Hugo J W L Aerts

Hugo J W L Aerts

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Hugo J W L Aerts

Publications by authors named "Hugo J W L Aerts"

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Density and morphology of coronary artery calcium for the prediction of cardiovascular events: insights from the Framingham Heart Study.

Eur Radiol 2019 Nov 2;29(11):6140-6148. Epub 2019 May 2.

Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00330-019-06223-7DOI Listing
November 2019

Distributed radiomics as a signature validation study using the Personal Health Train infrastructure.

Sci Data 2019 10 22;6(1):218. Epub 2019 Oct 22.

Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/s41597-019-0241-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805885PMC
October 2019

Deep Learning to Assess Long-term Mortality From Chest Radiographs.

JAMA Netw Open 2019 Jul 3;2(7):e197416. Epub 2019 Jul 3.

Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.7416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646994PMC
July 2019

Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging.

Clin Cancer Res 2019 Jun 22;25(11):3266-3275. Epub 2019 Apr 22.

Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-2495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548658PMC
June 2019

Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer.

J Am Coll Cardiol 2019 Jun;73(23):2976-2987

Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.03.500DOI Listing
June 2019

Peritumoral radiomics features predict distant metastasis in locally advanced NSCLC.

PLoS One 2018 2;13(11):e0206108. Epub 2018 Nov 2.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206108PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214508PMC
April 2019

Artificial intelligence in cancer imaging: Clinical challenges and applications.

CA Cancer J Clin 2019 Mar 5;69(2):127-157. Epub 2019 Feb 5.

Associate Professor, Departments of Radiation Oncology and Radiology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.3322/caac.21552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403009PMC
March 2019

Vulnerabilities of radiomic signature development: The need for safeguards.

Radiother Oncol 2019 01 8;130:2-9. Epub 2018 Nov 8.

Department of Medical Biophysics, University of Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada; IBBME, University of Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; The Techna Institute for the Advancement of Technology for Health, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.10.027DOI Listing
January 2019

Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats.

Cancer 2018 12 1;124(24):4633-4649. Epub 2018 Nov 1.

Department of Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, Florida.

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http://doi.wiley.com/10.1002/cncr.31630
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http://dx.doi.org/10.1002/cncr.31630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482447PMC
December 2018

Artificial Intelligence in Radiation Oncology Imaging.

Int J Radiat Oncol Biol Phys 2018 11 18;102(4):1159-1161. Epub 2018 Oct 18.

Oregon Health & Science University, Portland, Oregon.

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http://dx.doi.org/10.1016/j.ijrobp.2018.05.070DOI Listing
November 2018

Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study.

PLoS Med 2018 11 30;15(11):e1002711. Epub 2018 Nov 30.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.plos.org/10.1371/journal.pmed.1002711
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http://dx.doi.org/10.1371/journal.pmed.1002711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269088PMC
November 2018

Data Analysis Strategies in Medical Imaging.

Clin Cancer Res 2018 08 26;24(15):3492-3499. Epub 2018 Mar 26.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082690PMC
August 2018

Artificial intelligence in radiology.

Nat Rev Cancer 2018 08;18(8):500-510

Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41568-018-0016-5
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http://dx.doi.org/10.1038/s41568-018-0016-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268174PMC
August 2018

Histopathological Image QTL Discovery of Immune Infiltration Variants.

iScience 2018 Jul 6;5:80-89. Epub 2018 Jul 6.

Center for Cancer Computational Biology and Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, 667 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.isci.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123851PMC
July 2018

Data Science in Radiology: A Path Forward.

Authors:
Hugo J W L Aerts

Clin Cancer Res 2018 02 2;24(3):532-534. Epub 2017 Nov 2.

Harvard Medical School, Dana-Farber Cancer Institute, and Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810958PMC
February 2018

Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Authors:
Christopher Abbosh Nicolai J Birkbak Gareth A Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari John Le Quesne David A Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kirkizlar Thomas B K Watkins Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin Hiley Siow Ming Lee Martin D Forster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Martin Hayward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M Janes Ricky Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Joseph Anne Marie Quinn Phil A Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter Marianne Nicolson Hardy Remmen Keith Kerr Mahendran Chetty Lesley Gomersall Dean A Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash Jason F Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U Akarca John A Hartley Helen L Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltan Szallasi Roland F Schwarz Javier Herrero Aengus Stewart Sergio A Quezada Karl S Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J W L Aerts Allan Hackshaw Jacqui A Shaw Bernhard G Zimmermann Charles Swanton

Nature 2018 02 20;554(7691):264. Epub 2017 Dec 20.

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http://dx.doi.org/10.1038/nature25161DOI Listing
February 2018

Impact of experimental design on PET radiomics in predicting somatic mutation status.

Eur J Radiol 2017 Dec 9;97:8-15. Epub 2017 Oct 9.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA; Department of Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.ejrad.2017.10.009DOI Listing
December 2017

Quantitative imaging biomarkers for risk stratification of patients with recurrent glioblastoma treated with bevacizumab.

Neuro Oncol 2017 Nov;19(12):1688-1697

Departments of Radiation Oncology and Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA; Product Development, Pharma Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA; Department of Radiology, Columbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York, USA.

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http://academic.oup.com/neuro-oncology/article/19/12/1688/38
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http://dx.doi.org/10.1093/neuonc/nox092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716072PMC
November 2017

Computational Radiomics System to Decode the Radiographic Phenotype.

Cancer Res 2017 11;77(21):e104-e107

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-0339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672828PMC
November 2017

Lymph node volume predicts survival but not nodal clearance in Stage IIIA-IIIB NSCLC.

PLoS One 2017 20;12(4):e0174268. Epub 2017 Apr 20.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174268PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398511PMC
September 2017

Application of the 3D slicer chest imaging platform segmentation algorithm for large lung nodule delineation.

PLoS One 2017 8;12(6):e0178944. Epub 2017 Jun 8.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178944PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464594PMC
September 2017

Radiomics strategies for risk assessment of tumour failure in head-and-neck cancer.

Sci Rep 2017 08 31;7(1):10117. Epub 2017 Aug 31.

Department of Radiation Oncology, Physics Division, University of Michigan, 519 W. Williman St, Argus Bldg, Ann Arbor, Michigan, 48103-4943, USA.

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http://dx.doi.org/10.1038/s41598-017-10371-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579274PMC
August 2017

Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer.

Cancer Res 2017 07 31;77(14):3922-3930. Epub 2017 May 31.

Department of Radiation Oncology Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528160PMC
July 2017

Associations between radiologist-defined semantic and automatically computed radiomic features in non-small cell lung cancer.

Sci Rep 2017 06 14;7(1):3519. Epub 2017 Jun 14.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-017-02425-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471260PMC
June 2017

Associations Between Somatic Mutations and Metabolic Imaging Phenotypes in Non-Small Cell Lung Cancer.

J Nucl Med 2017 04 29;58(4):569-576. Epub 2016 Sep 29.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.2967/jnumed.116.181826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373502PMC
April 2017

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Authors:
Christopher Abbosh Nicolai J Birkbak Gareth A Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari John Le Quesne David A Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kirkizlar Thomas B K Watkins Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin Hiley Siow Ming Lee Martin D Forster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Martin Hayward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M Janes Ricky Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Joseph Anne Marie Quinn Phil A Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter Marianne Nicolson Hardy Remmen Keith Kerr Mahendran Chetty Lesley Gomersall Dean A Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash Jason F Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U Akarca John A Hartley Helen L Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltan Szallasi Roland F Schwarz Javier Herrero Aengus Stewart Sergio A Quezada Karl S Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J W L Aerts Allan Hackshaw Jacqui A Shaw Bernhard G Zimmermann Charles Swanton

Nature 2017 04;545(7655):446-451

Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.

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http://dx.doi.org/10.1038/nature22364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812436PMC
April 2017

Imaging biomarker roadmap for cancer studies.

Nat Rev Clin Oncol 2017 03 11;14(3):169-186. Epub 2016 Oct 11.

CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/nrclinonc.2016.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378302PMC
March 2017

Radiomic-Based Pathological Response Prediction from Primary Tumors and Lymph Nodes in NSCLC.

J Thorac Oncol 2017 03 27;12(3):467-476. Epub 2016 Nov 27.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jtho.2016.11.2226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318226PMC
March 2017

The Potential of Radiomic-Based Phenotyping in Precision Medicine: A Review.

Authors:
Hugo J W L Aerts

JAMA Oncol 2016 Dec;2(12):1636-1642

Departments of Radiation Oncology and Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2016.2631DOI Listing
December 2016

Radiologic-pathologic correlation of response to chemoradiation in resectable locally advanced NSCLC.

Lung Cancer 2016 12 14;102:1-8. Epub 2016 Oct 14.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.10.002DOI Listing
December 2016

Safikhani et al. reply.

Nature 2016 11;540(7631):E6-E8

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1038/nature20172DOI Listing
November 2016

Safikhani et al. reply.

Nature 2016 11;540(7631):E11-E12

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.email:

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http://dx.doi.org/10.1038/nature20581DOI Listing
November 2016

Safikhani et al. reply.

Nature 2016 11;540(7631):E2-E4

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1038/nature19839DOI Listing
November 2016

Defining a Radiomic Response Phenotype: A Pilot Study using targeted therapy in NSCLC.

Sci Rep 2016 09 20;6:33860. Epub 2016 Sep 20.

Departments of Radiology Columbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, NY, USA.

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http://dx.doi.org/10.1038/srep33860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028716PMC
September 2016

CT-based radiomic analysis of stereotactic body radiation therapy patients with lung cancer.

Radiother Oncol 2016 08 10;120(2):258-66. Epub 2016 Jun 10.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1016/j.radonc.2016.05.024DOI Listing
August 2016

Imaging-genomics reveals driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma.

BMC Cancer 2016 08 8;16:611. Epub 2016 Aug 8.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12885-016-2659-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977720PMC
August 2016

Assessing the Effects of Software Platforms on Volumetric Segmentation of Glioblastoma.

J Neuroimaging Psychiatry Neurol 2016 20;1(2):64-72. Epub 2016 Jul 20.

Departments of Biomedical Informatics and Neurology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.17756/jnpn.2016-008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870135PMC
July 2016

Applications and limitations of radiomics.

Phys Med Biol 2016 07 8;61(13):R150-66. Epub 2016 Jun 8.

Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1088/0031-9155/61/13/R150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927328PMC
July 2016

Radiomic phenotype features predict pathological response in non-small cell lung cancer.

Radiother Oncol 2016 06 13;119(3):480-6. Epub 2016 Apr 13.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1016/j.radonc.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930885PMC
June 2016

PharmacoGx: an R package for analysis of large pharmacogenomic datasets.

Bioinformatics 2016 04 9;32(8):1244-6. Epub 2015 Dec 9.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btv723DOI Listing
April 2016

Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology.

Front Oncol 2016 30;6:71. Epub 2016 Mar 30.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.3389/fonc.2016.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811956PMC
April 2016

Relationship between the Temporal Changes in Positron-Emission-Tomography-Imaging-Based Textural Features and Pathologic Response and Survival in Esophageal Cancer Patients.

Front Oncol 2016 29;6:72. Epub 2016 Mar 29.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School , Boston MA , USA.

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http://dx.doi.org/10.3389/fonc.2016.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810033PMC
April 2016

Characterization of Conserved Toxicogenomic Responses in Chemically Exposed Hepatocytes across Species and Platforms.

Environ Health Perspect 2016 Mar 14;124(3):313-20. Epub 2015 Jul 14.

Integrative systems biology, Institut de Recherches Cliniques de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1289/ehp.1409157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786983PMC
March 2016

Comparison of texture features derived from static and respiratory-gated PET images in non-small cell lung cancer.

PLoS One 2014 17;9(12):e115510. Epub 2014 Dec 17.

Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115510PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269460PMC
January 2016

Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma.

PLoS One 2015 4;10(3):e0118261. Epub 2015 Mar 4.

Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America; Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118261PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349806PMC
January 2016

External validation of a prognostic CT-based radiomic signature in oropharyngeal squamous cell carcinoma.

Acta Oncol 2015 12;54(9):1423-9. Epub 2015 Aug 12.

a Department of Radiation Oncology (MAASTRO) , GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC+) , Maastricht , The Netherlands.

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http://dx.doi.org/10.3109/0284186X.2015.1061214DOI Listing
January 2016

Use of registration-based contour propagation in texture analysis for esophageal cancer pathologic response prediction.

Phys Med Biol 2016 Jan 7;61(2):906-22. Epub 2016 Jan 7.

Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1088/0031-9155/61/2/906DOI Listing
January 2016

Somatic mutations associated with MRI-derived volumetric features in glioblastoma.

Neuroradiology 2015 Dec 4;57(12):1227-37. Epub 2015 Sep 4.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s00234-015-1576-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648958PMC
December 2015

Radiomic Machine-Learning Classifiers for Prognostic Biomarkers of Head and Neck Cancer.

Front Oncol 2015 3;5:272. Epub 2015 Dec 3.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA ; Department of Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA ; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute , Boston, MA , USA.

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http://dx.doi.org/10.3389/fonc.2015.00272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668290PMC
December 2015

Fully automatic GBM segmentation in the TCGA-GBM dataset: Prognosis and correlation with VASARI features.

Sci Rep 2015 Nov 18;5:16822. Epub 2015 Nov 18.

Departments of Radiation Oncology and Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/srep16822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649540PMC
November 2015

The effect of SUV discretization in quantitative FDG-PET Radiomics: the need for standardized methodology in tumor texture analysis.

Sci Rep 2015 Aug 5;5:11075. Epub 2015 Aug 5.

Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.

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http://dx.doi.org/10.1038/srep11075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525145PMC
August 2015

Radiomic feature clusters and prognostic signatures specific for Lung and Head & Neck cancer.

Sci Rep 2015 Jun 5;5:11044. Epub 2015 Jun 5.

1] Departments of Radiation Oncology [2] Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [3] Department of Biostatistics &Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/srep11044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937496PMC
June 2015

diXa: a data infrastructure for chemical safety assessment.

Bioinformatics 2015 May 12;31(9):1505-7. Epub 2014 Dec 12.

Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, 02215, MA, USA, European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, Department of Bioinformatics - BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, Genedata AG, CH-4053 Basel, Switzerland, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and European Commission, Joint Research Centre, 21027 Ispra VA, Italy.

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http://dx.doi.org/10.1093/bioinformatics/btu827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410652PMC
May 2015

Robust Radiomics feature quantification using semiautomatic volumetric segmentation.

PLoS One 2014 15;9(7):e102107. Epub 2014 Jul 15.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Department of Radiation Oncology (MAASTRO), Maastricht University, Maastricht, The Netherlands; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102107PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098900PMC
March 2015

CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma.

Radiother Oncol 2015 Mar 4;114(3):345-50. Epub 2015 Mar 4.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Radiation Oncology (MAASTRO), GROW Research Institute, Maastricht University, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2015.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400248PMC
March 2015

Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging.

Radiother Oncol 2014 Dec 24;113(3):324-30. Epub 2014 Oct 24.

Department of Radiation Oncology (MAASTRO), Research Institute GROW, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2014.09.005DOI Listing
December 2014

Sensitivity study of voxel-based PET image comparison to image registration algorithms.

Med Phys 2014 Nov;41(11):111714

Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1118/1.4898125DOI Listing
November 2014

Enhancing reproducibility in cancer drug screening: how do we move forward?

Cancer Res 2014 Aug 11;74(15):4016-23. Epub 2014 Jul 11.

Princess Margaret Cancer Centre, University Health Network; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119520PMC
August 2014

Importance of collection in gene set enrichment analysis of drug response in cancer cell lines.

Sci Rep 2014 Feb 13;4:4092. Epub 2014 Feb 13.

1] Bioinformatics and Computational Genomics Laboratory, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec, Canada [2] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/srep04092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923229PMC
February 2014

Inconsistency in large pharmacogenomic studies.

Nature 2013 Dec 27;504(7480):389-93. Epub 2013 Nov 27.

1] Department of Biostatistics and Computational Biology and Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [3].

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http://dx.doi.org/10.1038/nature12831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237165PMC
December 2013

Volumetric CT-based segmentation of NSCLC using 3D-Slicer.

Sci Rep 2013 Dec 18;3:3529. Epub 2013 Dec 18.

1] Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Radiation Oncology (MAASTRO), GROW Research Institute, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1038/srep03529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866632PMC
December 2013

Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability.

Acta Oncol 2013 Oct 9;52(7):1391-7. Epub 2013 Sep 9.

Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center (MUMC+) , Maastricht , The Netherlands.

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http://dx.doi.org/10.3109/0284186X.2013.812798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533992PMC
October 2013

Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer.

Acta Oncol 2013 Oct 9;52(7):1398-404. Epub 2013 Sep 9.

Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center (MUMC +) , Maastricht , the Netherlands.

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http://dx.doi.org/10.3109/0284186X.2013.812795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464799PMC
October 2013

Comparison and validation of genomic predictors for anticancer drug sensitivity.

J Am Med Inform Assoc 2013 Jul-Aug;20(4):597-602. Epub 2013 Jan 26.

Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montréal, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1136/amiajnl-2012-001442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721163PMC
September 2013

Predicting outcomes in radiation oncology--multifactorial decision support systems.

Nat Rev Clin Oncol 2013 Jan 20;10(1):27-40. Epub 2012 Nov 20.

Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, 6229 ET, The Netherlands.

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http://dx.doi.org/10.1038/nrclinonc.2012.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555846PMC
January 2013

Repeated positron emission tomography-computed tomography and perfusion-computed tomography imaging in rectal cancer: fluorodeoxyglucose uptake corresponds with tumor perfusion.

Int J Radiat Oncol Biol Phys 2012 Feb 9;82(2):849-55. Epub 2011 Mar 9.

Department of Radiation Oncology, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.ijrobp.2010.10.029DOI Listing
February 2012

Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: a prospective validation.

Lung Cancer 2012 Jan 22;75(1):73-6. Epub 2011 Jul 22.

Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.lungcan.2011.06.003DOI Listing
January 2012

The precision of pharmacokinetic parameters in dynamic contrast-enhanced magnetic resonance imaging: the effect of sampling frequency and duration.

Phys Med Biol 2011 Sep 10;56(17):5665-78. Epub 2011 Aug 10.

Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1088/0031-9155/56/17/013DOI Listing
September 2011

FDG for dose painting: a rational choice.

Radiother Oncol 2010 Nov 17;97(2):163-4. Epub 2010 Jun 17.

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http://dx.doi.org/10.1016/j.radonc.2010.05.001DOI Listing
November 2010

Prediction of residual metabolic activity after treatment in NSCLC patients.

Acta Oncol 2010 Oct;49(7):1033-9

Department of Radiation Oncology (MAASTRO), GROW- School for Oncology and Developmental Biology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

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http://dx.doi.org/10.3109/0284186X.2010.498441DOI Listing
October 2010

PET imaging of hypoxia using [18F]HX4: a phase I trial.

Eur J Nucl Med Mol Imaging 2010 Aug 6;37(9):1663-8. Epub 2010 Apr 6.

Department of Radiation Oncology (Maastro Clinic), GROW-School of Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s00259-010-1437-xDOI Listing
August 2010

Accurate prediction of pathological rectal tumor response after two weeks of preoperative radiochemotherapy using (18)F-fluorodeoxyglucose-positron emission tomography-computed tomography imaging.

Int J Radiat Oncol Biol Phys 2010 Jun 29;77(2):392-9. Epub 2009 Jul 29.

Department of Radiation Oncology (MAASTRO), GROW Research Institute, University Medical Centre Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.ijrobp.2009.04.030DOI Listing
June 2010

Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in rectal cancer.

Int J Radiat Oncol Biol Phys 2010 Jun 3;77(2):400-8. Epub 2009 Sep 3.

Department of Radiation Oncology, Maastricht University Medical Center, GROW School for Oncology and Developmental Biology, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.ijrobp.2009.05.015DOI Listing
June 2010

Tumor perfusion increases during hypofractionated short-course radiotherapy in rectal cancer: sequential perfusion-CT findings.

Radiother Oncol 2010 Feb 18;94(2):156-60. Epub 2010 Jan 18.

Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2009.12.013DOI Listing
February 2010