Hubert Hackl

Hubert Hackl

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Hubert Hackl

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The miR-34 family and its clinical significance in ovarian cancer.

J Cancer 2020 13;11(6):1446-1456. Epub 2020 Jan 13.

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

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http://dx.doi.org/10.7150/jca.33831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995379PMC
January 2020

Next-generation computational tools for interrogating cancer immunity.

Nat Rev Genet 2019 Dec 12;20(12):724-746. Epub 2019 Sep 12.

Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1038/s41576-019-0166-7DOI Listing
December 2019

Von Willebrand factor facilitates MELD-independent risk stratification on the waiting list for liver transplantation.

Hepatology 2019 Nov 27. Epub 2019 Nov 27.

Division of General Surgery, Department of Surgery, Medical University of Vienna, General Hospital Vienna, Austria.

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http://dx.doi.org/10.1002/hep.31047DOI Listing
November 2019

Microbial Colonization in Adulthood Shapes the Intestinal Macrophage Compartment.

J Crohns Colitis 2019 Sep;13(9):1173-1185

Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1093/ecco-jcc/jjz036DOI Listing
September 2019

Baseline Absolute Lymphocyte Count and ECOG Performance Score Are Associated with Survival in Advanced Non-Small Cell Lung Cancer Undergoing PD-1/PD-L1 Blockade.

J Clin Med 2019 Jul 10;8(7). Epub 2019 Jul 10.

Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, 5020 Salzburg, Austria.

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http://dx.doi.org/10.3390/jcm8071014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678702PMC
July 2019

Regorafenib Is Associated With Increased Skeletal Muscle Loss Compared to TAS-102 in Metastatic Colorectal Cancer.

Clin Colorectal Cancer 2019 06 11;18(2):159-166.e3. Epub 2019 Apr 11.

Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology, and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute, Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University Salzburg, Salzburg, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183055
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http://dx.doi.org/10.1016/j.clcc.2019.04.003DOI Listing
June 2019

Clinical Impact of RANK Signalling in Ovarian Cancer.

Cancers (Basel) 2019 Jun 8;11(6). Epub 2019 Jun 8.

Department of Obstetrics and Gynaecology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

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https://www.mdpi.com/2072-6694/11/6/791
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http://dx.doi.org/10.3390/cancers11060791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627676PMC
June 2019

The Effects of Endurance Exercise and Diet on Atherosclerosis in Young and Aged ApoE-/- and Wild-Type Mice.

Gerontology 2019 30;65(1):45-56. Epub 2018 Aug 30.

Laboratory of Autoimmunity, Division of Experimental Pathophysiology and Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1159/000492571DOI Listing
May 2019

Investigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia.

PLoS One 2018 20;13(12):e0208753. Epub 2018 Dec 20.

Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Salzburg, Austria, Cancer Cluster Salzburg, Salzburg, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208753PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301619PMC
May 2019

DNA Methylation Signatures Predicting Bevacizumab Efficacy in Metastatic Breast Cancer.

Theranostics 2018 11;8(8):2278-2288. Epub 2018 Mar 11.

III rd Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center; Salzburg Cancer Research Institute (SCRI) with Laboratory of Immunological and Molecular Cancer Research (LIMCR) and Center for Clinical Cancer and Immunology Trials (CCCIT); Paracelsus Medical University Salzburg, Salzburg, Austria.

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http://dx.doi.org/10.7150/thno.23544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928889PMC
April 2019

Modeling therapy resistance via the EGFR signaling pathway.

FEBS J 2019 Apr 20;286(7):1284-1286. Epub 2019 Mar 20.

Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Austria.

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http://dx.doi.org/10.1111/febs.14809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850018PMC
April 2019

Gestational diabetes alters microRNA signatures in human feto-placental endothelial cells depending on fetal sex.

Clin Sci (Lond) 2018 11 21;132(22):2437-2449. Epub 2018 Nov 21.

Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria

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http://clinsci.org/lookup/doi/10.1042/CS20180825
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http://dx.doi.org/10.1042/CS20180825DOI Listing
November 2018

Truncated isoform Vav3.1 is highly expressed in ovarian cancer stem cells and clinically relevant in predicting prognosis and platinum-response.

Int J Cancer 2018 04 14;142(8):1640-1651. Epub 2017 Dec 14.

Department of Obstetrics and Gynecology, Medical University Innsbruck, 6020, Innsbruck, Austria.

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http://doi.wiley.com/10.1002/ijc.31186
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http://dx.doi.org/10.1002/ijc.31186DOI Listing
April 2018

Enhanced Expression of Genes Related to Xenobiotic Metabolism in the Skin of Patients with Atopic Dermatitis but Not with Ichthyosis Vulgaris.

J Invest Dermatol 2018 01 9;138(1):98-108. Epub 2017 Sep 9.

Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X173293
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http://dx.doi.org/10.1016/j.jid.2017.08.036DOI Listing
January 2018

Sidedness and TP53 mutations impact OS in anti-EGFR but not anti-VEGF treated mCRC - an analysis of the KRAS registry of the AGMT (Arbeitsgemeinschaft Medikamentöse Tumortherapie).

BMC Cancer 2018 01 3;18(1):11. Epub 2018 Jan 3.

IIIrd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Paracelsus Medical University, 5020, Salzburg, Austria.

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http://dx.doi.org/10.1186/s12885-017-3955-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753540PMC
January 2018

MicroRNAs and their role for T stage determination and lymph node metastasis in early colon carcinoma.

Clin Exp Metastasis 2017 10 13;34(6-7):431-440. Epub 2017 Nov 13.

Department of Internal Medicine I: Medical Oncology, Hematology and Gastroenterology, Ordensklinikum Linz, Barmherzige Schwestern, Linz, Austria.

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http://dx.doi.org/10.1007/s10585-017-9863-9DOI Listing
October 2017

Dynamics of Bile Acid Profiles, GLP-1, and FGF19 After Laparoscopic Gastric Banding.

J Clin Endocrinol Metab 2017 08;102(8):2974-2984

Department of Medicine, Division of Internal Medicine I (Gastroenterology, Endocrinology, and Metabolism), Medical University of Innsbruck, Innsbruck A-6020, Austria.

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http://academic.oup.com/jcem/article/102/8/2974/3861921/Dyna
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http://dx.doi.org/10.1210/jc.2017-00235DOI Listing
August 2017

Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia.

J Hematol Oncol 2017 02 20;10(1):51. Epub 2017 Feb 20.

Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Wien, Austria.

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http://dx.doi.org/10.1186/s13045-017-0416-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322789PMC
February 2017

Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients.

BMC Cancer 2016 10 22;16(1):821. Epub 2016 Oct 22.

Department of Obstetrics and Gynaecology, Medical University of Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1186/s12885-016-2840-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075160PMC
October 2016

Formation of lipid bodies and changes in fatty acid composition upon pre-akinete formation in Arctic and Antarctic Zygnema (Zygnematophyceae, Streptophyta) strains.

FEMS Microbiol Ecol 2016 07 10;92(7). Epub 2016 May 10.

Institute of Botany, Functional Plant Biology, University of Innsbruck, Sternwartestraße 15, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1093/femsec/fiw096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892695PMC
July 2016

Computational genomics tools for dissecting tumour-immune cell interactions.

Nat Rev Genet 2016 07;17(8):441-58

Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1038/nrg.2016.67DOI Listing
July 2016

The colorectal cancer immune paradox revisited.

Oncoimmunology 2016 Feb 27;5(2):e1078058. Epub 2015 Aug 27.

Biocenter, Division of Bioinformatics, Medical University of Innsbruck Innrain 80 , Innsbruck, Austria.

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http://dx.doi.org/10.1080/2162402X.2015.1078058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801462PMC
February 2016

Amphotericin B Resistance in Aspergillus terreus Is Overpowered by Coapplication of Pro-oxidants.

Antioxid Redox Signal 2015 Dec 8;23(18):1424-38. Epub 2015 Oct 8.

1 Division of Hygiene and Medical Microbiology, Medical University of Innsbruck , Innsbruck, Austria .

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http://dx.doi.org/10.1089/ars.2014.6220DOI Listing
December 2015

Insights from computational modeling in inflammation and acute rejection in limb transplantation.

PLoS One 2014 13;9(6):e99926. Epub 2014 Jun 13.

Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057425PMC
May 2015

Differential gene expression in Aspergillus fumigatus induced by human platelets in vitro.

Int J Med Microbiol 2015 May 17;305(3):327-38. Epub 2015 Jan 17.

Division of Hygiene and Medical Microbiology, Innsbruck Medical University, 6020 Innsbruck, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S14384221150000
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http://dx.doi.org/10.1016/j.ijmm.2015.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415150PMC
May 2015

Mathematical models for translational and clinical oncology.

J Clin Bioinforma 2013 Nov 7;3(1):23. Epub 2013 Nov 7.

Biocenter, Division of Bioinformatics, Innsbruck Medical University, Innrain 80, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1186/2043-9113-3-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828625PMC
November 2013

GPViz: dynamic visualization of genomic regions and variants affecting protein domains.

Bioinformatics 2013 Sep 19;29(17):2195-6. Epub 2013 Jun 19.

Biocenter, Division of Bioinformatics, Innsbruck Medical University and Oncotyrol Center for Personalized Cancer Medicine GmbH, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1093/bioinformatics/btt354DOI Listing
September 2013

Nr4a1 is required for fasting-induced down-regulation of Pparγ2 in white adipose tissue.

Mol Endocrinol 2013 Jan 18;27(1):135-49. Epub 2012 Dec 18.

Division of Bioinformatics, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1210/me.2012-1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416946PMC
January 2013

Bioinformatics for cancer immunology and immunotherapy.

Cancer Immunol Immunother 2012 Nov 18;61(11):1885-903. Epub 2012 Sep 18.

Biocenter, Division of Bioinformatics, Innsbruck Medical University, Innrain 80, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00262-012-1354-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493665PMC
November 2012

Differential response of arterial and venous endothelial cells to extracellular matrix is modulated by oxygen.

Histochem Cell Biol 2012 May 1;137(5):641-55. Epub 2012 Feb 1.

Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.

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http://dx.doi.org/10.1007/s00418-012-0917-4DOI Listing
May 2012

Fetal HDL/apoE: a novel regulator of gene expression in human placental endothelial cells.

Physiol Genomics 2011 Nov 27;43(22):1255-62. Epub 2011 Sep 27.

Clinic of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1152/physiolgenomics.00109.2011DOI Listing
November 2011

Insights into global mechanisms and disease by gene expression profiling.

Methods Mol Biol 2011 ;719:269-98

Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.

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http://dx.doi.org/10.1007/978-1-61779-027-0_13DOI Listing
June 2011

Information technology solutions for integration of biomolecular and clinical data in the identification of new cancer biomarkers and targets for therapy.

Pharmacol Ther 2010 Dec 9;128(3):488-98. Epub 2010 Sep 9.

Biocenter, Section for Bioinformatics, Innsbruck Medical University, Schöpfstrasse 45, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.pharmthera.2010.08.012DOI Listing
December 2010

Tetracycline regulator expression alters the transcriptional program of mammalian cells.

PLoS One 2010 Sep 24;5(9):e13013. Epub 2010 Sep 24.

Biocenter, Section for Bioinformatics, Innsbruck Medical University, Innsbruck, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013013PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945318PMC
September 2010

Novel insights into adipogenesis from omics data.

Curr Med Chem 2009 ;16(23):2952-64

Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765082PMC
http://dx.doi.org/10.2174/092986709788803132DOI Listing
November 2009

Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes.

J Leukoc Biol 2009 Oct 15;86(4):813-22. Epub 2009 Jul 15.

Department of Medical Genetics, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1189/jlb.0109042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777892PMC
October 2009

Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis.

BMC Genomics 2008 Jul 17;9:340. Epub 2008 Jul 17.

Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria.

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http://dx.doi.org/10.1186/1471-2164-9-340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492879PMC
July 2008

Molecular processes during fat cell development revealed by gene expression profiling and functional annotation.

Genome Biol 2005 19;6(13):R108. Epub 2005 Dec 19.

Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2005-6-13-r108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414107PMC
July 2006

PathwayExplorer: web service for visualizing high-throughput expression data on biological pathways.

Nucleic Acids Res 2005 Jul;33(Web Server issue):W633-7

Institute for Genomics and Bioinformatics and Christian-Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, Graz 8010, Austria.

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http://dx.doi.org/10.1093/nar/gki391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160152PMC
July 2005

MARS: microarray analysis, retrieval, and storage system.

BMC Bioinformatics 2005 Apr 18;6:101. Epub 2005 Apr 18.

Institute for Genomics and Bioinformatics, Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria.

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http://dx.doi.org/10.1186/1471-2105-6-101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1090551PMC
April 2005

GOLD.db: genomics of lipid-associated disorders database.

BMC Genomics 2004 Dec 10;5(1):93. Epub 2004 Dec 10.

Institute for Genomics and Bioinformatics and Christian-Doppler-Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria.

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http://dx.doi.org/10.1186/1471-2164-5-93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544894PMC
December 2004

Analysis of DNA microarray data.

Curr Top Med Chem 2004 ;4(13):1357-70

Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, A-8010 Graz, Austria.

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http://dx.doi.org/10.2174/1568026043387773DOI Listing
November 2004

Java editor for biological pathways.

Bioinformatics 2003 Apr;19(6):786-7

Institute of Biomedical Engineering and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Krenngasse 37, 8010 Graz, Austria.

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http://dx.doi.org/10.1093/bioinformatics/btg052DOI Listing
April 2003