Hugo J Bellen

Hugo J Bellen

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Hugo J Bellen

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Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.

Am J Hum Genet 2019 Nov 10;105(5):907-920. Epub 2019 Oct 10.

Department of Genetic Medicine and Development, University of Geneva, 1211 Geneva, Switzerland; Service of Genetic Medicine, University Hospitals of Geneva, 1205 Geneva, Switzerland; iGE3 Institute of Genetics and Genomics of Geneva, 1211 Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848997PMC
November 2019

Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.

Dev Cell 2019 Nov 14. Epub 2019 Nov 14.

Howard Hughes Medical Institute, BCM, Houston, TX 77030, USA; Department of Molecular and Human Genetics, BCM, Houston, TX 77030, USA; Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; MD/PhD Medical Scientist Training Program and MHG Graduate program, BCM, Houston, TX 77030, USA; Program in Developmental Biology, BCM, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.10.009DOI Listing
November 2019

La CaSSA da Drosophila: A Versatile Expansion of the Tool Box.

Neuron 2019 Oct;104(2):177-179

Department of Molecular and Human Genetics, BCM, Houston, TX, USA; Neurological Research Institute, TCH, Houston, TX, USA; Department of Neuroscience, BCM, Houston, TX, USA; Howard Hughes Medical Institute, BCM, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.10.004DOI Listing
October 2019

Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes.

Autophagy 2019 Aug 28;15(8):1467-1469. Epub 2019 Apr 28.

b Program in Developmental Biology , Baylor College of Medicine (BCM) , Houston , TX , USA.

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http://dx.doi.org/10.1080/15548627.2019.1609863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613899PMC
August 2019

cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.

Cell Rep 2019 Aug;28(7):1799-1813.e5

Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703184PMC
August 2019

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information.

J Vis Exp 2019 Aug 15(150). Epub 2019 Aug 15.

Program in Developmental Biology, Baylor College of Medicine; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital; Department of Molecular and Human Genetics, Baylor College of Medicine; Department of Neuroscience, Baylor College of Medicine;

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http://dx.doi.org/10.3791/59542DOI Listing
August 2019

The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases.

Hum Mol Genet 2019 Jun 22. Epub 2019 Jun 22.

Department of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/hmg/ddz135DOI Listing
June 2019

Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.

Nat Cell Biol 2019 03 25;21(3):384-396. Epub 2019 Feb 25.

Program in Developmental Biology, Baylor College of Medicine (BCM), Houston, TX, USA.

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http://dx.doi.org/10.1038/s41556-019-0281-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534127PMC
March 2019

Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism.

Trends Endocrinol Metab 2019 02 6;30(2):106-117. Epub 2018 Dec 6.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2018.11.003DOI Listing
February 2019

Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.

Neuron 2018 12 19;100(6):1369-1384.e6. Epub 2018 Nov 19.

Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.11.001DOI Listing
December 2018

Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.

Neuron 2018 12 19;100(6):1385-1400.e6. Epub 2018 Nov 19.

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309224PMC
December 2018

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.

N Engl J Med 2018 11 10;379(22):2131-2139. Epub 2018 Oct 10.

From Harvard Medical School (K.S., C.E., I.S.K., J.L., A.T.M., D.A.S.), Brigham and Women's Hospital (J.L.), and Massachusetts General Hospital (D.A.S.) - all in Boston; the National Institutes of Health Clinical Center (D.R.A., W.A.G., J.J.M., C.J.T.) and the National Human Genome Research Institute (A.L.W.), Bethesda, and the University of Maryland, College Park (A.M.C.-J., B.K., L.P.) - all in Maryland; Baylor College of Medicine, Houston (C.A.B., H.J.B., C.M.E., B.H.L., X.L., M.F.W., S.Y.); Stanford University, Stanford (J.A.B., C.R., M.T.W., E.A.A.), and the University of California, Los Angeles, Los Angeles (S.F.N., C.G.S.P.) - both in California; Vanderbilt University, Nashville (R.H., J.A.P.); HudsonAlpha Institute for Biotechnology, Huntsville, AL (H.J.J., E.A.W.); Oregon Health and Science University, Portland (D.M.K.); the Pacific Northwest National Laboratory, Richland, WA (T.O.M.); the University of Oregon, Eugene (J.H.P., M.W.); and Duke University, Durham, NC (V.S., N.M.W.).

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http://www.nejm.org/doi/10.1056/NEJMoa1714458
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http://dx.doi.org/10.1056/NEJMoa1714458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481166PMC
November 2018

Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain.

Cell Metab 2018 10 14;28(4):605-618.e6. Epub 2018 Jun 14.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.05.019DOI Listing
October 2018

Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile Cataracts.

Am J Hum Genet 2018 10;103(4):568-578

Department of Genetic Medicine and Development, University of Geneva, Geneva 1211, Switzerland; Service of Genetic Medicine, University Hospitals of Geneva, Geneva 1205, Switzerland; iGE3 Institute of Genetics and Genomics of Geneva, Geneva 1211, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183031
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http://dx.doi.org/10.1016/j.ajhg.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174361PMC
October 2018

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Cell 2018 07;174(3):505-520

Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247911PMC
July 2018

Genetic strategies to tackle neurological diseases in fruit flies.

Curr Opin Neurobiol 2018 06 9;50:24-32. Epub 2017 Nov 9.

Program in Developmental Biology, Baylor College of Medicine (BCM), Houston, TX 77030, USA; Department of Molecular and Human Genetics, BCM, Houston TX 77030, USA; Department of Neuroscience, BCM, Houston TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston TX 77030, USA; Howard Hughes Medical Institute, BCM, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2017.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940587PMC
June 2018

Using to study mechanisms of hereditary hearing loss.

Dis Model Mech 2018 05 31;11(6). Epub 2018 May 31.

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA

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http://dx.doi.org/10.1242/dmm.031492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031363PMC
May 2018

The expanding neurological phenotype of DNM1L-related disorders.

Brain 2018 04;141(4):e28

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX 77030, USA.

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http://dx.doi.org/10.1093/brain/awy024DOI Listing
April 2018

Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.

Dev Cell 2018 04;45(2):226-244.e8

Program in Developmental Biology, Baylor College of Medicine (BCM), Houston, TX 77030, USA; Department of Molecular and Human Genetics, BCM, Houston, TX 77030, USA; Howard Hughes Medical Institute, BCM, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital (TCH), Houston, TX 77030, USA; Department of Neuroscience, BCM, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920516PMC
April 2018

A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.

Elife 2018 02 23;7. Epub 2018 Feb 23.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.

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http://dx.doi.org/10.7554/eLife.33007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825208PMC
February 2018

Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model.

Brain Res 2018 01 5;1679:155-170. Epub 2017 Dec 5.

Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.11.029DOI Listing
January 2018

The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.

Cell Rep 2017 12;21(13):3794-3806

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747319PMC
December 2017

The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.

Cell Metab 2017 Nov 28;26(5):719-737.e6. Epub 2017 Sep 28.

Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677551PMC
November 2017

Building dialogues between clinical and biomedical research through cross-species collaborations.

Semin Cell Dev Biol 2017 10 1;70:49-57. Epub 2017 Jun 1.

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, United States; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, United States; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, United States; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2017.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623622PMC
October 2017

Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in .

Genetics 2017 10;207(2):389-412

Developmental Biology Institute of Marseille (IBDM), UMR 7288, CNRS, Aix-Marseille Université, 13288, France

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http://dx.doi.org/10.1534/genetics.117.199968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629313PMC
October 2017

MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome.

Am J Hum Genet 2017 Jun 11;100(6):843-853. Epub 2017 May 11.

Program in Developmental Biology, Baylor College of Medicine (BCM), Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, BCM, Houston, TX 77030, USA; Howard Hughes Medical Institute, BCM, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670038PMC
June 2017

Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages.

Cell Host Microbe 2017 Jun 1;21(6):719-730.e6. Epub 2017 Jun 1.

Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA; Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Cell and Regulatory Biology, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Graduate Program in Neuroscience, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540652PMC
June 2017

A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3.

Am J Hum Genet 2017 Jan 22;100(1):128-137. Epub 2016 Dec 22.

Undiagnosed Diseases Program, NIH Common Fund, Office of the Director, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA; Office of the Clinical Director, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223093PMC
January 2017

Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration.

Neuron 2017 Jan 22;93(1):115-131. Epub 2016 Dec 22.

Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.11.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242142PMC
January 2017

Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals.

Elife 2016 11 30;5. Epub 2016 Nov 30.

Program in Developmental Biology, Baylor College of Medicine, Houston, United States.

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http://dx.doi.org/10.7554/eLife.20732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130293PMC
November 2016

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

PLoS Biol 2016 06 2;14(6):e1002472. Epub 2016 Jun 2.

Linda and Jack Gill Center, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1002472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890852PMC
June 2016

FlyVar: a database for genetic variation in Drosophila melanogaster.

Database (Oxford) 2015 19;2015. Epub 2015 Aug 19.

Human Genome Sequencing Center, Department of Molecular and Human Genetics, and

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http://dx.doi.org/10.1093/database/bav079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541374PMC
May 2016

Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila.

Hum Mol Genet 2016 05 29;25(9):1846-56. Epub 2016 Feb 29.

Department of Molecular and Human Genetics, Neurological Research Institute, Texas Children Hospital, Houston, TX 77030, USA

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http://dx.doi.org/10.1093/hmg/ddw059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007591PMC
May 2016

Drosophila tools and assays for the study of human diseases.

Dis Model Mech 2016 Mar;9(3):235-44

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA

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http://dx.doi.org/10.1242/dmm.023762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833332PMC
March 2016

WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.

Dev Cell 2016 Jan;36(2):139-51

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730548PMC
January 2016

Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila.

Cell 2015 Dec;163(7):1756-69

Department of Biological Chemistry, HHMI, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804707PMC
December 2015

Morgan's legacy: fruit flies and the functional annotation of conserved genes.

Cell 2015 Sep;163(1):12-4

Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.cell.2015.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783153PMC
September 2015

Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.

PLoS Biol 2015 Jul 15;13(7):e1002197. Epub 2015 Jul 15.

Department of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas, United States of America; Howard Hughes Medical Institute, BCM, Houston, Texas, United States of America; Program in Developmental Biology, BCM, Houston, Texas, United States of America; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital (TCH), Houston, Texas, United States of America; Department of Neuroscience, BCM, Houston, Texas, United States of America.

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https://dx.plos.org/10.1371/journal.pbio.1002197
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http://dx.doi.org/10.1371/journal.pbio.1002197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503542PMC
July 2015

The retromer complex in development and disease.

Development 2015 Jul;142(14):2392-6

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA

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http://dx.doi.org/10.1242/dev.123737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510866PMC
July 2015

A genetic toolkit for tagging intronic MiMIC containing genes.

Elife 2015 Jun 23;4. Epub 2015 Jun 23.

Howard Hughes Medical Institute, Baylor College of Medicine, Houston, United States.

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http://dx.doi.org/10.7554/eLife.08469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499919PMC
June 2015

Introduction to Notch signaling.

Methods Mol Biol 2014 ;1187:1-14

Department of Molecular and Human Genetics, Program in Developmental Biology, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA,

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http://link.springer.com/10.1007/978-1-4939-1139-4_1
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http://dx.doi.org/10.1007/978-1-4939-1139-4_1DOI Listing
March 2015

Preface. Notch signaling.

Methods Mol Biol 2014 ;1187

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March 2015

Fruit flies in biomedical research.

Genetics 2015 Mar 26;199(3):639-53. Epub 2015 Jan 26.

Department of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030 Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030 Program in Developmental Biology, Baylor College of Medicine (BCM), Texas 77030 Department of Neuroscience, Baylor College of Medicine (BCM), Texas 77030 Howard Hughes Medical Institute, Houston, Texas 77030

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http://dx.doi.org/10.1534/genetics.114.171785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349060PMC
March 2015

Huntingtin functions as a scaffold for selective macroautophagy.

Nat Cell Biol 2015 Mar 16;17(3):262-75. Epub 2015 Feb 16.

1] The Brown Foundation Institute of Molecular Medicine, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston (UTHealth), 1825 Pressler Street Houston, Texas 77030, USA [2] Programs in Human and Molecular Genetics and Neuroscience, The University of Texas Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston (UTHealth), 1825 Pressler Street Houston, Texas 77030, USA [3] Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston (UTHealth), 1825 Pressler Street Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncb3101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344873PMC
March 2015

Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration.

Cell 2015 Jan;160(1-2):177-90

Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Structural and Computational Biology & Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377295PMC
January 2015

A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.

Neuron 2014 Nov 30;84(4):764-77. Epub 2014 Oct 30.

Department of Integrative Biology and Pharmacology, University of Texas School of Medicine, 6431 Fannin Street, Houston, TX 77030, USA; Graduate Program in Developmental Biology, Baylor College of Medicine, 1250 Moursund Street, Suite N1125.14, Mailstop NR-1125, Houston, TX 77030, USA; Graduate Programs in Cell and Regulatory Biology (CRB) and Neuroscience, Graduate School of Biomedical Sciences, University of Texas School of Medicine, Houston, TX 77030. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254599PMC
November 2014

Large-scale identification of chemically induced mutations in Drosophila melanogaster.

Genome Res 2014 Oct;24(10):1707-18

Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA; Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas 77030, USA; Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA

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http://dx.doi.org/10.1101/gr.174615.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199363PMC
October 2014

Survival of the fittest tools.

Authors:
Hugo J Bellen

Genetics 2014 Oct;198(2):427-8

Program in Developmental Biology, Department of Molecular and Human Genetics, Department of Neuroscience, Jan and Dan Duncan Neurological Research Institute at Texas Children Hospital, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030.

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http://dx.doi.org/10.1534/genetics.114.169110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196594PMC
October 2014

A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases.

Cell 2014 Sep;159(1):200-214

Program in Developmental Biology, Baylor College of Medicine (BCM), Houston, TX 77030, USA; Department of Molecular and Human Genetics, BCM, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Houston, TX 77030, USA; Howard Hughes Medical Institute, Houston, TX 77030, USA; Program in Structural and Computational Biology and Molecular Biophysics, BCM, Houston, TX 77030, USA; Department of Neuroscience, BCM, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298142PMC
September 2014

Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases.

Curr Opin Neurobiol 2014 Aug 22;27:158-64. Epub 2014 Apr 22.

Program in Developmental Biology, Baylor College of Medicine (BCM), Houston, TX 77030, USA; Department of Molecular and Human Genetics, BCM, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, BCM, Houston, TX 77030, USA; Howard Hughes Medical Institute, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2014.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122633PMC
August 2014

Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster.

Methods 2014 Jun 28;68(1):15-28. Epub 2014 Feb 28.

Program in Developmental Biology, Departments of Molecular and Human Genetics, Department of Neuroscience, Howard Hughes Medical Institute, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2014.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061744PMC
June 2014

The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control.

Hum Mol Genet 2014 Apr 23;23(8):1975-89. Epub 2013 Nov 23.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4 Canada.

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http://dx.doi.org/10.1093/hmg/ddt594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959812PMC
April 2014

The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.

PLoS Biol 2014 Apr 29;12(4):e1001847. Epub 2014 Apr 29.

Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America; Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas, United States of America; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas, United States of America; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America; Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America; Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004542PMC
April 2014

Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.

PLoS One 2013 25;8(7):e70502. Epub 2013 Jul 25.

Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723691PMC
March 2014

VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.

PLoS Genet 2013 5;9(9):e1003738. Epub 2013 Sep 5.

Department of Cell, Developmental, and Integrative Biology, University of Alabama School of Medicine, Birmingham, Alabama, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764199PMC
March 2014

Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.

PLoS Biol 2014 Jan 28;12(1):e1001777. Epub 2014 Jan 28.

Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America ; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas, United States of America ; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America ; Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America ; Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904817PMC
January 2014

NMNATs, evolutionarily conserved neuronal maintenance factors.

Trends Neurosci 2013 Nov 20;36(11):632-40. Epub 2013 Aug 20.

The Cain Foundation Laboratories, Texas Children's Hospital, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2013.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857727PMC
November 2013

Rhodopsin homeostasis and retinal degeneration: lessons from the fly.

Trends Neurosci 2013 Nov 5;36(11):652-60. Epub 2013 Sep 5.

Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1016/j.tins.2013.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955215PMC
November 2013

Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition.

J Cell Sci 2013 Aug 20;126(Pt 16):3686-96. Epub 2013 Jun 20.

Department of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1242/jcs.126292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744027PMC
August 2013

The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit.

J Cell Biol 2013 Mar;200(6):807-20

Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1083/jcb.201208033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601355PMC
March 2013

The dynamin-binding domains of Dap160/intersectin affect bulk membrane retrieval in synapses.

J Cell Sci 2013 Feb 15;126(Pt 4):1021-31. Epub 2013 Jan 15.

Department of Neuroscience, DBRM, Karolinska Institutet, von Eulers väg 3, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1242/jcs.118968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067270PMC
February 2013

Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission.

J Neurosci 2012 Nov;32(45):16018-30

Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7545, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1685-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508708PMC
November 2012

An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells.

G3 (Bethesda) 2012 Sep 1;2(9):1095-102. Epub 2012 Sep 1.

Department of Biology, University of Szeged, H-6720 Szeged, Hungary.

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http://dx.doi.org/10.1534/g3.112.002899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429924PMC
September 2012