Huaibin Cai

Huaibin Cai

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Huaibin Cai

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Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice.

Sci Rep 2019 Mar 19;9(1):4857. Epub 2019 Mar 19.

Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41598-019-41091-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425036PMC
March 2019

Parkin and PINK1 mitigate STING-induced inflammation.

Nature 2018 09 22;561(7722):258-262. Epub 2018 Aug 22.

Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://www.nature.com/articles/s41586-018-0448-9
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http://dx.doi.org/10.1038/s41586-018-0448-9DOI Listing
September 2018

Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques.

Alzheimers Res Ther 2018 04 24;10(1):40. Epub 2018 Apr 24.

Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science, Changsha, 410013, Hunan, China.

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http://dx.doi.org/10.1186/s13195-018-0370-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978992PMC
April 2018

Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice.

Neuroscience 2018 03 11;373:52-59. Epub 2018 Jan 11.

Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China; Department of Anatomy & Research Center for Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819331PMC
March 2018

Genetic ablation of dynactin p150 in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice.

Mol Neurodegener 2018 03 1;13(1):10. Epub 2018 Mar 1.

Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A112, MSC 3707, 35 Convent Drive, Bethesda, MD, 20892-3707, USA.

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http://dx.doi.org/10.1186/s13024-018-0242-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831668PMC
March 2018

Autophagy in neurodegenerative diseases: pathogenesis and therapy.

Brain Pathol 2018 Jan 6;28(1):3-13. Epub 2017 Aug 6.

The Key Laboratory of Stem Cell Biology and Neurogenomic Laboratory, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1111/bpa.12545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739982PMC
January 2018

Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1 mouse model of amyotrophic lateral sclerosis.

Sci Rep 2018 01 26;8(1):1668. Epub 2018 Jan 26.

Institute of Neurology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, PR China.

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http://dx.doi.org/10.1038/s41598-018-19923-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786035PMC
January 2018

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.

Transl Neurodegener 2018 23;7. Epub 2018 Jan 23.

2Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A112, MSC 3707, 35 Convent Drive, Bethesda, MD 20892-3707 USA.

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http://dx.doi.org/10.1186/s40035-018-0106-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778750PMC
January 2018

Peptides derived from transcription factor EB bind to calcineurin at a similar region as the NFAT-type motif.

Biochimie 2017 Nov 7;142:158-167. Epub 2017 Sep 7.

Department of Biochemistry and Molecular Biology, College of Life Sciences, Beijing Normal University, Beijing, 100875, China. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774622PMC
November 2017

Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer's Disease Mice and Wild-Type Littermates.

Front Aging Neurosci 2017 25;9:282. Epub 2017 Aug 25.

Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical UniversityDalian, China.

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http://dx.doi.org/10.3389/fnagi.2017.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574879PMC
August 2017

Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.

Sci Rep 2017 07 13;7(1):5283. Epub 2017 Jul 13.

Laboratory of Neurogenetics, Transgenic Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41598-017-05598-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509666PMC
July 2017

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum.

Front Neuroanat 2017 7;11:45. Epub 2017 Jun 7.

Department of Anatomy and Neurobiology, Central South University School of Basic Medical ScienceChangsha, China.

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http://dx.doi.org/10.3389/fnana.2017.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461299PMC
June 2017

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.

Proc Natl Acad Sci U S A 2017 03 28;114(11):E2253-E2262. Epub 2017 Feb 28.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322;

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http://dx.doi.org/10.1073/pnas.1616892114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358362PMC
March 2017

Opioid system in L-DOPA-induced dyskinesia.

Transl Neurodegener 2017 17;6. Epub 2017 Jan 17.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A112, MSC 3707, 35 Convent Drive, Bethesda, MD 20892-3707 USA.

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http://dx.doi.org/10.1186/s40035-017-0071-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240307PMC
January 2017

Quercetin targets the interaction of calcineurin with LxVP-type motifs in immunosuppression.

Biochimie 2016 Aug 22;127:50-8. Epub 2016 Apr 22.

Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology Beijing Key Laboratory, Life Science Institute, Beijing Normal University, 100875 Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2016.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141604PMC
August 2016

LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.

Hum Mol Genet 2016 08 4;25(16):3515-3523. Epub 2016 Jul 4.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA

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http://dx.doi.org/10.1093/hmg/ddw194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179946PMC
August 2016

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.

PLoS One 2015 28;10(8):e0136612. Epub 2015 Aug 28.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, 20892, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136612PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552665PMC
May 2016

α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.

J Neurosci 2016 Apr;36(16):4408-14

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1523/JNEUROSCI.3627-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837680PMC
April 2016

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.

Hum Mol Genet 2016 Jan 26;25(2):211-22. Epub 2015 Oct 26.

Department of Pharmacology and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 874 Union Avenue/Crowe 401, Memphis, TN 38163, USA,

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http://dx.doi.org/10.1093/hmg/ddv445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706110PMC
January 2016

Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons.

PLoS One 2014 31;9(10):e111749. Epub 2014 Oct 31.

Laboratory of Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111749PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216119PMC
December 2015

No apparent transmission of transgenic α-synuclein into nigrostriatal dopaminergic neurons in multiple mouse models.

Transl Neurodegener 2015 3;4:23. Epub 2015 Dec 3.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A112, MSC 3707, 35 Convent Drive, Bethesda, MD 20892-3707 USA.

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http://dx.doi.org/10.1186/s40035-015-0046-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668690PMC
December 2015

Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum.

Oncotarget 2015 May;6(13):10772-85

Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science, Changsha, Hunan, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484418PMC
http://dx.doi.org/10.18632/oncotarget.3599DOI Listing
May 2015

Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain.

BMC Neurol 2015 May 2;15:71. Epub 2015 May 2.

Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science, Changsha, Hunan, 410013, China.

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http://dx.doi.org/10.1186/s12883-015-0327-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428107PMC
May 2015

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease.

Transl Neurodegener 2014 10;3:27. Epub 2014 Dec 10.

Computational Biology Core, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 USA.

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http://dx.doi.org/10.1186/2047-9158-3-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334846PMC
February 2015

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.

EMBO J 2014 Oct 8;33(20):2314-31. Epub 2014 Sep 8.

Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA

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http://dx.doi.org/10.15252/embj.201487807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253522PMC
October 2014

Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?

J Alzheimers Dis 2014 ;38(4):705-18

Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China.

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http://dx.doi.org/10.3233/JAD-131400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995167PMC
August 2014

Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.

Adv Exp Med Biol 2014 ;801:649-54

Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, The Cole Eye Institute, i31, 9500 Euclid Avenue, 44195, Cleveland, OH, USA,

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http://link.springer.com/content/pdf/10.1007%2F978-1-4614-32
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http://link.springer.com/10.1007/978-1-4614-3209-8_81
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http://dx.doi.org/10.1007/978-1-4614-3209-8_81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884105PMC
July 2014

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.

Nat Neurosci 2014 Mar 26;17(3):367-76. Epub 2014 Jan 26.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nn.3636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989289PMC
March 2014

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

Proc Natl Acad Sci U S A 2014 Mar 10;111(12):E1121-9. Epub 2014 Mar 10.

Departments of Biochemistry and Molecular Pharmacology, Neurology, Pathology, and Cell Biology, RNA Therapeutic Institute, Howard Hughes Medical Institute, and Neuroscience Program, University of Massachusetts Medical School, Worcester, MA 01605.

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http://dx.doi.org/10.1073/pnas.1322641111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970502PMC
March 2014

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.

Hum Mol Genet 2013 Nov 13;22(21):4293-305. Epub 2013 Jun 13.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA and.

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http://dx.doi.org/10.1093/hmg/ddt279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792689PMC
November 2013

γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ.

Eur J Neurosci 2013 May 22;37(10):1714-25. Epub 2013 Feb 22.

Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

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http://dx.doi.org/10.1111/ejn.12159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660538PMC
May 2013

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

Hum Mol Genet 2013 Feb 2;22(3):608-20. Epub 2012 Nov 2.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/hmg/dds470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542867PMC
February 2013

Animal models of Parkinson's disease.

Parkinsons Dis 2011 18;2011:364328. Epub 2011 Dec 18.

Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.4061/2011/364328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246788PMC
August 2012

BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice.

Exp Neurol 2012 May 11;235(1):228-37. Epub 2012 Jan 11.

Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China.

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http://dx.doi.org/10.1016/j.expneurol.2012.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514910PMC
May 2012

α-synuclein, LRRK2 and their interplay in Parkinson's disease.

Future Neurol 2012 Mar;7(2):145-153

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343692PMC
March 2012

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway.

Mol Neurodegener 2012 Jan 9;7. Epub 2012 Jan 9.

Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.

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http://molecularneurodegeneration.biomedcentral.com/articles
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http://dx.doi.org/10.1186/1750-1326-7-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296570PMC
January 2012

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.

Nat Immunol 2011 Oct 9;12(11):1063-70. Epub 2011 Oct 9.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ni.2113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140245PMC
October 2011

In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.

J Neurosci 2011 Sep;31(39):13699-704

Developmental Neural Plasticity Unit, National Institute of Neurological Disorders and Stroke, and Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda Maryland 20892, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1714-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190161PMC
September 2011

LRRK2 function on actin and microtubule dynamics in Parkinson disease.

Commun Integr Biol 2010 Sep;3(5):396-400

Unit of Transgenesis; Laboratory of Neurogenetics; National Institute on Aging; National Institutes of Health; Bethesda, MD USA.

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http://dx.doi.org/10.4161/cib.3.5.12286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974064PMC
September 2010

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.

Antioxid Redox Signal 2010 Apr;12(7):819-27

Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1089/ars.2009.2891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861544PMC
April 2010

Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.

Mol Brain 2010 Apr 21;3:12. Epub 2010 Apr 21.

Units of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1186/1756-6606-3-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873589PMC
April 2010

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.

Mol Brain 2009 Jul 24;2:23. Epub 2009 Jul 24.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1756-6606-2-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724476PMC
July 2009

DJ-1 is essential for long-term depression at hippocampal CA1 synapses.

Neuromolecular Med 2008 2;10(1):40-5. Epub 2008 Feb 2.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1007/s12017-008-8023-4DOI Listing
December 2008

ALS2/alsin knockout mice and motor neuron diseases.

Neurodegener Dis 2008 20;5(6):359-66. Epub 2008 Aug 20.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707, USA.

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http://dx.doi.org/10.1159/000151295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556598PMC
December 2008

Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.

Neurobiol Aging 2008 Mar 6;29(3):357-67. Epub 2006 Dec 6.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S019745800600405
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http://dx.doi.org/10.1016/j.neurobiolaging.2006.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278113PMC
March 2008

Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.

Neurobiol Dis 2008 Mar 4;29(3):505-14. Epub 2007 Dec 4.

Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.nbd.2007.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271119PMC
March 2008

Alsin and the molecular pathways of amyotrophic lateral sclerosis.

Mol Neurobiol 2007 Dec 10;36(3):224-31. Epub 2007 Jul 10.

Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892-3707, USA.

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http://dx.doi.org/10.1007/s12035-007-0034-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364715PMC
December 2007

The G59S mutation in p150(glued) causes dysfunction of dynactin in mice.

J Neurosci 2007 Dec;27(51):13982-90

Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4226-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367233PMC
December 2007

Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice.

Neurobiol Aging 2007 Oct 12;28(10):1628-30. Epub 2006 Sep 12.

Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S019745800600267
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http://dx.doi.org/10.1016/j.neurobiolaging.2006.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423343PMC
October 2007

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina.

Exp Brain Res 2007 Aug 12;181(3):435-46. Epub 2007 Apr 12.

Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.

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http://dx.doi.org/10.1007/s00221-007-0943-yDOI Listing
August 2007

Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.

J Neuroimmunol 2007 Jan 6;182(1-2):226-31. Epub 2006 Dec 6.

Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892-1202, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2006.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796843PMC
January 2007

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.

Proc Natl Acad Sci U S A 2004 Mar 20;101(10):3632-7. Epub 2004 Feb 20.

Haldeman Laboratory of Molecular and Cellular Neurobiology, L. J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, Sun City, AZ 85351, USA.

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http://dx.doi.org/10.1073/pnas.0205689101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC373514PMC
March 2004

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.

J Neurosci 2003 Apr;23(8):3272-7

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA.

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April 2003

Genetically engineered mouse models of neurodegenerative diseases.

Nat Neurosci 2002 Jul;5(7):633-9

Department of Pathology, The Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205-2196, USA.

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http://dx.doi.org/10.1038/nn0702-633DOI Listing
July 2002