Publications by authors named "Hugh Markus"

100Publications

Mood, cognition and fatigue, and advances in acute stroke care.

Authors:
Hugh S Markus

Int J Stroke 2020 Aug;15(6):589-590

University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493020941377DOI Listing
August 2020

Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease.

J Neurol Neurosurg Psychiatry 2020 Jul 10. Epub 2020 Jul 10.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2020-323092DOI Listing
July 2020

Thrombectomy, acute stroke care, and global health problems; cannabis and COVID-19.

Authors:
Hugh S Markus

Int J Stroke 2020 07;15(5):465-466

Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493020933852DOI Listing
July 2020

In Memoriam: John W Norris (1933-2020).

Int J Stroke 2020 Jun 29:1747493020925315. Epub 2020 Jun 29.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493020925315DOI Listing
June 2020

John W. Norris: 1933-2020.

Stroke 2020 Jul 22;51(7):1913-1915. Epub 2020 May 22.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (H.S.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.120.030168DOI Listing
July 2020

Network Efficiency Mediates the Relationship Between Vascular Burden and Cognitive Impairment: A Diffusion Tensor Imaging Study in UK Biobank.

Stroke 2020 Jun 11;51(6):1682-1689. Epub 2020 May 11.

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (J.S., D.J.T., H.S.M., J.T.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.119.028587DOI Listing
June 2020

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.

Nat Commun 2020 05 1;11(1):2175. Epub 2020 May 1.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-15932-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195435PMC
May 2020

COVID-19 and stroke-A global World Stroke Organization perspective.

Int J Stroke 2020 06 29;15(4):361-364. Epub 2020 Apr 29.

Department for Clinical Neuroscience and Preventive Medicine, Danube University Krems, Krems, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493020923472DOI Listing
June 2020

The global burden of stroke, and fluoxetine for stroke recovery.

Authors:
Hugh S Markus

Int J Stroke 2020 Jun 11;15(4):355. Epub 2020 Apr 11.

Stroke Research Group Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493020919047DOI Listing
June 2020

Lindsay Symon: A giant of stroke.

Int J Stroke 2020 Jun 3;15(4):356-360. Epub 2020 Apr 3.

Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493020913088DOI Listing
June 2020

Emotions and behavior after stroke.

Authors:
Hugh S Markus

Int J Stroke 2020 Apr 12;15(3):243. Epub 2020 Mar 12.

Editor-in-Chief.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493020913772DOI Listing
April 2020

Network neuroscience of apathy in cerebrovascular disease.

Prog Neurobiol 2020 05 6;188:101785. Epub 2020 Mar 6.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pneurobio.2020.101785DOI Listing
May 2020

Simple MRI score aids prediction of dementia in cerebral small vessel disease.

Neurology 2020 03 2;94(12):e1294-e1302. Epub 2020 Mar 2.

From the Stroke Research Group (A.A.A.O., H.S.M.), Clinical Neurosciences, University of Cambridge; MRC Biostatistics Unit (J.M.S.W.), Institute of Public Health, Cambridge; Institute of Health and Society (J.M.S.W.), Newcastle University, UK; Department of Neurology (A.M.T., E.M.C.v.L., F.-E.d.L.), Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Medical Neuroscience, Nijmegen, the Netherlands; Division of Neurogeriatrics (M.K., E.H., R.S.), Department of Neurology, Medical University of Graz; Institute for Medical Informatics (E.H.), Statistics and Documentation, Medical University of Graz, Austria; and Department of Psychology (R.G.M.), King's College, Institute of Psychiatry, Psychology and Neuroscience, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000009141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274929PMC
March 2020

Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans.

Neurology 2020 03 19;94(10):e998-e1012. Epub 2020 Feb 19.

From Kwame Nkrumah University of Science and Technology (F.S.S., L.A., A. Singh, D.O.), Kumasi, Ghana; University of California (B.O.), San Francisco; Medical University of South Carolina (M.G., D.L., C.J., F.M.), Charleston; College of Medicine (O. Akpa, G. Ogbole, M.O., J.A., A.O., A. Adeoye, L. Ogunjimi, O. Arulogun, F.A., O. Ogah, A. Makanjuola, O. Adebayo, A. Agunloye, S.L., S.D., M.F., C.E.), University of Ibadan, Nigeria; University of Ghana Medical School (A. Akpalu, R.L., B.C.-T.), Accra; University of Ilorin Teaching Hospital (K.W., L. Oyinloye, P.K., E.S.); Federal Medical Centre (R.A., O. Adeleye), Abeokuta; Ahmadu Bello University (R.O., O.B., V.S., H.I.), Zaria; Obafemi Awolowo University Teaching Hospital (M.K., B.F., O. Ajose, S.O.), Ile-Ife; Aminu Kano Teaching Hospital (L. Owolabi, A. Mande), Kano, Nigeria; University of Kentucky (D.A.), Lexington; University of Alabama at Birmingham (H.T.); University of Cambridge (H.S.M.), UK; Delta State University Teaching Hospital (O. Olugbo); Jos Teaching Hospital (G. Osaigbovo, A. Salaam, G.A., C.I.), Plateau State; Federal Medical Centre (I.C.), Umuahia, Abia State; Federal Medical Centre (T.S.), Owo, Ondo State; and Ladoke Akintola University of Technology Teaching Hospital (A. Akintunde), Ogbomosho, Oyo State, Nigeria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000009056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238923PMC
March 2020

Editorial.

Int J Stroke 2020 01;15(1):5-6

University of Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493019899833DOI Listing
January 2020

Influence of Genetic Variation in on Endothelial Function and Stroke.

Hypertension 2020 Feb 23;75(2):365-371. Epub 2019 Dec 23.

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., A.A.A.O., H.S.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.13513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055937PMC
February 2020

The role of haematological traits in risk of ischaemic stroke and its subtypes.

Brain 2020 01;143(1):210-221

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awz362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935746PMC
January 2020

New Treatment Approaches to Modify the Course of Cerebral Small Vessel Diseases.

Stroke 2020 01 22;51(1):38-46. Epub 2019 Nov 22.

Department of Clinical Neurosciences, Cambridge University, United Kingdom (H.S.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.119.024150DOI Listing
January 2020

Structural network changes in cerebral small vessel disease.

J Neurol Neurosurg Psychiatry 2020 02 19;91(2):196-203. Epub 2019 Nov 19.

Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2019-321767DOI Listing
February 2020

How common are single gene mutations as a cause for lacunar stroke? A targeted gene panel study.

Neurology 2019 11 12;93(22):e2007-e2020. Epub 2019 Nov 12.

From the Stroke Research Group, Department of Clinical Neurosciences (R.Y.Y.T., M.T., H.S.M.), Department of Haematology (K.M., D.D., S.V.V.D., O.S., R.P.M., W.H.O., S.G., K.D.), and Division of Respiratory Medicine, Department of Medicine (S.G.), University of Cambridge; and NIHR BioResource: Rare Diseases (K.M., S.V.V.D., O.S., R.P.M., W.H.O., S.G., H.S.M.), Biomedical Campus, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000008544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913325PMC
November 2019

Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.

J Neurol Sci 2019 Dec 13;407:116526. Epub 2019 Oct 13.

Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria; Department of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2019.116526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413646PMC
December 2019

Personalising secondary prevention: different treatments for different strokes.

Authors:
Hugh Markus

Pract Neurol 2020 Feb 4;20(1):34-38. Epub 2019 Sep 4.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/practneurol-2018-002006DOI Listing
February 2020

Vertebral artery stenting to prevent recurrent stroke in symptomatic vertebral artery stenosis: the VIST RCT.

Health Technol Assess 2019 08;23(41):1-30

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3310/hta23410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717908PMC
August 2019

Genetic Liability to Insomnia and Cardiovascular Disease Risk.

Circulation 2019 08 19;140(9):796-798. Epub 2019 Aug 19.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (H.S.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041830DOI Listing
August 2019

Do Cerebral Small Vessel Disease and Multiple Sclerosis Share Common Mechanisms of White Matter Injury?

Stroke 2019 08 21;50(8):1968-1972. Epub 2019 Jun 21.

From the Department of Clinical Neurosciences (R.B.B., M.T., S.S., H.S.M.), University of Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.023649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661245PMC
August 2019

Inflammation and cerebral small vessel disease: A systematic review.

Ageing Res Rev 2019 08 10;53:100916. Epub 2019 Jun 10.

Department of Psychiatry, University of Cambridge, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.100916DOI Listing
August 2019

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2019 Jul;51(7):1192-1193

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-019-0449-0DOI Listing
July 2019

Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis.

Lancet Neurol 2019 07 23;18(7):666-673. Epub 2019 May 23.

Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University, Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(19)30149-8DOI Listing
July 2019

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

Neurology 2019 02 25;92(9):e944-e950. Epub 2019 Jan 25.

From the Unit of Cardiovascular and Nutritional Epidemiology (S.C.L.), Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Stroke Research Group, Department of Clinical Neurosciences (M.T., H.S.M.), MRC Biostatistics Unit (S.B.), and Department of Public Health and Primary Care (S.B.), University of Cambridge, UK; Department of Cerebrovascular Diseases (G.B.B.), Fondazione IRCCS-Istituto Neurologico Carlo Besta, Milano, Italy; Department of Clinical Pathology and Genetics (C.J.), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg; and Department of Surgical Sciences (K.M.), Uppsala University, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404465PMC
February 2019

Homocysteine and small vessel stroke: A mendelian randomization analysis.

Ann Neurol 2019 04 11;85(4):495-501. Epub 2019 Mar 11.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594149PMC
April 2019

Apathy is associated with large-scale white matter network disruption in small vessel disease.

Neurology 2019 03 8;92(11):e1157-e1167. Epub 2019 Feb 8.

From the Department of Clinical Neurosciences (J.T., M.J.H., R.L.B., D.J.T., H.S.M.), University of Cambridge, UK; Department of Neurology (A.M.T., F.-E.d.L.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Neuroscience Research Centre (T.R.B.), Molecular and Clinical Sciences Research Institute, St. George's University of London; and Nuffield Department of Clinical Neurosciences (M.H.), University of Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511108PMC
March 2019

Genetics of Vascular Cognitive Impairment.

Stroke 2019 03;50(3):765-772

Department of Neurology, Medical University of Graz, Austria (R.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.020379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420146PMC
March 2019

Genetic variation in is associated with white matter hyperintensities (n = 11,226).

Neurology 2019 02 18;92(8):e749-e757. Epub 2019 Jan 18.

From the Department of Clinical Neurosciences, Stroke Research Group (M.T., D.J.T., I.D.C., D.M.L.F., A.O.O., L.R.-J., H.S.M.), University of Cambridge, UK; Department of Cerebrovascular Diseases (G.B.), Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan, Italy; Institute for Stroke and Dementia Research (M.D.), Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich; German Center for Neurodegenerative Diseases (DZNE) and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany; Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND) (R.L.), KU Leuven-University of Leuven; Department of Neurology (R.L.), University Hospitals Leuven; Laboratory of Neurobiology (R.L.), VIB Center for Brain and Disease Research, Leuven, Belgium; Center for Human Genetic Research (J.R.) and Division of Neurocritical Care and Emergency Neurology (J.R.) and J. Philip Kistler Stroke Research Center (J.R., N.S.R.), Department of Neurology, Massachusetts General Hospital, Boston; Nuffield Department of Clinical Neurosciences (Clinical Neurology), Stroke Prevention Research Unit (P.M.R.), University of Oxford; Centre for Clinical Brain Sciences and Institute for Genetics and Molecular Medicine (C.L.M.S.), University of Edinburgh, UK; Stroke Division, Florey Institute of Neuroscience and Mental Health (V.T.), University of Melbourne; and Department of Neurology (V.T.), Austin Health, Heidelberg, Victoria, Australia.

View Article

Download full-text PDF

Source
http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000006952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396967PMC
February 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Telemedicine for Follow-Up of Rare Neurological Disease.

Stroke 2019 03;50(3):750-753

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023779
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.118.023779DOI Listing
March 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Encephalopathy in a Large Cohort of British Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients.

Stroke 2019 02;50(2):283-290

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (A.M.D., R.Y.Y.T., J.T., M.T., H.S.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.023661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358181PMC
February 2019

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Authors:
Nora Franceschini Claudia Giambartolomei Paul S de Vries Chris Finan Joshua C Bis Rachael P Huntley Ruth C Lovering Salman M Tajuddin Thomas W Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V Smith Edith Hofer Elisabeth M van Leeuwen Ilja M Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K Joshi Raymond Noordam Riccardo E Marioni Shih-Jen Hwang Solomon K Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B Zonderman Albert Hofman Alexander Teumer Amanda J Cox André G Uitterlinden Andrew Wong Andries J Smit Anne B Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W Penninx Carl D Langefeld Christina L Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H O'Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S Markus Ian J Deary J Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D Taylor Klodian Dhana Lambertus A L M Kiemeney Lars Lind Laura M Raffield Lenore J Launer Lesca M Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A Nalls Olle Melander Olli Raitakari Oscar H Franco Oscar L Rueda-Ochoa Panos Roussos Peter H Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W Morris Rona J Strawbridge S Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R Heckbert Susan Ring Tamara B Harris Terho Lehtimäki Tessel E Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba Abbas Dehghan Adrie Seldenrijk Alanna C Morrison Anders Hamsten Bruce M Psaty Cornelia M van Duijn Deborah A Lawlor Dennis O Mook-Kanamori Donald W Bowden Helena Schmidt James F Wilson James G Wilson Jerome I Rotter Joanna M Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K Evans Stéphanie Debette Steve E Humphries Uwe Völker Vilmundur Gudnason Aroon D Hingorani Johan L M Björkegren Juan P Casas Christopher J O'Donnell

Nat Commun 2018 12 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-07340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277418PMC
December 2018

Interpreting CT perfusion in stroke.

Pract Neurol 2019 Apr 13;19(2):136-142. Epub 2018 Nov 13.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/practneurol-2018-001917DOI Listing
April 2019

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 01;76(1):81-94

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
https://jamanetwork.com/journals/jamaneurology/fullarticle/2
Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2018.3122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439887PMC
January 2019

Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.

PLoS One 2018 1;13(11):e0206554. Epub 2018 Nov 1.

University of Maryland School of Medicine, Baltimore, MD, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206554PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211695PMC
April 2019

Genome-wide meta-analysis identifies 3 novel loci associated with stroke.

Ann Neurol 2018 12 30;84(6):934-939. Epub 2018 Nov 30.

Institute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ana.25369
Publisher Site
http://dx.doi.org/10.1002/ana.25369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644297PMC
December 2018

Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Nutrients 2018 Oct 25;10(11). Epub 2018 Oct 25.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB20QQ, UK.

View Article

Download full-text PDF

Source
http://www.mdpi.com/2072-6643/10/11/1575
Publisher Site
http://dx.doi.org/10.3390/nu10111575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266991PMC
October 2018

Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes.

Stroke 2018 10;49(10):2508-2511

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., H.S.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.022242DOI Listing
October 2018

Memory decline in elderly with cerebral small vessel disease explained by temporal interactions between white matter hyperintensities and hippocampal atrophy.

Hippocampus 2019 06 23;29(6):500-510. Epub 2018 Nov 23.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Donders Center for Medical Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/hipo.23039
Publisher Site
http://dx.doi.org/10.1002/hipo.23039DOI Listing
June 2019

Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease: A Mendelian Randomization Study.

Nutrients 2018 Sep 6;10(9). Epub 2018 Sep 6.

Department of Surgical Sciences, Uppsala University, 75105 Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu10091243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165184PMC
September 2018

Framingham vascular age is associated with worse cognitive performance in the middle-aged and elderly.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 07 27;26(4):531-540. Epub 2018 Jul 27.

b Department of Clinical Neurosciences , University of Cambridge, Addenbrookes Biomedical Campus , Cambridge , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13825585.2018.1499866DOI Listing
July 2019

Top research priorities for stroke genetics.

Lancet Neurol 2018 08 17;17(8):663-665. Epub 2018 Jul 17.

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France; CHU de Bordeaux, Department of Neurology, Bordeaux, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(18)30243-6DOI Listing
August 2018

Analysis of shared heritability in common disorders of the brain.

Authors:
Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell J Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018

Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer's Disease? A Systematic Review and Meta-Analysis.

J Alzheimers Dis 2018 ;64(2):657-668

Stroke Research Group, Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180288DOI Listing
July 2019

Texture Analysis of T1-Weighted and Fluid-Attenuated Inversion Recovery Images Detects Abnormalities That Correlate With Cognitive Decline in Small Vessel Disease.

Stroke 2018 07 4;49(7):1656-1661. Epub 2018 Jun 4.

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (D.J.T., A.J.L., H.S.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.117.019970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022812PMC
July 2018

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.

Stroke 2018 06 11;49(6):1340-1347. Epub 2018 May 11.

From the Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (L.C.A.R.-J., D.J.T., H.S.M., M.T.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.020811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976227PMC
June 2018

Longitudinal decline in structural networks predicts dementia in cerebral small vessel disease.

Neurology 2018 05 25;90(21):e1898-e1910. Epub 2018 Apr 25.

From the Stroke Research Group (A.J.L., H.S.M.), Clinical Neurosciences, University of Cambridge; Neurosciences Research Centre (E.A.Z., P.B., C.P.L., T.R.B.), Molecular and Clinical Sciences Research Institute (E.A.Z., P.B., C.P.L., T.R.B.), St George's University of London; and Department of Psychology (R.G.M.), King's College Institute of Psychiatry, Psychology and Neuroscience, London, UK.

View Article

Download full-text PDF

Source
http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000005551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962914PMC
May 2018

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis.

Stroke 2018 06 23;49(6):1325-1331. Epub 2018 Apr 23.

Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (J.L., L.R.-J., H.S.M., M.T.)

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.020536
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.117.020536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976219PMC
June 2018

A comparison of functional and tractography based networks in cerebral small vessel disease.

Neuroimage Clin 2018 8;18:425-432. Epub 2018 Feb 8.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2018.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849860PMC
February 2019

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study.

Stroke 2018 04 13;49(4):820-827. Epub 2018 Mar 13.

From the Department of Clinical Sciences, Lund University, Malmö, Sweden (G.H., G.E., O.M., M.O.-M.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (G.H.); Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.C.L.); and Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., H.S.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.117.019653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895121PMC
April 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 04 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830PMC
April 2018

Involvement of the reward network is associated with apathy in cerebral small vessel disease.

J Affect Disord 2018 05 15;232:116-121. Epub 2018 Feb 15.

Stroke Research Group, University of Cambridge, Department of Clinical Neurosciences, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884309PMC
May 2018

Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease.

Stroke 2018 03 2;49(3):586-593. Epub 2018 Feb 2.

From the Department of Radiology, Imperial College NHS Trust, London, United Kingdom (P.B.); Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, United Kingdom (S.T., A.D.M.); Neuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University of London, United Kingdom (C.L., E.Z., O.A.W., B.P., T.R.B.); Department of Psychology, King's College Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom (A.J.L., R.G.M.); and Stroke Research Group, Clinical Neurosciences, University of Cambridge, United Kingdom (H.S.M).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.017526
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.117.017526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832012PMC
March 2018

Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack.

Stroke 2018 01 15;49(1):54-61. Epub 2017 Dec 15.

From the Stroke Research Group, Clinical Neurosciences, University of Cambridge, United Kingdom (R.L.B., H.S.M.); Division of Health and Social Care Research, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (S.C., C.D.A.W.); National Epidemiology and Surveillance, Canadian Blood Services, Ottawa, Ontario (Q.Y.); School of Medicine and Pharmacology, The University of Western Australia, Perth (G.J.H.); Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Western Australian Neuroscience Research Institute, Perth (G.J.H.); and Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom (L.L., P.M.R.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.117.016674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753817PMC
January 2018

Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.

BMJ 2017 12 6;359:j5375. Epub 2017 Dec 6.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717765PMC
http://dx.doi.org/10.1136/bmj.j5375DOI Listing
December 2017

Cerebrovascular abnormalities in Alzheimer's dementia: a more tractable treatment target?

Authors:
Hugh S Markus

Brain 2017 07;140(7):1822-1825

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awx161DOI Listing
July 2017

Cerebral amyloid angiopathy associated with inflammation: A systematic review of clinical and imaging features and outcome.

Int J Stroke 2018 04 14;13(3):257-267. Epub 2017 Nov 14.

2 Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493017741569DOI Listing
April 2018

Recent advances in the management of symptomatic vertebral artery stenosis.

Curr Opin Neurol 2018 Feb;31(1):1-7

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WCO.0000000000000515DOI Listing
February 2018

Branched-chain amino acids and Alzheimer's disease: a Mendelian randomization analysis.

Sci Rep 2017 10 19;7(1):13604. Epub 2017 Oct 19.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-12931-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648806PMC
October 2017

PET imaging of the neurovascular interface in cerebrovascular disease.

Nat Rev Neurol 2017 Nov 6;13(11):676-688. Epub 2017 Oct 6.

Department of Clinical Neurosciences, University of Cambridge, Box 83, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2017.129DOI Listing
November 2017

Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease.

Neurology 2017 Oct 4;89(18):1869-1876. Epub 2017 Oct 4.

From the Neuroscience Research Centre (E.A.Z., C.L., P.B., T.R.B.), Cardiovascular and Cell Sciences Research Institute, St George's University of London; Stroke Research Group (A.J.L., R.L.B., H.S.M.), Clinical Neurosciences, University of Cambridge; Atkinson Morley Regional Neuroscience Centre (A.D.M.), St George's NHS Healthcare Trust; and Department of Psychology (R.G.M.), King's College Institute of Psychiatry, Psychology, and Neuroscience, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664300PMC
October 2017

Cervical artery dissection and iliac artery aneurysm in an SMAD-4 mutation carrier.

Neurol Genet 2017 Oct 25;3(5):e191. Epub 2017 Sep 25.

Department of Stroke Medicine (E.W., P.M., H.S.M.) and Department of Genetics (S.M.), Addenbrooke's Hospital, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXG.0000000000000191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619912PMC
October 2017

is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

Neurology 2017 Oct 27;89(17):1829-1839. Epub 2017 Sep 27.

From the Centre for Clinical Brain Sciences (K.R., C.L.M.S.), College of Medicine and Veterinary Medicine (V.S., H.M.), and Institute for Genetics and Molecular Medicine (C.L.M.S.), University of Edinburgh, UK; Institute for Stroke and Dementia Research (R.M., M.D.), Klinikum der Universität München, Munich, Germany; Center for Human Genetic Research (C.D.A., F.R., J.R.) and J. Philip Kistler Stroke Research Center (C.D.A., F.R., N.S.R., J.R.) and Division of Neurocritical Care and Emergency Neurology (C.D.A., F.R., J.R.), Department of Neurology, Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (C.D.A., F.R., J.R.), Broad Institute, Cambridge, MA; Population Health Research Institute (M.C., M.O., G.P.), McMaster University, Hamilton Health Sciences Centre, Ontario, Canada; Department of Medicine (T.D., B.D.M.), University of Maryland School of Medicine, Baltimore; Division of Neurocritical Care and Emergency Neurology (G.J.F.), Department of Neurology, Yale University School of Medicine, New Haven, CT; Stroke Pharmacogenomics and Genetics (I.F.-C.), Fundació Docència i Recerca Mutua Terrassa, Mutua de Terrassa Hospital; Neurovascular Research Unit (J.J.-C.), Department of Neurology, and Program in Inflammation and Cardiovascular Disorders (J.J.-C.), Institut Municipal d'Investigacio´Medica-Hospital del Mar, Universitat Autonoma de Barcelona, Spain; Department of Clinical Sciences Lund (A.L.), Neurology, Lund University; Department of Neurology and Rehabilitation Medicine (A.L., M.S.), Neurology, Skåne University Hospital, Lund, Sweden; Neurovascular Research Laboratory and Neurovascular Unit (J.M.), Institut de Recerca, Hospital Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; HRB Clinical Research Facility (M.O.), NUI Galway, and University Hospital Galway, Ireland; Department of Neurology (A.S.), Jagiellonian University Medical College, Krakow, Poland; Cardiovascular Epidemiology Research Group (M.S.), Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Clinical Neurosciences (M.T., H.S.M.), University of Cambridge, UK; Department of Neurology (S.L.P.), Brain Centre Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Boston University Schools of Medicine and Public Health (S.S.); Framingham Heart Study (S.S.), Framingham, MA; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville; Department of Neurology (D.W.), University of Cincinnati College of Medicine, OH; Geriatrics Research and Education Clinical Center (B.D.M.), Baltimore Veterans Administration Medical Center, MD; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664302PMC
October 2017

The Brief Memory and Executive Test (BMET): A cognitive screening tool to detect and differentiate vascular cognitive impairment and Alzheimer's disease.

Int J Geriatr Psychiatry 2018 02 7;33(2):e273-e279. Epub 2017 Sep 7.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gps.4787DOI Listing
February 2018

Genetically-Predicted Adult Height and Alzheimer's Disease.

J Alzheimers Dis 2017 ;60(2):691-698

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-170528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037293PMC
April 2018

Neuropathology of White Matter Lesions, Blood-Brain Barrier Dysfunction, and Dementia.

Stroke 2017 10 30;48(10):2799-2804. Epub 2017 Aug 30.

From the Cell Biology and Genetics Research Centre (A.H.H., J.A., I.B., L.R.B.) and Neuroscience Research Centre (A.H.H., J.A., I.B., T.R.B., L.R.B.), Molecular and Clinical Sciences Research Institute, St George's University of London, United Kingdom; Department of Neurology (A.H.H.) and Department of Cellular Pathology (K.E., J.J., L.R.B.), St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Department of Public Health and Primary Care (T.M.), Department of Radiology (T.M.), and Stroke Research Group, Department of Clinical Neurosciences (H.S.M.), University of Cambridge, United Kingdom; and The Sheffield Institute for Translational Neuroscience, University of Sheffield, United Kingdom (G.F.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.117.018101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986073PMC
October 2017

Stenting for symptomatic vertebral artery stenosis: The Vertebral Artery Ischaemia Stenting Trial.

Neurology 2017 Sep 23;89(12):1229-1236. Epub 2017 Aug 23.

From the Stroke Research Group (H.S.M., S.C.L.), Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus; Nuffield Department of Clinical Neurosciences (W.K., U.G.S., P.M.R.), John Radcliffe Hospital, University of Oxford; Robertson Centre for Biostatistics (I.F.), University of Glasgow; and Department of Neuroradiology (A.C.), St. George's Hospital, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606920PMC
September 2017

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke.

Stroke 2017 09 1;48(9):2405-2411. Epub 2017 Aug 1.

From the Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.117.017813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571884PMC
September 2017

Mnemonic function in small vessel disease and associations with white matter tract microstructure.

Neuropsychologia 2017 Sep 24;104:1-7. Epub 2017 Jul 24.

Department of Psychology, Goldsmiths University of London, New Cross, London SE14 6NW, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropsychologia.2017.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637155PMC
September 2017