Publications by authors named "Howard Schulman"

42Publications

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.

Elife 2020 Mar 9;9. Epub 2020 Mar 9.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.

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http://dx.doi.org/10.7554/eLife.53670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141811PMC
March 2020

CaM Kinase: Still Inspiring at 40.

Neuron 2019 08;103(3):380-394

Allosteros Therapeutics, Inc., Sunnyvale, CA 94089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688632PMC
August 2019

Conformational coupling by trans-phosphorylation in calcium calmodulin dependent kinase II.

PLoS Comput Biol 2019 05 31;15(5):e1006796. Epub 2019 May 31.

Computational Cell and Molecular Biology, the Francis Crick Institute, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1006796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576796PMC
May 2019

Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor.

J Mol Cell Cardiol 2018 02 30;115:73-81. Epub 2017 Dec 30.

Dept. of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2017.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820112PMC
February 2018

CaMKII inhibitors: from research tools to therapeutic agents.

Front Pharmacol 2014 20;5:21. Epub 2014 Feb 20.

Allosteros Therapeutics, Inc., Sunnyvale CA, USA.

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http://dx.doi.org/10.3389/fphar.2014.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929941PMC
June 2014

Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.

Curr Opin Struct Biol 2013 Apr 27;23(2):292-301. Epub 2013 Apr 27.

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1016/j.sbi.2013.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788167PMC
April 2013

Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis.

Ann Neurol 2012 May 4;71(5):601-13. Epub 2012 Apr 4.

Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Quebec, Canada.

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http://dx.doi.org/10.1002/ana.22693DOI Listing
May 2012

In search of cellular immunophenotypes in the blood of children with autism.

PLoS One 2011 May 4;6(5):e19299. Epub 2011 May 4.

Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019299PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087757PMC
May 2011

Ca/Calmodulin-dependent Protein Kinase II in Heart Failure.

Drug Discov Today Dis Mech 2010 ;7(2):e117-e122

Allosteros Therapeutics, Inc., 1230 Bordeaux Drive, Sunnyvale, CA 94089-1202.

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http://linkinghub.elsevier.com/retrieve/pii/S174067651000015
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http://dx.doi.org/10.1016/j.ddmec.2010.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077766PMC
January 2010

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.

Nat Struct Mol Biol 2010 Mar 7;17(3):264-72. Epub 2010 Feb 7.

Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.

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http://dx.doi.org/10.1038/nsmb.1751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855215PMC
March 2010

Global changes to the ubiquitin system in Huntington's disease.

Nature 2007 Aug;448(7154):704-8

Department of Biological Sciences, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature06022DOI Listing
August 2007

[Cellular mechanisms of protein quality control].

Rinsho Shinkeigaku 2006 Nov;46(11):805

Department of Biological Sciences, Stanford University, USA.

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November 2006

Mitochondrial myopathy complicated by eating disorder: a case report highlighting the potential interaction of genetic, metabolic, and psychodynamic factors.

CNS Spectr 2007 Apr;12(4):289-92

Mental Health Service Line (116A), Department of Veterans Affairs Medical Center, Washington, DC 20422, USA.

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http://dx.doi.org/10.1017/s1092852900021040DOI Listing
April 2007

Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease.

Nat Clin Pract Cardiovasc Med 2006 Aug;3(8):437-45

Cardiovascular Research Center at the University of Iowa, Iowa City 52242-1081, USA.

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http://dx.doi.org/10.1038/ncpcardio0585DOI Listing
August 2006

Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.

J Neurosci 2006 Jan;26(4):1164-74

Department of Pharmacology, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3116-05.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890238PMC
January 2006

CaMKII structure--an elegant design.

Cell 2005 Dec;123(5):765-7

Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.cell.2005.11.017DOI Listing
December 2005

Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis.

Exp Cell Res 2005 Mar 26;304(1):244-55. Epub 2004 Nov 26.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.

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http://dx.doi.org/10.1016/j.yexcr.2004.11.002DOI Listing
March 2005

Calcium/calmodulin-dependent protein kinase II (CaMKII) localization acts in concert with substrate targeting to create spatial restriction for phosphorylation.

J Biol Chem 2005 Mar 6;280(10):9210-6. Epub 2004 Dec 6.

Neurosciences Program, Stanford University School of Medicine, Stanford, California 94304, USA.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M407653200
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http://dx.doi.org/10.1074/jbc.M407653200DOI Listing
March 2005

Promiscuous protein biotinylation by Escherichia coli biotin protein ligase.

Protein Sci 2004 Nov 30;13(11):3043-50. Epub 2004 Sep 30.

Departments of Microbiology and Biochemistry, University of Illinois, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1110/ps.04911804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2286582PMC
November 2004

Activity-dependent regulation of calcium/calmodulin-dependent protein kinase II localization.

Authors:
Howard Schulman

J Neurosci 2004 Sep;24(39):8399-403

SurroMed Inc., Menlo Park, California 94025-1432, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3606-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729891PMC
September 2004

An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling.

Proc Natl Acad Sci U S A 2003 Sep 19;100(18):10512-7. Epub 2003 Aug 19.

Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1932759100
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http://dx.doi.org/10.1073/pnas.1932759100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193592PMC
September 2003

Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII.

Neuron 2003 Jul;39(2):283-97

Department of Molecular Pharmacology, Stanford University Medical School, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/s0896-6273(03)00428-8DOI Listing
July 2003

Alternative splicing modulates the frequency-dependent response of CaMKII to Ca(2+) oscillations.

EMBO J 2002 Jul;21(14):3590-7

Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA.

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http://dx.doi.org/10.1093/emboj/cdf360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126106PMC
July 2002

Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function.

Annu Rev Biochem 2002 9;71:473-510. Epub 2001 Nov 9.

Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Stanford, California 94305, USA.

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http://dx.doi.org/10.1146/annurev.biochem.71.110601.135410DOI Listing
November 2002

Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.

Biochem J 2002 Jun;364(Pt 3):593-611

Department of Neurobiology, Fairchild Bldg, D217 299 Campus Drive, Stanford University Medical School, Stanford, CA 94305-5125, USA.

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http://dx.doi.org/10.1042/BJ20020228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222606PMC
June 2002

Chemical quenched flow kinetic studies indicate an intraholoenzyme autophosphorylation mechanism for Ca2+/calmodulin-dependent protein kinase II.

J Biol Chem 2002 Jun 29;277(23):20991-8. Epub 2002 Mar 29.

Department of Neurobiology, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1074/jbc.M202154200DOI Listing
June 2002

Ca2+/calmodulin-dependent protein kinase II is required for microcystin-induced apoptosis.

J Biol Chem 2002 Jan 16;277(4):2804-11. Epub 2001 Nov 16.

Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, N-5009 Bergen, Norway.

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http://dx.doi.org/10.1074/jbc.M109049200DOI Listing
January 2002