Hsin-Yao Tang

Hsin-Yao Tang

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Hsin-Yao Tang

Hsin-Yao Tang

Publications by authors named "Hsin-Yao Tang"

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59Publications

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Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits.

Oncogene 2019 Aug 12. Epub 2019 Aug 12.

Prostate Cancer Discovery and Development Program, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41388-019-0939-7DOI Listing
August 2019

Experimental Assignment of Disulfide-Bonds in Purified Proteins.

Curr Protoc Protein Sci 2019 Jun 12;96(1):e86. Epub 2019 Feb 12.

The Wistar Institute, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/cpps.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647852PMC
June 2019

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.

Dev Cell 2019 Jun 16;49(6):920-935.e5. Epub 2019 May 16.

Molecular & Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA; Orthopaedic Surgery and Cell & Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581604PMC
June 2019

Proteome Analysis Using Gel-LC-MS/MS.

Curr Protoc Protein Sci 2019 Jun 10;96(1):e93. Epub 2019 Jun 10.

Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/cpps.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653605PMC
June 2019

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.

Matrix Biol 2018 09 9;70:20-35. Epub 2018 Mar 9.

Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081240PMC
September 2018

Generation of a recombinant Aggregatibacter actinomycetemcomitans RTX toxin in Escherichia coli.

Gene 2018 Sep 4;672:106-114. Epub 2018 Jun 4.

Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640136PMC
September 2018

Research Techniques Made Simple: Mass Spectrometry for Analysis of Proteins in Dermatological Research.

J Invest Dermatol 2018 06;138(6):1236-1242

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.01.001DOI Listing
June 2018

Detection of the Ubiquitinome in Cells Undergoing Oncogene-Induced Senescence.

Methods Mol Biol 2017 ;1534:127-137

Gene Expression and Regulation Program, The Wistar Institute, Room 312, 3601 Spruce Street, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/978-1-4939-6670-7_12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572468PMC
January 2018

Expanded subgenomic mRNA transcriptome and coding capacity of a nidovirus.

Proc Natl Acad Sci U S A 2017 10 4;114(42):E8895-E8904. Epub 2017 Oct 4.

Department of Biology, Georgia State University, Atlanta, GA 30303;

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http://dx.doi.org/10.1073/pnas.1706696114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651751PMC
October 2017

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.

Cancer Cell 2016 08;30(2):257-272

Prostate Cancer Discovery and Development Program, Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131882PMC
August 2016

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts.

Cell Cycle 2015 ;14(10):1540-7

a Gene Expression and Regulation Program ; The Wistar Institute Cancer Center; The Wistar Institute ; Philadelphia , PA USA.

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http://dx.doi.org/10.1080/15384101.2015.1026492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614229PMC
February 2016

Nonenzymatic Protein Acetylation Detected by NAPPA Protein Arrays.

ACS Chem Biol 2015 Sep 23;10(9):2034-47. Epub 2015 Jun 23.

Department of Biochemistry & Biophysics, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1021/acschembio.5b00342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610810PMC
September 2015

Label-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells.

Nucleus 2013 Nov-Dec;4(6):450-9. Epub 2013 Dec 6.

Molecular & Cell Biophysics Laboratory, University of Pennsylvania; Philadelphia PA USA; Center for Systems and Computational Biology; Wistar Institute; Philadelphia PA USA.

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http://www.tandfonline.com/doi/abs/10.4161/nucl.27413
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http://dx.doi.org/10.4161/nucl.27413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925690PMC
October 2014

Dysferlin and other non-red cell proteins accumulate in the red cell membrane of Diamond-Blackfan Anemia patients.

PLoS One 2014 14;9(1):e85504. Epub 2014 Jan 14.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America ; Department of Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085504PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891812PMC
September 2014

Enhanced identification of zero-length chemical cross-links using label-free quantitation and high-resolution fragment ion spectra.

J Proteome Res 2014 Feb 7;13(2):898-914. Epub 2014 Jan 7.

Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute , 3601 Spruce Street, Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/pr400953wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975668PMC
February 2014

Probing large conformational rearrangements in wild-type and mutant spectrin using structural mass spectrometry.

Proc Natl Acad Sci U S A 2014 Feb 22;111(5):1801-6. Epub 2014 Jan 22.

Center for Systems and Computational Biology, and Molecular and Cellular Oncogenesis Program, Wistar Institute, Philadelphia, PA 19104.

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http://dx.doi.org/10.1073/pnas.1317620111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918770PMC
February 2014

The common hereditary elliptocytosis-associated α-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation.

Blood 2013 Oct 23;122(17):3045-53. Epub 2013 Aug 23.

The Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2013-02-487702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811177PMC
October 2013

Identification of multiple novel protein biomarkers shed by human serous ovarian tumors into the blood of immunocompromised mice and verified in patient sera.

PLoS One 2013 27;8(3):e60129. Epub 2013 Mar 27.

Center for Systems and Computational Biology, and Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060129PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609810PMC
September 2013

Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer.

J Proteomics 2013 Aug 21;89:165-78. Epub 2013 Jun 21.

Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jprot.2013.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779132PMC
August 2013

A label-free proteome analysis strategy for identifying quantitative changes in erythrocyte membranes induced by red cell disorders.

J Proteomics 2012 Dec 29;76 Spec No.:194-202. Epub 2012 Aug 29.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jprot.2012.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508302PMC
December 2012

Systematic comparison of fractionation methods for in-depth analysis of plasma proteomes.

J Proteome Res 2012 Jun 18;11(6):3090-100. Epub 2012 May 18.

Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute , Philadelphia, Pennsylvania, United States.

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http://pubs.acs.org/doi/10.1021/pr201068b
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http://dx.doi.org/10.1021/pr201068bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430803PMC
June 2012

A xenograft mouse model coupled with in-depth plasma proteome analysis facilitates identification of novel serum biomarkers for human ovarian cancer.

J Proteome Res 2012 Feb 18;11(2):678-91. Epub 2011 Nov 18.

Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute , Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1021/pr200603hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272104PMC
February 2012

Rapid verification of candidate serological biomarkers using gel-based, label-free multiple reaction monitoring.

J Proteome Res 2011 Sep 26;10(9):4005-17. Epub 2011 Jul 26.

Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1021/pr2002098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166403PMC
September 2011

Plasma biomarker discovery using 3D protein profiling coupled with label-free quantitation.

Methods Mol Biol 2011 ;728:3-27

Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-61779-068-3_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157887PMC
July 2011

In-depth analysis of a plasma or serum proteome using a 4D protein profiling method.

Methods Mol Biol 2011 ;728:47-67

Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-61779-068-3_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157844PMC
July 2011

Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells.

Proc Natl Acad Sci U S A 2011 May 28;108(20):8269-74. Epub 2011 Apr 28.

Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1018887108
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http://dx.doi.org/10.1073/pnas.1018887108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100976PMC
May 2011

Systematic discovery of ectopic pregnancy serum biomarkers using 3-D protein profiling coupled with label-free quantitation.

J Proteome Res 2011 Mar 7;10(3):1126-38. Epub 2011 Jan 7.

Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1021/pr1008866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048922PMC
March 2011

Deciphering the human platelet sheddome.

Blood 2011 Jan 20;117(1):e15-26. Epub 2010 Oct 20.

Department of Medicine, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2010-05-283838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037762PMC
January 2011

A comprehensive model of the spectrin divalent tetramer binding region deduced using homology modeling and chemical cross-linking of a mini-spectrin.

J Biol Chem 2010 Sep 6;285(38):29535-45. Epub 2010 Jul 6.

Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M110.145573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937985PMC
September 2010

Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating.

J Cell Sci 2008 Nov 28;121(Pt 22):3794-802. Epub 2008 Oct 28.

Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1242/jcs.029678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740334PMC
November 2008

A structural model of the erythrocyte spectrin heterodimer initiation site determined using homology modeling and chemical cross-linking.

J Biol Chem 2008 Jan 31;283(3):1553-62. Epub 2007 Oct 31.

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M706981200DOI Listing
January 2008

Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity.

Cell Microbiol 2007 Nov 24;9(11):2689-99. Epub 2007 Jun 24.

Leon Levy Research Center for Oral Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1462-5822.2007.00989.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459317PMC
November 2007

Forced unfolding of proteins within cells.

Science 2007 Aug;317(5838):663-6

Biophysical Engineering Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.1139857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741095PMC
August 2007

Complex proteome prefractionation using microscale solution isoelectrofocusing.

Expert Rev Proteomics 2005 Jun;2(3):295-306

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1586/14789450.2.3.295DOI Listing
June 2005

Identification of alternative products and optimization of 2-nitro-5-thiocyanatobenzoic acid cyanylation and cleavage at cysteine residues.

Anal Biochem 2004 Nov;334(1):48-61

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ab.2004.08.008DOI Listing
November 2004

Determination of disulfide-bond linkages in proteins.

Curr Protoc Protein Sci 2004 Sep;Chapter 11:Unit 11.11

The Wistar Institute, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/0471140864.ps1111s37DOI Listing
September 2004

In vivo phosphorylation of human erythrocyte spectrin occurs in a sequential manner.

Biochemistry 2004 Apr;43(14):4251-62

The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/bi036092xDOI Listing
April 2004