa396DOI Listing
January 2021

YAP in pancreatic cancer: oncogenic role and therapeutic strategy.

Theranostics 2021 1;11(4):1753-1762. Epub 2021 Jan 1.

Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC), remains a fatal disease with few efficacious treatments. The Hippo signaling pathway, an evolutionarily conserved signaling module, plays critical roles in tissue homeostasis, organ size control and tumorigenesis. The transcriptional coactivator yes-associated protein (YAP), a major downstream effector of the Hippo pathway, is associated with various human cancers including PDAC. Considering its importance in cancer, YAP is emerging as a promising therapeutic target. In this review, we summarize the current understanding of the oncogenic role and regulatory mechanism of YAP in PDAC, and the potential therapeutic strategies targeting YAP.
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http://dx.doi.org/10.7150/thno.53438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778590PMC
January 2021

Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential.

Biomed Pharmacother 2021 Jan 8;133:111072. Epub 2020 Dec 8.

State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address:

Idiopathic pulmonary fibrosis (IPF) is a progressive pulmonary interstitial inflammatory disease of unknown etiology, and is also a sequela in severe patients with the Coronavirus Disease 2019 (COVID-19). Nintedanib and pirfenidone are the only two known drugs which are conditionally recommended for the treatment of IPF by the FDA. However, these drugs pose some adverse side effects such as nausea and diarrhoea during clinical applications. Therefore, it is of great value and significance to identify effective and safe therapeutic drugs to solve the clinical problems associated with intake of western medicine. As a unique medical treatment, Traditional Chinese Medicine (TCM) has gradually exerted its advantages in the treatment of IPF worldwide through a multi-level and multi-target approach. Further, to overcome the current clinical problems of oral and injectable intakes of TCM, pulmonary drug delivery system (PDDS) could be designed to reduce the systemic metabolism and adverse reactions of the drug and to improve the bioavailability of drugs. Through PubMed, Google Scholar, Web of Science, and CNKI, we retrieved articles published in related fields in recent years, and this paper has summarized twenty-seven Chinese compound prescriptions, ten single TCM, and ten active ingredients for effective prevention and treatment of IPF. We also introduce three kinds of inhaling PDDS, which supports further research of TCM combined with PDDS to treat IPF.
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http://dx.doi.org/10.1016/j.biopha.2020.111072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836923PMC
January 2021

A Multichannel Flexible Optoelectronic Fiber Device for Distributed Implantable Neurological Stimulation and Monitoring.

Small 2021 Jan 29;17(4):e2005925. Epub 2020 Dec 29.

Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China.

Optical fibers made of polymeric materials possess high flexibility that can potentially integrate with flexible electronic devices to realize complex functions in biology and neurology. Here, a multichannel flexible device based on four individually addressable optical fibers transfer-printed with flexible electronic components and controlled by a wireless circuit is developed. The resulting device offers excellent mechanics that is compatible with soft and curvilinear tissues, and excellent diversity through switching different light sources. The combined configuration of optical fibers and flexible electronics allows optical stimulation in selective wavelengths guided by the optical fibers, while conducting distributed, high-throughput biopotential sensing using the flexible microelectrode arrays. The device has been demonstrated in vivo with rats through optical stimulation and simultaneously monitoring of spontaneous/evoked spike signals and local field potentials using 32 microelectrodes in four brain regions. Biocompatibility of the device has been characterized by behavior and immunohistochemistry studies, demonstrating potential applications of the device in long-term animal studies. The techniques to integrate flexible electronics with optical fibers may inspire the development of more flexible optoelectronic devices for sophisticated applications in biomedicine and biology.
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http://dx.doi.org/10.1002/smll.202005925DOI Listing
January 2021

Contemporary impact of circadian symptom-onset patterns of acute ST-Segment elevation myocardial infarction on long-term outcomes after primary percutaneous coronary intervention.

Ann Med 2021 12;53(1):247-256

Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China.

Background: Daytime variation with regard to onset time of ST-elevation myocardial infarction (STEMI) symptoms has been observed. Nevertheless, with the advanced medical therapy, it is not uncertainty if a similar circadian pattern of STEMI symptom onset occurs, as well as its possible impact on clinical outcomes. Few long-term data are available. We assess the impact of circadian symptom-onset patterns of STEMI on major adverse cardiovascular events (MACE) in more contemporary patients treated with primary percutaneous coronary intervention (PPCI).

Methods And Results: A total of 1099 consecutive STEMI patients undergoing PPCI ≤12h from symptom onset during 2013 to 2019 were classified into 4 groups by 6-h intervals according to time-of-day at symptom onset: night (0:00-5:59), morning (6:00-11:59), afternoon (12:00-17:59), and evening (18:00-23:59). Incidence of MACE including cardiovascular death and nonfatal MI during a median follow-up of 48 months was compared among the 4 groups. A morning peak of symptom onset of STEMI was detected during the period 06:00-11:59 ( < .001). Compared with other three 6-h intervals, the incidence of long-term MACE during night onset-time (18.8%, 10.1%, 10.7% and 12.4%,  = .020) was significant higher that was driven by more mortality (13.1%, 6.5%, 7.1%and 7.7%,  = .044). Night symptom-onset STEMI was independently associated with subsequent MACE (hazard ratio = 1.57, 95%CI: 1.09-2.27,  = .017) even after multivariable adjustment.

Conclusions: Circadian variation of STEMI symptom-onset with morning predominance still exists in contemporary practice. Night symptom-onset STEMI was independently associated with increased risk of MACE in Chinese patients treated with PPCI.
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http://dx.doi.org/10.1080/07853890.2020.1863457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877989PMC
December 2021

Identification of with potential roles in metabolic disorders.

Aging (Albany NY) 2020 12 9;13(2):2149-2167. Epub 2020 Dec 9.

Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.

Obesity is characterized by the expansion of adipose tissue which is partially modulated by adipogenesis. In the present study, we identified five differentially expressed genes by incorporating two adipogenesis-related datasets from the GEO database and their correlation with adipogenic markers. However, the role of scavenger receptor class A member 3 () in obesity-related disorders has been rarely reported. We found that expression in old adipose tissue-derived mesenchymal stem cells (Ad-MSCs) was lower than it in young Ad-MSCs. Obese mice caused by deletion of the leptin receptor gene () or by a high-fat diet both showed reduced expression in inguinal white adipose tissue. Moreover, hypermethylation of was observed in patients with type 2 diabetes and atherosclerosis. Data from the CTD database indicated that is a potential target for metabolic diseases. Mechanistically, was predicted as a transcriptional factor of in different databases which is consistent with our further bioinformatics analysis. Collectively, our study suggested that is potentially associated with age-related metabolic dysfunction, which provided new insights into the pathogenesis and treatment of obesity as well as other obesity-associated metabolic complications.
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http://dx.doi.org/10.18632/aging.202228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880357PMC
December 2020

Simultaneous adsorption of Cd and photocatalytic degradation of tris-(2-chloroisopropyl) phosphate (TCPP) by mesoporous TiO.

Chemosphere 2021 Mar 7;267:129238. Epub 2020 Dec 7.

Key Laboratory of Ministry of Education on Pollution Control and Ecosystem Restoration in Industry Clusters, Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling, School of Environment and Energy, South China University of Technology, Guangzhou, 510006, Guangdong, China. Electronic address:

In this work, the prepared mesoporous TiO was employed to eliminate the environmental risk induced by the combined pollution (tris-(2-chloroisopropyl) phosphate (TCPP) and Cd). The prepared material was characterized by X-ray diffraction (XRD), UV-vis diffuse reflectance spectra (UV-DRS), Raman imaging spectrometer (Raman), N adsorption/desorption isotherm and X-ray photoelectron spectroscopy (XPS). In the combined pollution system, the prepared TiO simultaneously exhibited a higher adsorption and photocatalytic activity for Cd and TCPP at neutral condition, respectively. The adsorption of Cd and photo-degradation of TCPP by mesoporous TiO followed pseudo-second-order and pseudo-first-order kinetics model, respectively. The removal efficiency of TCPP was improved from 67% to 100% when the concentration of co-existed Cd increased from 0.5 mg L to 2 mg L, due to the fact that the adsorbed Cd on the surface of TiO scavenged electron and thus inhibited the photo-generated electron-hole pairs recombination. In addition, six degradation intermediates were determined by high resolution mass spectrum (HRMS) and potential transformation pathways of TCPP under the co-existence of Cd were proposed. The results suggested that rapid and high-efficient simultaneous removal of Cd and TCPP was feasible, which laid the basis for the remediation of other combined pollution in the future.
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http://dx.doi.org/10.1016/j.chemosphere.2020.129238DOI Listing
March 2021

Targeted Therapy of -Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy.

Clin Cancer Res 2021 Mar 11;27(5):1438-1451. Epub 2020 Dec 11.

Department of Pathology, School of Medical Sciences, UNSW Sydney, Sydney, New South Wales, Australia.

Purpose: gene rearrangement with transcriptional superenhancers leads to overexpression and neuroblastoma. No targeted therapy is available for clinical trials in patients with -rearranged neuroblastoma.

Experimental Design: Anticancer agents exerting the best synergistic anticancer effects with BET bromodomain inhibitors were identified by screening an FDA-approved oncology drug library. The synergistic effects of the BET bromodomain inhibitor OTX015 and the proteasome inhibitor carfilzomib were examined by immunoblot and flow cytometry analysis. The anticancer efficacy of OTX015 and carfilzomib combination therapy was investigated in mice xenografted with -rearranged neuroblastoma cell lines or patient-derived xenograft (PDX) tumor cells, and the role of TERT reduction in the anticancer efficacy was examined through rescue experiments in mice.

Results: The BET bromodomain protein BRD4 promoted -rearranged neuroblastoma cell proliferation through upregulating TERT expression. Screening of an approved oncology drug library identified the proteasome inhibitor carfilzomib as the agent exerting the best synergistic anticancer effects with BET bromodomain inhibitors including OTX015. OTX015 and carfilzomib synergistically reduced TERT protein expression, induced endoplasmic reticulum stress, and induced -rearranged neuroblastoma cell apoptosis which was blocked by TERT overexpression and endoplasmic reticulum stress antagonists. In mice xenografted with -rearranged neuroblastoma cell lines or PDX tumor cells, OTX015 and carfilzomib synergistically blocked TERT expression, induced tumor cell apoptosis, suppressed tumor progression, and improved mouse survival, which was largely reversed by forced TERT overexpression.

Conclusions: OTX015 and carfilzomib combination therapy is likely to be translated into the first clinical trial of a targeted therapy in patients with -rearranged neuroblastoma.
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http://dx.doi.org/10.1158/1078-0432.CCR-20-3044DOI Listing
March 2021

Antifouling Surfaces Enabled by Surface Grafting of Highly Hydrophilic Sulfoxide Polymer Brushes.

Biomacromolecules 2021 02 11;22(2):330-339. Epub 2020 Dec 11.

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia.

Antifouling surfaces are important in a broad range of applications. An effective approach to antifouling surfaces is to covalently attach antifouling polymer brushes. This work reports the synthesis of a new class of antifouling polymer brushes based on highly hydrophilic sulfoxide polymers by surface-initiated photoinduced electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization. The sulfoxide polymer brushes are able to effectively reduce nonspecific adsorption of proteins and cells, demonstrating remarkable antifouling properties. Given the outstanding antifouling behavior of the sulfoxide polymers and versatility of surface-initiated PET-RAFT technology, this work presents a useful and general approach to engineering various material surfaces with antifouling properties, for potential biomedical applications in areas such as tissue engineering, medical implants, and regenerative medicine.
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http://dx.doi.org/10.1021/acs.biomac.0c01193DOI Listing
February 2021