Hugh S Markus

Hugh S Markus

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Hugh S Markus

Hugh S Markus

Publications by authors named "Hugh S Markus"

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Inflammation and cerebral small vessel disease: A systematic review.

Ageing Res Rev 2019 Aug 10;53:100916. Epub 2019 Jun 10.

Department of Psychiatry, University of Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2019.100916DOI Listing
August 2019

Do Cerebral Small Vessel Disease and Multiple Sclerosis Share Common Mechanisms of White Matter Injury?

Stroke 2019 Aug 21;50(8):1968-1972. Epub 2019 Jun 21.

From the Department of Clinical Neurosciences (R.B.B., M.T., S.S., H.S.M.), University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1161/STROKEAHA.118.023649DOI Listing
August 2019

Genetic Liability to Insomnia and Cardiovascular Disease Risk.

Circulation 2019 Aug 19. Epub 2019 Aug 19.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041830DOI Listing
August 2019

Vertebral artery stenting to prevent recurrent stroke in symptomatic vertebral artery stenosis: the VIST RCT.

Health Technol Assess 2019 Aug;23(41):1-30

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.3310/hta23410DOI Listing
August 2019

Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer's Disease? A Systematic Review and Meta-Analysis.

J Alzheimers Dis 2018 ;64(2):657-668

Stroke Research Group, Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.3233/JAD-180288DOI Listing
July 2019

Framingham vascular age is associated with worse cognitive performance in the middle-aged and elderly.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Jul 27;26(4):531-540. Epub 2018 Jul 27.

b Department of Clinical Neurosciences , University of Cambridge, Addenbrookes Biomedical Campus , Cambridge , UK.

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http://dx.doi.org/10.1080/13825585.2018.1499866DOI Listing
July 2019

Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis.

Lancet Neurol 2019 Jul 23;18(7):666-673. Epub 2019 May 23.

Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, Netherlands.

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http://dx.doi.org/10.1016/S1474-4422(19)30149-8DOI Listing
July 2019

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2019 Jul;51(7):1192-1193

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-019-0449-0DOI Listing
July 2019

Memory decline in elderly with cerebral small vessel disease explained by temporal interactions between white matter hyperintensities and hippocampal atrophy.

Hippocampus 2019 Jun 23;29(6):500-510. Epub 2018 Nov 23.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Donders Center for Medical Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1002/hipo.23039
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http://dx.doi.org/10.1002/hipo.23039DOI Listing
June 2019

Interpreting CT perfusion in stroke.

Pract Neurol 2019 Apr 13;19(2):136-142. Epub 2018 Nov 13.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1136/practneurol-2018-001917DOI Listing
April 2019

Homocysteine and small vessel stroke: A mendelian randomization analysis.

Ann Neurol 2019 Apr 11;85(4):495-501. Epub 2019 Mar 11.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/ana.25440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594149PMC
April 2019

Telemedicine for Follow-Up of Rare Neurological Disease.

Stroke 2019 Mar;50(3):750-753

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023779
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http://dx.doi.org/10.1161/STROKEAHA.118.023779DOI Listing
March 2019

Genetics of Vascular Cognitive Impairment.

Stroke 2019 Mar;50(3):765-772

Department of Neurology, Medical University of Graz, Austria (R.S.).

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http://dx.doi.org/10.1161/STROKEAHA.118.020379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420146PMC
March 2019

Apathy is associated with large-scale white matter network disruption in small vessel disease.

Neurology 2019 Mar 8;92(11):e1157-e1167. Epub 2019 Feb 8.

From the Department of Clinical Neurosciences (J.T., M.J.H., R.L.B., D.J.T., H.S.M.), University of Cambridge, UK; Department of Neurology (A.M.T., F.-E.d.L.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Neuroscience Research Centre (T.R.B.), Molecular and Clinical Sciences Research Institute, St. George's University of London; and Nuffield Department of Clinical Neurosciences (M.H.), University of Oxford, UK.

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http://dx.doi.org/10.1212/WNL.0000000000007095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511108PMC
March 2019

A comparison of functional and tractography based networks in cerebral small vessel disease.

Neuroimage Clin 2018 8;18:425-432. Epub 2018 Feb 8.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1016/j.nicl.2018.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849860PMC
February 2019

Encephalopathy in a Large Cohort of British Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients.

Stroke 2019 Feb;50(2):283-290

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (A.M.D., R.Y.Y.T., J.T., M.T., H.S.M.).

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http://dx.doi.org/10.1161/STROKEAHA.118.023661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358181PMC
February 2019

Genetic variation in is associated with white matter hyperintensities (n = 11,226).

Neurology 2019 02 18;92(8):e749-e757. Epub 2019 Jan 18.

From the Department of Clinical Neurosciences, Stroke Research Group (M.T., D.J.T., I.D.C., D.M.L.F., A.O.O., L.R.-J., H.S.M.), University of Cambridge, UK; Department of Cerebrovascular Diseases (G.B.), Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan, Italy; Institute for Stroke and Dementia Research (M.D.), Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich; German Center for Neurodegenerative Diseases (DZNE) and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany; Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND) (R.L.), KU Leuven-University of Leuven; Department of Neurology (R.L.), University Hospitals Leuven; Laboratory of Neurobiology (R.L.), VIB Center for Brain and Disease Research, Leuven, Belgium; Center for Human Genetic Research (J.R.) and Division of Neurocritical Care and Emergency Neurology (J.R.) and J. Philip Kistler Stroke Research Center (J.R., N.S.R.), Department of Neurology, Massachusetts General Hospital, Boston; Nuffield Department of Clinical Neurosciences (Clinical Neurology), Stroke Prevention Research Unit (P.M.R.), University of Oxford; Centre for Clinical Brain Sciences and Institute for Genetics and Molecular Medicine (C.L.M.S.), University of Edinburgh, UK; Stroke Division, Florey Institute of Neuroscience and Mental Health (V.T.), University of Melbourne; and Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396967PMC
February 2019

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

Neurology 2019 Feb 25;92(9):e944-e950. Epub 2019 Jan 25.

From the Unit of Cardiovascular and Nutritional Epidemiology (S.C.L.), Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Stroke Research Group, Department of Clinical Neurosciences (M.T., H.S.M.), MRC Biostatistics Unit (S.B.), and Department of Public Health and Primary Care (S.B.), University of Cambridge, UK; Department of Cerebrovascular Diseases (G.B.B.), Fondazione IRCCS-Istituto Neurologico Carlo Besta, Milano, Italy; Department of Clinical Pathology and Genetics (C.J.), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg; and Department of Surgical Sciences (K.M.), Uppsala University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000007001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404465PMC
February 2019

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jan;76(1):81-94

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.

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https://jamanetwork.com/journals/jamaneurology/fullarticle/2
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http://dx.doi.org/10.1001/jamaneurol.2018.3122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439887PMC
January 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Genome-wide meta-analysis identifies 3 novel loci associated with stroke.

Ann Neurol 2018 12 30;84(6):934-939. Epub 2018 Nov 30.

Institute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

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http://doi.wiley.com/10.1002/ana.25369
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http://dx.doi.org/10.1002/ana.25369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644297PMC
December 2018

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Authors:
Nora Franceschini Claudia Giambartolomei Paul S de Vries Chris Finan Joshua C Bis Rachael P Huntley Ruth C Lovering Salman M Tajuddin Thomas W Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V Smith Edith Hofer Elisabeth M van Leeuwen Ilja M Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K Joshi Raymond Noordam Riccardo E Marioni Shih-Jen Hwang Solomon K Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B Zonderman Albert Hofman Alexander Teumer Amanda J Cox André G Uitterlinden Andrew Wong Andries J Smit Anne B Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W Penninx Carl D Langefeld Christina L Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H O'Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S Markus Ian J Deary J Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D Taylor Klodian Dhana Lambertus A L M Kiemeney Lars Lind Laura M Raffield Lenore J Launer Lesca M Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A Nalls Olle Melander Olli Raitakari Oscar H Franco Oscar L Rueda-Ochoa Panos Roussos Peter H Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W Morris Rona J Strawbridge S Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R Heckbert Susan Ring Tamara B Harris Terho Lehtimäki Tessel E Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba Abbas Dehghan Adrie Seldenrijk Alanna C Morrison Anders Hamsten Bruce M Psaty Cornelia M van Duijn Deborah A Lawlor Dennis O Mook-Kanamori Donald W Bowden Helena Schmidt James F Wilson James G Wilson Jerome I Rotter Joanna M Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K Evans Stéphanie Debette Steve E Humphries Uwe Völker Vilmundur Gudnason Aroon D Hingorani Johan L M Björkegren Juan P Casas Christopher J O'Donnell

Nat Commun 2018 12 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-07340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277418PMC
December 2018

Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes.

Stroke 2018 Oct;49(10):2508-2511

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., H.S.M.).

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http://dx.doi.org/10.1161/STROKEAHA.118.022242DOI Listing
October 2018

Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Nutrients 2018 Oct 25;10(11). Epub 2018 Oct 25.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB20QQ, UK.

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http://www.mdpi.com/2072-6643/10/11/1575
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http://dx.doi.org/10.3390/nu10111575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266991PMC
October 2018

Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease: A Mendelian Randomization Study.

Nutrients 2018 Sep 6;10(9). Epub 2018 Sep 6.

Department of Surgical Sciences, Uppsala University, 75105 Uppsala, Sweden.

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http://dx.doi.org/10.3390/nu10091243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165184PMC
September 2018

Top research priorities for stroke genetics.

Lancet Neurol 2018 08 17;17(8):663-665. Epub 2018 Jul 17.

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France; CHU de Bordeaux, Department of Neurology, Bordeaux, France.

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http://dx.doi.org/10.1016/S1474-4422(18)30243-6DOI Listing
August 2018

Texture Analysis of T1-Weighted and Fluid-Attenuated Inversion Recovery Images Detects Abnormalities That Correlate With Cognitive Decline in Small Vessel Disease.

Stroke 2018 07 4;49(7):1656-1661. Epub 2018 Jun 4.

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (D.J.T., A.J.L., H.S.M.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022812PMC
July 2018

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis.

Stroke 2018 06 23;49(6):1325-1331. Epub 2018 Apr 23.

Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (J.L., L.R.-J., H.S.M., M.T.)

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.020536
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http://dx.doi.org/10.1161/STROKEAHA.117.020536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976219PMC
June 2018

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.

Stroke 2018 06 11;49(6):1340-1347. Epub 2018 May 11.

From the Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (L.C.A.R.-J., D.J.T., H.S.M., M.T.)

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http://dx.doi.org/10.1161/STROKEAHA.118.020811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976227PMC
June 2018

Involvement of the reward network is associated with apathy in cerebral small vessel disease.

J Affect Disord 2018 05 15;232:116-121. Epub 2018 Feb 15.

Stroke Research Group, University of Cambridge, Department of Clinical Neurosciences, Cambridge, UK.

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http://dx.doi.org/10.1016/j.jad.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884309PMC
May 2018

Longitudinal decline in structural networks predicts dementia in cerebral small vessel disease.

Neurology 2018 05 25;90(21):e1898-e1910. Epub 2018 Apr 25.

From the Stroke Research Group (A.J.L., H.S.M.), Clinical Neurosciences, University of Cambridge; Neurosciences Research Centre (E.A.Z., P.B., C.P.L., T.R.B.), Molecular and Clinical Sciences Research Institute (E.A.Z., P.B., C.P.L., T.R.B.), St George's University of London; and Department of Psychology (R.G.M.), King's College Institute of Psychiatry, Psychology and Neuroscience, London, UK.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962914PMC
May 2018

Genetically-Predicted Adult Height and Alzheimer's Disease.

J Alzheimers Dis 2017 ;60(2):691-698

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.3233/JAD-170528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037293PMC
April 2018

Cerebral amyloid angiopathy associated with inflammation: A systematic review of clinical and imaging features and outcome.

Int J Stroke 2018 04 14;13(3):257-267. Epub 2017 Nov 14.

2 Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1177/1747493017741569DOI Listing
April 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 04 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830PMC
April 2018

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study.

Stroke 2018 04 13;49(4):820-827. Epub 2018 Mar 13.

From the Department of Clinical Sciences, Lund University, Malmö, Sweden (G.H., G.E., O.M., M.O.-M.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (G.H.); Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.C.L.); and Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., H.S.M.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895121PMC
April 2018

Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease.

Stroke 2018 03 2;49(3):586-593. Epub 2018 Feb 2.

From the Department of Radiology, Imperial College NHS Trust, London, United Kingdom (P.B.); Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, United Kingdom (S.T., A.D.M.); Neuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University of London, United Kingdom (C.L., E.Z., O.A.W., B.P., T.R.B.); Department of Psychology, King's College Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom (A.J.L., R.G.M.); and Stroke Research Group, Clinical Neurosciences, University of Cambridge, United Kingdom (H.S.M).

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.017526
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http://dx.doi.org/10.1161/STROKEAHA.117.017526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832012PMC
March 2018

The Brief Memory and Executive Test (BMET): A cognitive screening tool to detect and differentiate vascular cognitive impairment and Alzheimer's disease.

Int J Geriatr Psychiatry 2018 02 7;33(2):e273-e279. Epub 2017 Sep 7.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/gps.4787DOI Listing
February 2018

Recent advances in the management of symptomatic vertebral artery stenosis.

Curr Opin Neurol 2018 Feb;31(1):1-7

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1097/WCO.0000000000000515DOI Listing
February 2018

Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack.

Stroke 2018 01 15;49(1):54-61. Epub 2017 Dec 15.

From the Stroke Research Group, Clinical Neurosciences, University of Cambridge, United Kingdom (R.L.B., H.S.M.); Division of Health and Social Care Research, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (S.C., C.D.A.W.); National Epidemiology and Surveillance, Canadian Blood Services, Ottawa, Ontario (Q.Y.); School of Medicine and Pharmacology, The University of Western Australia, Perth (G.J.H.); Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Western Australian Neuroscience Research Institute, Perth (G.J.H.); and Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom (L.L., P.M.R.).

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http://dx.doi.org/10.1161/STROKEAHA.117.016674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753817PMC
January 2018

Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.

BMJ 2017 12 6;359:j5375. Epub 2017 Dec 6.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717765PMC
http://dx.doi.org/10.1136/bmj.j5375DOI Listing
December 2017

PET imaging of the neurovascular interface in cerebrovascular disease.

Nat Rev Neurol 2017 Nov 6;13(11):676-688. Epub 2017 Oct 6.

Department of Clinical Neurosciences, University of Cambridge, Box 83, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/nrneurol.2017.129DOI Listing
November 2017

Neuropathology of White Matter Lesions, Blood-Brain Barrier Dysfunction, and Dementia.

Stroke 2017 10 30;48(10):2799-2804. Epub 2017 Aug 30.

From the Cell Biology and Genetics Research Centre (A.H.H., J.A., I.B., L.R.B.) and Neuroscience Research Centre (A.H.H., J.A., I.B., T.R.B., L.R.B.), Molecular and Clinical Sciences Research Institute, St George's University of London, United Kingdom; Department of Neurology (A.H.H.) and Department of Cellular Pathology (K.E., J.J., L.R.B.), St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Department of Public Health and Primary Care (T.M.), Department of Radiology (T.M.), and Stroke Research Group, Department of Clinical Neurosciences (H.S.M.), University of Cambridge, United Kingdom; and The Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom (G.F.).

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http://dx.doi.org/10.1161/STROKEAHA.117.018101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986073PMC
October 2017

is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

Neurology 2017 Oct 27;89(17):1829-1839. Epub 2017 Sep 27.

From the Centre for Clinical Brain Sciences (K.R., C.L.M.S.), College of Medicine and Veterinary Medicine (V.S., H.M.), and Institute for Genetics and Molecular Medicine (C.L.M.S.), University of Edinburgh, UK; Institute for Stroke and Dementia Research (R.M., M.D.), Klinikum der Universität München, Munich, Germany; Center for Human Genetic Research (C.D.A., F.R., J.R.) and J. Philip Kistler Stroke Research Center (C.D.A., F.R., N.S.R., J.R.) and Division of Neurocritical Care and Emergency Neurology (C.D.A., F.R., J.R.), Department of Neurology, Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (C.D.A., F.R., J.R.), Broad Institute, Cambridge, MA; Population Health Research Institute (M.C., M.O., G.P.), McMaster University, Hamilton Health Sciences Centre, Ontario, Canada; Department of Medicine (T.D., B.D.M.), University of Maryland School of Medicine, Baltimore; Division of Neurocritical Care and Emergency Neurology (G.J.F.), Department of Neurology, Yale University School of Medicine, New Haven, CT; Stroke Pharmacogenomics and Genetics (I.F.-C.), Fundació Docència i Recerca Mutua Terrassa, Mutua de Terrassa Hospital; Neurovascular Research Unit (J.J.-C.), Department of Neurology, and Program in Inflammation and Cardiovascular Disorders (J.J.-C.), Institut Municipal d'Investigacio´Medica-Hospital del Mar, Universitat Autonoma de Barcelona, Spain; Department of Clinical Sciences Lund (A.L.), Neurology, Lund University; Department of Neurology and Rehabilitation Medicine (A.L., M.S.), Neurology, Skåne University Hospital, Lund, Sweden; Neurovascular Research Laboratory and Neurovascular Unit (J.M.), Institut de Recerca, Hospital Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; HRB Clinical Research Facility (M.O.), NUI Galway, and University Hospital Galway, Ireland; Department of Neurology (A.S.), Jagiellonian University Medical College, Krakow, Poland; Cardiovascular Epidemiology Research Group (M.S.), Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Clinical Neurosciences (M.T., H.S.M.), University of Cambridge, UK; Department of Neurology (S.L.P.), Brain Centre Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Boston University Schools of Medicine and Public Health (S.S.); Framingham Heart Study (S.S.), Framingham, MA; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville; Department of Neurology (D.W.), University of Cincinnati College of Medicine, OH; Geriatrics Research and Education Clinical Center (B.D.M.), Baltimore Veterans Administration Medical Center, MD; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664302PMC
October 2017

Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease.

Neurology 2017 Oct 4;89(18):1869-1876. Epub 2017 Oct 4.

From the Neuroscience Research Centre (E.A.Z., C.L., P.B., T.R.B.), Cardiovascular and Cell Sciences Research Institute, St George's University of London; Stroke Research Group (A.J.L., R.L.B., H.S.M.), Clinical Neurosciences, University of Cambridge; Atkinson Morley Regional Neuroscience Centre (A.D.M.), St George's NHS Healthcare Trust; and Department of Psychology (R.G.M.), King's College Institute of Psychiatry, Psychology, and Neuroscience, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664300PMC
October 2017

Branched-chain amino acids and Alzheimer's disease: a Mendelian randomization analysis.

Sci Rep 2017 10 19;7(1):13604. Epub 2017 Oct 19.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-12931-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648806PMC
October 2017

Apathy, but not depression, is associated with executive dysfunction in cerebral small vessel disease.

PLoS One 2017 11;12(5):e0176943. Epub 2017 May 11.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176943PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426624PMC
September 2017

Mnemonic function in small vessel disease and associations with white matter tract microstructure.

Neuropsychologia 2017 Sep 24;104:1-7. Epub 2017 Jul 24.

Department of Psychology, Goldsmiths University of London, New Cross, London SE14 6NW, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.neuropsychologia.2017.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637155PMC
September 2017

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke.

Stroke 2017 09 1;48(9):2405-2411. Epub 2017 Aug 1.

From the Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1161/STROKEAHA.117.017813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571884PMC
September 2017

Stenting for symptomatic vertebral artery stenosis: The Vertebral Artery Ischaemia Stenting Trial.

Neurology 2017 Sep 23;89(12):1229-1236. Epub 2017 Aug 23.

From the Stroke Research Group (H.S.M., S.C.L.), Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus; Nuffield Department of Clinical Neurosciences (W.K., U.G.S., P.M.R.), John Radcliffe Hospital, University of Oxford; Robertson Centre for Biostatistics (I.F.), University of Glasgow; and Department of Neuroradiology (A.C.), St. George's Hospital, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606920PMC
September 2017

Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study.

Neurology 2017 Aug 30;89(5):454-460. Epub 2017 Jun 30.

From the Stroke Research Group (S.L.C., M.T., H.S.M.), Department of Clinical Neurosciences, and MRC Epidemiology Unit (R.A.S., C.C.L., N.J.W.), University of Cambridge, UK; Unit of Nutritional Epidemiology (S.C.L.), Institute of Environmental Medicine, Karolinska Institutet, Stockholm; Department of Clinical Sciences (G.H., O.M., M.O.-M.), Lund University, Malmö, Sweden; and Boston University School of Medicine (S.S.), MA.

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http://dx.doi.org/10.1212/WNL.0000000000004173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539736PMC
August 2017

Cerebrovascular abnormalities in Alzheimer's dementia: a more tractable treatment target?

Authors:
Hugh S Markus

Brain 2017 07;140(7):1822-1825

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1093/brain/awx161DOI Listing
July 2017

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms.

Stroke 2017 06 3;48(6):1451-1456. Epub 2017 May 3.

From the Stroke Research Center (C.D.A., J.R.), Center for Human Genetic Research (C.D.A., J.R.), and Cardiovascular Research Center (S.A.L., L.-C.W., P.T.E.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, The Broad Insitute of Harvard and MIT, Cambridge, MA (S.A.L., L.-C.W., C.D.A., J.R., P.T.E.); Autism Research Centre (O.E.P.) and Department of Clinical Neurosciences (H.S.M., M.T.), University of Cambridge, United Kingdom; Boston University and National Heart, Lung and Blood Institute's Framingham Heart Study, MA (E.J.B.); Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (E.J.B.); Department of Epidemiology, Boston University School of Public Health, MA (E.J.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians Universität, Germany (R.M., M.D.); Munich Cluster of Systems Neurology (SyNergy), Germany (M.D.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom (C.L.S.); and Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, United Kingdom (P.M.R.).

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http://dx.doi.org/10.1161/STROKEAHA.116.016198DOI Listing
June 2017

Disruption of rich club organisation in cerebral small vessel disease.

Hum Brain Mapp 2017 04 9;38(4):1751-1766. Epub 2016 Dec 9.

Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/hbm.23479DOI Listing
April 2017

Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study.

Neurol Genet 2017 Apr 15;3(2):e142. Epub 2017 Mar 15.

Department of Medical and Molecular Genetics (M.T., C.M.L.), King's College London, Guy's Hospital; Stroke Research Group (M.T., L.R.-J., H.S.M.), Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus; and SGDP Centre (C.C., H.P., G.B., S.N., C.M.L.), Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1212/NXG.0000000000000142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354108PMC
April 2017

An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis.

Biol Psychiatry 2017 03 6;81(6):470-477. Epub 2016 Aug 6.

Medical Research Council, Social, Genetic & Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Mental Health Biomedical Research Centre, South London and Maudsley National Health Service Foundation Trust and King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2016.06.028DOI Listing
March 2017

Early-onset and delayed-onset poststroke dementia - revisiting the mechanisms.

Nat Rev Neurol 2017 03 17;13(3):148-159. Epub 2017 Feb 17.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 9th floor, Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1038/nrneurol.2017.16DOI Listing
March 2017

Prognosis of carotid dissecting aneurysms: Results from CADISS and a systematic review.

Neurology 2017 Feb 13;88(7):646-652. Epub 2017 Jan 13.

From the Stroke Research Group (S.C.L., H.S.M.), Department of Clinical Neurosciences, University of Cambridge; Primary Care and Public Heath (A.K.), School of Public Health, Imperial College London; Neuroradiology (J.M.), Atkinson Morley Neuroscience Centre, St. George's Healthcare Foundation Trust, London, UK; Department of Neurology (C.L.), John Hunter Hospital, Hunter New England Local Health District and University of Newcastle, Australia; and St. George's (J.W.N.), University of London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000003617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317384PMC
February 2017

Seasonal Variation in Spontaneous Cervical Artery Dissection: Comparing between UK and Australian Sites.

J Stroke Cerebrovasc Dis 2017 Jan 10;26(1):177-185. Epub 2016 Oct 10.

Faculty of Health and Medicine, The University of Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia; John Hunter Hospital, New Lambton Heights, Australia.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.09.006DOI Listing
January 2017

Differing association of alcohol consumption with different stroke types: a systematic review and meta-analysis.

BMC Med 2016 11 24;14(1):178. Epub 2016 Nov 24.

Stroke Research Group, Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1186/s12916-016-0721-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121939PMC
November 2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Authors:
Georg B Ehret Teresa Ferreira Daniel I Chasman Anne U Jackson Ellen M Schmidt Toby Johnson Gudmar Thorleifsson Jian'an Luan Lousie A Donnelly Stavroula Kanoni Ann-Kristin Petersen Vasyl Pihur Rona J Strawbridge Dmitry Shungin Maria F Hughes Osorio Meirelles Marika Kaakinen Nabila Bouatia-Naji Kati Kristiansson Sonia Shah Marcus E Kleber Xiuqing Guo Leo-Pekka Lyytikäinen Cristiano Fava Niclas Eriksson Ilja M Nolte Patrik K Magnusson Elias L Salfati Loukianos S Rallidis Elizabeth Theusch Andrew J P Smith Lasse Folkersen Kate Witkowska Tune H Pers Roby Joehanes Stuart K Kim Lazaros Lataniotis Rick Jansen Andrew D Johnson Helen Warren Young Jin Kim Wei Zhao Ying Wu Bamidele O Tayo Murielle Bochud Devin Absher Linda S Adair Najaf Amin Dan E Arking Tomas Axelsson Damiano Baldassarre Beverley Balkau Stefania Bandinelli Michael R Barnes Inês Barroso Stephen Bevan Joshua C Bis Gyda Bjornsdottir Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Stefan R Bornstein Morris J Brown Michel Burnier Claudia P Cabrera John C Chambers I-Shou Chang Ching-Yu Cheng Peter S Chines Ren-Hua Chung Francis S Collins John M Connell Angela Döring Jean Dallongeville John Danesh Ulf de Faire Graciela Delgado Anna F Dominiczak Alex S F Doney Fotios Drenos Sarah Edkins John D Eicher Roberto Elosua Stefan Enroth Jeanette Erdmann Per Eriksson Tonu Esko Evangelos Evangelou Alun Evans Tove Fall Martin Farrall Janine F Felix Jean Ferrières Luigi Ferrucci Myriam Fornage Terrence Forrester Nora Franceschini Oscar H Franco Duran Anders Franco-Cereceda Ross M Fraser Santhi K Ganesh He Gao Karl Gertow Francesco Gianfagna Bruna Gigante Franco Giulianini Anuj Goel Alison H Goodall Mark O Goodarzi Mathias Gorski Jürgen Gräßler Christopher Groves Vilmundur Gudnason Ulf Gyllensten Göran Hallmans Anna-Liisa Hartikainen Maija Hassinen Aki S Havulinna Caroline Hayward Serge Hercberg Karl-Heinz Herzig Andrew A Hicks Aroon D Hingorani Joel N Hirschhorn Albert Hofman Jostein Holmen Oddgeir Lingaas Holmen Jouke-Jan Hottenga Phil Howard Chao A Hsiung Steven C Hunt M Arfan Ikram Thomas Illig Carlos Iribarren Richard A Jensen Mika Kähönen Hyun Kang Sekar Kathiresan Brendan J Keating Kay-Tee Khaw Yun Kyoung Kim Eric Kim Mika Kivimaki Norman Klopp Genovefa Kolovou Pirjo Komulainen Jaspal S Kooner Gulum Kosova Ronald M Krauss Diana Kuh Zoltan Kutalik Johanna Kuusisto Kirsti Kvaløy Timo A Lakka Nanette R Lee I-Te Lee Wen-Jane Lee Daniel Levy Xiaohui Li Kae-Woei Liang Honghuang Lin Li Lin Jaana Lindström Stéphane Lobbens Satu Männistö Gabriele Müller Martina Müller-Nurasyid François Mach Hugh S Markus Eirini Marouli Mark I McCarthy Colin A McKenzie Pierre Meneton Cristina Menni Andres Metspalu Vladan Mijatovic Leena Moilanen May E Montasser Andrew D Morris Alanna C Morrison Antonella Mulas Ramaiah Nagaraja Narisu Narisu Kjell Nikus Christopher J O'Donnell Paul F O'Reilly Ken K Ong Fred Paccaud Cameron D Palmer Afshin Parsa Nancy L Pedersen Brenda W Penninx Markus Perola Annette Peters Neil Poulter Peter P Pramstaller Bruce M Psaty Thomas Quertermous Dabeeru C Rao Asif Rasheed N William N W R Rayner Frida Renström Rainer Rettig Kenneth M Rice Robert Roberts Lynda M Rose Jacques Rossouw Nilesh J Samani Serena Sanna Jouko Saramies Heribert Schunkert Sylvain Sebert Wayne H-H Sheu Young-Ah Shin Xueling Sim Johannes H Smit Albert V Smith Maria X Sosa Tim D Spector Alena Stančáková Alice Stanton Kathleen E Stirrups Heather M Stringham Johan Sundstrom Amy J Swift Ann-Christine Syvänen E-Shyong Tai Toshiko Tanaka Kirill V Tarasov Alexander Teumer Unnur Thorsteinsdottir Martin D Tobin Elena Tremoli Andre G Uitterlinden Matti Uusitupa Ahmad Vaez Dhananjay Vaidya Cornelia M van Duijn Erik P A van Iperen Ramachandran S Vasan Germaine C Verwoert Jarmo Virtamo Veronique Vitart Benjamin F Voight Peter Vollenweider Aline Wagner Louise V Wain Nicholas J Wareham Hugh Watkins Alan B Weder Harm-Jan Westra Rainford Wilks Tom Wilsgaard James F Wilson Tien Y Wong Tsun-Po Yang Jie Yao Loic Yengo Weihua Zhang Jing Hua Zhao Xiaofeng Zhu Pascal Bovet Richard S Cooper Karen L Mohlke Danish Saleheen Jong-Young Lee Paul Elliott Hinco J Gierman Cristen J Willer Lude Franke G Kees Hovingh Kent D Taylor George Dedoussis Peter Sever Andrew Wong Lars Lind Themistocles L Assimes Inger Njølstad Peter Eh Schwarz Claudia Langenberg Harold Snieder Mark J Caulfield Olle Melander Markku Laakso Juha Saltevo Rainer Rauramaa Jaakko Tuomilehto Erik Ingelsson Terho Lehtimäki Kristian Hveem Walter Palmas Winfried März Meena Kumari Veikko Salomaa Yii-Der I Chen Jerome I Rotter Philippe Froguel Marjo-Riitta Jarvelin Edward G Lakatta Kari Kuulasmaa Paul W Franks Anders Hamsten H-Erich Wichmann Colin N A Palmer Kari Stefansson Paul M Ridker Ruth J F Loos Aravinda Chakravarti Panos Deloukas Andrew P Morris Christopher Newton-Cheh Patricia B Munroe

Nat Genet 2016 10 12;48(10):1171-1184. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/ng.3667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042863PMC
October 2016

Brief Screening of Vascular Cognitive Impairment in Patients With Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Without Dementia.

Stroke 2016 10 13;47(10):2482-7. Epub 2016 Sep 13.

From the Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Biomedical Campus, United Kingdom (R.L.B., M.J.H., R.Y.Y.T., H.S.M.); and Department of Psychology, Psychology and Neurosciences, Institute of Psychiatry, King's College London, London, United Kingdom (R.G.M.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049939PMC
October 2016

Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype.

Arterioscler Thromb Vasc Biol 2016 06 14;36(6):1240-6. Epub 2016 Apr 14.

From the Laboratory of Experimental Cardiology, Division Heart and Lungs (G.P., S.W.v.d.L., S.H., M.A.S., T.B., J.v.S., I.E.H., S.C.A.d.J., H.M.d.R.), Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy (G.P.), and Division Heart and Lungs, Department of Cardiology (F.W.A.), University Medical Center Utrecht, Utrecht, The Netherlands; Vascular Biology Unit, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (H.F.A., J.L.M.B.); Institut für Schlaganfall- und Demenzforschung (ISD) Klinikum der Universität München, Munich, Germany (M.D., R.M.); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.); Department of Neurology, University of Virginia, Charlottesville (B.B.W.); Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (H.S.); Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., Partner Site Munich Heart Alliance, Munich, Germany (H.S.); Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (N.J.S.); Leicester National Institute of Health Research Biomedical Research Unit in Cardiovascular Disease, Leicester, United Kingdom (N.J.S.); Department of Surgery, National University of Singapore, Singapore (D.P.V.d.K.); Cardiovascular Research Institute (CVRI), National University Health System, Singapore, Singapore (D.P.V.d.K.); Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (D.P.V.d.K.); Department of Neurosciences, University of Cambridge, Cambridge, United Kingdom (H.S.M.); The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom (T.M.); Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (J.L.M.B.); Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estoni

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http://dx.doi.org/10.1161/ATVBAHA.115.306958DOI Listing
June 2016

Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease.

Ann Neurol 2016 05 23;79(5):739-747. Epub 2016 Feb 23.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/ana.24621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864940PMC
May 2016

Associations between the Brief Memory and Executive Test (BMET), Activities of Daily Living, and Quality of Life in Patients with Cerebral Small Vessel Disease.

J Int Neuropsychol Soc 2016 May 6;22(5):561-9. Epub 2016 Apr 6.

1University of Cambridge,Department of Clinical Neurosciences,R3,Box 183,Addenbrookes Biomedical Campus,Cambridge,CB2 0QQ,United Kingdom.

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http://dx.doi.org/10.1017/S1355617716000187DOI Listing
May 2016

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.

Stroke 2016 05 12;47(5):1174-9. Epub 2016 Apr 12.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., L.C.A.R.-J., H.S.M.); Department of Medical and Molecular Genetics, King's College London, London, United Kingdom (M.T.); Laboratory of Neurobiology, Vesalius Research Center, VIB, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease, University of Leuven, Leuven, Belgium (V.T.); Department of Neurology, Austin Health and Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia (V.T.); School of Medicine and Public Health (E.G.H.) and Centre for Clinical Epidemiology and Biostatistics, Hunter Medical Research Institute and School of Medicine and Public Health (C.L.), University of Newcastle, Newcastle, NSW, Australia; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia (E.G.H.); School of Life Science, University of Lincoln, Lincoln, United Kingdom (S.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany (R.M., M.D.); Department of Cerebrovascular Disease, IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (G.B.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (C.S.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, Oxford, United Kingdom (P.M.R.); and Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839546PMC
May 2016

Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease.

Brain 2016 Apr 1;139(Pt 4):1136-51. Epub 2016 Mar 1.

Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1093/brain/aww009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806220PMC
April 2016

Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.

Stroke 2016 Mar 2;47(3):646-51. Epub 2016 Feb 2.

From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (L.C.A.R.-J., M.T., H.S.M.); Department of Medical & Molecular Genetics, King's College London, London, UK (M.T.); Stroke and Dementia Research Centre, Department of Clinical Neuroscience, St George's University of London, London, UK (P.A.-S.); KULeuven Department of Experimental Neurology and Leuven Research Institute for Neuroscience and Disease, University of Leuven, and Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium and Department of Neurology, Austin Health and Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia (V.T.); Division of Clinical Neurosciences, Neuroimaging Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Neuroscience, University of Oxford, UK (P.M.R.); Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, Italy (G.B.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich and Munich Cluster of Systems Neurology, SyNergy, Munich, Germany (M.D.); Department of Neurology, Mayo Clinic, Jacksonville (J.M.); School of Nursing and Midwifery (J.M.) and Hunter Medical Research Institute (J.M., C.L.), University of Newcastle, NSW, Australia; Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston (N.S.R., J.R.); Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK (A.H.); and School of Life Science, University of Lincoln, Lincoln, UK (S.B.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760380PMC
March 2016

Structural network efficiency predicts conversion to dementia.

Neurology 2016 Mar 17;86(12):1112-9. Epub 2016 Feb 17.

From the Departments of Neurology (A.M.T., I.W.M.v.U., H.v.d.H., E.v.D., F.-E.d.L.), Geriatrics (J.A.H.R.C., R.P.C.K.), and Medical Psychology (R.P.C.K.), Radboudumc, and Centre for Cognitive Neuroimaging, Radboud University Nijmegen (A.M.T., D.G.N.), Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands; Department of Clinical Neurosciences, Neurology Unit (L.C.A.R.-J., A.L., H.S.M.), University of Cambridge, UK; Department of Neurology (A.v.N.), Amphia ziekenhuis Breda; Department of Neurology (K.d.L.), HagaZiekenhuis Den Haag, the Netherlands; Erwin L. Hahn Institute for Magnetic Resonance Imaging (D.G.N.), University of Duisburg-Essen, Essen, Germany; and MIRA Institute for Biomedical Technology and Technical Medicine (D.G.N.), University of Twente, Enschede, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000002502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820137PMC
March 2016

Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

Stroke 2016 Feb 5;47(2):307-16. Epub 2016 Jan 5.

From the Veterans Affairs Maryland Health Care System, Baltimore, MD (Y.-C.C., S.J.K., J.W.C., B.D.M.); University of Maryland School of Medicine, Baltimore (Y.-C.C., H.X., S.J.K., J.W.C., J.R.O., B.D.M.); The University of Gothenburg, Gothenburg, Sweden (T.M.S., C.J.); University of Rostock, Rostock, Germany (A.-K.G., A. Rolfs); University of Nottingham Malaysia Campus, Selangor Darul Ehsa, Malaysia (W.K.H.); University of Cambridge, Cambridge, UK (M.T., J.D., S.B., H.S.M., S.D., D.S.); Institut Pasteur de Lille, F-59000 Lille, France (P.A.); University of Newcastle, Australia (E.G.H.); Ludwig-Maximilians-Universität, Munich, Germany (R.M., K.S., M.D.); Wellcome Trust Sanger Institute, Cambridge, UK (J.D.); Center for Non-Communicable Diseases, Karachi, Pakistan (A. Rasheed, D.S.); University of Pennsylvania (W.Z., D.S.); Basel University Hospital, Switzerland (S.E.); Heidelberg University Hospital, Germany (C.G.-G.); Centre d'Étude du Polymorphisme Humain, Paris, France (Y.K.); RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (Y.K.); National Genotyping Center, Evry, France (M.L.); Genome Quebec, McGill University, Montreal, Canada (M.L.); Lille University Hospital, France (D.L., S.D.); KU Leuven - University of Leuven, Leuven, Belgium (V.T.); Vesalius Research Center, VIB, Leuven, Belgium (V.T.); University Hospitals Leuven, Leuven, Belgium (V.T.); Helsinki University Central Hospital, Helsinki, Finland (T.M.M., T.T.); Università degli Studi di Brescia, Brescia, Italy (A. Pezzini); Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy (E.A.P., G.B.B.); University of Lund, Sweden (B.N.); University of Oxford, John Radcliffe Hospital (P.M.R.); University of Edinburgh, Edinburgh, UK (C.S.); Jagiellonian University Medical College, Krakow, Poland (A.S.); Lund University, Lund, Sweden (A.L.); Skåne University Hospital, Lund, Sweden (A.L.); University of Glasgow, Glasgow, UK (M.R.W.); University of Adelaide, Australia (J.J.); Mount Sinai Hos

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http://dx.doi.org/10.1161/STROKEAHA.115.011328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729659PMC
February 2016