Publications by authors named "Huda Zoghbi"

100Publications

miR760 regulates ATXN1 levels via interaction with its 5' untranslated region.

Genes Dev 2020 Sep 6;34(17-18):1147-1160. Epub 2020 Aug 6.

Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gad.339317.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462065PMC
September 2020

Advances in understanding of Rett syndrome and MECP2 duplication syndrome: prospects for future therapies.

Lancet Neurol 2020 08;19(8):689-698

Department of Pediatrics, Section of Neurology and Developmental Neurosciences, Baylor College of Medicine, Houston, TX, USA; Howard Hughes Medical Institute, and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(20)30217-9DOI Listing
August 2020

Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders.

Neuroscience 2020 Oct 29;445:190-206. Epub 2020 Apr 29.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.neuroscience.2020.04.037DOI Listing
October 2020

Development of the brainstem respiratory circuit.

Wiley Interdiscip Rev Dev Biol 2020 05 9;9(3):e366. Epub 2019 Dec 9.

Department of Neuroscience, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/wdev.366DOI Listing
May 2020

Strategy to selectively remove mutant proteins could combat neurodegeneration.

Authors:
Huda Y Zoghbi

Nature 2019 11;575(7781):57-58

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http://dx.doi.org/10.1038/d41586-019-03243-7DOI Listing
November 2019

The distinct methylation landscape of maturing neurons and its role in Rett syndrome pathogenesis.

Curr Opin Neurobiol 2019 12 19;59:180-188. Epub 2019 Sep 19.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2019.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892602PMC
December 2019

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Cell 2019 08;178(5):1159-1175.e17

Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726125PMC
August 2019

Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives.

Genome Res 2019 06 23;29(6):999-1008. Epub 2019 Apr 23.

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gr.245571.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581060PMC
June 2019

RBM17 Interacts with U2SURP and CHERP to Regulate Expression and Splicing of RNA-Processing Proteins.

Cell Rep 2018 10;25(3):726-736.e7

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.09.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292215PMC
October 2018

Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome.

eNeuro 2018 May-Jun;5(3). Epub 2018 Aug 10.

Department of Neurology, Brigham and Women's Hospital and Jamaica Plain Veterans Administration Hospital, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1523/ENEURO.0056-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086213PMC
January 2019

Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations.

Nat Commun 2018 08 13;9(1):3225. Epub 2018 Aug 13.

Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-018-05627-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089998PMC
August 2018

Mouse models as a tool for discovering new neurological diseases.

Neurobiol Learn Mem 2019 11 17;165:106902. Epub 2018 Jul 17.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nlm.2018.07.006DOI Listing
November 2019

Impaired spatial memory codes in a mouse model of Rett syndrome.

Elife 2018 07 20;7. Epub 2018 Jul 20.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.

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http://dx.doi.org/10.7554/eLife.31451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054527PMC
July 2018

Loss of from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice.

Elife 2018 07 4;7. Epub 2018 Jul 4.

Department of Neuroscience, Baylor College of Medicine, Houston, United States.

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http://dx.doi.org/10.7554/eLife.38455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067883PMC
July 2018

Genome-wide distribution of linker histone H1.0 is independent of MeCP2.

Nat Neurosci 2018 06 25;21(6):794-798. Epub 2018 May 25.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41593-018-0155-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099063PMC
June 2018

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.

Neurobiol Dis 2018 08 11;116:93-105. Epub 2018 May 11.

Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, United States; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States; Skidmore College Neuroscience Program, Saratoga Springs, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028938PMC
August 2018

A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures.

Cell 2018 02;172(5):924-936.e11

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832058PMC
February 2018

Motor neuron degeneration correlates with respiratory dysfunction in SCA1.

Dis Model Mech 2018 02 26;11(2). Epub 2018 Feb 26.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA

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http://dx.doi.org/10.1242/dmm.032623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894948PMC
February 2018

Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome.

Am J Hum Genet 2018 02;102(2):296-308

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985472PMC
February 2018

Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.

Proc Natl Acad Sci U S A 2018 02 30;115(7):E1511-E1519. Epub 2018 Jan 30.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1716452115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816173PMC
February 2018

Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.

Elife 2017 11 23;6. Epub 2017 Nov 23.

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.

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http://dx.doi.org/10.7554/eLife.31181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736349PMC
November 2017

An RNA interference screen identifies druggable regulators of MeCP2 stability.

Sci Transl Med 2017 Aug;9(404)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf7588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736385PMC
August 2017

An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment.

J Neurosci 2017 09 20;37(36):8583-8594. Epub 2017 Jul 20.

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030,

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http://dx.doi.org/10.1523/JNEUROSCI.0295-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596675PMC
September 2017

CRISPRcloud: a secure cloud-based pipeline for CRISPR pooled screen deconvolution.

Bioinformatics 2017 Sep;33(18):2963-2965

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.

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http://dx.doi.org/10.1093/bioinformatics/btx335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870715PMC
September 2017

Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.

Neuron 2017 Apr 6;94(2):294-303.e4. Epub 2017 Apr 6.

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702257PMC
April 2017

An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant Pathways.

Mol Cell Proteomics 2017 04 2;16(4):581-593. Epub 2017 Feb 2.

From the ‡Verna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77003;

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http://dx.doi.org/10.1074/mcp.M116.061440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383780PMC
April 2017

The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.

PLoS One 2016 14;11(12):e0166703. Epub 2016 Dec 14.

Institute for Regenerative Medicine, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Civic Center Blvd., Philadelphia, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166703PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156359PMC
July 2017

Neurodegeneration: From cellular concepts to clinical applications.

Sci Transl Med 2016 11;8(364):364ps18

Baylor College of Medicine, Howard Hughes Medical Institute, and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.aal2074DOI Listing
November 2016

Lessons learned from studying syndromic autism spectrum disorders.

Nat Neurosci 2016 10;19(11):1408-1417

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1038/nn.4420DOI Listing
October 2016

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.

Neuron 2016 Oct 6;92(2):407-418. Epub 2016 Oct 6.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745060PMC
October 2016

Rett Syndrome and the Ongoing Legacy of Close Clinical Observation.

Authors:
Huda Y Zoghbi

Cell 2016 Oct;167(2):293-297

Baylor College of Medicine, Howard Hughes Medical Institute, and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.039DOI Listing
October 2016

Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model.

Neuron 2016 Aug 4;91(4):739-747. Epub 2016 Aug 4.

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute,, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019177PMC
August 2016

Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.

Neuron 2016 Mar 3;89(6):1194-1207. Epub 2016 Mar 3.

Institute for Translational Neuroscience, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.

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http://dx.doi.org/10.1016/j.neuron.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795980PMC
March 2016

Epigenetics and Human Disease.

Cold Spring Harb Perspect Biol 2016 Feb 1;8(2):a019497. Epub 2016 Feb 1.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030.

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http://dx.doi.org/10.1101/cshperspect.a019497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743078PMC
February 2016

Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis.

Cell 2016 Jan;164(3):460-75

VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium; Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium; Program in Molecular and Developmental Genetics, Doctoral School for Biomedical Sciences, University of Leuven School Group Biomedicine, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.12.048DOI Listing
January 2016

Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides.

Nature 2015 Dec 25;528(7580):123-6. Epub 2015 Nov 25.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature16159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839300PMC
December 2015

Loss of MeCP2 in Parvalbumin-and Somatostatin-Expressing Neurons in Mice Leads to Distinct Rett Syndrome-like Phenotypes.

Neuron 2015 Nov;88(4):651-8

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656196PMC
November 2015

Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice.

Nature 2015 Oct;526(7573):430-4

Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature15694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828032PMC
October 2015

Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.

J Biol Chem 2015 Sep 5;290(37):22485-93. Epub 2015 Aug 5.

From the Program in Developmental Biology, the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030 Department of Molecular and Human Genetics and Howard Hughes Medical Institute, Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 and

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http://dx.doi.org/10.1074/jbc.M115.658104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566224PMC
September 2015

Rett syndrome: disruption of epigenetic control of postnatal neurological functions.

Hum Mol Genet 2015 Oct 9;24(R1):R10-6. Epub 2015 Jun 9.

Department of Neuroscience, Baylor College of Medicine, Houston 77030, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston 77030, USA Howard Hughes Medical Institute, Baylor College of Medicine, Houston 77030, USA and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston 77030, USA

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http://dx.doi.org/10.1093/hmg/ddv217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571996PMC
October 2015

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.

Elife 2015 May 19;4. Epub 2015 May 19.

Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, United States.

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http://dx.doi.org/10.7554/eLife.07558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462648PMC
May 2015

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome.

Proc Natl Acad Sci U S A 2015 Apr 13;112(17):5509-14. Epub 2015 Apr 13.

Department of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030 Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030; and

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http://dx.doi.org/10.1073/pnas.1505909112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418849PMC
April 2015

Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.

Cell 2015 Mar;160(6):1087-98

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383046PMC
March 2015

Deficiency of Capicua disrupts bile acid homeostasis.

Sci Rep 2015 Feb 5;5:8272. Epub 2015 Feb 5.

1] Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea [2] Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea.

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http://dx.doi.org/10.1038/srep08272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317698PMC
February 2015

Deep brain stimulation for Parkinson disease: the 2014 Lasker-DeBakey Clinical Medical Research Award.

JAMA Neurol 2015 Mar;72(3):259-60

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas2Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston3Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1001/jamaneurol.2014.4109DOI Listing
March 2015

Fragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.

Hum Mol Genet 2015 Apr 28;24(7):1813-23. Epub 2014 Nov 28.

Department of Molecular and Human Genetics, The Howard Hughes Medical Institute, Departments of Pediatrics and, Program in Developmental Biology and Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA, Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA

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http://dx.doi.org/10.1093/hmg/ddu595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355018PMC
April 2015

From anatomy to electrophysiology: clinical Lasker goes deep.

Authors:
Huda Y Zoghbi

Cell 2014 Sep;158(6):1225-1229

Baylor College of Medicine, Howard Hughes Medical institute, and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.08.021DOI Listing
September 2014

Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice.

Elife 2014 Jun 26;3. Epub 2014 Jun 26.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.

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http://dx.doi.org/10.7554/eLife.02676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102243PMC
June 2014

NR2F1 mutations cause optic atrophy with intellectual disability.

Am J Hum Genet 2014 Feb 23;94(2):303-9. Epub 2014 Jan 23.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928641PMC
February 2014

Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome.

J Neurosci 2013 Dec;33(50):19518-33

Department of Neuroscience, Department of Neurology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, and Department of Molecular and Human Genetics at Baylor College of Medicine, Houston, Texas 77030.

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http://dx.doi.org/10.1523/JNEUROSCI.1745-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858623PMC
December 2013

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

Nature 2013 Nov 23;503(7474):72-7. Epub 2013 Oct 23.

1] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA [2] Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA [3] Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature12630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923348PMC
November 2013

Scientists. Curiosity and observation.

Biotechniques 2013 Aug;55(2):53

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http://dx.doi.org/10.2144/000114060DOI Listing
August 2013

Brief report: MECP2 mutations in people without Rett syndrome.

J Autism Dev Disord 2014 Mar;44(3):703-11

Section of Child Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1007/s10803-013-1902-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880396PMC
March 2014

Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.

J Neurosci 2013 May;33(22):9328-36

Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3465-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710458PMC
May 2013

Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery.

PLoS Genet 2013 Mar 28;9(3):e1003359. Epub 2013 Mar 28.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610904PMC
March 2013

Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.

J Neurosci 2013 Mar;33(13):5806-20

Institute of Translational Neuroscience, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6311-11.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633086PMC
March 2013

Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua.

Genes Dev 2013 Mar;27(6):590-5

Department of Biological Sciences, Graduate School of Nanoscience and Technology (World Class University), KAIST (Korea Advanced Institute of Science and Technology) Institute for the BioCentury, KAIST, Daejeon 305-701, Korea.

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http://dx.doi.org/10.1101/gad.212068.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613606PMC
March 2013

The basics of translation.

Authors:
Huda Y Zoghbi

Science 2013 Jan;339(6117):250

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http://dx.doi.org/10.1126/science.1234799DOI Listing
January 2013

Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses.

Sci Transl Med 2012 Dec;4(163):163ra158

Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628825PMC
December 2012