Publications by authors named "Hua Li"

3,219 Publications

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Efficacy and Safety of the Ketogenic Diet for Mitochondrial Disease With Epilepsy: A Prospective, Open-labeled, Controlled Study.

Front Neurol 2022 1;13:880944. Epub 2022 Aug 1.

Department of Neurology, Tongji Medical College, Wuhan Children's Hospital, Huazhong University of Science and Technology, Wuhan, China.

Background: The ketogenic diet (KD) is increasingly used to treat drug-resistant epilepsy because of its favorable effect on seizure reduction. Patients with mitochondrial diseases tend to experience seizures. Therefore, this study aimed to test the efficacy of the KD on participants with mitochondrial diseases in a controlled trial.

Methods: Participants from fourteen clinical centers who were diagnosed with mitochondrial disease were semi-randomized to either the intervention (KD) or control group. The KD group followed a 3-month KD intervention, while the control group received a 1-month normal diet initially and then a 3-month KD intervention. The primary outcome measure was seizure reduction. Biomarker changes, cognitive impairments, and side effects were also recorded, if available.

Result: A total of 33 participants were assigned to the KD ( = 22) and control groups ( = 11). In the KD group, 31.8% (7/22) of participants achieved ≥50% seizure reduction after 1 month of diet intervention, which increased to 40.9% (9/22) at 3 months. In the control group, only 18.2% (2/11) of the participants had ≥50% seizure reduction during the normal diet period. After the control group was transferred to the KD, 63.6% (7/11) of participants had >50% seizure reduction, and this rate increased to 72.7% (8/11) at 3 months. The KD also showed high efficacy in participants with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) or pathogenic variants in mitochondrial DNA (mtDNA) (90% and 93.3% response rates, respectively). The most frequent side effects reported at the 3-month review were vomiting, cold, hyperlipidemia, and bloating.

Conclusion: The KD is a safe and effective therapy for seizure control in mitochondrial diseases, especially MELAS and pathogenic variants of mtDNA. KD intervention can be considered in the management of these patients.
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http://dx.doi.org/10.3389/fneur.2022.880944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377015PMC
August 2022

Construction of Perylene-based Amphiphilic Micelle and Its Efficient Adsorption and In-situ Photodegradation of Bisphenol A in Aqueous Solution.

Angew Chem Int Ed Engl 2022 Aug 16. Epub 2022 Aug 16.

Soochow University, College of Chemistry, Chemical Engineering and Materials Science, No.199 Renai Road, Suzhou Industrial Park, 215123, Suzhou, CHINA.

Low mass-transfer efficiency and reaction-driving force make it difficult to realize thorough purification in traditional low-concentration pollutant treatments. Herein, we propose an "adsorption/catalysis in situ" perylene based bifunctional micelle for efficient, accurate and rapid adsorption and catalytic degradation of low-concentration bisphenol A (BPA). They show super-fast (within 10 s), high capacity (448 mg g-1) and selectivity for BPA adsorption, due to π-π, hydrophobic interactions and hydrogen bonding. The BPA degradation efficiency improves by up to 8 times after forming micelles compared with simple perylene nanorods, which is primarily due to the superior mass-transfer from adsorption. Moreover, self-assembly can optimize the stacking of the perylene moieties and facilitate charge transfer in micelle, and the regular π-π stacking of inside perylene units enhances the response to visible light, resulting in high catalytic capacity and good cycling stability.
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http://dx.doi.org/10.1002/anie.202210619DOI Listing
August 2022

Effects of Market Incentives and Livelihood Dependence on Farmers' Multi-Stage Pesticide Application Behavior-A Case Study of Four Provinces in China.

Int J Environ Res Public Health 2022 Aug 1;19(15). Epub 2022 Aug 1.

College of Economics and Management, Northwest A&F University, Xianyang 712100, China.

Improvement in pesticide application and efficiency structure has long been recognized as having great significance in reducing pollution, ensuring food safety, and promoting green agricultural development. Based on theoretical analysis, using the survey data of 766 farmers in key tea areas in Shaanxi, Sichuan, Zhejiang, and Anhui provinces in China, the study empirically analyzes the influence of market incentives and livelihood dependence on farmers' multi-stage pesticide application behavior. More specifically, the study employed ordered probit analysis to craft its findings. The dependent variable of this study is the multi-stage pesticide application problem of farmers, and the core independent variables are market incentives and livelihood dependence, and the judgment is based on the core variable coefficients of the econometric model of farmers at each stage. The study found the following: (i) Market incentives significantly prompted some farmers to give up synthetic pesticide application and farmers tend to choose green pesticides in the type of pesticide application. (ii) Livelihood dependence meant that the proportion of tea income significantly prompts farmers to apply pesticides, and also creates a tendency for farmers to choose green and low-toxic pesticides in the type of pesticide application. The planting period tends to have a moderate impact on applying green and low-toxic pesticides. (iii) The interaction term of market incentives and the proportion of tea income has no significant impact on farmers' multi-stage pesticide application behavior. The interaction term of market incentives and planting years has impacted negatively on whether farmers apply pesticides, and has no significant impact on farmers' choice of pesticide application types, but makes farmers increase the amount of green and low-toxic pesticides. (iv) The education level of the household head significantly promotes farmers to choose green and low-toxic pesticides. Seemingly, the brand effect of pesticides significantly encourages farmers to choose green and low-toxic pesticides. In external support, technical training significantly encourages farmers to choose green and low-toxic pesticides. Furthermore, better infrastructure and local market conditions significantly encourage farmers to reduce the use of conventional pesticides.
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http://dx.doi.org/10.3390/ijerph19159431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368658PMC
August 2022

Fungal endophytes from salt-adapted plants confer salt tolerance and promote growth in wheat ( L.) at early seedling stage.

Microbiology (Reading) 2022 08;168(8)

ICAR-National Research Centre on Pomegranate, Solapur-413255, Maharashtra, India.

With increasing human global population, increased yield under saline conditions is a desirable trait for major food crops. Use of endophytes, isolated from halophytic hosts, seems to be an exciting approach for conferring salt tolerance to a salt-sensitive crop. Therefore, in the current study, fungal endophytes were isolated from halophytic plants' roots and their ability to withstand salt stress was evaluated. The fungal endophytes could withstand up to 1M NaCl concentrations and this tolerance was independent of their host or tissue source. When inoculated on salt-sensitive wheat seeds/seedlings, several of the endophytes showed a positive impact on germination and biomass-related parameters upon salt stress, both and under glasshouse conditions. One of the isolates from dicot plants (identified as ) could successfully colonize wheat and promote its growth under salt and no-salt conditions. Amongst the fungal isolates that are known to be natural endophytes of wheat, was the best performing isolate and has previously been reported to be an effective biocontrol agent. Based on the results of our preliminary study, we suggest that these fungal endophytes could prove beneficial for enhancing the salt stress tolerance of wheat crop.
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http://dx.doi.org/10.1099/mic.0.001225DOI Listing
August 2022

Langerhans cell histiocytosis of the rib in an adult: A case report and review of the literature.

Int J Surg Case Rep 2022 Jul 21;97:107432. Epub 2022 Jul 21.

Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China. Electronic address:

Introduction And Importance: Langerhans cell histiocytosis (LCH) is a rare neoplastic hyperplasia with an unknown etiology. It is clinically rare for patients with solitary rib lesion and pathological fracture. In this article, we report a case of LCH in solitary involvement of rib and provide a review of the available literature.

Case Presentation: A 24-year-old female patient complained of right chest and back pain for 10 days. CT showed a fracture in the right 6th rib. Findings on X-ray, and CT were suggestive of homogeneous osteolytic lesion of the right 6th rib. The rib tumor was then resected and the surrounding muscles and soft tissues were accordingly resected.

Clinical Discussion: The patient was diagnosed with pathological rib fracture, and the patient was pathologically diagnosed with LCH. After surgery, no local recurrence or distant metastasis was reported during the one-year follow-up.

Conclusions: Most of the solitary tumorous lesions in rib in adults call for various differential diagnoses. Although single-site, single-system LCH of the rib is one of the rarest causes of bone tumor in adults, it can be treated successfully with surgical intervention. LCH should be considered in the diagnosis of an adult patient with a rib mass.
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http://dx.doi.org/10.1016/j.ijscr.2022.107432DOI Listing
July 2022

Comparative analysis of arthroscopic-assisted Tight-rope technique and clavicular hook plate fixation in the treatment of Neer type IIB distal clavicle fractures.

BMC Musculoskelet Disord 2022 Aug 6;23(1):756. Epub 2022 Aug 6.

Department of Orthopedics SurgeryDonghu DistrictJiangxi Province, Jiangxi Provincial People's Hospital, (The First Affiliated Hospital of Nanchang Medical College), 330006. No. 92 Aiguo Road, Nanchang, People's Republic of China.

Background: The aim of the present study was to compare the clinical efficacy of arthroscopic-assisted fixation using the Tight-rope system and clavicular hook plate fixation in the treatment of Neer IIB distal clavicle fractures.

Methods: We enrolled 48 consecutive patients with Neer IIB distal clavicle fractures who were treated at our institution from February 2016 and August 2020. These patients were divided into 2 groups based on the fixation method (16 cases with Tight-rope system and 32 cases with clavicular hook plate), and demographics and clinical characteristics of patients in different groups were compared.

Results: All 48 patients had functional outcome scores of the affected shoulder available at a mean of 23.8 ± 5.1 months, and there was a statistically significant improvement in the constant score, American shoulder and elbow surgeons (ASES) score, visual analogue scale (VAS) score at the end of follow-up (p < 0.001 respectively). However, the smaller length of skin incision, less estimated blood loss and shorter hospital stay were detected in the Tight-rope technique group patients than those of clavicular hook plate group patients (p < 0.001, respectively). Furthermore, the constant score, ASES score and VAS score were significantly improved in the Tight-rope technique group patients than those of clavicular hook plate group patients (p < 0.05, respectively).

Conclusions: Both Tight-rope technique and clavicular hook plate fixation can provide satisfactory clinical and radiological results in the treatment of distal clavicular Neer IIB fracture. However, arthroscopic-assisted fixation using the Tight-rope technique showed better results in terms of length of hospital stay, surgical trauma, clinical scores, and diagnose and treat concomitant glenohumeral pathologies.

Levels Of Evidence: III, Case-control study Retrospective comparative study.
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http://dx.doi.org/10.1186/s12891-022-05724-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356490PMC
August 2022

STAT3 activation as a predictive biomarker for ruxolitinib response in head and neck cancer.

Clin Cancer Res 2022 Aug 5. Epub 2022 Aug 5.

University of California, San Francisco, San Francisco, CA, United States.

Purpose: Increased activity of STAT3 is associated with progression of head and neck squamous cell carcinoma (HNSCC). Upstream activators of STAT3, such as JAKs, represent potential targets for therapy of solid tumors, including HNSCC. In this study we investigated the anti-cancer effects of ruxolitinib, a clinical JAK1/2 inhibitor, in HNSCC preclinical models including patient-derived xenografts (PDXs) from patients treated on a window-of-opportunity trial.

Methods: HNSCC cell lines were treated with ruxolitinib, and the impact on activated STAT3 levels, cell growth, and colony formation was assessed. PDXs were generated from HNSCC patients who received a brief course of neoadjuvant ruxolitinib on a clinical trial. The impact of ruxolitinib on tumor growth and STAT3 activation was assessed.

Results: Ruxolitinib inhibited STAT3 activation, cellular growth and colony formation of HNSCC cell lines. Ruxolitinib treatment of mice bearing a HNSCC cell line-derived xenograft significantly inhibited tumor growth compared with vehicle-treated controls. The response of HNSCC PDXs derived from patients on the clinical trial mirrored the responses seen in the neoadjuvant setting. Baseline active STAT3 (pSTAT3) and total STAT3 levels were lower, and ruxolitinib inhibited STAT3 activation in a PDX from a patient whose disease was stable on ruxolitinib, compared to a PDX from a patient whose disease progressed on ruxolitinib and where ruxolitinib treatment had minimal impact on STAT3 activation.

Conclusions: Ruxolitinib exhibits antitumor effects in HNSCC preclinical models. Baseline pSTAT3 or total STAT3 levels in the tumor may serve as predictive biomarkers to identify patients most likely to respond to ruxolitinib.
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http://dx.doi.org/10.1158/1078-0432.CCR-22-0744DOI Listing
August 2022

Phytochrome Interacting Factor regulates stomatal aperture by coordinating red light and abscisic acid.

Plant Cell 2022 Aug 5. Epub 2022 Aug 5.

Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou 225009, China.

Stomata are crucial valves coordinating the fixation of carbon dioxide by photosynthesis and water loss through leaf transpiration. Phytochrome interacting factors (PIFs) are negative regulators of red light responses that belong to the basic helix-loop-helix (bHLH) family of transcription factors. Here, we show that the rice (Oryza sativa) PIF family gene OsPIL15 acts as a negative regulator of stomatal aperture to control transpiration in rice. OsPIL15 reduces stomatal aperture by activating rice ABSCISIC ACID INSENSITIVE 5 (OsABI5), which encodes a critical positive regulator of abscisic acid (ABA) signaling in rice. Moreover, OsPIL15 interacts with the NIGT1/HRS1/HHO family transcription factor rice HRS1 HOMOLOG 3 (OsHHO3) to possibly enhance the regulation of stomatal aperture. Notably, we discovered that the maize (Zea mays) PIF family genes ZmPIF1 and ZmPIF3, which are homologous to OsPIL15, are also involved in the regulation of stomatal aperture in maize, indicating that PIF-mediated regulation of stomatal aperture may be conserved in the plant lineage. Our findings explain the molecular mechanism by which PIFs play a role in red-light-mediated stomatal opening, and demonstrate that PIFs regulate stomatal aperture by coordinating the red light and ABA signaling pathways.
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http://dx.doi.org/10.1093/plcell/koac244DOI Listing
August 2022

The Use of Infrared Thermography in Determining Timing for Early Pedicle Division of the Preexpanded Bipedicled Visor Flap after Ischemic Preconditioning.

Appl Bionics Biomech 2022 26;2022:8564922. Epub 2022 Jul 26.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: The preexpanded bipedicled visor flap, supported by the bilateral superficial temporal vessels, stands as an ideal choice for upper and lower lip reconstruction in males. However, the bilateral tissue bridges after flap transfer caused patients significant cosmetic deformity and psychological burden. Early division of bilateral pedicles reduced the length of hospitalization and expenses. In this study, infrared thermography (IRT) was used to guide the early pedicle division after ischemic preconditioning.

Methods: This study retrospectively analyzed patients who underwent preexpanded bipedicled visor flap surgery from April 2018 to October 2021. Pedicle division was scheduled at two weeks postflap transfer. Ischemic preconditioning was initiated 3-5 days in advance by repeatedly clamping both pedicles. The temperature alteration of the flap and the temperature difference compared to the normal adjacent tissue were evaluated by IRT. The division surgery was not scheduled until the perfusion assessment indicated adequate. This comprised of subjective examination and indocyanine green angiography. The threshold of temperature difference to determine the pedicle division was analyzed based on the temperature changes between the clamps.

Results: A total of 8 male patients successfully conducted the pedicle division without any complications. The delay period after ischemic preconditioning ranged from 14 to 19 days (average 16 days). Through ischemic preconditioning training, the average temperature of the flap gradually increased from 31.85 ± 0.36°C to 33.89 ± 0.50°C, and the temperature difference with the normal surrounding tissues decreased from 2.89 ± 0.30°C to 1.15 ± 0.46°C (95% confidence interval (1.5, 0.8)). The temperature difference stayed unchanged after pedicle division.

Conclusion: Ischemic preconditioning shortens the perioperative period to pedicle division. Monitoring the temperature change reflects the revascularization between the flap and the recipient site, thus guiding the pedicle division. The temperature difference less than 1.5°C after clamping both pedicles can be set as the safe threshold for pedicle division.
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http://dx.doi.org/10.1155/2022/8564922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345714PMC
July 2022

Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction.

Drug Des Devel Ther 2022 26;16:2383-2393. Epub 2022 Jul 26.

Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

Purpose: This study aimed to characterize the pharmacokinetics of nalbuphine in patients undergoing general anesthesia with varying degrees of liver dysfunction.

Patients And Methods: Twenty-four patients were enrolled and divided into three cohorts based on liver function: normal liver function (n = 13), mild liver dysfunction (n = 5), and moderate/severe liver dysfunction (n = 6). During the induction of anesthesia, they received 15 mg of nalbuphine intravenously. Venous blood samples were collected from each patient. The plasma concentration of nalbuphine was determined using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The pharmacokinetic parameters of nalbuphine were calculated by non-compartmental analysis (NCA) using Phoenix WinNonlin software.

Results: Compared with the normal liver function group, the plasma elimination half-life (T) of nalbuphine was increased by approximately 33% in the moderate/severe liver dysfunction group (2.66 h vs 3.54 h, <0.05), and the volume of distribution (V) increased by approximately 85% (100.08 L vs 184.95 L, <0.05). Multivariate analysis revealed that weight and platelet were associated with clearance (CL); total bilirubin as an independent factor was associated with T, and weight associated with area under the curve (AUC) independently.

Conclusion: The T, mean residence time, and V of nalbuphine in patients with moderate/severe liver dysfunction were prolonged or increased significantly compared with those in the normal liver function group. These data suggest that it may need to be used with caution when nalbuphine is administered to patients with moderate or severe liver dysfunction.
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http://dx.doi.org/10.2147/DDDT.S371596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341258PMC
August 2022

Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on HO-induced BV-2 microglial cells injury.

Bioorg Chem 2022 Jul 30;128:106067. Epub 2022 Jul 30.

Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Thirteen undescribed diterpenoids, including an ent-isopimarane (1), ten ent-atisanes (2-8 and 15-17), and two ingenanes (20 and 21) and ten known compounds, were separated from the whole plant of E. wallichii. The structures and absolute stereochemistry of these compounds were delineated by 1D and 2D NMR, mass spectrometry, pyridine-induced solvent shifts, and X-ray diffraction analyses. Euphwanoid A (1) is elucidated as an ent-16‑norisopimarane type diterpenoid featuring a C-8-O-C-15 lactone fragment. And euphwanoid B (2) represents a rare ent-atisane type tetranorditerpene possessing a tetrahydrofuran moiety. In addition, all these isolated compounds were assayed for their protective effects on HO-induced BV-2 microglial cells damage. And representative compound 1 could protect BV-2 cells against oxidative damage via the NRF2/HO-1 signaling pathway.
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http://dx.doi.org/10.1016/j.bioorg.2022.106067DOI Listing
July 2022

Impact of economic growth target constraints on enterprise technological innovation: Evidence from China.

PLoS One 2022 2;17(8):e0272003. Epub 2022 Aug 2.

School of Business Administration, University of Science and Technology Liaoning, Anshan, Liaoning, China.

By using the data from Chinese listed companies in the Shanghai and Shenzhen A-share market for the period 2007 to 2019 and the Report on the Work of the Government, this paper investigates the impact of the local government's economic growth target constraints on enterprise technological innovation and its mechanism. It is found that the local government's economic growth target constraints significantly inhibit enterprise technological innovation, which is more obvious in the samples of SOEs, regulated industries, and enterprises at low marketization levels. The change of government officials' performance appraisal indicators from the quantity to quality of economic growth can alleviate the negative effect. The mechanism effect test indicates that the local government's economic growth target constraints will aggravate enterprise financing constraints and decrease the contribution of R&D investment to enterprise performance, and further inhibit enterprise technological innovation.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272003PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374057PMC
August 2022

Pharmacokinetics and metabolites of glycosides and lignans of the stem bark of Magnolia officinalis in functional dyspepsia and normal rats using liquid chromatography-tandem mass spectrometry.

J Sep Sci 2022 Jul 31. Epub 2022 Jul 31.

Research Center for Analytical Chemistry of Traditional Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, P. R. China.

The stem bark of Magnolia officinalis is a traditional Chinese medicine for the treatment of abdominal distention and functional dyspepsia. The pharmacokinetics of three glycosides (magnoloside A, magnoloside B, and syringin) and two lignans (honokiol and magnolol) in both normal and functional dyspepsia rats were firstly investigated by ultra-performance liquid chromatography-triple quadrupole mass spectrometry method and the influences of the coexisting compounds on the pharmacokinetic parameters of honokiol and magnolol were also studied. It was found that all of the five target compounds were quickly absorbed and eliminated in both normal and functional dyspepsia rats, while, their residence time was significantly decreased in pathological states except magnoloside A. The coexisting compounds in the stem bark of M. officinalis significantly reduced absorption and increased elimination of honokiol in vivo. It's worth noticing that the volume of distribution of lignan was quite lower than that of a glycoside. Moreover, the metabolic profiling of magnoloside A, honokiol, and magnolol in vivo was analyzed by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry method, from which three prototypes were identified and 35 metabolites were putatively characterized, and 18 unknown metabolites were reasonably characterized for the first time. The results indicated that sulfation and glucuronidation were the main metabolic pathways of honokiol and magnolol.
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http://dx.doi.org/10.1002/jssc.202100982DOI Listing
July 2022

Unraveling the Organic and Inorganic Passivation Mechanism of ZnO Nanowires for Construction of Efficient Bulk Heterojunction Quantum Dot Solar Cells.

ACS Appl Mater Interfaces 2022 Aug 27;14(31):36268-36276. Epub 2022 Jul 27.

Faculty of Informatics and Engineering, The University of Electro Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan.

Zinc oxide (ZnO) nanowire (NW) based lead sulfide (PbS) quantum dot solar cells (QDSCs), i.e., bulk heterojunction QDSCs, have been widely investigated because of the excellent photoelectronic properties of PbS QDs and ZnO NWs. To further improve the efficiency of this type of QDSCs, various passivation methods are applied to ZnO NWs to suppress interface recombination caused by trap defects. However, the comparison among passivation using organic, inorganic, and inorganic-organic hybrid materials with different properties has been less studied. In this work, the effect of passivation with inorganic Mg-doped ZnO (ZMO), organic 1,2-ethanedithiol (EDT) and both of them on ZnO NWs and PbS QDSCs are investigated. As a result, ZnO NWs purely passivated by organic material EDT show the best performance with fewer surface defects and better matched energy level with the PbS QD layer. A nearly 1.7 times larger power conversion efficiency (PCE) of 6.9% is achieved for the solar device using ZnO NW @EDT, compared with that (4.1%) of the untreated one. The work provides a promising way to impede interlayer charge recombination and facilitate carrier transport, thus enhancing the photovoltaic performance of the device.
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http://dx.doi.org/10.1021/acsami.2c10508DOI Listing
August 2022

Knowledge Domain and Emerging Trends of Social Vulnerability Research: A Bibliometric Analysis (1991-2021).

Authors:
Hua Li Weijun Wang

Int J Environ Res Public Health 2022 Jul 8;19(14). Epub 2022 Jul 8.

College of Tourism, Northwest Normal University, Lanzhou 730070, China.

Carrying out social vulnerability research has become an important way to understand the sustainable development of resources, the environment, populations, and societies. Clarifying the research context and development trend of social vulnerability is of great significance to the follow-up theoretical research on and practical exploration of sustainable social development. With the help of a CiteSpace knowledge map analysis, this study reveals the research hotspots and their evolution in different periods and puts forward the key problems in and future direction of social vulnerability research in the future. This study found that the number of articles on social vulnerability research showed a steady upward trend and that the research experienced roughly three stages: an embryonic stage, a development stage, and a stable stage. The United States, Brazil, the United Kingdom, and China accounted for the majority of the research, but the intensity of cooperation between them is still weak. Vulnerability assessment and risk assessment in the context of policy and environmental change are hot topics in the current research. In the future, it is necessary to focus on the comprehensive research on the integrated and cross-scale research on social vulnerability, research on its occurrence and evolution, and on the dynamic monitoring as well as optimal regulation of social vulnerability under multiple pressures.
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http://dx.doi.org/10.3390/ijerph19148342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315777PMC
July 2022

Analysis of the Influence of Sports on College Students' Music Vocalization Training Based on Monte Carlo and Dynamic Adjustment Factor Algorithm.

Authors:
Li Hua Lin Yu

J Environ Public Health 2022 16;2022:3443404. Epub 2022 Jul 16.

Jiangxi University of Technology, Nanchang 330098, China.

With the continuous improvement of people's living standards, the requirements of music majors for their training standards are also increasing, which leads to the development of music training in the direction of intelligence. This paper discusses the problems of breathing, coordination, and muscle control ability in vocal training and puts forward a vocal training method based on dynamic adjustment factor and Monte Carlo algorithm to solve the difficult problem of vocal training for college students and understand the relationship between vocal training and exercise. Firstly, the sports training set and vocal pronunciation training set are constructed in the form of clustering, and the samples in the set are analyzed discretely to ensure that the samples conform to normal distribution; then, using the Monte Carlo algorithm analyzes the two sample sets and finds out the relationship between exercise and vocal training. Finally, according to breathing, coordination, muscle control ability, and other indicators, calculate the impact of exercise on vocal sound. MATLAB simulation shows that the method proposed in this paper can analyze the influence of exercise on vocal vocalization from the perspective of breathing, coordination, muscle control ability, and other indicators. The accuracy of judgment results is more than 95%, and the time is less than 1 min. All indicators are better than traditional vocal training methods (90%, 2 min), which shows the effectiveness of the method proposed in this paper.
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http://dx.doi.org/10.1155/2022/3443404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308556PMC
July 2022

Functional Imaging in Improving Children's Mental Health Based on Behavior.

Comput Math Methods Med 2022 16;2022:4774771. Epub 2022 Jul 16.

School of Education and Psychology, Chengdu Normal University, Chengdu, 611130 Sichuan, China.

At present, children's psychological and behavioral health care is mainly based on the doctor's observation and diagnosis. On the whole, it is inefficient, and the effect of health care cannot meet the current needs of children's behavior. Therefore, this paper uses the method of functional imaging to study the key factors of children's behavioral health care. In this paper, the structure and function of children's brain are associated with children's psychological behavior. The brain structure of 64 children in our city is detected by functional image processing, and 64 children are divided into groups according to the detection results. According to the children's performance, the children were divided into physical disorder (11 cases), emotional disorder (14 cases), cognitive disorder (12 cases), and normal group (42 cases). Among them, 3 cases had three kinds of disorders, 6 cases had both emotional and cognitive disorders, 7 cases had physical and emotional disorders, and 5 cases had physical and cognitive disorders. In this paper, according to the research data of functional imaging on different levels of children's brain, we use computer to model and simulate through digital conversion technology, draw the neural network Atlas of children's psychological behavior, compare the children's representation and image characteristics according to functional imaging, and then, study the relationship between children's signs and images, to make a plan for improving children's psychological behavior health care. The study shows that in the above different groups, the linear correlation between the functional imaging results and the representation of 22 abnormal children is 98%, and the fuzzy deviation is only 3.52%, which indicates that functional imaging can be used as the basic judgment basis in improving children's psychological and behavioral health care and can predict and reasonably prevent children's potential psychological behavior according to the images.
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http://dx.doi.org/10.1155/2022/4774771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308513PMC
July 2022

Impact of Subintimal Plaque Modification on Reattempted Chronic Total Occlusions Percutaneous Coronary Intervention.

JACC Cardiovasc Interv 2022 07;15(14):1427-1437

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China. Electronic address:

Background: Predictors of success in reattempted chronic total occlusion (CTO) percutaneous coronary intervention (PCI) procedures remain obscure, mainly owing to the lack of consecutive angiograms and procedural records of initial attempts in the same cohort.

Objectives: This study sought to investigate the factors predicting the success of reattempted CTO PCI procedures.

Methods: A total of 208 consecutive patients who underwent a failed CTO PCI attempt and received reattempted procedure at the same cardiac center were retrospectively analyzed. Predictors of the success of reattempted procedures were evaluated.

Results: The overall technical success rate of reattempted CTO PCI procedures was 71.2%. Subintimal plaque modification (SPM) was implemented in 35 (16.8%) procedures in initial attempts. The reattempted technical success rate was 93.3% in cases in which SPM with guidewire (GW) crossing was achieved in the initial attempt; however, the success rate was 55.0% for procedures involving SPM without GW crossing. SPM with GW crossing (OR: 11.21; 95% CI: 1.31-96.16; P = 0.028), referral to high-volume operators (OR: 2.38; 95% CI: 1.14-4.98; P = 0.021), and a bidirectional approach (OR: 2.31; 95% CI: 1.12-4.79; P = 0.024) were positive independent predictors of technical success in the subsequent reattempt. The time interval for reattempt (per 90-day increment) was negatively correlated with the technical success of the reattempted procedures (OR: 0.85; 95% CI: 0.73-0.98; P = 0.030).

Conclusions: This study identified independent predictors of success in reattempted CTO PCI procedures. SPM with GW crossing achieved in the initial attempt is associated with a higher success rate in the subsequent reattempt.
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http://dx.doi.org/10.1016/j.jcin.2022.06.015DOI Listing
July 2022

Exploration of molecular targets and mechanisms of Chinese medicinal formula Acacia Catechu -Scutellariae Radix in the treatment of COVID-19 by a systems pharmacology strategy.

Phytother Res 2022 Jul 20. Epub 2022 Jul 20.

Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an, China.

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In China, the Acacia catechu (AC)-Scutellariae Radix (SR) formula has been widely used for pulmonary infection in clinical practice for several centuries. However, the potential role and mechanisms of this formula against COVID-19 remains unclear. The present study was designed to dissect the active ingredients, molecular targets, and the therapeutic mechanisms of AC-SR formula in the treatment of COVID-19 based on a systems pharmacology strategy integrated by ADME screening, target prediction, network analysis, GO and KEGG enrichment analysis, molecular docking, and molecular dynamic (MD) simulations. Finally, Quercetin, Fisetin(1-), kaempferol, Wogonin, Beta-sitosterol, Baicalein, Skullcapflavone II, Stigmasterol were primarily screened to be the potentially effective active ingredients against COVID-19. The hub-proteins were TP53, JUN, ESR1, MAPK1, Akt1, HSP90AA1, TNF, IL-6, SRC, and RELA. The potential mechanisms of AC-SR formula in the treatment of COVID-19 were the TNF signaling pathway, PI3K-Akt signaling pathway and IL-17 signaling pathway, etc. Furthermore, virtual docking revealed that baicalein, (+)-catechin and fisetin(1-) exhibited high affinity to SARS-CoV-2 3CLpro, which has validated by the FRET-based enzymatic inhibitory assays with the IC of 11.3, 23.8, and 44.1 μM, respectively. And also, a concentration-dependent inhibition of baicalein, quercetin and (+)-catechin against SARS-CoV-2 ACE2 was observed with the IC of 138.2, 141.3, and 348.4 μM, respectively. These findings suggested AC-SR formula exerted therapeutic effects involving "multi-compounds and multi-targets." It might be working through directly inhibiting the virus, improving immune function, and reducing the inflammatory in response to anti-COVID-19. Ultimately, this study would provide new perspective for discovering potential drugs and mechanisms against COVID-19.
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http://dx.doi.org/10.1002/ptr.7554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349561PMC
July 2022

APOA1 mRNA and protein in kidney renal clear cell carcinoma correlate with the disease outcome.

Sci Rep 2022 Jul 20;12(1):12406. Epub 2022 Jul 20.

Department of Oncology, The Second Affiliated Hospital of Jianghan University, 122 Xianzheng Road, Wuhan, 430050, Hubei Province, People's Republic of China.

Renal cancer is one of the most common malignant tumors with high mortality, and kidney renal clear cell carcinoma (KIRC) is the most common type of renal cancer. We attempted to evaluate the clinical and prognostic significance of Apolipoprotein A1 (APOA1) mRNA and protein in KIRC patients. Clinical data along with RNA-sequencing data were downloaded from UCSC Xena. The Human Protein Atlas database was searched to reveal APOA1 protein expression profiles in KIRC and normal renal tissues. The TIMER database was applied to determine the correlations of APOA1 with immune cells and PD-1 and PD-L1 in KIRC. Ninety-one cases of KIRC patients and 93 healthy controls from our hospital were enrolled for clinical validation. Levels of APOA1 mRNA in KIRC tissues (N = 535) are not only lower than the levels in normal renal tissues (N = 117), but also in paired normal renal tissues (N = 72). High expression of APOA1 mRNA at the time of surgery was correlated with worse overall survival (OS) (HR 1.66; p = 0.037) and disease-free survival (DFS) (HR 1.65; p = 0.047), and APOA1 DNA methylation was linked to worse OS (HR 2.1; p = 0.001) rather than DFS (HR 1.12; p = 0.624) in KIRC patients. Concentrations of preoperative serum APOA1 protein were markedly decreased in KIRC patients compared to healthy controls (p < 0.01), and low levels of APOA1 protein predicted less favorable OS than those with high levels (HR = 2.84, p = 0.0407). APOA1 negatively correlated with various immune cell infiltrates and PD-L1 expression (r = - 0.283, p = 2.74e-11) according to the TIMER database. Low levels of APOA1 mRNA at the time of surgery predict favorable survival in KIRC patients. Our results provide insights to identify a novel prognostic index with great clinical utility.
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http://dx.doi.org/10.1038/s41598-022-16434-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300670PMC
July 2022

[Simultaneous determination of glucosinolates and flavonoids in leaves of Moringa oleifera by quantitative analysis of multi-components by single-marker (QAMS)].

Zhongguo Zhong Yao Za Zhi 2022 Jun;47(12):3285-3294

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.

To establish a method for simultaneously determining the content of four glucosinolates and five flavonoids in leaves of Moringa oleifera via quantitative analysis of multi-components by single-marker(QAMS) and verify the feasibility and applicability of the established method. The glucosinolates and flavonoids were analyzed via Waters Acquity UPLC HSS T_3 column(2.1 mm × 100 mm, 1.8 μm). The gradient elution was carried out with the mobile phase composed of 0.1% formic acid-acetonitrile and 0.3% formic acid at the flow rate of 0.4 mL·min~(-1) and the column temperature of 40 ℃. The wavelengths for the detection of glucosinolates and flavonoids were 225 nm and 260 nm, respectively. With 4-O-(α-L-rhamnoyloxy)-benzyl glucosinolate and vecenin-2 as internal reference substances, the relative correction factors of four glucosinolates and five flavonoids were respectively calculated for determining the content of the 9 ingredients in leaves of M. oleifera. To verify the accuracy and feasibility of QAMS, we used internal standard method(ISM) and external standard method(ESM) to determine the content of glucosinolates and flavonoids, respectively. The t-test results showed that there was no significant difference in the content of glucosinolates obtained by ISM and QAMS methods or in the content of flavonoids obtained by ESM and QAMS methods. The content of glucosinolates and flavonoids varied among M. oleifera of different varieties and from different producing areas. The total glucosinolates and total flavonoids had the highest content in the Indian variety while the lowest content in the variety ■Honghe No. 1'. The established QAMS method is rapid, simple and accurate and can be used for simultaneous determination of glucosinolates and flavonoids in the leaves of M. oleifera. This study provides experimental data for the quality control and utilization of M. oleifera leaves.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20211214.203DOI Listing
June 2022

Comparison of wavefront-optimized and corneal wavefront-guided transepithelial photorefractive keratectomy for high-order aberrations (>0.35μm) in myopia.

J Cataract Refract Surg 2022 Jul 15. Epub 2022 Jul 15.

Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, Shandong Province, China.

Purpose: To compare the clinical outcomes mainly including contrast sensitivity and high-order aberrations (HOAs) between wavefront-optimized (WFO) and corneal wavefront-guided (CWFG) transepithelial photorefractive keratectomy (T-PRK) for preoperative HOAs >0.35 μm.

Setting: Qingdao Eye Hospital of Shandong First Medical University, Qingdao, Shandong Province, China.

Design: Prospective randomized controlled study.

Methods: 71 patients with preoperative total ocular and corneal aberrations >0.35 μm who underwent T-PRK for the treatment of myopia and myopic astigmatism were randomly divided into the aberration optimization mode group (WFO group; 36 eyes) and corneal wavefront-guided mode group (CWFG group; 35 eyes). Preoperative and postoperative visual outcome, refraction, contrast sensitivity, and HOAs were compared.

Results: The CWFG group had significantly lower total HOA and coma values in the corneal aberration compared with the WFO group at 3 (P = 0.009; P < 0.001) and 6 months postoperatively (P = 0.006; P < 0.001). In addition, the CWFG group had significantly lower total HOA and coma values in the whole eye aberration compared with the WFO group at 3 (P = 0.044; P = 0.004) and 6 months postoperatively (P = 0.026; P = 0.001). The CWFG group had significantly better improvement in contrast sensitivity than the WFO group at spatial frequencies of 3, 6, 12, and 18 cycles per degree (P = 0.005, P = 0.007, P = 0.001, and P < 0.001, respectively).

Conclusions: CWFG T-PRK is associated with better visual and refractive outcomes and less HOAs than WFO T-PRK in eyes with preoperative aberrations > 0.35 μm.
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http://dx.doi.org/10.1097/j.jcrs.0000000000001012DOI Listing
July 2022

Diversity and Dynamics of Epidermal Microbes During Grape Development of Cabernet Sauvignon ( L.) in the Ecological Viticulture Model in Wuhai, China.

Front Microbiol 2022 30;13:935647. Epub 2022 Jun 30.

College of Enology, Northwest A&F University, Xianyang, China.

Grapevine-related microorganisms affect the health and yield of grapes, the metabolic pathways of the fermentation process, and the regional characteristics of wine. However, the diversity of epidermal microorganisms during the development of berries under the ecological viticulture model has not been described in detail. In this study, high-throughput amplicon sequencing technology was used to perform ITS and 16S sequencing of Cabernet Sauvignon epidermal microbes at different developmental stages in the Wuhai region to investigate the succession of epidermal microbes and their response to developmental stages and vineyard weather. The results showed that the diversity of fungi and bacteria decreased during development. Epidermal microorganisms recruited members according to their developmental stages, but retained the core taxa, such as the fungi genera , , and and the bacteria genera , , , and . In addition, the microbial diversity was associated with specific meteorological parameters, implying that there was a connection between the environmental conditions of the vineyard and the microbial distribution pattern such as the fungus genus was positively correlated with relative humidity and negatively correlated with average high temperature, average low temperature, and average ground temperature; the bacterium genus was positively correlated with sunlight time, and negatively correlated with relative humidity. In conclusion, this study can help vineyard managers understand the microbial consortia associated with particular diseases, and also the dynamics of infection processes in order to take preventive actions, especially at the most critical moments.
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http://dx.doi.org/10.3389/fmicb.2022.935647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280189PMC
June 2022

Successful secondary radical operation on unretractable metastatic platinum-sensitive recurrent ovarian cancer by immunotherapy: a case report.

Ann Transl Med 2022 Jun;10(12):718

National Cancer Center/National Clinical Research Center for Cancer/Department of Gynecology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Background: Although rechallenge with platinum-based chemotherapy is effective for most platinum-sensitive recurrent ovarian cancer (ROC) patients, there is still a subset of patients who have no responses to the standard care. Overcoming multidrug resistance (MDR) is a top priority in oncology clinics, but it remains intricate. It is difficult for clinicians to manage unretractable ROC when conventional therapy yields no results. The rational and effective use of immunotherapy will contribute to the clinical benefit of these patients, especially in patients without approved immunotherapy biomarkers. Here we present a case of successful secondary radical surgery for unretractable metastatic MDR ROC by immunotherapy based on her immune-infiltrating tumor microenvironment signatures.

Case Description: A 57-year-old woman, diagnosed with IC2 stage high-grade serous ovarian cancer in 2015, underwent immediate ultra-radical cytoreductive surgery followed by 6 cycles of platinum-containing adjuvant chemotherapy. After nearly 37 months of disease-free status, the woman complained of spontaneous pain from the right subcostal margin for 1 month and was diagnosed with ROC accompanied by multiple unretractable colorectal and hepatic metastases. Standard chemotherapies were ineffective and quickly resulted in disease progression and grade IV myelosuppression followed impaired gastrointestinal function. Notably, after standard chemotherapy, the patient was tested negative for all immune biomarkers, but multiple fluorescence immunohistochemistry indicated that her tumor tissue was significantly infiltrated with the cluster of differentiation 8 (CD8) T cells and natural killer (NK) cells, implying potential benefits of immunotherapy. Then changed to 3 cycles of intravenous pembrolizumab, the main pelvic tumor and hepatic metastases showed significant shrinkage and achieved partial response, but the disease progressed after 8.7 months. Subsequently, arterial perfusion with pembrolizumab was performed combined with the chemotherapy. A comfortingly partial response was achieved again that enabled the patient to successfully undergo a secondary radical surgery for colorectal and liver metastases. Since that time the patient's postoperative course has been favorable, and she remains disease-free at present for at least 17 months.

Conclusions: Immune infiltration signatures of the tumor microenvironment could serve as an indication for immunotherapy in patients with unretractable platinum-sensitive ROC with MDR. In addition, the introduction of immunotherapy might bring some degree of chemotherapy resensitization.
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http://dx.doi.org/10.21037/atm-22-2128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279770PMC
June 2022

NH-MIL-125(Ti) modified graphitic carbon nitride with carbon vacancy for efficient photocatalytic NO removal.

Chemosphere 2022 Jul 11:135660. Epub 2022 Jul 11.

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Suzhou Industrial Park, Suzhou, 215123, China. Electronic address:

This paper reports the application of NH-MIL-125(Ti) modified carbon nitride C-CN with carbon vacancies in the removal of NO. We performed a series of characterizations of the complex and compared various ratios with the individual components. The results of UV spectrum analysis show that the composite's range of light absorption expanded due to the modification of Ti metal-organic framework. Furthermore, the results of photocurrent and electrical impedance indicate the compound has a better ability to generate and transfer electrons. The increase in the compound's NO removal efficiency (up to 63%) indicates that MOF has a positive effect on C-CN modification-a good method for photocatalysis. Moreover, the compound can promote photocatalysis in a favorable direction.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135660DOI Listing
July 2022

Nanomicelles Array for Ultrahigh-Density Data Storage.

Small 2022 Aug 10;18(32):e2202637. Epub 2022 Jul 10.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.

High-density data storage devices based on organic and polymer materials are currently restricted by two key issues, size limitations and uniformity of memory cells. Herein, one triblock polymer is synthesized by ring-opening metathesis polymerization, where the polymer contains an electron-donor-acceptor (A D) segment, an electron-acceptor (A ) segment, and a hydrophilic segment, that shows ternary memory behavior in a conventional sandwich-type device. The polymers that have monodisperse molecular weight dispersity self-assemble into nanomicelles with a uniform size of 80 nm. Each nanomicelle is composed of an A DA -type hydrophobic core stabilized with a hydrophilic shell. Nanobowls based on conductive oxide are prepared via the template method, wherein the nanomicelles are present as independent nanoscale memory units to produce an array of micelle matrices. Investigations of the resulting nanomemory device using conductive atomic force microscopy show that the micelles exhibit a predominant semiconductor memory behavior. Compared to traditional ternary devices with a memory unit size of ≈1 mm, this innovative fabrication method based on arrayed uniform nanomicelles downscales the size of storage cells to 80 nm. Furthermore, the described system leads to a greatly enhanced storage density (>10 times over the same area), which opens up new paths for further development of ultrahigh-density data storage devices.
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http://dx.doi.org/10.1002/smll.202202637DOI Listing
August 2022

Evaluation of the Ecological Effects of Ecological Restoration Programs: A Case Study of the Sloping Land Conversion Program on the Loess Plateau, China.

Int J Environ Res Public Health 2022 Jun 26;19(13). Epub 2022 Jun 26.

College of Economics and Management, Northwest A&F University, Yangling 712100, China.

The Sloping Land Conversion Program (SLCP) is the largest ecological restoration program in the world. Evaluating the ecological effects of the SLCP not only provides a scientific basis for China to improve the SLCP but also provides a reference for other countries in the world to evaluate the ecological effects of ecological restoration programs being implemented or to be implemented. To this end, we took the Loess Plateau, the core area for the implementation of the SLCP, as an example and, based on multi-source remote sensing data and GIS technology, we conducted a comprehensive evaluation of the ecological effects of the implementation of the SLCP on the Loess Plateau. The results showed that, first, from 2000 to 2018, a total of 12,372.05 km of cultivated land was converted into forest land and grassland on the Loess Plateau, and this contributed to an increase in vegetation cover from 45.09% in 2000 to 64.15% in 2018, and a decrease in the soil erosion modulus from 26.41 t·hm·yr in 2000 to 17.92 t·hm·yr in 2018. Second, the 6-25° slope range is the core area of the Loess Plateau for implementation of the SLCP. In this range, the area of cultivated land converted into forest land and grassland accounts for 60.16% of the total area of transferred cultivated land. As a result, the 6-25° slope range has become the most significant area for improving vegetation cover and reducing the soil erosion intensity, and it is mainly concentrated in the southwestern, central and central-eastern hilly and gully areas of the Loess Plateau. Third, from 2000 to 2018, the climate of the Loess Plateau tended to be warm and humid and was conducive to the implementation of the SLCP. Among these factors, precipitation is the dominant factor in determining the spatial distribution of vegetation on the Loess Plateau, and the increase in precipitation is also the main reason for the promotion of vegetation growth. Fourthly, from 2000 to 2018, the ecological environment of the Loess Plateau was significantly improved as a result of the combined effects of the implementation of the SLCP and climate warming and humidification, but the primary reason is still the implementation of the SLCP.
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http://dx.doi.org/10.3390/ijerph19137841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265944PMC
June 2022

The Effect of Non-Cognitive Ability on Farmer's Ecological Protection of Farmland: Evidence from Major Tea Producing Areas in China.

Int J Environ Res Public Health 2022 Jun 21;19(13). Epub 2022 Jun 21.

College of Economics and Management, Northwest A&F University, Xianyang 712100, China.

Ecological protection of farmland is an important means to reduce agricultural non-point source pollution and improve the quality of agricultural products. As the main body of current agricultural production and operation, the aging labor force has insufficient cognitive ability and low ability to learn actively, which is not conducive to transforming the green output. However, non-cognitive abilities closely related to the acquired environment can promote the elderly farmers' farmland ecological protection behavior by improving life satisfaction and social adaptability. Based on the above background, using the survey data of 964 farmers in China, the bivariate Probit model was used to empirically test the influence mechanism of non-cognitive ability on the ecological protection behavior of farmland. The study found that non-cognitive ability significantly promoted farmer's ecological protection of farmland in China. Specifically, the variables of non-cognitive ability, social communication ability, active learning ability, self-efficacy, stress resistance, altruistic tendency and individual resilience were found to significantly promote ecological protection of farmland. Mechanism analysis showed that non-cognitive ability promoted the ecological protection behavior of farmland by expanding social capital, information channels and improving technical value perception. A heterogeneity analysis revealed that non-cognitive ability had a greater impact on ecological protection behavior of farmland in the elderly and low-income groups. Therefore, government should attach importance to improving farmers' non-cognitive abilities, further increase technical publicity, and build a communication platform for farmers in order to promote the ecological protection of farmland.
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http://dx.doi.org/10.3390/ijerph19137598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266024PMC
June 2022

Editorial: High-Throughput Sequencing-Based Investigation of Chronic Disease Markers and Mechanisms.

Front Genet 2022 21;13:922206. Epub 2022 Jun 21.

Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.3389/fgene.2022.922206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253685PMC
June 2022

Inquiry of the Practice of Leadership in Chengguan: A Study Based on the Ethnographic Research of Z City.

Authors:
Hua Li Yifan Li

Front Psychol 2022 21;13:857043. Epub 2022 Jun 21.

School of Management, Xi'an Jiaotong University, Xi'an, China.

Chengguan, the Urban Administrative Law Enforcement Bureau, has been criticized for its dismal public image and poor job performance. Based on an ethnographic case study in Z City, we analyzed the type of leadership that results in passive work performance in Chengguan, and we examined whether any leadership style can be used to improve Chengguan's image and performance. We developed a new leadership ontology of CNP (Cognition-Normalization-Performance) on this foundation, and ethnographic research was conducted in three phases: leader's cognition, followers' normalization, and organization performance. Several implications were drawn. Leader selection should be cautious and can be improved by studying the leader's traits and behavior. This is done by investigating candidates' leadership career paths, trait characteristics, motive profiles, and other qualities. It is useful to change leaders by strengthening followers' unity and cohesion by setting up a labor union, youth federation, women's federation, and other groups. A leader should be selected among individuals who have completed leadership training as opposed to appointing one from outside the organization. On the one hand, the superior should help to improve the leadership environment (context), supervise problems in the organization's operation and performance, and track changes over time. On the other hand, the leader can also provide the followers with a flexible and adaptive place of work.
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http://dx.doi.org/10.3389/fpsyg.2022.857043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253826PMC
June 2022
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