Huan-Xiang Zhou

Huan-Xiang Zhou

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Huan-Xiang Zhou

Huan-Xiang Zhou

Publications by authors named "Huan-Xiang Zhou"

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100Publications

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Atomistic Modeling of Intrinsically Disordered Proteins Under Polyethylene Glycol Crowding: Quantitative Comparison with Experimental Data and Implication of Protein-Crowder Attraction.

J Phys Chem B 2018 Oct 3. Epub 2018 Oct 3.

Department of Physics and Institute of Molecular Biophysics , Florida State University , Tallahassee , Florida 32306 , United States.

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October 2018

A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca permeability.

Nat Commun 2018 Sep 14;9(1):3748. Epub 2018 Sep 14.

Center for Nervous System Disorders, Stony Brook University, Stony Brook, NY, 11794-5230, USA.

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September 2018

Temperature-induced collapse of a disordered peptide observed by three sampling methods in molecular dynamics simulations.

J Chem Phys 2018 Aug;149(7):072313

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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August 2018

Why Do Disordered and Structured Proteins Behave Differently in Phase Separation?

Trends Biochem Sci 2018 Jul 30;43(7):499-516. Epub 2018 Apr 30.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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July 2018

Hinge-Shift Mechanism Modulates Allosteric Regulations in Human Pin1.

J Phys Chem B 2018 May 7;122(21):5623-5629. Epub 2018 Feb 7.

Department of Physics and Center for Biological Physics , Arizona State University , Tempe , Arizona 85287 , United States.

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May 2018

Using the fast fourier transform in binding free energy calculations.

J Comput Chem 2018 Apr 22;39(11):621-636. Epub 2017 Dec 22.

Department of Chemistry, Illinois Institute of Technology, Chicago, Illinois, 60616.

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April 2018

Liquid-Liquid Phase Separation of Patchy Particles Illuminates Diverse Effects of Regulatory Components on Protein Droplet Formation.

Sci Rep 2018 Apr 30;8(1):6728. Epub 2018 Apr 30.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, 32306, United States.

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April 2018

Intrinsically Disordered Protein Exhibits Both Compaction and Expansion under Macromolecular Crowding.

Biophys J 2018 Mar;114(5):1067-1079

Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida; Department of Chemistry and Department of Physics, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

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March 2018

Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation.

Chem Rev 2018 Feb 10;118(4):1691-1741. Epub 2018 Jan 10.

Department of Physics and Institute of Molecular Biophysics, Florida State University , Tallahassee, Florida 32306, United States.

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February 2018

Structural modeling for the open state of an NMDA receptor.

J Struct Biol 2017 Dec 22;200(3):369-375. Epub 2017 Jul 22.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, United States. Electronic address:

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December 2017

The dock-and-coalesce mechanism for the association of a WASP disordered region with the Cdc42 GTPase.

FEBS J 2017 10 30;284(20):3381-3391. Epub 2017 Aug 30.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.

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October 2017

Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors.

J Gen Physiol 2017 Jun 15;149(6):661-680. Epub 2017 May 15.

Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794

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June 2017

Rate Constants and Mechanisms of Protein-Ligand Binding.

Annu Rev Biophys 2017 05 30;46:105-130. Epub 2017 Mar 30.

Department of Physics, Florida State University, Tallahassee, Florida 32306; email:

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May 2017

Protein folding, binding, and droplet formation in cell-like conditions.

Curr Opin Struct Biol 2017 04 20;43:28-37. Epub 2016 Oct 20.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

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April 2017

Gating Motions and Stationary Gating Properties of Ionotropic Glutamate Receptors: Computation Meets Electrophysiology.

Authors:
Huan-Xiang Zhou

Acc Chem Res 2017 04 10;50(4):814-822. Epub 2017 Feb 10.

Department of Physics and Institute of Molecular Biophysics, Florida State University , Tallahassee, Florida 32306, United States.

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April 2017

Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.

Trends Neurosci 2017 03 8;40(3):129-137. Epub 2017 Feb 8.

Department of Neurobiology and Behavior, and Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address:

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March 2017

Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.

Proc Natl Acad Sci U S A 2016 11 17;113(44):E6776-E6785. Epub 2016 Oct 17.

Department of Physics, Florida State University, Tallahassee, FL 32306;

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November 2016

Semiclosed Conformations of the Ligand-Binding Domains of NMDA Receptors during Stationary Gating.

Biophys J 2016 Oct;111(7):1418-1428

Department of Physics, Florida State University, Tallahassee, Florida; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida. Electronic address:

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October 2016

Prediction of homoprotein and heteroprotein complexes by protein docking and template-based modeling: A CASP-CAPRI experiment.

Authors:
Marc F Lensink Sameer Velankar Andriy Kryshtafovych Shen-You Huang Dina Schneidman-Duhovny Andrej Sali Joan Segura Narcis Fernandez-Fuentes Shruthi Viswanath Ron Elber Sergei Grudinin Petr Popov Emilie Neveu Hasup Lee Minkyung Baek Sangwoo Park Lim Heo Gyu Rie Lee Chaok Seok Sanbo Qin Huan-Xiang Zhou David W Ritchie Bernard Maigret Marie-Dominique Devignes Anisah Ghoorah Mieczyslaw Torchala Raphaël A G Chaleil Paul A Bates Efrat Ben-Zeev Miriam Eisenstein Surendra S Negi Zhiping Weng Thom Vreven Brian G Pierce Tyler M Borrman Jinchao Yu Françoise Ochsenbein Raphaël Guerois Anna Vangone João P G L M Rodrigues Gydo van Zundert Mehdi Nellen Li Xue Ezgi Karaca Adrien S J Melquiond Koen Visscher Panagiotis L Kastritis Alexandre M J J Bonvin Xianjin Xu Liming Qiu Chengfei Yan Jilong Li Zhiwei Ma Jianlin Cheng Xiaoqin Zou Yang Shen Lenna X Peterson Hyung-Rae Kim Amit Roy Xusi Han Juan Esquivel-Rodriguez Daisuke Kihara Xiaofeng Yu Neil J Bruce Jonathan C Fuller Rebecca C Wade Ivan Anishchenko Petras J Kundrotas Ilya A Vakser Kenichiro Imai Kazunori Yamada Toshiyuki Oda Tsukasa Nakamura Kentaro Tomii Chiara Pallara Miguel Romero-Durana Brian Jiménez-García Iain H Moal Juan Férnandez-Recio Jong Young Joung Jong Yun Kim Keehyoung Joo Jooyoung Lee Dima Kozakov Sandor Vajda Scott Mottarella David R Hall Dmitri Beglov Artem Mamonov Bing Xia Tanggis Bohnuud Carlos A Del Carpio Eichiro Ichiishi Nicholas Marze Daisuke Kuroda Shourya S Roy Burman Jeffrey J Gray Edrisse Chermak Luigi Cavallo Romina Oliva Andrey Tovchigrechko Shoshana J Wodak

Proteins 2016 09 1;84 Suppl 1:323-48. Epub 2016 Jun 1.

Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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September 2016

Fast Method for Computing Chemical Potentials and Liquid-Liquid Phase Equilibria of Macromolecular Solutions.

J Phys Chem B 2016 08 5;120(33):8164-74. Epub 2016 Jul 5.

Department of Physics and Institute of Molecular Biophysics, Florida State University , Tallahassee, Florida 32306, United States.

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August 2016

Electrostatic effects on the folding stability of FKBP12.

Protein Eng Des Sel 2016 08 5;29(8):301-308. Epub 2016 Jul 5.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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August 2016

Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism.

Elife 2016 08 31;5. Epub 2016 Aug 31.

Department of Physics, Institute of Molecular Biophysics, Florida State University, Tallahassee, United States.

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August 2016

Challenges in structural approaches to cell modeling.

J Mol Biol 2016 07 30;428(15):2943-64. Epub 2016 May 30.

Center for Computational Biology and Department of Molecular Biosciences, The University of Kansas, Lawrence, KS 66047, United States. Electronic address:

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July 2016

Protein Allostery and Conformational Dynamics.

Chem Rev 2016 06 15;116(11):6503-15. Epub 2016 Feb 15.

Department of Physics and Institute of Molecular Biophysics, Florida State University , Tallahassee, Florida 32306, United States.

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June 2016

Mechanism and rate constants of the Cdc42 GTPase binding with intrinsically disordered effectors.

Proteins 2016 May 9;84(5):674-85. Epub 2016 Mar 9.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, 32306.

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May 2016

The Transmembrane Domain Mediates Tetramerization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.

J Biol Chem 2016 Mar 2;291(12):6595-606. Epub 2016 Feb 2.

From the Department of Neurobiology and Behavior, the Department of Biochemistry and Cell Biology, and the Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York 11794-5230 and

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March 2016

Differential Binding of Rimantadine Enantiomers to Influenza A M2 Proton Channel.

J Am Chem Soc 2016 Feb 28;138(5):1506-9. Epub 2016 Jan 28.

National High Magnetic Field Laboratory, Florida State University , Tallahassee, Florida 32310, United States.

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February 2016

Dynamic Short Hydrogen Bonds in Histidine Tetrad of Full-Length M2 Proton Channel Reveal Tetrameric Structural Heterogeneity and Functional Mechanism.

Structure 2015 Dec 30;23(12):2300-2308. Epub 2015 Oct 30.

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA; National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

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December 2015

Disorder-to-Order Transition of an Active-Site Loop Mediates the Allosteric Activation of Sortase A.

Biophys J 2015 Oct;109(8):1706-15

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida. Electronic address:

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October 2015

Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors.

J Phys Chem B 2015 Aug 1;119(34):10934-40. Epub 2015 Apr 1.

Department of Physics and Institute of Molecular Biophysics, Florida State University , Tallahassee, Florida 32306, United States.

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August 2015

Dynamically Driven Protein Allostery Exhibits Disparate Responses for Fast and Slow Motions.

Biophys J 2015 Jun;108(12):2771-4

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida. Electronic address:

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June 2015

Design rules for selective binding of nuclear localization signals to minor site of importin α.

PLoS One 2014 7;9(3):e91025. Epub 2014 Mar 7.

Department of Physics, Florida State University, Tallahassee, Florida, United States of America; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America.

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February 2015

Reduced curvature of ligand-binding domain free-energy surface underlies partial agonism at NMDA receptors.

Structure 2015 Jan 24;23(1):228-236. Epub 2014 Dec 24.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

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January 2015

Two pathways mediate interdomain allosteric regulation in pin1.

Structure 2015 Jan 24;23(1):237-247. Epub 2014 Dec 24.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

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January 2015

Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers.

Proc Natl Acad Sci U S A 2015 Jan 29;112(2):E119-26. Epub 2014 Dec 29.

Institute of Molecular Biophysics, and National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310; and Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306;

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January 2015

Multidimensional reaction rate theory with anisotropic diffusion.

J Chem Phys 2014 Nov;141(20):204106

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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November 2014

General rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels.

Nat Commun 2014 Aug 8;5:4641. Epub 2014 Aug 8.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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August 2014

Competitive interactions of ligands and macromolecular crowders with maltose binding protein.

PLoS One 2013 4;8(10):e74969. Epub 2013 Oct 4.

Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America.

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July 2014

Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents.

Nat Neurosci 2014 Jul 25;17(7):914-22. Epub 2014 May 25.

1] Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, USA. [2] Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA.

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July 2014

Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fit.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10197-202. Epub 2014 Jun 30.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306

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July 2014

Further Development of the FFT-based Method for Atomistic Modeling of Protein Folding and Binding under Crowding: Optimization of Accuracy and Speed.

J Chem Theory Comput 2014 Jul 6;10(7):2824-2835. Epub 2014 May 6.

Department of Physics and Institute of Molecular Biophysics, Florida State University , Tallahassee, Florida, United States.

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July 2014

Distinct mechanisms of a phosphotyrosyl peptide binding to two SH2 domains.

J Theor Comput Chem 2014 May;13(3):1440003

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306.

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May 2014

Theoretical frameworks for multiscale modeling and simulation.

Authors:
Huan-Xiang Zhou

Curr Opin Struct Biol 2014 Apr 1;25:67-76. Epub 2014 Feb 1.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

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April 2014

SAXS/SANS probe of intermolecular interactions in concentrated protein solutions.

Biophys J 2014 Feb;106(4):771-3

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts.

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February 2014

Binding of MgtR, a Salmonella transmembrane regulatory peptide, to MgtC, a Mycobacterium tuberculosis virulence factor: a structural study.

J Mol Biol 2014 Jan 17;426(2):436-46. Epub 2013 Oct 17.

National High Magnetic Field Laboratory, Tallahassee, FL 32306, USA; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

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January 2014

Modeling protein association mechanisms and kinetics.

Curr Opin Struct Biol 2013 Dec 12;23(6):887-93. Epub 2013 Jul 12.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

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December 2013

Using the concept of transient complex for affinity predictions in CAPRI rounds 20-27 and beyond.

Proteins 2013 Dec 14;81(12):2229-36. Epub 2013 Sep 14.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, 32306.

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December 2013

Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels.

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):E4045-54. Epub 2013 Sep 30.

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

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October 2013

An FFT-based method for modeling protein folding and binding under crowding: benchmarking on ellipsoidal and all-atom crowders.

J Chem Theory Comput 2013 Oct;9(10)

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida.

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October 2013

Effects of Macromolecular Crowding on the Conformational Ensembles of Disordered Proteins.

J Phys Chem Lett 2013 Oct;4(20)

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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October 2013

Molecular structure of RADA16-I designer self-assembling peptide nanofibers.

ACS Nano 2013 Sep 5;7(9):7562-72. Epub 2013 Sep 5.

Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering , 2525 Pottsdamer Street, Tallahassee, Florida 32310-6046, United States.

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September 2013

Folding free energy surfaces of three small proteins under crowding: validation of the postprocessing method by direct simulation.

Phys Biol 2013 Aug 2;10(4):045001. Epub 2013 Aug 2.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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August 2013

Influences of membrane mimetic environments on membrane protein structures.

Annu Rev Biophys 2013 1;42:361-92. Epub 2013 Mar 1.

Institute of Molecular Biophysic, Florida State University, Tallahassee, USA.

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July 2013

Solid-state NMR evidence for β-hairpin structure within MAX8 designer peptide nanofibers.

Biophys J 2013 Jul;105(1):222-30

Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida, USA.

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July 2013

calculations and validation of the pH-dependent structures of the His37-Trp41 quartet, the heart of acid activation and proton conductance in the M2 protein of Influenza A virus.

Chem Sci 2013 Jul;4(7):2776-2787

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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July 2013

Simulation and Modeling of Crowding Effects on the Thermodynamic and Kinetic Properties of Proteins with Atomic Details.

Biophys Rev 2013 Jun;5(2):207-215

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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June 2013

Activation of signaling receptors: do ligands bind to receptor monomer, dimer, or both?

BMC Biophys 2013 Jun 3;6. Epub 2013 Jun 3.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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June 2013

Prediction and dissection of widely-varying association rate constants of actin-binding proteins.

PLoS Comput Biol 2012 4;8(10):e1002696. Epub 2012 Oct 4.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America.

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May 2013

An NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.

Biophys J 2013 May;104(10):2170-81

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.

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May 2013

Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.

Protein Sci 2013 Apr 1;22(4):381-94. Epub 2013 Mar 1.

Department of Physics, Florida State University, Tallahassee, Florida 32306, USA.

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April 2013

Influence of crowded cellular environments on protein folding, binding, and oligomerization: biological consequences and potentials of atomistic modeling.

Authors:
Huan-Xiang Zhou

FEBS Lett 2013 Apr 5;587(8):1053-61. Epub 2013 Feb 5.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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April 2013

Polymer crowders and protein crowders act similarly on protein folding stability.

Authors:
Huan-Xiang Zhou

FEBS Lett 2013 Mar 23;587(5):394-7. Epub 2013 Jan 23.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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March 2013

PIPE: A Suite of Web Servers for Predictions Ranging From Protein Structure to Binding Kinetics.

Biophys Rev 2013 Mar 25;5(1):41-46. Epub 2012 Jul 25.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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March 2013

Poisson-Boltzmann Calculations: van der Waals or Molecular Surface?

Commun Comput Phys 2013 Jan 12;13(1):1-12. Epub 2012 Jun 12.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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January 2013

Persistence length of human cardiac α-tropomyosin measured by single molecule direct probe microscopy.

PLoS One 2012 21;7(6):e39676. Epub 2012 Jun 21.

Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America.

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December 2012

A method for computing association rate constants of atomistically represented proteins under macromolecular crowding.

Phys Biol 2012 Dec 29;9(6):066008. Epub 2012 Nov 29.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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December 2012

Recent progress in structure-based anti-influenza drug design.

Drug Discov Today 2012 Oct 13;17(19-20):1111-20. Epub 2012 Jun 13.

Department of Physics, Florida State University, Tallahassee, FL 32306, USA.

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October 2012

BDflex: a method for efficient treatment of molecular flexibility in calculating protein-ligand binding rate constants from brownian dynamics simulations.

J Chem Phys 2012 Oct;137(13):135105

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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October 2012

Size matters in activation/inhibition of ligand-gated ion channels.

Trends Pharmacol Sci 2012 Sep 11;33(9):482-93. Epub 2012 Jul 11.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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September 2012

Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin.

FEBS Lett 2012 Sep 14;586(19):3503-7. Epub 2012 Aug 14.

Department of Biological Science, The Florida State University, Tallahassee, FL 32306-4370, USA.

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September 2012

Contrasting factors on the kinetic path to protein complex formation diminish the effects of crowding agents.

Biophys J 2012 Sep;103(5):1011-9

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.

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September 2012

Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets.

Phys Chem Chem Phys 2012 Aug 28;14(30):10466-76. Epub 2012 Jun 28.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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August 2012

A common model for cytokine receptor activation: combined scissor-like rotation and self-rotation of receptor dimer induced by class I cytokine.

PLoS Comput Biol 2012 8;8(3):e1002427. Epub 2012 Mar 8.

Department of Physics, Florida State University, Tallahassee, Florida, United States of America.

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June 2012

Glycines: role in α-helical membrane protein structures and a potential indicator of native conformation.

Biochemistry 2012 Jun 7;51(24):4779-89. Epub 2012 Jun 7.

Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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June 2012

M2 protein from influenza A: from multiple structures to biophysical and functional insights.

Curr Opin Virol 2012 Apr 16;2(2):128-33. Epub 2012 Feb 16.

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, United States.

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April 2012

Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulations.

Proc Natl Acad Sci U S A 2012 Mar 29;109(11):4140-5. Epub 2012 Feb 29.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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March 2012

Intrinsic disorder: signaling via highly specific but short-lived association.

Authors:
Huan-Xiang Zhou

Trends Biochem Sci 2012 Feb 7;37(2):43-8. Epub 2011 Dec 7.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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February 2012

Role of diffusion in the kinetics of reversible enzyme-catalyzed reactions.

Bull Korean Chem Soc 2012 6;33(3):925-928. Epub 2012 Jan 6.

Laboratory of Chemical Physics, National Institute of Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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January 2012

Automated prediction of protein association rate constants.

Structure 2011 Dec;19(12):1744-51

Department of Physics and Institute of Molecular Biophysics, Tallahassee, FL 32306, USA.

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December 2011

Community-wide assessment of protein-interface modeling suggests improvements to design methodology.

J Mol Biol 2011 Nov 29;414(2):289-302. Epub 2011 Sep 29.

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

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November 2011

Mechanistic insight into the h(2)o/d (2)o isotope effect in the proton transport of the influenza virus m2 protein.

Authors:
Huan-Xiang Zhou

J Membr Biol 2011 Nov 1;244(2):93-6. Epub 2011 Nov 1.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, USA.

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November 2011

Theory and simulation of diffusion-influenced, stochastically gated ligand binding to buried sites.

J Chem Phys 2011 Oct;135(14):145101

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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October 2011

Structural models of protein-DNA complexes based on interface prediction and docking.

Curr Protein Pept Sci 2011 Sep;12(6):531-9

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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September 2011

Rationalizing 5000-fold differences in receptor-binding rate constants of four cytokines.

Biophys J 2011 Sep;101(5):1175-83

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA.

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September 2011

Diffusion-influenced ligand binding to buried sites in macromolecules and transmembrane channels.

J Chem Phys 2011 Aug;135(7):075103

Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA.

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August 2011

Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptor.

Nat Commun 2011 Jun 14;2:354. Epub 2011 Jun 14.

Department of Physics, Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

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June 2011

Rapid search for specific sites on DNA through conformational switch of nonspecifically bound proteins.

Authors:
Huan-Xiang Zhou

Proc Natl Acad Sci U S A 2011 May 4;108(21):8651-6. Epub 2011 May 4.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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May 2011

Equivalence of two approaches for modeling ion permeation through a transmembrane channel with an internal binding site.

Authors:
Huan-Xiang Zhou

J Chem Phys 2011 Apr;134(13):135101

Department of Physics and Institute of Molecular Biophysics, Tallahassee, Florida 32306, USA.

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April 2011

Q&A: What is biophysics?

Authors:
Huan-Xiang Zhou

BMC Biol 2011 Mar 2;9:13. Epub 2011 Mar 2.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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March 2011

Theory and simulation on the kinetics of protein-ligand binding coupled to conformational change.

J Chem Phys 2011 Mar;134(10):105101

Department of Polymer Science and Engineering, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.

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March 2011

A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction.

BMC Biophys 2011 Mar 2;4. Epub 2011 Mar 2.

Department of Physics and Institute of Molecular Biophysics, Tallahassee, Florida 32306, USA.

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March 2011

Influence of solubilizing environments on membrane protein structures.

Trends Biochem Sci 2011 Feb 18;36(2):117-25. Epub 2010 Aug 18.

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.

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February 2011

A theory for the proton transport of the influenza virus M2 protein: extensive test against conductance data.

Authors:
Huan-Xiang Zhou

Biophys J 2011 Feb;100(4):912-21

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA.

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February 2011

Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations.

J Biol Chem 2010 Dec 24;285(49):38167-72. Epub 2010 Sep 24.

Center for Biologically Inspired Materials and Material Systems and Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA.

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December 2010

Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer.

Science 2010 Oct;330(6003):509-12

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.

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October 2010

Speeding by a crowd.

Authors:
Huan-Xiang Zhou

Physics (College Park Md) 2010 Sep;3

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306.

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September 2010

Rate theories for biologists.

Authors:
Huan-Xiang Zhou

Q Rev Biophys 2010 May 9;43(2):219-93. Epub 2010 Aug 9.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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May 2010