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Publications Authored by Hubing Shi | PubFacts
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33Publications

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Inhibition of programmed cell death protein ligand-1 (PD-L1) by benzyl ether derivatives: analyses of conformational change, molecular recognition and binding free energy.

J Biomol Struct Dyn 2019 Nov 24;37(18):4801-4812. Epub 2019 Jan 24.

College of Pharmacy and Biological Engineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Chengdu University , Chengdu , China.

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http://dx.doi.org/10.1080/07391102.2018.1563568DOI Listing
November 2019

A novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic.

Cancer Sci 2019 Sep 9;110(9):2941-2959. Epub 2019 Aug 9.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1111/cas.14143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726694PMC
September 2019

The global motion affecting electron transfer in Plasmodium falciparum type II NADH dehydrogenases: a novel non-competitive mechanism for quinoline ketone derivative inhibitors.

Phys Chem Chem Phys 2019 Aug;21(33):18105-18118

College of Pharmacy and Biological Engineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Chengdu University, Chengdu, 610106, China.

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http://dx.doi.org/10.1039/c9cp02645bDOI Listing
August 2019

Management of Adverse Events in Cancer Patients Treated With PD-1/PD-L1 Blockade: Focus on Asian Populations.

Front Pharmacol 2019 2;10:726. Epub 2019 Jul 2.

Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.3389/fphar.2019.00726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614522PMC
July 2019

Author Correction: Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours.

Nat Biomed Eng 2019 May;3(5):414

State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1038/s41551-019-0402-7DOI Listing
May 2019

Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma.

Front Immunol 2019 7;10:990. Epub 2019 May 7.

Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.3389/fimmu.2019.00990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513976PMC
May 2019

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours.

Nat Biomed Eng 2019 Apr 25;3(4):306-317. Epub 2019 Mar 25.

State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1038/s41551-019-0375-6DOI Listing
April 2019

HIP1R targets PD-L1 to lysosomal degradation to alter T cell-mediated cytotoxicity.

Nat Chem Biol 2019 01 5;15(1):42-50. Epub 2018 Nov 5.

State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, Shanghai, China.

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http://www.nature.com/articles/s41589-018-0161-x
Publisher Site
http://dx.doi.org/10.1038/s41589-018-0161-xDOI Listing
January 2019

PD-L1 Nanobody Competitively Inhibits the Formation of the PD-1/PD-L1 Complex: Comparative Molecular Dynamics Simulations.

Int J Mol Sci 2018 07 7;19(7). Epub 2018 Jul 7.

College of Pharmacy and Biological Engineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu 610106, China.

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http://dx.doi.org/10.3390/ijms19071984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073277PMC
July 2018

A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.

Cell Chem Biol 2018 06 19;25(6):761-774.e5. Epub 2018 Apr 19.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.03.010DOI Listing
June 2018

PD-L2 expression in colorectal cancer: Independent prognostic effect and targetability by deglycosylation.

Oncoimmunology 2017 16;6(7):e1327494. Epub 2017 May 16.

MOH Key Laboratory of Gastroenterology and Hepatology, State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1080/2162402X.2017.1327494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543903PMC
May 2017

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma.

Cell Discov 2016 6;2:16028. Epub 2016 Sep 6.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA; Crump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA; California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/celldisc.2016.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012007PMC
September 2016

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.

Cell 2015 Sep;162(6):1271-85

Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821508PMC
September 2015

Therapy-induced tumour secretomes promote resistance and tumour progression.

Nature 2015 Apr 25;520(7547):368-72. Epub 2015 Mar 25.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature14336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507807PMC
April 2015

Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction.

Cancer Cell 2015 Feb 15;27(2):240-56. Epub 2015 Jan 15.

Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326539PMC
February 2015

Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma.

Methods Mol Biol 2014 ;1102:163-74

Department of Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-62703-727-3_10DOI Listing
June 2014

A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition.

Cancer Discov 2014 Jan 21;4(1):69-79. Epub 2013 Nov 21.

1The Division of Dermatology, Department of Medicine, 2Division of Surgical Oncology, Department of Surgery, 3Division of Hematology and Oncology, Department of Medicine, 4Jonsson Comprehensive Cancer Center, 5Department of Molecular and Medical Pharmacology, 6David Geffen School of Medicine, University of California, Los Angeles, California; 7Melanoma Institute of Australia, 8Royal Prince Alfred Hospital, 9Westmead Millennium Institute, and 10Westmead Hospital, University of Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893054PMC
January 2014

MDM4 is a key therapeutic target in cutaneous melanoma.

Nat Med 2012 Aug 22;18(8):1239-47. Epub 2012 Jul 22.

Center for the Biology of Disease, Laboratory for Molecular Cancer Biology, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium; Center for Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/nm.2863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744207PMC
August 2012

Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition.

Cancer Res 2011 Aug;71(15):5067-74

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149831PMC
August 2011

Suppression of leukemia development caused by PTEN loss.

Proc Natl Acad Sci U S A 2011 Jan 6;108(4):1409-14. Epub 2011 Jan 6.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.

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http://www.pnas.org/content/108/4/1409.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029702PMC
January 2011

The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis.

J Biol Chem 2010 Dec 11;285(51):40039-49. Epub 2010 Oct 11.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1074/jbc.M110.181941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000986PMC
December 2010

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.

Nature 2010 Dec 24;468(7326):973-7. Epub 2010 Nov 24.

Division of Dermatology/Department of Medicine, UCLA's Jonsson Comprehensive Cancer Center, 52-121 CHS, Los Angeles, California 90095-1750, USA.

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http://dx.doi.org/10.1038/nature09626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143360PMC
December 2010

The heparin binding motif of endostatin mediates its interaction with receptor nucleolin.

Biochemistry 2009 Dec;48(49):11655-63

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing 100084, PR China.

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http://dx.doi.org/10.1021/bi901265zDOI Listing
December 2009

The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy.

Proc Natl Acad Sci U S A 2009 Dec 24;106(50):21288-93. Epub 2009 Nov 24.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1073/pnas.0908151106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795546PMC
December 2009

Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis.

Cancer Res 2009 Oct 22;69(19):7529-37. Epub 2009 Sep 22.

Cancer Biology Laboratory and Beijing Key Laboratory of Protein Therapeutics, Department of Biological Sciences and Biotechnology and National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing, People's Republic of China.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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October 2009

Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1alpha/CXCR4 axis.

Cancer Res 2009 Aug 7;69(15):6057-64. Epub 2009 Jul 7.

Department of Biological Sciences and Biotechnology, National Engineering Laboratory for Antitumor Protein Therapeutics, Tsinghua University, Beijing, PR China.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2007DOI Listing
August 2009

Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis.

FASEB J 2008 Aug 1;22(8):2809-20. Epub 2008 Apr 1.

Beijing Key Laboratory for Protein Therapeutics, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://www.fasebj.org/doi/10.1096/fj.08-107417
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August 2008

Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin.

Blood 2007 Oct 5;110(8):2899-906. Epub 2007 Jul 5.

Laboratory of Protein Chemistry, the Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China.

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http://dx.doi.org/10.1182/blood-2007-01-064428DOI Listing
October 2007

The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.

Blood 2006 May 10;107(9):3564-71. Epub 2006 Jan 10.

Laboratory of Protein Chemistry, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, PR China.

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http://dx.doi.org/10.1182/blood-2005-07-2961DOI Listing
May 2006