Publications by authors named "Hui Gao"

1,016 Publications

  • Page 1 of 1

Rh(III)-Catalyzed and synergistic dual directing group-enabled redox-neutral [3+3] annulation of -phenoxyacetamides with α-allenols.

Chem Commun (Camb) 2021 Sep 14;57(73):9284-9287. Epub 2021 Sep 14.

Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, P. R. China.

By virtue of α-allenols as innovative three-carbon annulation components, the Rh(III)-catalyzed redox-neutral C-H coupling of -phenoxyacetamides with α-allenols has been realized for the assembly of 4-alkylidene chroman-2-ol frameworks an unusual [3+3] annulation. This transformation features good functional group tolerance, specific regio-/chemoselectivity and potential synthetic utility. Mechanistic studies reveal that synergistic coordination modes between the dual directing groups (-ONHAc and -OH) and the rhodium metal center account for the observed exclusive selectivity.
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http://dx.doi.org/10.1039/d1cc03206bDOI Listing
September 2021

Visualization analysis of lecithin in drugs based on electrochemiluminescent single gold microbeads.

J Pharm Anal 2021 Aug 9;11(4):515-522. Epub 2021 Feb 9.

College of Chemistry and Material Science, Huaibei Normal University, Huaibei, 235000, Anhui, China.

Fast and high-throughput determination of drugs is a key trend in clinical medicine. Single particles have increasingly been adopted in a variety of photoanalytical and electroanalytical applications, and microscopic analysis has been a hot topic in recent years, especially for electrochemiluminescence (ECL). This paper describes a simple ECL method based on single gold microbeads to image lecithin. Lecithin reacts to produce hydrogen peroxide under the successive enzymatic reaction of phospholipase D and choline oxidase. ECL was generated by the electrochemical reaction between a luminol analog and hydrogen peroxide, and ECL signals were imaged by a camera. Despite the heterogeneity of single gold microbeads, their luminescence obeyed statistical regularity. The average luminescence of 30 gold microbeads is correlated with the lecithin concentration, and thus, a visualization method for analyzing lecithin was established. Calibration curves were constructed for ECL intensity and lecithin concentration, achieving detection limits of 0.05 mM lecithin. This ECL imaging platform based on single gold microbeads exhibits outstanding advantages, such as high throughput, versatility and low cost, and holds great potential in disease diagnostics, environmental monitoring and food safety.
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http://dx.doi.org/10.1016/j.jpha.2021.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424370PMC
August 2021

Association between phthalate exposure and insulin resistance: a systematic review and meta-analysis update.

Environ Sci Pollut Res Int 2021 Sep 8. Epub 2021 Sep 8.

School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.

An update on systematic review and meta-analysis was performed to explore effects of phthalate exposure on insulin resistance. A systematic literature search was performed in MEDLINE, Web of Science, and CNKI until March 2021. A conceptual framework was constructed to guide the organization and presentation of results. Besides, beta coefficients with corresponding confidence intervals were extracted from the most adjusted models. Extracted beta coefficients were transformed into correlation, and z Fisher transformation of correlation with the corresponding standard error was included in meta-analysis. Subgroup analyses were performed by age (adult vs. adolescent) and sex (female vs. male) of participants and site of study (America and Europe vs. Asia) to explore potential sources of heterogeneity. Nineteen literatures with 12,533 participants reporting on the association of exposure to specific phthalates and insulin resistance were selected. The majority of included studies revealed positive relationships of insulin resistance with different phthalate metabolites exposure. Meta-analyses were performed on 16 studies. Exposure to MnBP, MBzP, MCPP, MEHP, MEOHP, MEHHP, ∑DEHP, and high-molecular weight phthalate (∑HMWP) was associated with the increase of the homeostasis model assessment of insulin resistance (HOMA-IR) index. The results of sensitivity analyses stratified by age, sex, and site of study remained stable, suggesting the robustness of these meta-analyses. Most of heterogeneity in sensitivity analyses decreased to moderate or low degree. Exposure to MnBP, MBzP, MCPP, MEHP, MEOHP, MEHHP, ∑DEHP, and ∑HMWP was associated with the increased risk of HOMA-IR. Age, sex, and site of study might provide limited source of heterogeneity.
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http://dx.doi.org/10.1007/s11356-021-16252-9DOI Listing
September 2021

NEAT1/miR-146a-3p/TrkB/ShcB axis regulates the development and function of chondrocyte.

Cell Cycle 2021 Sep 8:1-21. Epub 2021 Sep 8.

Department of Orthopaedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

The current study aimed to explored the regulatory effect of Tropomyosin-related kinases B (TrkB) in the development and function of chondrocyte. Correlation between clinicopathological characteristics and osteoarthritis (OA) were analyzed. The expressions of TrkA, brain-derived neurotrophic factor (BDNF), TrkB, Src homolog and collagen homolog B (ShcB), and ShcC in OA cartilage tissue and IL-1β-stimulated chondrocytes from normal cartilage were determined by Western blot/qRT-PCR. After manipulating the expressions of TrkA, shTrkB, ShcB, miR-146a-3p and nuclear paraspeckle assembly transcript 1 (NEAT1), the differentiation-related molecules, and apoptosis-related molecules were examined by Western blot/qRT-PCR, and migration, invasion, proliferation, tube formation, and apoptosis rate in IL-1β-stimulated chondrocyte were examined by scratch, Transwell, colony formation, and tube formation, and flow cytometry assays, respectively. Bioinformatics, dual-luciferase and Spearman were used to analyze the binding and correlation of target genes. The findings showed that OA was related to body mass Index (BMI). The expressions of TrkA, TrkB and ShcB and NEAT1 were up-regulated in OA and IL-1β-stimulated chondrocytes, while miR-146a-3p was donwnregulated and was negatively correlated with TrkB or NEAT1. NEAT1 competed with TrkB in chondrocytes for miR-146a-3p binding. ShTrkB reversed the decrease in expressions of differentiation-related molecules, migration, invasion and proliferation, and the increase in ShcB expression and tube formation, of IL-1β-stimulated chondrocytes. Overexpressed ShcB reversed effect of shTrkB on the functions of IL-1β-stimulated chondrocytes. MiR-146a-3p inhibitor reversed effects of shTrkB on the function and apoptosis-related molecules on IL-1β-stimulated chondrocytes, while NEAT1 reversed role of miR-146a-3p. This paper demonstrated that NEAT1/miR-146a-3p/TrkB/ShcB axis regulates the development and function of chondrocyte.
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http://dx.doi.org/10.1080/15384101.2021.1974787DOI Listing
September 2021

Retraction Note: Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation.

Acta Pharmacol Sin 2021 Sep 7. Epub 2021 Sep 7.

Medical College, Qingdao University, Qingdao, 266071, China.

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http://dx.doi.org/10.1038/s41401-021-00731-3DOI Listing
September 2021

Characteristics and mortality in primary Sjögren syndrome-related interstitial lung disease.

Medicine (Baltimore) 2021 Sep;100(35):e26777

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.

Abstract: Aim of the study was to determine the characteristics and prognosis, and to identify the risk factors for mortality in patients with primary Sjögren syndrome (pSS) with interstitial lung disease (pSS-ILD).A total of 1422 patients with SS were screened and 178 patients with pSS-ILD were recruited. The medical records and outcomes were retrospectively reviewed. Overall survival and case control study were performed to explore the predictors of death.Among 178 pSS-ILD patients, 87.1% were women. Mean age was 61.59 ± 11.69-year-old. Median disease duration was 72.0 (24.0, 156.0) months. Nonspecific interstitial pneumonia was the predominant high-resolution computed tomography pattern (44.9%). Impairment in diffusion capacity was the most common abnormality of pulmonary function test (75.8%) and the most severe consequence. Type 1 respiratory failure and hypoxia were observed in 15.0% and 30.0% patients, respectively. Mean survival time after confirmation of pSS-ILD diagnosis was 9.0 (6.8, 13.0) years. The 10-year survival rate for all patients with pSS-ILD was 81.7%. Forty-four (24.7%) of 178 patients died during the follow-up period. The most predominant cause of death was respiratory failure (n = 27). Twenty-seven patients died of ILD and formed study group. The 78 patients who survived formed control group. Age and smoking were risk factors for mortality in patients with pSS-ILD. In addition, severity of ILD, as reflected by high-resolution computed tomography, pulmonary function test, and arterial blood gas, was an independent risk factor. However, inflammation status (erythrocyte sedimentation rate, C-reactive protein) and anti-Sjögren syndrome-related antigen A and anti-Sjögren syndrome-related antigen B were not.ILD is a severe complication of pSS. Age, smoking, and severity of lung involvement are more critical for prognosis rather than inflammation status and autoantibodies.
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http://dx.doi.org/10.1097/MD.0000000000026777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415932PMC
September 2021

Trans-ethnic genome-wide association study of severe COVID-19.

Commun Biol 2021 08 31;4(1):1034. Epub 2021 Aug 31.

College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.

COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of Chinese ancestry. We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. We identified three significant signals outside the well-established 3p21.31 locus: an intronic variant in FOXP4-AS1 (rs1853837, odds ratio OR = 1.28, P = 2.51 × 10, allele frequencies in Chinese/European AF = 0.345/0.105), a frameshift insertion in ABO (rs8176719, OR = 1.19, P = 8.98 × 10, AF = 0.422/0.395) and a Chinese-specific intronic variant in MEF2B (rs74490654, OR = 8.73, P = 1.22 × 10, AF = 0.004/0). These findings highlight an important role of the adaptive immunity and the ABO blood-group system in protection from developing severe COVID-19.
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http://dx.doi.org/10.1038/s42003-021-02549-5DOI Listing
August 2021

Engineering of microbial cells for L-valine production: challenges and opportunities.

Microb Cell Fact 2021 Aug 30;20(1):172. Epub 2021 Aug 30.

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China.

L-valine is an essential amino acid that has wide and expanding applications with a suspected growing market demand. Its applicability ranges from animal feed additive, ingredient in cosmetic and special nutrients in pharmaceutical and agriculture fields. Currently, fermentation with the aid of model organisms, is a major method for the production of L-valine. However, achieving the optimal production has often been limited because of the metabolic imbalance in recombinant strains. In this review, the constrains in L-valine biosynthesis are discussed first. Then, we summarize the current advances in engineering of microbial cell factories that have been developed to address and overcome major challenges in the L-valine production process. Future prospects for enhancing the current L-valine production strategies are also discussed.
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http://dx.doi.org/10.1186/s12934-021-01665-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406616PMC
August 2021

Identification of the anti-fungal drug fenticonazole nitrate as a novel PPARγ-modulating ligand with good therapeutic index: Structure-based screening and biological validation.

Pharmacol Res 2021 Aug 28;173:105860. Epub 2021 Aug 28.

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation & Molecular Target and Clinical Pharmacology, the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China. Electronic address:

In this study, SB-VHTS of the old drug library was conducted to seek for novel PPARγ ligand. In the end, an antifungal drug, FN, was identified in vitro and in vivo as a new and potent PPARγ-modulating ligand to demonstrate significantly anti-diabetic and anti-NAFLD efficacies with minimized side effects induced by PPARγ full agonists TZDs drugs. Further mechanistic investigations revealed that FN showed such desired pharmacological properties mainly through selectively activating the expressions of Adiponectin and GLUT4, effectively promoting the Akt Ser473 phosphorylation, inhibiting the expressions of proinflammatory genes including TNF-α, IL-1β and IL-6 and blocking the PPARγ Ser273 phosphorylation mediated by CDK5 without leading to adipogenesis and increasing the expressions of key adipogenic genes CD36, AP2, LPL, C/EBPα, FASN and PPARγ. Subsequently, a molecular docking study revealed an interesting binding mode between FN and PPARγ LBD including the hydrogen-bonding network among oxygen atom, sulfur atom and nitrogen atom in FN respectively with the PPARγ residues Cys285, Tyr327 and Ser342, which gave proof of concept for the above anti-diabetic action mechanism. Taken together, our findings not only suggest that FN can serve as the new, safe and highly efficacious anti-diabetic and anti-NAFLD agents for clinical use, they can also provide a molecular basis for the future development of PPARγ modulators with a high therapeutic index and the possibility to explore new uses of old drugs for immediate drug discovery.
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http://dx.doi.org/10.1016/j.phrs.2021.105860DOI Listing
August 2021

Estrogen and cerebral small vessel disease.

Chin Med J (Engl) 2021 Jul;134(14):1753-1755

School of Biological Science and Biomedical Engineering, Beihang University, Beijing 100191, China.

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http://dx.doi.org/10.1097/CM9.0000000000001646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318660PMC
July 2021

Blood urea nitrogen, blood urea nitrogen to creatinine ratio and incident stroke: The Dongfeng-Tongji cohort.

Atherosclerosis 2021 Sep 6;333:1-8. Epub 2021 Aug 6.

Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background And Aims: It remains unclear whether extreme levels of blood urea nitrogen (BUN) and BUN to creatinine ratio (BUN/Cr) can increase future risk of stroke. We conducted this study to investigate the associations of BUN and BUN/Cr with incident stroke and its subtypes.

Methods: A total of 26,835 and 26,379 participants with a mean follow-up of 7.9 years were included to investigate the associations of BUN and BUN/Cr with incident stroke, respectively. Cox proportional hazard models were used to evaluate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident stroke and its subtypes.

Results: Compared with participants in the third quintile of BUN, the adjusted HRs (95% CIs) for participants in the lowest quintile were 1.21 (1.04-1.40), 1.41 (1.18-1.68) and 1.36 (0.97-1.91) for total, ischemic and hemorrhagic stroke, respectively; while for those in the highest quintile, the corresponding HRs (95% CIs) were 1.16 (1.01-1.32), 1.30 (1.11-1.53), and 1.24 (0.90-1.71). The associations remained robust when restricting the analyses to participants within clinically normal range of BUN. For BUN/Cr, compared with participants in the third quintile, participants in the lowest quintile had significant higher risks of stroke (HRs [95% CIs] were 1.19 [1.04-1.37], 1.26 [1.07-1.48], and 1.22 [0.90-1.67] for total, ischemic and hemorrhagic stroke).

Conclusions: Both high and low levels of BUN were associated with higher risks of total and ischemic stroke. Low level of BUN/Cr was associated with excess risks of total and ischemic stroke.
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http://dx.doi.org/10.1016/j.atherosclerosis.2021.08.011DOI Listing
September 2021

The Value of Convolutional Neural Network-Based Magnetic Resonance Imaging Image Segmentation Algorithm to Guide Targeted Controlled Release of Doxorubicin Nanopreparation.

Contrast Media Mol Imaging 2021 26;2021:9032017. Epub 2021 Jul 26.

Department of Pharmaceuticals, Affiliated Hospital of Yan'an University, Yan'an 716000, Shaanxi, China.

There was an investigation of the auxiliary role of convolutional neural network- (CNN-) based magnetic resonance imaging (MRI) image segmentation algorithm in MRI image-guided targeted drug therapy of doxorubicin nanomaterials so that the value of drug-controlled release in liver cancer patients was evaluated. In this study, 80 patients with liver cancer were selected as the research objects. It was hoped that the CNN-based MRI image segmentation algorithm could be applied to the guided analysis of MRI images of the targeted controlled release of doxorubicin nanopreparation to analyze the imaging analysis effect of this algorithm on the targeted treatment of liver cancer with doxorubicin nanopreparation. The results of this study showed that the upgraded three-dimensional (3D) CNN-based MRI image segmentation had a better effect compared with the traditional CNN-based MRI image segmentation, with significant improvement in indicators such as accuracy, precision, sensitivity, and specificity, and the differences were all statistically marked ( < 0.05). In the monitoring of the targeted drug therapy of doxorubicin nanopreparation for liver cancer patients, it was found that the MRI images of liver cancer patients processed by 3D CNN-based MRI image segmentation neural algorithm could be observed more intuitively and guided to accurately reach the target of liver cancer. The accuracy of targeted release determination of nanopreparation reached 80 ± 6.25%, which was higher markedly than that of the control group (66.6 ± 5.32%) ( < 0.05). In a word, the MRI image segmentation algorithm based on CNN had good application potential in guiding patients with liver cancer for targeted therapy with doxorubicin nanopreparation, which was worth promoting in the adjuvant treatment of targeted drugs for cancer.
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http://dx.doi.org/10.1155/2021/9032017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331278PMC
July 2021

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin.

Cell Metab 2021 Sep 10;33(9):1869-1882.e6. Epub 2021 Aug 10.

Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden. Electronic address:

The contribution of cellular heterogeneity and architecture to white adipose tissue (WAT) function is poorly understood. Herein, we combined spatially resolved transcriptional profiling with single-cell RNA sequencing and image analyses to map human WAT composition and structure. This identified 18 cell classes with unique propensities to form spatially organized homo- and heterotypic clusters. Of these, three constituted mature adipocytes that were similar in size, but distinct in their spatial arrangements and transcriptional profiles. Based on marker genes, we termed these Adipo, Adipo, and Adipo. We confirmed, in independent datasets, that their respective gene profiles associated differently with both adipocyte and whole-body insulin sensitivity. Corroborating our observations, insulin stimulation in vivo by hyperinsulinemic-euglycemic clamp showed that only Adipo displayed a transcriptional response to insulin. Altogether, by mining this multimodal resource we identify that human WAT is composed of three classes of mature adipocytes, only one of which is insulin responsive.
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http://dx.doi.org/10.1016/j.cmet.2021.07.018DOI Listing
September 2021

[Effects of ARC-hippocampus obestatin neural pathway on gastric motility and gastric emptying in diabetic rats].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2021 May;37(3):230-234

Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao 266071, China.

To investigate the obestatin neural projections from arcuate nucleus (ARC) to hippocampus in diabetic rats, and its effects on gastric motility and gastric emptying of rats. Diabetic model was established by fructose intake combined with streptozotocin injected intraperitoneally in healthy male Wistar rats. Diabetic rats were randomly divided into five groups: control group (NS group), 0.1, 1 and 10 pmol obestatin group, and obestatin + NBI27914 group, with 7 rats in each group. 0.5 μl saline (NS), obestatin (0.1 pmol, 1 pmol, 10 pmol) or the mixture (10 pmol obestatin + 60 pmol NBI27914) was injected into the hippocampus respectively, the gastric motility was recorded immediately after administration, and the gastric emptying was studied 15 min later. ARC-hippocampus obestatin neural pathway and ARC obestatin mRNA expression were compared between normal and diabetic rats with fluorogold (FG) retrograde tracing and immunofluorescence histochemical staining. Compared with normal rats, the number of ARC FG/obestatin double labeled neurons and the expression level of ARC obestatin mRNA were decreased significantly in diabetic rats (<0.05); Obestatin could inhibit gastric motility and gastric emptying in a dose-dependent manner (<0.05~0.01) and the effects of obestatin could be partially blocked by NBI27914, an antagonist of corticotropin releasing factor receptor 1 (CRFR1) (<0.05). Compared with normal rats, the inhibitory effects of obestatin on gastric motility and gastric emptying were significantly decreased in diabetic rats (<0.05). There is an obestatin neural pathway between ARC and hippocampus, which participates in the regulation of gastric motility and gastric emptying in diabetic rats, and CRFR1 signal pathway is involved in this process. The damage of this neural pathway may participate in gastric motility dysfunction in early stage of diabetes.
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http://dx.doi.org/10.12047/j.cjap.6034.2021.010DOI Listing
May 2021

Aliovalent Nickle Substitution and Acidic Modification of Nanowalls Promoted Proton Conductivity in InOF with 1D Helical Channel.

ACS Appl Mater Interfaces 2021 Aug 9;13(32):38289-38295. Epub 2021 Aug 9.

Key Laboratory of Magnetic Molecules & Magnetic Information Materials, Ministry of Education, School of Chemistry & Material Science, Shanxi Normal University, 1 Gongyuan Street, Linfen, Shanxi 041004, P. R. China.

Proton-conductive materials have attracted increasing attention because of their broad explorations in chemical sensors, water electrolysis, fuel cells, and biological systems. Especially, metal-organic frameworks (MOFs) have been demonstrated to be extremely promising candidates as proton-exchange membrane (PEM) fuel cells. Compared with other configurations, MOFs with one-dimensional (1D) channels have the characteristics of enhancing the host-guest interaction and promoting the anisotropic motion of proton carriers in restricted volume, which are beneficial for acquiring rich proton sources and forming successive hydrogen bonds to improve proton conductivity. We are endeavored to screen and find a helical three-dimensional (3D) framework , namely, [In(OH)(BPTC)]·6HO (BPTC = 3,3',5,5'-biphenyl tetracarboxylate), as a typical 1D-channel MOF, which is pristinely grafted with spirally distributed -OH groups on the channel surface. Accompanied by an aliovalent substitution Ni(II) for In(III), isostructural ([Ni(BPTC)(HCOOH)]·3HO) is successfully prepared and massive formic acids are anchored at interior walls, which are interacted with adsorbed water molecules the formation of stronger O-H···O bonds. This interaction between host-guest molecules and dynamics of lattice water has already led to a remarkable conductivity of (σ = 7.86 × 10 S/cm at 328 K under 95% RH). The synergistic effect of the acidic-modified nanowall, contracted volume, and enhanced adsorption of water molecules in the channel contributes to a high conductivity value of 3.41 × 10 S/cm (at 328 K under 95% RH). Moreover, the proton conduction mechanism is further visually presented by molecular dynamic (MD) simulation. In contrast to , aliovalent-substituted and acidic-modified has a stronger host-guest interaction and more abundant hydrogen-bond networks, resulting in shorter proton migration distances and more frequent proton hopping, in agreement with the experimental results.
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http://dx.doi.org/10.1021/acsami.1c09001DOI Listing
August 2021

Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-B and Nrf2 Signaling Pathways.

Oxid Med Cell Longev 2021 28;2021:1622375. Epub 2021 Jul 28.

Department of Clinical Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

() is a probiotic yeast that is widely used to treat gastrointestinal disorders. The present study is aimed to explore the therapeutic effects of on dextran sulfate sodium- (DSS-) induced murine ulcerative colitis (UC) and illustrate the mechanisms of action. C57BL/6 mice were administered (10 and 10 CFU/ml, ) for 3 weeks and then given DSS [2.5% (/)] for one week. Administration of prevented DSS-induced reduction in body weight, diarrhea, bloody feces, decreased colon length, and loss of histological structure. Moreover, protected the intestinal barrier by increasing the levels of tight junction proteins zona occludens-1 and Occludin and exerted immunomodulatory effects in DSS-induced mice. Furthermore, suppressed the colonic inflammation by reducing the levels of Interleukin-1, Interleukin-6, and Tumor necrosis factor alpha and restored myeloperoxidase activity in mice exposed to DSS. also mitigated colonic oxidative damage by increasing the levels of antioxidant enzymes (superoxide dismutase, catalase, and heme oxygenase 1) and glutathione and decreasing malondialdehyde accumulation. Further studies identified that suppressed the nuclear translocation of nuclear factor kappa B (NF-B) p65 subunit by decreasing IK/ levels, while promoted the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in DSS-exposed mice. Collectively, possessed an appreciable therapeutic effect against the experimental mice model of UC. The protective mechanism of may involve inhibition of NF-B-mediated proinflammatory signaling and activation of Nrf2-modulated antioxidant defense in addition to intestinal barrier protective and immunomodulatory effects.
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http://dx.doi.org/10.1155/2021/1622375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342159PMC
July 2021

Prognostic Implications of Immune-Related Gene Pairs Signatures in Bladder Cancer.

J Oncol 2021 26;2021:5345181. Epub 2021 Jul 26.

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.

Compelling evidence indicates that immune function is correlated with the prognosis of bladder cancer (BC). Here, we aimed to develop a clinically translatable immune-related gene pairs (IRGPs) prognostic signature to estimate the overall survival (OS) of bladder cancer. From the 251 prognostic-related IRGPs, 37 prognostic-related IRGPs were identified using LASSO regression. We identified IRGPs with the potential to be prognostic markers. The established risk scores divided BC patients into high and low risk score groups, and the survival analysis showed that risk score was related to OS in the TCGA-training set ( < 0.001; HR = 7.5 [5.3, 10]). ROC curve analysis showed that the AUC for the 1-year, 3-year, and 5-year follow-up was 0.820, 0.883, and 0.879, respectively. The model was verified in the TCGA-testing set and external dataset GSE13507. Multivariate analysis showed that risk score was an independent prognostic predictor in patients with BC. In addition, significant differences were found in gene mutations, copy number variations, and gene expression levels in patients with BC between the high and low risk score groups. Gene set enrichment analysis showed that, in the high-risk score group, multiple immune-related pathways were inhibited, and multiple mesenchymal phenotype-related pathways were activated. Immune infiltration analysis revealed that immune cells associated with poor prognosis of BC were upregulated in the high-risk score group, whereas immune cells associated with a better prognosis of BC were downregulated in the high-risk score group. Other immunoregulatory genes were also differentially expressed between high and low risk score groups. A 37 IRGPs-based risk score signature is presented in this study. This signature can efficiently classify BC patients into high and low risk score groups. This signature can be exploited to select high-risk BC patients for more targeted treatment.
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http://dx.doi.org/10.1155/2021/5345181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331311PMC
July 2021

A mesoporous nanocellulose/sodium alginate/carboxymethyl-chitosan gel beads for efficient adsorption of Cu and Pb.

Int J Biol Macromol 2021 Sep 31;187:922-930. Epub 2021 Jul 31.

School of Forestry and Landscape Architecture, Anhui Agricultural University, Hefei 230036, China. Electronic address:

In this study, a novel mesoporous nanocellulose/sodium alginate (SA)/carboxymethyl-chitosan (CMC) aerogel was fabricated using a simple method. The adsorption of Cu and Pb on the aerogel in aqueous solutions was investigated. The obtained aerogel was characterized using scanning electron microscopy, fourier-transform infrared spectroscopy, transmission microscope, atomic force microscopy and N adsorption-desorption. Furthermore, the fundamental Cu and Pb adsorption behaviours of the mesoporous aerogel, including the effect of pH, adsorption equilibrium and kinetics were investigated. The adsorption isotherms and kinetics of aerogel closely followed the Langmuir model and pseudo-second-order model, respectively, indicating that the adsorption behaviours can be classified as monolayer chemical adsorption. The aerogel exhibited high efficiency for the adsorption of Cu (169.94 mg/g) and Pb (472.59 mg/g). The aerogel maintained a high adsorption capacity for Cu (56 mg/g) and Pb (245 mg/g) after five adsorption-desorption cycles. Therefore, the as-prepared mesoporous aerogel has great potential in wastewater treatment.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.07.181DOI Listing
September 2021

AIEgens for Bacterial Imaging and Ablation.

Adv Healthc Mater 2021 Aug 3:e2100877. Epub 2021 Aug 3.

International Joint Research Laboratory of Nano-Micro Architecture Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.

Accurate and sensitive diagnosis of pathogenic bacterial infection is a fundamental first step for correct bacteria management, helping to avoid the development of drug-resistant bacteria caused by the inappropriate use and overuse of antibiotics. Fluorescence probes as a promising visual tool can help identify pathogens rapidly and reliably. However, rigidly structured traditional fluorescence probes generally suffer from the drawback of aggregation-caused quenching (ACQ) effect, which greatly undermines their advantages with respect to sensitivity. Luminogens with aggregation-induced emission properties, namely AIEgens, can overcome the ACQ effect and certain AIEgen-based materials are capable of generating reactive oxygen species (ROS) in the aggregate states. Hence, they have become powerful tools for imaging and killing bacteria. This review summarizes the recent advances in AIEgens for the diagnosis and treatment of pathogen infections. Special attention has been paid to the molecular design, the application in bacterial imaging and ablation in vitro and in vivo, and the biocompatibility of AIEgens. Finally, the challenges and prospects are discussed in terms of using AIEgens to advance precision therapies for pathogen infections.
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http://dx.doi.org/10.1002/adhm.202100877DOI Listing
August 2021

The effects of early enteral nutrition on the nutritional statuses, gastrointestinal functions, and inflammatory responses of gastrointestinal tumor patients.

Am J Transl Res 2021 15;13(6):6260-6269. Epub 2021 Jun 15.

Clinical Nutrition Division, Wujin Hospital Affiliated With Jiangsu University Changzhou 213017, Jiangsu Province, China.

Objective: This paper was designed to investigate the effects of early enteral nutrition (EEN) on the nutritional statuses, gastrointestinal functions, and inflammatory responses of gastrointestinal tumor patients.

Methods: A total of 194 gastrointestinal tumor patients treated in our hospital from May 2017 to February 2019 were recruited as the study cohort. Among them, 101 patients were administered enteral nutrition (the study group), and 93 patients were administered parenteral nutrition (the control group). The two groups were compared in terms of their nutritional statuses, gastrointestinal functions, inflammatory responses, and other indicators.

Results: On the third day after the operation (postoperative 3 d), the serum albumin (ALB) and prealbumin (PA) levels were significantly reduced in both groups (P>0.05). On the seventh day after the operation (postoperative 7 d), the two nutritional indices increased significantly in both groups (P<0.05), and were significantly higher in the study group (P<0.05). Compared with the control group, the patients in the study group experienced shorter lengths of stay (LOS), earlier first anal exhaust times, and faster intestinal peristalsis recovery times (P<0.05). On the third day after the operations, the high-sensitive C-reactive protein (hs-CRP) and prostaglandin E (PGE) levels were significantly reduced in both groups (P<0.05), and the decrease was significantly greater in the study group (P<0.05). In addition, the CD3, CD4, CD8 and CD4/CD8 levels were significantly reduced in both groups on the third day after the operation (P>0.05). On the seventh day after the operation, the first three immune indices increased significantly in both groups (P<0.05), and they were significantly higher in the study group (P<0.05). The incidences of vomiting, diarrhea, and abdominal distension in the study group were significantly lower than they were in the control group (P<0.05). After the treatment, the patients' quality of life (QOL) was significantly higher in the study group (P<0.05).

Conclusion: For gastrointestinal tumor patients, EEN can improve their gastrointestinal functions, enhance their immune functions, and reduce their expressions of inflammatory cytokines while improving their nutritional statuses and QOL.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290805PMC
June 2021

Associations of Baseline and Changes in Leukocyte Counts with Incident Cardiovascular Events: The Dongfeng-Tongji Cohort Study.

J Atheroscler Thromb 2021 Jul 26. Epub 2021 Jul 26.

Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology.

Aim: The aim of the present study was to investigate the associations of baseline and longitudinal changes in leukocyte counts with incident cardiovascular disease (CVD).

Methods: We conducted a prospective study to investigate the associations of baseline and 5-year changes in leukocyte counts with incident CVD and its subtypes in middle-aged and elderly Chinese. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD using the Cox proportional-hazards models.

Results: In the analyses of baseline total leukocyte count of 26,655 participants, compared with the lowest quartile (<4.71×10/L), participants in the fourth quartile (>6.70×10/L) had 11% higher risk for CVD. Consistent with total leukocyte count, neutrophil count also exhibited a significant positive association with the risk of CVD. In the analyses of 5-year changes in total leukocyte count of 11,594 participants, the changes in leukocyte count were categorized into three groups, i.e., the decreased group (<25%), stable group (25%-75%), and increased group (>75%). Compared with participants in the stable group (-1.18 to 0.44×10/L), participants in the increased group (>0.44×10/L) had 14% higher risk for CVD. We also observed significant positive associations of the changes in neutrophil and monocyte counts with the risk of CVD. Furthermore, the total leukocyte count in the second or third tertile at the first follow-up with a 5-year increase was related to higher CVD risk.

Conclusion: High baseline total leukocyte count and a 5-year increase in total leukocyte count were related to higher CVD risk.
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http://dx.doi.org/10.5551/jat.62970DOI Listing
July 2021

NLRP1 in Bone Marrow Microenvironment Controls Hematopoietic Reconstitution After Transplantation.

Transplant Cell Ther 2021 Jul 21. Epub 2021 Jul 21.

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, China. Electronic address:

Pretreatment before transplantation initiates an inflammatory response. Inflammasomes are key regulators of immune and inflammatory responses, but their role in regulating hematopoiesis is unclear. Our study intended to assess the role and mechanism of nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1) in the bone marrow microenvironment on hematopoiesis regulation. To explore the effects of an absence of NLRP1 on hematopoietic reconstitution, we established a hematopoietic cell transplantation model by infusing bone marrow mononuclear cells of wild-type C57BL/6 mice into either NLRP1 knockout (NLRP1-KO) or wild-type C57BL/6 mice. Using the transplantation model, the role of NLRP1 in the bone marrow microenvironment was determined by flow cytometry, hemacytometry, and hematoxylin and eosin staining. As the major component of the bone marrow microenvironment, mesenchymal stem cells (MSCs) were isolated to analyze the effects of NLRP1 on them by osteogenic and adipogenic induction. Endothelial cells (ECs) were isolated and sorted by magnetic beads. The expression of adhesion molecules and their relationship with nuclear factor kappa B (NF-κB) were measured by immunofluorescence, enzyme-linked immunosorbent assay, and western blot. Finally, the effect of NLRP1-deleted MSCs or ECs on hematopoietic stem and progenitor cells (HSPCs) was examined by establishing co-culture models. Compared with C57BL/6 recipients, reduced inflammatory cell infiltration, decreased levels of proinflammatory cytokines interleukin (IL)-18, IL-1β, IL-6, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ), together with reduced pathological injury of bone marrow, were observed in NLRP1-KO recipients after transplantation. However, increased HSPC engraftment and hematopoietic reconstitution were detected in NLRP1-KO recipients after transplantation. Furthermore, MSCs isolated from NLRP1-KO mice had decreased osteogenic and adipogenic differentiation and increased proliferation and differentiation of HSPCs. The expression of adhesion molecules in ECs from NLRP1-KO mice was increased due to the promotion of nuclear translocation of NF-κB; these adhesion molecules are critical for hematopoietic stem cell homing. Knockout of NLRP1 in the bone marrow microenvironment could significantly relieve bone marrow inflammatory response and promote hematopoietic reconstitution, perhaps by regulating MSCs and ECs, indicating that NLRP1 might be a target for the treatment of delayed hematopoietic and immune recovery in patients after hematopoietic stem cell transplantation.
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http://dx.doi.org/10.1016/j.jtct.2021.07.016DOI Listing
July 2021

Impacts of PBDE-47 exposure before, during and after pregnancy on the maternal gut microbiome and its association with host metabolism.

Ecotoxicol Environ Saf 2021 Oct 17;222:112530. Epub 2021 Jul 17.

Department of Occupational and Environmental Health, MOE Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, China. Electronic address:

Maternal gut microbiota play an important role in the modulation of offspring disease susceptibility and gut microbiota dysbiosis has been proposed as a mechanism through which toxic environmental chemicals exert their adverse impacts on health. The brominated flame retardants polybrominated diphenyl ethers (PBDEs) are developmental toxicants and induce dysbiotic gut microbiota in offspring. Yet, whether and how PBDEs impact the maternal gut microbiota remain unclear. Here, we sought to investigate the effect of 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) exposure from preconception through lactation cessation on maternal gut microbiota and its link to host serum metabolic consequences. Female Sprague-Dawley rats were daily exposed to 10 mg/kg PBDE-47 via oral gavage from ten days before conception until offspring were weaned on postnatal day 21, then maternal fecal and blood samples were collected for microbiome and metabolome analyses by using 16S ribosomal RNA gene sequencing and gas chromatography-mass spectrometry, respectively. Maternal exposure to PBDE-47 showed a distinct profile in gut microbiota compared to control dams, as evidenced by increased Actinobacteria phylum and genera Blautia, Gemella and Phascolarctobacterium, and decreased genera AF12 and Oscillospira. Additionally, global metabolomics analysis identified 26 differential serum metabolites to distinguish PBDE-47 from controls, which were mainly involved in amino acid, lipid, carbohydrate and energy metabolism, further confirmed by pathway analysis. Importantly, the differential serum metabolites are closely correlated with the disturbed gut microbiota in response to PBDE-47. Collectively, our results suggest that maternal gut microbial dysbiosis may serve as a potential mechanism underlying PBDE-47-elicited health hazards to mothers or even offspring.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112530DOI Listing
October 2021

Mechanistic Insights into the Dual Directing Group-Mediated C-H Functionalization/Annulation a Hydroxyl Group-Assisted M-M-M Pathway.

ACS Omega 2021 Jul 1;6(27):17642-17650. Epub 2021 Jul 1.

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation & Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.

The experimental investigations on the catalyst [Cp*Rh(OAc) and Cp*Ir (OAc))]-controlled [3 + 2] and [4 + 2] annulations of oximes with propargyl alcohols have been finished in our previous work and a supposed dual directing group-mediated reaction pathway has been deduced for the chemodivergent product synthesis. However, the detailed interaction modes of the dual directing groups binding with the corresponding metal center to achieve the above observed chemoselectivity remain unclear and even contradict. For instance, the calculational traditional dual direct coupling transition states suggested that both Cp*Rh(OAc)- and Cp*Ir(OAc)-catalyzed reactions would generate five-membered indenamines as the dominant products [3 + 2] annulation. To address this concern, herein, systematic DFT calculations combined with proof-of-concept experiments have been carried out. Accordingly, a novel and more favorable M-M-M reaction mechanism, which involves an unprecedented HOAc together with a hydroxyl group-assisted reaction pathway in which the hydroxyl group acts as double effectors for the formation of M-O coordination and [MeO···H···O(CCH)O···H···O] bonding interactions, was deduced. Taken together, the present results would provide a rational basis for future development of the dual directing group-mediated C-H activation reactions.
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http://dx.doi.org/10.1021/acsomega.1c02183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280669PMC
July 2021

Metabolism-Relevant Molecular Classification Identifies Tumor Immune Microenvironment Characterization and Immunotherapeutic Effect in Cervical Cancer.

Front Mol Biosci 2021 1;8:624951. Epub 2021 Jul 1.

Institude of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou, China.

Cervical cancer (CESC) is a gynecologic malignant tumor associated with high incidence and mortality rates because of its distinctive management complexity. Herein, we characterized the molecular features of CESC based on the metabolic gene expression profile by establishing a novel classification system and a scoring system termed as METAscore. Integrative analysis was performed on human CESC samples from TCGA dataset. Unsupervised clustering of RNA sequencing data on 2,752 formerly described metabolic genes identified three METAclusters. These METAclusters for overall survival time, immune characteristics, metabolic features, transcriptome features, and immunotherapeutic effectiveness existed distinct differences. Then we analyzed 207 DEGs among the three METAclusters and as well identified three geneclusters. Correspondingly, these three geneclusters also differently expressed among the aforementioned features, supporting the reliability of the metabolism-relevant molecular classification. Finally METAscore was constructed which emerged as an independent prognostic biomarker, related to CESC transcriptome features, metabolic features, immune characteristics, and linked to the sensitivity of immunotherapy for individual patient. These findings depicted a new classification and a scoring system in CESC based on the metabolic pattern, thereby furthering the understanding of CESC genetic signatures and aiding in the prediction of the effectiveness to anticancer immunotherapies.
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http://dx.doi.org/10.3389/fmolb.2021.624951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280349PMC
July 2021

Nanocellulose aerogel inserts for quantitative lateral flow immunoassays.

Biosens Bioelectron 2021 Nov 9;192:113491. Epub 2021 Jul 9.

Swiss Center for Electronics and Microtechnology CSEM, Landquart Regional Center, Bahnhofstrasse 1, 7302, Landquart, Switzerland. Electronic address:

The Lateral Flow Immuno Assay (LFIA) is a well-established technique that provides immediate results without high-cost laboratory equipment and technical skills from the users. However, conventional colorimetric LFIA strips suffer from high limits of detection, mainly due to the analysis of a limited sample volume, short reaction time between the target analyte and the conjugation molecules, and a weak optical signal. Thus, LFIAs are mainly employed as a medical diagnostic tool for qualitative and semi/quantitative detection, respectively. We applied a novel cellulose nanofiber (CNF) aerogel material incorporated into LFIA strips to increase the sample flow time, which in turn extends the binding interactions between the analyte of interest and the detection antibody, thus improving the limit of detection (LOD). Compared to a conventional LFIA strip, the longer sample flow time in the aerogel modified LFIA strips improved the LOD for the detection of mouse IgG in a buffer solution by a 1000-fold. The accomplished LOD (0.01 ng/mL) even outperformed specifications of a commercial ELISA kit by a factor of 10, and the CNF aerogel assisted LFIA was successfully applied to detect IgG in human serum with a LOD of 0.72 ng/mL. Next to the improved LOD, the aerogel assisted LFIA could quantify IgG samples in buffer and human serum in the concentration ranges of 0.17 ng/mL - 100 ng/mL (in buffer) and 4.6 ng/mL - 100 ng/mL (in human serum). The presented solution thus poses a unique potential to transform lateral flow assays into highly sensitive, fully quantitative point-of-care diagnostics.
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http://dx.doi.org/10.1016/j.bios.2021.113491DOI Listing
November 2021

Flavor classification and year prediction of Chinese Baijiu by time-resolved fluorescence.

Appl Opt 2021 Jul;60(19):5480-5487

Baijiu is a traditional and popular Chinese liquor with enormous sale potential, which is affected by factors such as flavor and storage time. Chinese Baijiu is a complex and transparent mixture that makes analyzing difficult. The utility of time-resolved fluorescence helped to develop a new method to analyze Baijiu. Forty-two Baijiu samples among six brands with three flavors were prepared, and their fluorescence spectra were analyzed with an excitation light of 374.2 nm. Hexanoic acid and ethyl butyrate were found to have an impact on Baijiu fluorescence. The properties of lifetimes in Baijiu were investigated, and its mechanism was studied by calculations through density function theory. Using parameters of fluorescence lifetimes, Baijiu samples were classified according to their flavors. Additionally, the correlations between fluorescence lifetimes and storage time of Baijiu in Luzhou flavor were obtained, leading to a reliable and efficient method to establish the year forecast model of Chinese Baijiu with a mean error of 2.79 months. It also provides an important reference of the utility of time-resolved fluorescence for quantitative research of multi-component systems.
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http://dx.doi.org/10.1364/AO.424015DOI Listing
July 2021

Snail/HDAC1/2 mediate skeletal growth retardation in fetuses caused by prenatal nicotine exposure.

Toxicology 2021 07 7;459:152847. Epub 2021 Jul 7.

Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 430071, China. Electronic address:

Previous findings have confirmed that prenatal nicotine exposure (PNE) leads to retarded cartilage development in the fetal growth plate. It is characterized by insufficient matrix synthesis and decreased expression of matrix phenotype genes aggrecan (ACAN) and Col2A1 in the fetal growth plate chondrocytes; however, the specific molecular mechanism is yet unclear. This study intends to clarify the specific molecular mechanism of fetal osteochondral retardation caused by PNE through animal and cellular experiments. The present study demonstrated that in male offspring of the PNE group (the pregnant rats were subcutaneously administered nicotine 1.0 mg/kg twice per day (2.0 mg/kg.d) at GD11-20), the cartilage matrix of the fetal growth plate was lightly stained, the collagen was reduced, and expression of the matrix phenotype genes, ACAN and Col2A1, was significantly decreased. It was further found that PNE decreased histone acetylation (H3K9/H3K14) levels in the ACAN and Col2A1 promoter regions. Moreover, the expression of Snail and HDAC1/2 was increased in the PNE group. in vitro, the nicotine treatment at different concentrations elevated the expression of Snail/HDAC1/2 while decreasing the H3K9/H3K14 levels in the ACAN and Col2A1 promoter regions. Snail-siRNA transfection partially abolished the nicotine-induced increase in HDAC1/2 expression and decreased the histone acetylation levels in the ACAN and Col2A1 promoter regions. Trichostatin A (TSA) treatment partially reversed the nicotine-induced changes in downstream parameters. In summary, PNE-induced decreased cartilage matrix synthesis in the fetal growth plate of male offspring is effectuated by Snail/HDAC1/2-mediated decreased H3K9/H3K14 levels in the ACAN and Col2A1 promoter regions.
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http://dx.doi.org/10.1016/j.tox.2021.152847DOI Listing
July 2021

Magnetic sulfur-doped carbons for mercury adsorption.

J Colloid Interface Sci 2021 Dec 24;603:728-737. Epub 2021 Jun 24.

Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK; College of Chemistry and Chemical Engineering, Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Northwest Normal University, Lanzhou 730070, China. Electronic address:

Mercury pollution is a significant threat to the environment and health worldwide. Therefore, effective and low-cost absorbents that are easily scalable are needed for real-world applications. Enlarging the surface area of the materials and doping with heteroatoms are two of the most common strategies to cope with this problem. Sulfur-doped activated carbon synthesized from the carbonization of inverse vulcanized thiopolymers makes it possible to combine both large specific surface area and doping of heteroatoms, resulting in outperformance in mercury uptake against commercial activated carbons. Convenient recovery of mercury absorbents after treatment should be beneficial in mercury collecting and recycling. Therefore, magnetic sulfur-doped carbons (MSCs) were prepared by functionalizing sulfur doped carbons through chemical precipitation with magnetic iron oxides. Besides the characterisations of materials, mercury uptake experiments, such as stactic test, capacity test, impact of solution pH, and mixed ions interferences were performed. These MSCs exhibit high specific surface area (1,329 m/g), high sulfur content (up to 14.8 wt%), porous structure, low cost, and are convenient for retrieval. MSCs are demonstrated high uptake capacity (187 mg g) and efficiency in mercury solution and multifunctional absorption in mixed ions solution, showing their potential to be applied in water purification and environmental remediation.
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http://dx.doi.org/10.1016/j.jcis.2021.06.129DOI Listing
December 2021
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