Publications by authors named "Hui Hua Li"

100Publications

Gallic Acid Attenuates Angiotensin II-Induced Hypertension and Vascular Dysfunction by Inhibiting the Degradation of Endothelial Nitric Oxide Synthase.

Front Pharmacol 2020 22;11:1121. Epub 2020 Jul 22.

Emergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, and Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing, China.

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http://dx.doi.org/10.3389/fphar.2020.01121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396711PMC
July 2020

Selective blocking of CXCR2 prevents and reverses atrial fibrillation in spontaneously hypertensive rats.

J Cell Mol Med 2020 Aug 18. Epub 2020 Aug 18.

Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1111/jcmm.15694DOI Listing
August 2020

Chemokine Receptor CXCR-2 Initiates Atrial Fibrillation by Triggering Monocyte Mobilization in Mice.

Hypertension 2020 Aug 8;76(2):381-392. Epub 2020 Jul 8.

From the Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, China (Y.-L.Z., X.H., F.T., X.Y., P.-B.L., S.-B.G., H.-H.L.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14698DOI Listing
August 2020

Selective Inhibition of the Immunoproteasome β5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy.

Front Pharmacol 2020 12;11:885. Epub 2020 Jun 12.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.

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http://dx.doi.org/10.3389/fphar.2020.00885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303343PMC
June 2020

Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R.

Front Physiol 2020 9;11:625. Epub 2020 Jun 9.

Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.3389/fphys.2020.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296172PMC
June 2020

Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats.

Hypertens Res 2020 Jun 15. Epub 2020 Jun 15.

Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

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http://dx.doi.org/10.1038/s41440-020-0486-1DOI Listing
June 2020

The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor.

Sci Adv 2020 Apr 17;6(16):eaax4826. Epub 2020 Apr 17.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 11600, China.

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http://dx.doi.org/10.1126/sciadv.aax4826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164950PMC
April 2020

Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway.

J Cell Mol Med 2020 Jun 28;24(11):6233-6241. Epub 2020 Apr 28.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1111/jcmm.15257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294125PMC
June 2020

Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice.

J Immunol Res 2020 20;2020:7812709. Epub 2020 Mar 20.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.

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http://dx.doi.org/10.1155/2020/7812709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109586PMC
March 2020

Counting Mitoses With Digital Pathology in Breast Phyllodes Tumors.

Arch Pathol Lab Med 2020 Mar 9. Epub 2020 Mar 9.

From the Department of Anatomical Pathology (Mr Chow, Drs Thike and Tan, and Ms Nasir), Division of Pathology (Drs Yeong and Tan), and Division of Research (Dr Li), Singapore General Hospital, Singapore; the Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (ASTAR), Singapore (Dr Yeong); the Duke-NUS Medical School, Singapore (Drs Thike and Tan); and the University of Tasmania, Tasmania, Australia (Mr Chow).

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http://dx.doi.org/10.5858/arpa.2019-0435-OADOI Listing
March 2020

Four-Year Longitudinal Study of Motor and Non-motor Symptoms in -Related Parkinson's Disease.

Front Neurol 2019 17;10:1379. Epub 2020 Jan 17.

Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.3389/fneur.2019.01379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978710PMC
January 2020

Association of Visceral Adiposity Surrogates with Impaired Fasting Glucose in Nonobese Individuals.

Metab Syndr Relat Disord 2020 04 30;18(3):128-133. Epub 2020 Jan 30.

Hangzhou Aeronautical Sanatorium of Chinese Air Force, Hangzhou, China.

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http://dx.doi.org/10.1089/met.2019.0078DOI Listing
April 2020

Association between cardiovascular risk factors and stage 1 hypertension defined by the 2017 ACC/AHA guidelines.

Clin Exp Hypertens 2020 Aug 18;42(6):483-489. Epub 2020 Jan 18.

Management department, Hangzhou Aeronautical Sanatorium of Chinese Air Force , Hangzhou, China.

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http://dx.doi.org/10.1080/10641963.2020.1714639DOI Listing
August 2020

Body Roundness Index Is Significantly Associated with Prehypertension and Hypertension in Nonobese Chinese Subjects.

Biomed Environ Sci 2019 Nov;32(11):854-859

Thyroid Disease Research Center, Tenth People's Hospital of Tongji University, Shanghai 200072, China; Obesity and Diabetes Center of Naval Medical University, Shanghai 200433, China.

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http://dx.doi.org/10.3967/bes2019.106DOI Listing
November 2019

Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function.

Small 2020 01 26;16(4):e1905925. Epub 2019 Dec 26.

Key Laboratory of Remodeling-Related Cardiovascular Diseases (Ministry of Education), Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, 100029, China.

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http://dx.doi.org/10.1002/smll.201905925DOI Listing
January 2020

Immunoproteasome subunit β5i regulates diet-induced atherosclerosis through altering MERTK-mediated efferocytosis in Apoe knockout mice.

J Pathol 2020 03 14;250(3):275-287. Epub 2020 Jan 14.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, PR China.

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http://dx.doi.org/10.1002/path.5368DOI Listing
March 2020

Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1 monocytes.

Am J Physiol Heart Circ Physiol 2019 12 15;317(6):H1301-H1311. Epub 2019 Nov 15.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian, Medical University, Dalian, China.

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http://dx.doi.org/10.1152/ajpheart.00566.2019DOI Listing
December 2019

Inhibition of UCHL1 by LDN-57444 attenuates Ang II-Induced atrial fibrillation in mice.

Hypertens Res 2020 03 7;43(3):168-177. Epub 2019 Nov 7.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, 116000, China.

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http://dx.doi.org/10.1038/s41440-019-0354-zDOI Listing
March 2020

Resveratrol Attenuates Pressure Overload-Induced Cardiac Fibrosis and Diastolic Dysfunction via PTEN/AKT/Smad2/3 and NF-κB Signaling Pathways.

Mol Nutr Food Res 2019 12 8;63(24):e1900418. Epub 2019 Nov 8.

Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

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http://dx.doi.org/10.1002/mnfr.201900418DOI Listing
December 2019

Ablation of Immunoproteasome β5i Subunit Suppresses Hypertensive Retinopathy by Blocking ATRAP Degradation in Mice.

Mol Ther 2020 01 5;28(1):279-292. Epub 2019 Oct 5.

Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953897PMC
January 2020

Genetic ablation and pharmacological inhibition of immunosubunit β5i attenuates cardiac remodeling in deoxycorticosterone-acetate (DOCA)-salt hypertensive mice.

J Mol Cell Cardiol 2019 12 17;137:34-45. Epub 2019 Oct 17.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116000, China. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.09.010DOI Listing
December 2019

Validation of the ILD-GAP Model and a Local Nomogram in a Singaporean Cohort.

Respiration 2019;98(5):383-390. Epub 2019 Oct 2.

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1159/000502985DOI Listing
September 2020

Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction.

Lab Invest 2020 03 16;100(3):378-386. Epub 2019 Sep 16.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, No.193, Lianhe Road, Xigang District, 116011, Dalian, China.

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http://dx.doi.org/10.1038/s41374-019-0320-zDOI Listing
March 2020

Chronic inhibition of chemokine receptor CXCR2 attenuates cardiac remodeling and dysfunction in spontaneously hypertensive rats.

Biochim Biophys Acta Mol Basis Dis 2019 12 5;1865(12):165551. Epub 2019 Sep 5.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.165551DOI Listing
December 2019

Renal outcomes of intensive care burn patients in an Asian tertiary centre.

Burns 2020 03 23;46(2):400-406. Epub 2019 Aug 23.

Department of Renal Medicine, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1016/j.burns.2019.07.038DOI Listing
March 2020

Alteration of the IL-33-sST2 pathway in hypertensive patients and a mouse model.

Hypertens Res 2019 11 24;42(11):1664-1671. Epub 2019 Jun 24.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.

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http://dx.doi.org/10.1038/s41440-019-0291-xDOI Listing
November 2019

Single-Cell Transcriptomics Reveals Chemotaxis-Mediated Intraorgan Crosstalk During Cardiogenesis.

Circ Res 2019 08 21;125(4):398-410. Epub 2019 Jun 21.

From the Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine (H.X., Y.L., Y.Y., J.Z., S.A., X.L., X.W., X.H., A.H.), Peking University, China.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315243DOI Listing
August 2019

Time Series Gene Expression Profiling and Temporal Regulatory Pathway Analysis of Angiotensin II Induced Atrial Fibrillation in Mice.

Front Physiol 2019 29;10:597. Epub 2019 May 29.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.

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http://dx.doi.org/10.3389/fphys.2019.00597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548816PMC
May 2019

The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.

Sci Adv 2019 05 8;5(5):eaau0495. Epub 2019 May 8.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.

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http://dx.doi.org/10.1126/sciadv.aau0495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506244PMC
May 2019

Rituximab prevents and reverses cardiac remodeling by depressing B cell function in mice.

Biomed Pharmacother 2019 Jun 22;114:108804. Epub 2019 Mar 22.

Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116004, China; Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116000, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07533322193016
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http://dx.doi.org/10.1016/j.biopha.2019.108804DOI Listing
June 2019

Applying the China-PAR Risk Algorithm to Assess 10-year Atherosclerotic Cardiovascular Disease Risk in Populations Receiving Routine Physical Examinations in Eastern China.

Biomed Environ Sci 2019 Feb;32(2):87-95

Obesity and Diabetes Center of Naval Medical University, Shanghai 200433, China.

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http://dx.doi.org/10.3967/bes2019.014DOI Listing
February 2019

MicroRNA-27a regulates angiotensin II-induced vascular smooth muscle cell proliferation and migration by targeting α-smooth muscle-actin in vitro.

Biochem Biophys Res Commun 2019 02 14;509(4):973-977. Epub 2019 Jan 14.

Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, 116044, Dalian, China; Department of Cardiology, Institute of Cardiovascular Diseases, First Affliated Hospital of Dalian Medical University, 116011, Dalian, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.01.047DOI Listing
February 2019

Ablation and Inhibition of the Immunoproteasome Catalytic Subunit LMP7 Attenuate Experimental Abdominal Aortic Aneurysm Formation in Mice.

J Immunol 2019 02 14;202(4):1176-1185. Epub 2019 Jan 14.

Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing 100730, People's Republic of China;

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http://dx.doi.org/10.4049/jimmunol.1800197DOI Listing
February 2019

CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy.

Theranostics 2018 15;8(21):5995-6007. Epub 2018 Nov 15.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.

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http://www.thno.org/v08p5995.htm
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http://dx.doi.org/10.7150/thno.27706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299438PMC
September 2019

Preprodynorphin gene mutation causes progressive cardiac conduction disease: A whole-exome analysis of a pedigree.

Life Sci 2019 Feb 3;219:74-81. Epub 2019 Jan 3.

Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2018.12.062DOI Listing
February 2019

Immunoproteasome Subunit β5i Promotes Ang II (Angiotensin II)-Induced Atrial Fibrillation by Targeting ATRAP (Ang II Type I Receptor-Associated Protein) Degradation in Mice.

Hypertension 2019 01;73(1):92-101

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, China (Q.-Y. L., X.-H.Y., H.-H.L.).

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11813DOI Listing
January 2019

A correlational study between serum asymmetric dimethylarginine level and impaired glucose tolerance patients associated with obesity.

J Cell Physiol 2019 07 7;234(7):10640-10645. Epub 2018 Dec 7.

Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.27743
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http://dx.doi.org/10.1002/jcp.27743DOI Listing
July 2019

Chemokine (C-X-C motif) receptor 2 blockade by SB265610 inhibited angiotensin II-induced abdominal aortic aneurysm in Apo E mice.

Heart Vessels 2019 May 7;34(5):875-882. Epub 2018 Dec 7.

Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing, 100005, People's Republic of China.

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http://dx.doi.org/10.1007/s00380-018-1301-7DOI Listing
May 2019

Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure.

Mol Nutr Food Res 2019 03 27;63(5):e1800807. Epub 2018 Dec 27.

Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian, 116044, China.

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http://doi.wiley.com/10.1002/mnfr.201800807
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http://dx.doi.org/10.1002/mnfr.201800807DOI Listing
March 2019

Asymmetric dimethylarginine targets MAPK pathway to regulate insulin resistance in liver by activating inflammation factors.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://doi.wiley.com/10.1002/jcb.28021
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http://dx.doi.org/10.1002/jcb.28021DOI Listing
December 2018

Association between hyperuricemia and nontraditional adiposity indices.

Clin Rheumatol 2019 Apr 29;38(4):1055-1062. Epub 2018 Nov 29.

Department of Rheumatology, Changhai Hospital, Naval Military Medical University (The Second Military Medical University), Shanghai, China.

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http://dx.doi.org/10.1007/s10067-018-4374-xDOI Listing
April 2019

Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload.

Redox Biol 2019 01 1;20:390-401. Epub 2018 Nov 1.

Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China; Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183093
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http://dx.doi.org/10.1016/j.redox.2018.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226597PMC
January 2019

Administration of ubiquitin-activating enzyme UBA1 inhibitor PYR-41 attenuates angiotensin II-induced cardiac remodeling in mice.

Biochem Biophys Res Commun 2018 10 22;505(1):317-324. Epub 2018 Sep 22.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, 116000, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.09.100DOI Listing
October 2018

Totally-laparoscopic versus laparoscopic-assisted low anterior resection for rectal cancer: are outcomes different?

ANZ J Surg 2018 12 13;88(12):E818-E823. Epub 2018 Sep 13.

Department of Colorectal Surgery, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1111/ans.14841DOI Listing
December 2018

Analysis of Genes Related to Angiotensin II-Induced Arterial Injury Using a Time Series Microarray.

Cell Physiol Biochem 2018 23;48(3):983-992. Epub 2018 Jul 23.

School of Public Health, Dalian Medical University, Dalian, China.

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http://dx.doi.org/10.1159/000491966DOI Listing
September 2018

CD1d-dependent natural killer T cells attenuate angiotensin II-induced cardiac remodelling via IL-10 signalling in mice.

Cardiovasc Res 2019 01;115(1):83-93

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.

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http://dx.doi.org/10.1093/cvr/cvy164DOI Listing
January 2019

Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice.

Cell Physiol Biochem 2018 10;47(1):140-150. Epub 2018 May 10.

Department of Occupational and Environmental Health, School of Public Health, Dalian Medical University, Dalian, China.

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http://dx.doi.org/10.1159/000489757DOI Listing
August 2018

Elevated Circulating Fibrocytes Is a Marker of Left Atrial Fibrosis and Recurrence of Persistent Atrial Fibrillation.

J Am Heart Assoc 2018 03 13;7(6). Epub 2018 Mar 13.

Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China

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http://dx.doi.org/10.1161/JAHA.117.008083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907563PMC
March 2018

CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration.

Eur Heart J 2018 05;39(20):1818-1831

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, No.193, Lianhe Road, Xigang District, Dalian 116011, China.

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http://dx.doi.org/10.1093/eurheartj/ehy085DOI Listing
May 2018

Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.

Hypertension 2018 05 5;71(5):866-876. Epub 2018 Mar 5.

From the Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, China (J.L., X.-L.Y., Y.-L.Z., Y.-Z.Y., H.-H.L.); Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, China (J.B., H.-H.L.); and Department of Ophthalmology (S.W.) and Department of Radiotherapy Oncology (Y.-L.C.), The Second Affiliated Hospital of Dalian Medical University, China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10390DOI Listing
May 2018

The immunoproteasome subunit LMP10 mediates angiotensin II-induced retinopathy in mice.

Redox Biol 2018 06 1;16:129-138. Epub 2018 Mar 1.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 11600, China; School of Public Health, Dalian Medical University, Dalian 116004, China. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952914PMC
June 2018

Angiotensin II Regulates Th1 T Cell Differentiation Through Angiotensin II Type 1 Receptor-PKA-Mediated Activation of Proteasome.

Cell Physiol Biochem 2018 15;45(4):1366-1376. Epub 2018 Feb 15.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.

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http://dx.doi.org/10.1159/000487562DOI Listing
May 2018

Vitamin D attenuates pressure overload-induced cardiac remodeling and dysfunction in mice.

J Steroid Biochem Mol Biol 2018 04 11;178:293-302. Epub 2018 Jan 11.

Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China; Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.01.009DOI Listing
April 2018

The key genes underlying pathophysiology association between the type 2-diabetic and colorectal cancer.

J Cell Physiol 2018 11 15;233(11):8551-8557. Epub 2018 Jun 15.

Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1002/jcp.26440DOI Listing
November 2018

Effects of different storage solutions on renal ischemia tolerance after kidney transplantation in mice.

Am J Physiol Renal Physiol 2018 03 15;314(3):F381-F387. Epub 2017 Nov 15.

Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine , Tampa, Florida.

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http://dx.doi.org/10.1152/ajprenal.00475.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899228PMC
March 2018

Systematic-analysis of mRNA expression profiles in skeletal muscle of patients with type II diabetes: The glucocorticoid was central in pathogenesis.

J Cell Physiol 2018 05 18;233(5):4068-4076. Epub 2017 Dec 18.

Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an, China.

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http://dx.doi.org/10.1002/jcp.26174DOI Listing
May 2018

Angiotensin II Regulates Dendritic Cells through Activation of NF-κB /p65, ERK1/2 and STAT1 Pathways.

Cell Physiol Biochem 2017 19;42(4):1550-1558. Epub 2017 Jul 19.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.

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http://dx.doi.org/10.1159/000479272DOI Listing
October 2017

Physicochemical Properties and Antioxidant Capacity of Chinese Olive (Canarium album L.) Cultivars.

J Food Sci 2017 Jun 11;82(6):1369-1377. Epub 2017 May 11.

College of Horticulture, Fujian Agricultural and Forestry Univ., Fuzhou, 350002, China.

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http://dx.doi.org/10.1111/1750-3841.13740DOI Listing
June 2017

Knockout of immunoproteasome subunit β2i ameliorates cardiac fibrosis and inflammation in DOCA/Salt hypertensive mice.

Biochem Biophys Res Commun 2017 08 4;490(2):84-90. Epub 2017 May 4.

Department of Physiology and Physiopathology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.05.011DOI Listing
August 2017

Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells.

Inflammation 2017 Aug;40(4):1123-1130

Department of Psychiatry and Psychology, Xuzhou Medical University Affiliated Xuzhou Oriental Hospital, No. 379 Tongshan Road, Xuzhou, Jiangsu Province, 221000, China.

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http://dx.doi.org/10.1007/s10753-017-0556-yDOI Listing
August 2017

EGb-761 Attenuates the Anti-proliferative Activity of Fluoride via DDK1 in PC-12 Cells.

Neurochem Res 2017 Feb 25;42(2):606-614. Epub 2016 Nov 25.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

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http://dx.doi.org/10.1007/s11064-016-2115-6DOI Listing
February 2017

Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction.

Circulation 2016 Nov 27;134(18):1353-1368. Epub 2016 Sep 27.

From Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084654PMC
November 2016

Gut microbiota after Roux-en-Y gastric bypass and sleeve gastrectomy in a diabetic rat model: Increased diversity and associations of discriminant genera with metabolic changes.

Diabetes Metab Res Rev 2017 03 8;33(3). Epub 2016 Nov 8.

Department of Endocrinology, Changhai Hospital, the Second Military Medical University, Shanghai, China.

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http://dx.doi.org/10.1002/dmrr.2857DOI Listing
March 2017

Vascular tortuosity in relationship with hypertension and posterior fossa volume in hemifacial spasm.

BMC Neurol 2016 Jul 29;16:120. Epub 2016 Jul 29.

Department of Diagnostic Radiology, Singapore General Hospital, Singapore, 169608, Singapore.

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http://dx.doi.org/10.1186/s12883-016-0634-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966585PMC
July 2016

Susceptibility-weighted MRI of extrapyramidal brain structures in Parkinsonian disorders.

Medicine (Baltimore) 2016 Jun;95(26):e3730

aDepartments of Diagnostic Radiology bClinical Research, Singapore General Hospital cDepartment of Neurology, National Neuroscience Institute dDuke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1097/MD.0000000000003730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937893PMC
June 2016

Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein.

Sci Rep 2016 06 21;6:28399. Epub 2016 Jun 21.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.

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http://dx.doi.org/10.1038/srep28399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914971PMC
June 2016

[Change of Serum Angiopoietin-related Growth Factor in Patients with Abdominal Aortic Aneurysm and Its Clinical Significance].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016 Apr;38(2):150-4

Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

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http://dx.doi.org/10.3881/j.issn.1000-503X.2016.02.005DOI Listing
April 2016

PARK16 is associated with PD in the Malaysian population.

Am J Med Genet B Neuropsychiatr Genet 2016 09 13;171(6):839-47. Epub 2016 May 13.

Department of Neurology, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1002/ajmg.b.32454DOI Listing
September 2016

Revisiting the link between hypertension and hemifacial spasm.

Sci Rep 2016 Feb 19;6:21082. Epub 2016 Feb 19.

Singapore General Hospital, Departments of Diagnostic Radiology and Neurology, National Neuroscience Institute, Singapore, 169608, Singapore.

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http://dx.doi.org/10.1038/srep21082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759578PMC
February 2016

Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system.

Free Radic Biol Med 2016 05 12;94:17-26. Epub 2016 Feb 12.

Department of Cardiology, Beijing Tian Tan Hospital, Capital Medical University, 6 Tiantan Xili, Dongcheng District, Beijing 100050, China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.011DOI Listing
May 2016

NOD2 contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and inflammation.

Life Sci 2016 Mar 10;149:10-7. Epub 2016 Feb 10.

Department of Physiology and Physiopathology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2016.02.039DOI Listing
March 2016

"Angiotensin II memory" contributes to the development of hypertension and vascular injury via activation of NADPH oxidase.

Life Sci 2016 Mar 10;149:18-24. Epub 2016 Feb 10.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing 100069, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2016.02.037DOI Listing
March 2016

Putaminal Diffusivity Correlates With Disease Progression in Parkinson's Disease: Prospective 6-Year Study.

Medicine (Baltimore) 2016 Feb;95(6):e2594

From the Departments of Diagnostic Radiology, Clinical Research and Neurology, Singapore General Hospital (L-LC, K-MN, C-SY, HR, H-HL, E-KT); National Neuroscience Institute (E-KT); and Duke-NUS Medical School, Singapore (L-LC, K-MN, E-KT).

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http://dx.doi.org/10.1097/MD.0000000000002594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753874PMC
February 2016

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.

J Biol Chem 2016 Apr 9;291(15):8070-89. Epub 2015 Dec 9.

the Departments of Biomedical Sciences and Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1074/jbc.M115.701433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825011PMC
April 2016

Folic acid protects against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1.

Sci Rep 2015 Nov 5;5:16093. Epub 2015 Nov 5.

Graduate School of Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/srep16093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633590PMC
November 2015

Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E(-/-) Mice.

Sci Rep 2015 Oct 28;5:15730. Epub 2015 Oct 28.

Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing, PR China.

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http://dx.doi.org/10.1038/srep15730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623715PMC
October 2015

MicroRNA Let-7i negatively regulates cardiac inflammation and fibrosis.

Hypertension 2015 Oct 10;66(4):776-85. Epub 2015 Aug 10.

From the Department of Pathology and Pathophysiology, School of Basic Medical Sciences (X.W., H.-X.W., C.-Y.Z., H.-H.L.) and Beijing AnZhen Hospital, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart Lung and Blood Vessel Diseases (Y.-L.L., C.-C.Z., J.D., H.-H.L.), Capital Medical University, Beijing, China; and Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., Y.-L.X.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05548DOI Listing
October 2015

Sexual dysfunction is associated with postural instability gait difficulty subtype of Parkinson's disease.

J Neurol 2015 Nov 26;262(11):2433-9. Epub 2015 Jul 26.

Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, 169608, Singapore.

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http://dx.doi.org/10.1007/s00415-015-7855-8DOI Listing
November 2015

Gene expression profiling identifies the novel role of immunoproteasome in doxorubicin-induced cardiotoxicity.

Toxicology 2015 Jul 17;333:76-88. Epub 2015 Apr 17.

Department of Physiology and Pathophysiology, Beijing Anzhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100069, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2015.04.009DOI Listing
July 2015

A soluble receptor for advanced glycation end-products inhibits myocardial apoptosis induced by ischemia/reperfusion via the JAK2/STAT3 pathway.

Apoptosis 2015 Aug;20(8):1033-47

Department of Cardiology, Beijing Tian Tan Hospital, Capital Medical University, 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China.

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http://link.springer.com/content/pdf/10.1007/s10495-015-1130
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http://link.springer.com/10.1007/s10495-015-1130-4
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http://dx.doi.org/10.1007/s10495-015-1130-4DOI Listing
August 2015

Combining detection of Notch1 and tumor necrosis factor-α converting enzyme is a reliable biomarker for the diagnosis of abdominal aortic aneurysms.

Life Sci 2015 Apr 2;127:39-45. Epub 2015 Mar 2.

Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2015.02.009DOI Listing
April 2015

Gene expression profile in the early stage of angiotensin II-induced cardiac remodeling: a time series microarray study in a mouse model.

Cell Physiol Biochem 2015 15;35(2):467-76. Epub 2015 Jan 15.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, PR China.

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http://dx.doi.org/10.1159/000369712DOI Listing
October 2015

Activation of NOD1 by DAP contributes to myocardial ischemia/reperfusion injury via multiple signaling pathways.

Apoptosis 2015 Apr;20(4):512-22

Department of Physiology, Pathology and Pathophysiology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, 100069, China.

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http://dx.doi.org/10.1007/s10495-015-1089-1DOI Listing
April 2015

Circulating E3 ligases are novel and sensitive biomarkers for diagnosis of acute myocardial infarction.

Clin Sci (Lond) 2015 Jun;128(11):751-60

*Department of Physiology, Pathology and Pathophysiology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100069, China.

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http://dx.doi.org/10.1042/CS20140663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557400PMC
June 2015

Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-γ ligand 15d-PGJ₂ in macrophages.

Cell Physiol Biochem 2015 28;35(2):689-98. Epub 2015 Jan 28.

Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Beijing AnZhen Hospital, the Key Laboratory of Remodeling-related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing, China.

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http://dx.doi.org/10.1159/000369729DOI Listing
October 2015

Microarray and Co-expression Network Analysis of Genes Associated with Acute Doxorubicin Cardiomyopathy in Mice.

Cardiovasc Toxicol 2015 Oct;15(4):377-93

Department of Physiology and Pathophysiology, Beijing Anzhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, China.

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http://dx.doi.org/10.1007/s12012-014-9306-7DOI Listing
October 2015

Activation of the cardiac proteasome promotes angiotension II-induced hypertrophy by down-regulation of ATRAP.

J Mol Cell Cardiol 2015 Feb 16;79:303-14. Epub 2014 Dec 16.

Department of Physiology and Pathophysiology, AnZhen Hospital, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, China; Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, China. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.12.007DOI Listing
February 2015

Baicalein attenuates angiotensin II-induced cardiac remodeling via inhibition of AKT/mTOR, ERK1/2, NF-κB, and calcineurin signaling pathways in mice.

Am J Hypertens 2015 Apr 31;28(4):518-26. Epub 2014 Oct 31.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China; Center for Prevention and Control of Non-communicable Chronic Diseases, School of Public Health, Dalian Medical University, Dalian, China.

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http://ajh.oxfordjournals.org/content/28/4/518.full.pdf
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http://ajh.oxfordjournals.org/cgi/doi/10.1093/ajh/hpu194
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http://dx.doi.org/10.1093/ajh/hpu194DOI Listing
April 2015

Identification of genes related to the early stage of Angiotensin II-induced acute renal injury by microarray and integrated gene network analysis.

Cell Physiol Biochem 2014 22;34(4):1137-51. Epub 2014 Sep 22.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, PR China.

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http://dx.doi.org/10.1159/000366327DOI Listing
June 2015

Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats.

Toxicol Appl Pharmacol 2014 11 16;281(1):101-8. Epub 2014 Sep 16.

Department of Physiology and Pathophysiology, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2014.09.004DOI Listing
November 2014

AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis.

Apoptosis 2014 Aug;19(8):1254-68

Department of Pathology, Physiology and Pathophysiology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China.

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http://dx.doi.org/10.1007/s10495-014-1001-4DOI Listing
August 2014