Hozumi Motohashi

Hozumi Motohashi

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Hozumi Motohashi

Publications by authors named "Hozumi Motohashi"

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Mitochondrial cysteinyl-tRNA synthetase is expressed via alternative transcriptional initiation regulated by energy metabolism in yeast cells.

J Biol Chem 2019 Sep 26;294(37):13781-13788. Epub 2019 Jul 26.

Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan

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http://dx.doi.org/10.1074/jbc.RA119.009203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746459PMC
September 2019

From germ cells to neonates: the beginning of life and the KEAP1-NRF2 system.

J Biochem 2019 Sep 13. Epub 2019 Sep 13.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, Japan.

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http://dx.doi.org/10.1093/jb/mvz070DOI Listing
September 2019

Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.

PLoS One 2018 30;13(11):e0203978. Epub 2018 Nov 30.

Department of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203978PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267955PMC
April 2019

Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.

J Biochem 2019 Apr;165(4):323-334

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Japan.

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http://dx.doi.org/10.1093/jb/mvy108DOI Listing
April 2019

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response.

J Immunol 2019 03 23;202(5):1331-1339. Epub 2019 Jan 23.

Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Medeshima-Shiode, Natori 981-1293, Japan;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801180
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http://dx.doi.org/10.4049/jimmunol.1801180DOI Listing
March 2019

Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells.

Br J Pharmacol 2019 02 7;176(4):607-615. Epub 2018 Jun 7.

Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1111/bph.14356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346073PMC
February 2019

Tumors sweeten macrophages with acids.

Nat Immunol 2018 12;19(12):1281-1283

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

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http://www.nature.com/articles/s41590-018-0258-0
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http://dx.doi.org/10.1038/s41590-018-0258-0DOI Listing
December 2018

-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1.

Mol Cell Biol 2018 09 15;38(17). Epub 2018 Aug 15.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

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http://dx.doi.org/10.1128/MCB.00252-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094050PMC
September 2018

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.

Physiol Rev 2018 07;98(3):1169-1203

Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University , Sendai , Japan ; Department of Pharmacology & Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University , Sendai , Japan.

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http://dx.doi.org/10.1152/physrev.00023.2017DOI Listing
July 2018

Nucleomethylin deficiency impairs embryonic erythropoiesis.

J Biochem 2018 May;163(5):413-423

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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https://academic.oup.com/jb/article/163/5/413/4735253
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http://dx.doi.org/10.1093/jb/mvx086DOI Listing
May 2018

Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo.

Genes Cells 2018 May 15;23(5):386-392. Epub 2018 Mar 15.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://doi.wiley.com/10.1111/gtc.12579
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http://dx.doi.org/10.1111/gtc.12579DOI Listing
May 2018

NRF2 addiction in cancer cells.

Cancer Sci 2018 Apr 10;109(4):900-911. Epub 2018 Mar 10.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

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http://dx.doi.org/10.1111/cas.13537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891176PMC
April 2018

Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau.

Biochem Biophys Res Commun 2017 11 21;493(2):946-951. Epub 2017 Sep 21.

Molecular Enzymology, Department of Molecular Cell Science, Tohoku University, 468-1 Aoba, Aramaki, Aoba, Sendai, Miyagi 980-0845, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.09.115DOI Listing
November 2017

NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells.

Mol Cell Biol 2017 Oct 12;37(19). Epub 2017 Sep 12.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

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http://dx.doi.org/10.1128/MCB.00086-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599717PMC
October 2017

Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells.

Cell Rep 2017 Sep;20(13):3199-3211

CEA/DRF/IBFJ/iRCM/LRTS, 92265 Fontenay-aux-Roses Cedex, France; Inserm U967, 92265 Fontenay-aux-Roses Cedex, France; Université Paris-Diderot, Paris 7, France; Université Paris-Sud, Paris 11, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.013DOI Listing
September 2017

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.

Free Radic Biol Med 2017 08 18;109:132-140. Epub 2017 Jan 18.

Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.024DOI Listing
August 2017

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice.

Mol Cell Biol 2017 08 14;37(15). Epub 2017 Jul 14.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

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http://dx.doi.org/10.1128/MCB.00063-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514445PMC
August 2017

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2.

J Biol Chem 2017 05 17;292(18):7519-7530. Epub 2017 Mar 17.

From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575,

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http://dx.doi.org/10.1074/jbc.M116.773960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418050PMC
May 2017

Recent advances in elucidating KEAP1-NRF2 functions in hematopoietic/immune cells and leukemic cells.

Rinsho Ketsueki 2016 ;57(10):1860-1868

Department of Gene Expression Regulation in Institute of Development, Aging and Cancer, Tohoku University.

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http://dx.doi.org/10.11406/rinketsu.57.1860DOI Listing
February 2017

Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1.

Biochem Biophys Res Commun 2016 11 11;480(2):180-186. Epub 2016 Oct 11.

Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X163168
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http://dx.doi.org/10.1016/j.bbrc.2016.10.022DOI Listing
November 2016

Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin.

Sci Rep 2016 09 16;6:33536. Epub 2016 Sep 16.

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan.

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http://dx.doi.org/10.1038/srep33536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025857PMC
September 2016

Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo.

Exp Lung Res 2015 7;41(8):422-34. Epub 2015 Jul 7.

a Department of Advanced Preventive Medicine for Infectious Disease , Tohoku University Graduate School of Medicine , 2-1 Seiryoumachi, Aobaku , Sendai , Japan.

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http://dx.doi.org/10.3109/01902148.2015.1060275DOI Listing
June 2016

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.

Nat Commun 2016 05 23;7:11624. Epub 2016 May 23.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1038/ncomms11624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879264PMC
May 2016

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.

Arch Biochem Biophys 2016 Apr;595:140-6

Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.11.008DOI Listing
April 2016

Redox signaling regulated by electrophiles and reactive sulfur species.

J Clin Biochem Nutr 2016 Mar 17;58(2):91-8. Epub 2016 Feb 17.

Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.3164/jcbn.15-111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788399PMC
March 2016

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression.

Mol Cell Biol 2016 02 16;36(3):407-20. Epub 2015 Nov 16.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan

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http://mcb.asm.org/content/36/3/407.full.pdf
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http://mcb.asm.org/content/early/2015/11/13/MCB.00785-15.ful
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http://mcb.asm.org/lookup/doi/10.1128/MCB.00785-15
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http://dx.doi.org/10.1128/MCB.00785-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719425PMC
February 2016

Simultaneous Quantification of Sphingolipids in Small Quantities of Liver by LC-MS/MS.

Mass Spectrom (Tokyo) 2014 7;3(Spec Iss 3):S0046. Epub 2015 Jan 7.

CREST, Japan Science and Technology Corporation (JST); Department of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University.

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http://dx.doi.org/10.5702/massspectrometry.S0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570946PMC
January 2016

The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization.

J Biol Chem 2016 Jan 30;291(4):1826-40. Epub 2015 Nov 30.

From the Departments of Biochemistry, CREST, Japan Science and Technology Agency, Seiryo-machi 2-1, Sendai 980-8575, and Center for Regulatory Epigenome and Diseases, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Sendai 980-8575,

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http://dx.doi.org/10.1074/jbc.M115.661702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722461PMC
January 2016

NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.

Sci Rep 2016 Jan 18;6:19329. Epub 2016 Jan 18.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

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http://dx.doi.org/10.1038/srep19329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726010PMC
January 2016

Roles of Nrf2 in cell proliferation and differentiation.

Free Radic Biol Med 2015 Nov 25;88(Pt B):168-178. Epub 2015 Jun 25.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.06.030DOI Listing
November 2015

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.

Sci Signal 2015 Nov 24;8(404):ra120. Epub 2015 Nov 24.

Chemical Genetics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan. Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan. Graduate School of Science and Engineering, Saitama University, 645 Shimo-Okubo, Sakura-ku, Saitama 338-8570, Japan. Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.

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http://dx.doi.org/10.1126/scisignal.aad0667DOI Listing
November 2015

Whole-Body In Vivo Monitoring of Inflammatory Diseases Exploiting Human Interleukin 6-Luciferase Transgenic Mice.

Mol Cell Biol 2015 Oct 17;35(20):3590-601. Epub 2015 Aug 17.

Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Sendai, Japan

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http://dx.doi.org/10.1128/MCB.00506-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573709PMC
October 2015

An integrative approach to analyze microarray datasets for prioritization of genes relevant to lens biology and disease.

Genom Data 2015 Aug;5:223-227

Department of Biological Sciences, University of Delaware, Newark, DE, USA ; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22135960150012
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http://dx.doi.org/10.1016/j.gdata.2015.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500531PMC
August 2015

Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.

Genes Cells 2015 Jun 16;20(6):464-80. Epub 2015 Mar 16.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

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http://dx.doi.org/10.1111/gtc.12237DOI Listing
June 2015

Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.

Neuro Oncol 2015 Apr 10;17(4):555-65. Epub 2014 Oct 10.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (M.K., Y.S., I.S., R.S., T.K., T.T.); Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (T.H., S.M., M.D., H.K., K.T., H.M.); Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (T.H.); Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (S.M., K.T., M.Y.); Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan (T.S.); Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan (M.W.); Department of Pathology and Laboratory Medicine, Sendai Medical Center, Sendai, Miyagi, Japan (H.S.); Department of Neurosurgery, Miyagi Cancer Center, Natori, Miyagi, Japan (Y.Y.).

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http://dx.doi.org/10.1093/neuonc/nou282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483074PMC
April 2015

MAFG is a transcriptional repressor of bile acid synthesis and metabolism.

Cell Metab 2015 Feb;21(2):298-311

Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA. Electronic address:

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(16)30055-
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http://linkinghub.elsevier.com/retrieve/pii/S155041311500008
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http://dx.doi.org/10.1016/j.cmet.2015.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317590PMC
February 2015

Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM.

Ultramicroscopy 2014 Aug 22;143:52-66. Epub 2013 Oct 22.

Biomedical Research Institute, National Institute of Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba 305-8566, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ultramic.2013.10.010DOI Listing
August 2014

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.

Genes Cells 2014 Aug 6;19(8):650-65. Epub 2014 Jul 6.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

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http://dx.doi.org/10.1111/gtc.12165DOI Listing
August 2014

NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice.

Hepatology 2014 Jun 25;59(6):2371-82. Epub 2014 Apr 25.

Departments of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Sendai, Japan; Gastroenterological Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan; Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

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http://dx.doi.org/10.1002/hep.27020DOI Listing
June 2014

NRF2 immunolocalization in human breast cancer patients as a prognostic factor.

Endocr Relat Cancer 2014 Apr 27;21(2):241-52. Epub 2014 Feb 27.

Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan Department of Pathology, Tohoku University Hospital, Sendai, Japan Department of Surgical Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Surgery, Tohoku Kosai Hospital, Sendai, Japan Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1530/ERC-13-0234DOI Listing
April 2014

[Contribution of Nrf2 to stress response and metabolic reprogramming in cell proliferation].

Authors:
Hozumi Motohashi

Seikagaku 2014 Apr;86(2):269-73

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April 2014

Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by Keratin 14 promoter.

Toxicol Sci 2014 Mar 28;138(1):47-58. Epub 2013 Nov 28.

* Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

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http://dx.doi.org/10.1093/toxsci/kft273DOI Listing
March 2014

Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.

Mol Cell Biol 2014 Mar 30;34(5):900-13. Epub 2013 Dec 30.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

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http://dx.doi.org/10.1128/MCB.01384-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023823PMC
March 2014

Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.

Genes Cells 2014 Mar 21;19(3):239-53. Epub 2014 Jan 21.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

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http://dx.doi.org/10.1111/gtc.12126DOI Listing
March 2014

A promoter-level mammalian expression atlas.

Authors:
Alistair R R Forrest Hideya Kawaji Michael Rehli J Kenneth Baillie Michiel J L de Hoon Vanja Haberle Timo Lassmann Ivan V Kulakovskiy Marina Lizio Masayoshi Itoh Robin Andersson Christopher J Mungall Terrence F Meehan Sebastian Schmeier Nicolas Bertin Mette Jørgensen Emmanuel Dimont Erik Arner Christian Schmidl Ulf Schaefer Yulia A Medvedeva Charles Plessy Morana Vitezic Jessica Severin Colin A Semple Yuri Ishizu Robert S Young Margherita Francescatto Intikhab Alam Davide Albanese Gabriel M Altschuler Takahiro Arakawa John A C Archer Peter Arner Magda Babina Sarah Rennie Piotr J Balwierz Anthony G Beckhouse Swati Pradhan-Bhatt Judith A Blake Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher A Maxwell Burroughs Andrea Califano Carlo V Cannistraci Daniel Carbajo Yun Chen Marco Chierici Yari Ciani Hans C Clevers Emiliano Dalla Carrie A Davis Michael Detmar Alexander D Diehl Taeko Dohi Finn Drabløs Albert S B Edge Matthias Edinger Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Michela Fagiolini Lynsey Fairbairn Hai Fang Mary C Farach-Carson Geoffrey J Faulkner Alexander V Favorov Malcolm E Fisher Martin C Frith Rie Fujita Shiro Fukuda Cesare Furlanello Masaaki Furino Jun-ichi Furusawa Teunis B Geijtenbeek Andrew P Gibson Thomas Gingeras Daniel Goldowitz Julian Gough Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Matthias Harbers Jayson Harshbarger Akira Hasegawa Yuki Hasegawa Takehiro Hashimoto Meenhard Herlyn Kelly J Hitchens Shannan J Ho Sui Oliver M Hofmann Ilka Hoof Furni Hori Lukasz Huminiecki Kei Iida Tomokatsu Ikawa Boris R Jankovic Hui Jia Anagha Joshi Giuseppe Jurman Bogumil Kaczkowski Chieko Kai Kaoru Kaida Ai Kaiho Kazuhiro Kajiyama Mutsumi Kanamori-Katayama Artem S Kasianov Takeya Kasukawa Shintaro Katayama Sachi Kato Shuji Kawaguchi Hiroshi Kawamoto Yuki I Kawamura Tsugumi Kawashima Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura S Peter Klinken Alan J Knox Miki Kojima Soichi Kojima Naoto Kondo Haruhiko Koseki Shigeo Koyasu Sarah Krampitz Atsutaka Kubosaki Andrew T Kwon Jeroen F J Laros Weonju Lee Andreas Lennartsson Kang Li Berit Lilje Leonard Lipovich Alan Mackay-Sim Ri-ichiroh Manabe Jessica C Mar Benoit Marchand Anthony Mathelier Niklas Mejhert Alison Meynert Yosuke Mizuno David A de Lima Morais Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Efthymios Motakis Hozumi Motohashi Christine L Mummery Mitsuyoshi Murata Sayaka Nagao-Sato Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Kenichi Nakazato Erik van Nimwegen Noriko Ninomiya Hiromi Nishiyori Shohei Noma Shohei Noma Tadasuke Noazaki Soichi Ogishima Naganari Ohkura Hiroko Ohimiya Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Arnab Pain Robert Passier Margaret Patrikakis Helena Persson Silvano Piazza James G D Prendergast Owen J L Rackham Jordan A Ramilowski Mamoon Rashid Timothy Ravasi Patrizia Rizzu Marco Roncador Sugata Roy Morten B Rye Eri Saijyo Antti Sajantila Akiko Saka Shimon Sakaguchi Mizuho Sakai Hiroki Sato Suzana Savvi Alka Saxena Claudio Schneider Erik A Schultes Gundula G Schulze-Tanzil Anita Schwegmann Thierry Sengstag Guojun Sheng Hisashi Shimoji Yishai Shimoni Jay W Shin Christophe Simon Daisuke Sugiyama Takaai Sugiyama Masanori Suzuki Naoko Suzuki Rolf K Swoboda Peter A C 't Hoen Michihira Tagami Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Zuotian Tatum Mark Thompson Hiroo Toyodo Tetsuro Toyoda Elvind Valen Marc van de Wetering Linda M van den Berg Roberto Verado Dipti Vijayan Ilya E Vorontsov Wyeth W Wasserman Shoko Watanabe Christine A Wells Louise N Winteringham Ernst Wolvetang Emily J Wood Yoko Yamaguchi Masayuki Yamamoto Misako Yoneda Yohei Yonekura Shigehiro Yoshida Susan E Zabierowski Peter G Zhang Xiaobei Zhao Silvia Zucchelli Kim M Summers Harukazu Suzuki Carsten O Daub Jun Kawai Peter Heutink Winston Hide Tom C Freeman Boris Lenhard Vladimir B Bajic Martin S Taylor Vsevolod J Makeev Albin Sandelin David A Hume Piero Carninci Yoshihide Hayashizaki

Nature 2014 Mar;507(7493):462-70

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http://dx.doi.org/10.1038/nature13182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529748PMC
March 2014

NF-E2 p45 is important for establishing normal function of platelets.

Mol Cell Biol 2013 Jul 6;33(14):2659-70. Epub 2013 May 6.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1128/MCB.01274-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700136PMC
July 2013

Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.

J Biol Chem 2013 Jul 4;288(28):20658-67. Epub 2013 Jun 4.

Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences and Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.

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http://dx.doi.org/10.1074/jbc.M113.450478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711329PMC
July 2013

Toward clinical application of the Keap1-Nrf2 pathway.

Trends Pharmacol Sci 2013 Jun 9;34(6):340-6. Epub 2013 May 9.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1016/j.tips.2013.04.005DOI Listing
June 2013

Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model.

Mol Cell Biol 2013 Apr 19;33(8):1687-95. Epub 2013 Feb 19.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1128/MCB.01617-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624254PMC
April 2013

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism.

Front Oncol 2012 26;2:200. Epub 2012 Dec 26.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine Sendai, Japan ; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine Sendai, Japan.

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http://dx.doi.org/10.3389/fonc.2012.00200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530133PMC
December 2012

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.

Free Radic Biol Med 2012 Aug 23;53(4):817-27. Epub 2012 Jun 23.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539416PMC
August 2012

Keap1 degradation by autophagy for the maintenance of redox homeostasis.

Proc Natl Acad Sci U S A 2012 Aug 7;109(34):13561-6. Epub 2012 Aug 7.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.

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http://dx.doi.org/10.1073/pnas.1121572109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427110PMC
August 2012

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

Cancer Cell 2012 Jul;22(1):66-79

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

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http://dx.doi.org/10.1016/j.ccr.2012.05.016DOI Listing
July 2012

Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.

Mol Cell Biol 2012 Feb 12;32(4):808-16. Epub 2011 Dec 12.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.06543-11
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http://dx.doi.org/10.1128/MCB.06543-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272985PMC
February 2012

The Keap1-Nrf2 system as an in vivo sensor for electrophiles.

Nitric Oxide 2011 Aug 6;25(2):153-60. Epub 2011 Mar 6.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1016/j.niox.2011.02.007DOI Listing
August 2011

Inducible disruption of autophagy in the lung causes airway hyper-responsiveness.

Biochem Biophys Res Commun 2011 Feb 23;405(1):13-8. Epub 2010 Dec 23.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.12.092DOI Listing
February 2011

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Genes Cells 2011 Feb;16(2):123-40

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2010.01473.xDOI Listing
February 2011

Molecular determinants for small Maf protein control of platelet production.

Mol Cell Biol 2011 Jan 25;31(1):151-62. Epub 2010 Oct 25.

Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1128/MCB.00798-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019851PMC
January 2011

MafB as a type I interferon rheostat.

Nat Immunol 2010 Aug;11(8):695-6

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http://dx.doi.org/10.1038/ni0810-695DOI Listing
August 2010

Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.

Mol Cell Biol 2010 Jun 29;30(11):2668-80. Epub 2010 Mar 29.

Center of Radioisotope Science, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1128/MCB.01304-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876514PMC
June 2010

Genetic analysis of cytoprotective functions supported by graded expression of Keap1.

Mol Cell Biol 2010 Jun 19;30(12):3016-26. Epub 2010 Apr 19.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

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http://dx.doi.org/10.1128/MCB.01591-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876677PMC
June 2010

NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.

Blood 2010 Jan 9;115(3):677-86. Epub 2009 Nov 9.

Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1182/blood-2009-05-223107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810977PMC
January 2010

Structural basis of alternative DNA recognition by Maf transcription factors.

Mol Cell Biol 2009 Dec 21;29(23):6232-44. Epub 2009 Sep 21.

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, Japan.

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http://dx.doi.org/10.1128/MCB.00708-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786689PMC
December 2009

[Transcriptional regulation of thrombogenesis and stress response of megakaryocytes].

Authors:
Hozumi Motohashi

Seikagaku 2009 Jun;81(6):511-9

Center for Radioisotope Science, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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June 2009

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.

Mol Cell Biol 2008 Apr 11;28(8):2758-70. Epub 2008 Feb 11.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1128/MCB.01704-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293100PMC
April 2008

Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.

Biochem Biophys Res Commun 2008 Jan 20;365(3):562-7. Epub 2007 Nov 20.

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.11.016DOI Listing
January 2008

Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2.

J Biol Chem 2008 Jan 26;283(4):2021-30. Epub 2007 Nov 26.

Exploratory Research for Advanced Technology Environmental Response Project, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan.

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http://dx.doi.org/10.1074/jbc.M708352200DOI Listing
January 2008

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer.

J Biol Chem 2007 Nov 17;282(46):33681-90. Epub 2007 Sep 17.

Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8572, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M706863200
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November 2007

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.

Biochem J 2007 Jun;404(3):459-66

Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1042/BJ20061611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1896277PMC
June 2007

Carcinogenesis and transcriptional regulation through Maf recognition elements.

Cancer Sci 2007 Feb 15;98(2):135-9. Epub 2006 Nov 15.

Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2006.00358.xDOI Listing
February 2007

Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation.

Mol Cell Biol 2006 Nov 28;26(21):7953-65. Epub 2006 Aug 28.

Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1128/MCB.00718-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636724PMC
November 2006

Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements.

Genes Cells 2006 Jun;11(6):575-91

Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2006.00965.xDOI Listing
June 2006

MafG sumoylation is required for active transcriptional repression.

Mol Cell Biol 2006 Jun;26(12):4652-63

Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.02193-05
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http://dx.doi.org/10.1128/MCB.02193-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489127PMC
June 2006

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

Biochem Biophys Res Commun 2006 Jan 8;339(1):79-88. Epub 2005 Nov 8.

Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.10.185DOI Listing
January 2006

Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions.

Mol Cell Biol 2005 Nov;25(21):9360-8

Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1128/MCB.25.21.9360-9368.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265822PMC
November 2005

Nrf2 transcriptionally activates the mafG gene through an antioxidant response element.

J Biol Chem 2005 Feb 1;280(6):4483-90. Epub 2004 Dec 1.

Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8577, Japan.

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http://dx.doi.org/10.1074/jbc.M411451200DOI Listing
February 2005

Nrf2-Keap1 defines a physiologically important stress response mechanism.

Trends Mol Med 2004 Nov;10(11):549-57

Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology-Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305-8577, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S147149140400235
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http://dx.doi.org/10.1016/j.molmed.2004.09.003DOI Listing
November 2004