Howard McLeod

Howard McLeod

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Howard McLeod

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Demographic Composition of Select Oncologic New Molecular Entities Approved by the FDA Between 2008 and 2017.

Clin Pharmacol Ther 2018 Nov 14;104(5):940-948. Epub 2018 Sep 14.

Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA), Silver Spring, Maryland, USA.

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http://dx.doi.org/10.1002/cpt.1180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220929PMC
November 2018

The influence of Neanderthal alleles on cytotoxic response.

PeerJ 2018 23;6:e5691. Epub 2018 Oct 23.

Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America.

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https://peerj.com/articles/5691
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http://dx.doi.org/10.7717/peerj.5691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202974PMC
October 2018

Genome-scale analysis identifies SERPINE1 and SPARC as diagnostic and prognostic biomarkers in gastric cancer.

Onco Targets Ther 2018 15;11:6969-6980. Epub 2018 Oct 15.

Hunan Key Laboratory of Pharmacogenetics, Department of Clinical Pharmacology, Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China,

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http://dx.doi.org/10.2147/OTT.S173934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199229PMC
October 2018

Clinical and pharmacogenetics associated with recovery time from general anesthesia.

Pharmacogenomics 2018 Sep 23;19(14):1111-1123. Epub 2018 Aug 23.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.

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http://dx.doi.org/10.2217/pgs-2018-0085DOI Listing
September 2018

Value of Supportive Care Pharmacogenomics in Oncology Practice.

Oncologist 2018 Aug 5;23(8):956-964. Epub 2018 Apr 5.

The DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, Tampa, Florida, USA.

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http://dx.doi.org/10.1634/theoncologist.2017-0599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156181PMC
August 2018

The relationship between miR-302b and EphA2 and their clinical significance in gastric cancer.

J Cancer 2018 6;9(17):3109-3116. Epub 2018 Aug 6.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China.

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http://dx.doi.org/10.7150/jca.25235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134821PMC
August 2018

Avoidance of Severe Cutaneous Adverse Drug Events as a First Step in Precision Neurology.

JAMA Neurol 2018 Jul;75(7):793-795

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

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http://dx.doi.org/10.1001/jamaneurol.2018.0001DOI Listing
July 2018

Geographic variation in molecular subtype for gastric adenocarcinoma.

Gut 2018 Jun 29. Epub 2018 Jun 29.

Hunan Key Laboratory of Pharmacogenetics, Department of Clinical Pharmacology, Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

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http://dx.doi.org/10.1136/gutjnl-2018-316605DOI Listing
June 2018

Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.

Contemp Clin Trials 2018 May 10;68:7-13. Epub 2018 Mar 10.

Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA; Center for Pharmacogenomics, University of Florida, Gainesville, FL, USA; Clinical and Translational Science Institute, University of Florida, Gainesville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cct.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899651PMC
May 2018

When will clinical trials finally reflect diversity?

Nature 2018 05;557(7704):157-159

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http://dx.doi.org/10.1038/d41586-018-05049-5DOI Listing
May 2018

The pharmacogenetics of medications used in general anesthesia.

Pharmacogenomics 2018 02 10;19(3):285-298. Epub 2018 Jan 10.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, P.R. China.

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http://dx.doi.org/10.2217/pgs-2017-0168DOI Listing
February 2018

Immunoclassification characterized by CD8 and PD-L1 expression is associated with the clinical outcome of gastric cancer patients.

Oncotarget 2018 Feb 6;9(15):12164-12173. Epub 2018 Jan 6.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China.

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http://dx.doi.org/10.18632/oncotarget.24037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844736PMC
February 2018

miR-302b inhibits tumorigenesis by targeting EphA2 via Wnt/ β-catenin/EMT signaling cascade in gastric cancer.

BMC Cancer 2017 12 22;17(1):886. Epub 2017 Dec 22.

Department of General Surgery, Xiangya Hospital of Central South University, No.87 Xiangya Road, Changsha, 410008, People's Republic of China.

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http://dx.doi.org/10.1186/s12885-017-3875-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741943PMC
December 2017

Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment.

Pharmacogenet Genomics 2017 11;27(11):402-409

aDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan bUNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina cDeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, Tampa, Florida dDepartment of Clinical Pharmacology, Indiana University, Indianapolis, Indiana eBon Secours Cancer Institute, Richmond, Virginia, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659294PMC
November 2017

Quantitation of Targetable Somatic Mutations Among Patients Evaluated by a Personalized Medicine Clinical Service: Considerations for Off-Label Drug Use.

Pharmacotherapy 2017 Sep 2;37(9):1043-1051. Epub 2017 Apr 2.

Division of Population Science, DeBartolo Family Personalized Medicine Institute, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1002/phar.1917DOI Listing
September 2017

Incidence and Triggers of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in a Large Cancer Patient Cohort.

J Invest Dermatol 2017 09 23;137(9):2021-2023. Epub 2017 May 23.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA; DeBartolo Family Personalized Medicine Institute, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.05.010DOI Listing
September 2017

EBV infection and MSI status significantly influence the clinical outcomes of gastric cancer patients.

Clin Chim Acta 2017 Aug 7;471:216-221. Epub 2017 Jun 7.

Department of Clinical Pharmacology, Xiangya Hospital, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, China; Moffitt Cancer Center, DeBartolo Family Personalized Medicine Institute, Tampa, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2017.06.006DOI Listing
August 2017

Prospect for immune checkpoint blockade: dynamic and comprehensive monitorings pave the way.

Pharmacogenomics 2017 Aug 26;18(13):1299-1304. Epub 2017 Jul 26.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China.

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http://dx.doi.org/10.2217/pgs-2017-0053DOI Listing
August 2017

Clinical Response to Pazopanib in a Patient With KDR-Mutated Metastatic Basal Cell Carcinoma.

JAMA Dermatol 2017 Jun;153(6):607-609

Department of Oncological Sciences, University of South Florida, Tampa, Florida5Head and Neck and Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1001/jamadermatol.2017.0187DOI Listing
June 2017

Discordance of Somatic Mutations Between Asian and Caucasian Patient Populations with Gastric Cancer.

Mol Diagn Ther 2017 04;21(2):179-185

Institute for Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

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http://dx.doi.org/10.1007/s40291-016-0250-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357153PMC
April 2017

American Society of Clinical Oncology Value Framework: Importance of Accurate Toxicity Data.

J Clin Oncol 2017 Apr 6;35(10):1133-1134. Epub 2017 Feb 6.

Heather S.L. Jim and Howard L. McLeod, Moffitt Cancer Center, Tampa, FL.

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http://dx.doi.org/10.1200/JCO.2016.69.2079DOI Listing
April 2017

Strategies for integrating personalized medicine into healthcare practice.

Per Med 2017 03 19;14(2):141-152. Epub 2017 Jan 19.

Moffitt Cancer Center, Tampa, FL 33612, USA.

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http://dx.doi.org/10.2217/pme-2016-0064DOI Listing
March 2017

A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study.

Lancet Oncol 2017 02 18;18(2):202-211. Epub 2016 Dec 18.

Department of Radiation Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Chemical Biology and Molecular Medicine, Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30648-9DOI Listing
February 2017

Pharmacoepidemiology of Clinically Relevant Hypothyroidism and Hypertension from Sunitinib and Sorafenib.

Oncologist 2017 02 6;22(2):208-212. Epub 2017 Feb 6.

DeBartolo Family Personalized Medicine Institute, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.

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http://dx.doi.org/10.1634/theoncologist.2016-0233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330710PMC
February 2017

Key Lessons Learned from Moffitt's Molecular Tumor Board: The Clinical Genomics Action Committee Experience.

Oncologist 2017 02 8;22(2):144-151. Epub 2017 Feb 8.

DeBartolo Family Personalized Medicine Institute, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

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http://dx.doi.org/10.1634/theoncologist.2016-0195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330702PMC
February 2017

Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers.

Xenobiotica 2016 Oct 29;46(10):896-900. Epub 2016 Feb 29.

a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , China .

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http://dx.doi.org/10.3109/00498254.2015.1132792DOI Listing
October 2016

Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway.

Oncotarget 2016 10;7(42):68314-68327

Department of Clinical Pharmacology, XiangYa Hospital, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, China.

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http://dx.doi.org/10.18632/oncotarget.11599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356557PMC
October 2016

The potential anticancer effect of beta-blockers and the genetic variations involved in the interindividual difference.

Pharmacogenomics 2016 14;17(1):74-9. Epub 2015 Dec 14.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, P.R. China.

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http://dx.doi.org/10.2217/pgs.15.152DOI Listing
September 2016

The pharmacogenomics of drug resistance to protein kinase inhibitors.

Drug Resist Updat 2016 09 5;28:28-42. Epub 2016 Jul 5.

H. Lee Moffitt Cancer Center and Research Institute, DeBartolo Family Personalized Medicine Institute, Tampa, FL, United States; Xiangya Hospital, Central South University, Changsha, China. Electronic address:

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http://dx.doi.org/10.1016/j.drup.2016.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022787PMC
September 2016

Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations.

Pharmacogenomics 2015 28;16(13):1451-63. Epub 2015 Aug 28.

Lineberger Comprehensive Cancer Center, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27514, USA.

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http://dx.doi.org/10.2217/PGS.15.85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810848PMC
June 2016

Pharmacogenomic assessment of Mexican and Peruvian populations.

Pharmacogenomics 2015 ;16(5):441-8

Faculty of Pharmacy & Pharmaceutical Sciences, 3142F Katz Centre for Pharmacy & Health Research, University of Alberta, Edmonton, AB T6G 2E1, Canada.

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http://dx.doi.org/10.2217/pgs.15.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515450PMC
January 2016

A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure.

Pharmacogenet Genomics 2016 Jan 1. Epub 2016 Jan 1.

aDepartment of Statistics bBioinformatics Research Center, North Carolina State University cOrtelion LLC dPharmacogenetics for Every Nation Initiative, Raleigh, North Carolina eDeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, Tampa, Florida, USA fXiangya Hospital, Central South University, Changsha, China.

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http://dx.doi.org/10.1097/FPC.0000000000000200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746476PMC
January 2016

PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics.

Pharmacogenet Genomics 2015 Dec;25(12):622-30

Departments of aGenetics bBioengineering, Stanford University, Stanford, California cDepartment of Anesthesiology dMoffitt Cancer Center, DeBartolo Family Personalized Medicine Institute, Tampa, Florida, USA eGenomics England, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1097/FPC.0000000000000170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631707PMC
December 2015

Budget impact analysis of CYP2C19-guided voriconazole prophylaxis in AML.

J Antimicrob Chemother 2015 Nov 1;70(11):3124-6. Epub 2015 Aug 1.

H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., MRC-CANCONT, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1093/jac/dkv224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613741PMC
November 2015

Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance).

J Natl Cancer Inst 2015 Oct 9;107(10). Epub 2015 Jul 9.

Personalized Medicine, Mission Cancer Care, Mission Health, Asheville, NC (LGD); Biostatistics Core, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC (AMD); Alliance Statistics and Data Center, Duke University, Durham, NC (formerly the Cancer and Leukemia Group B Statistical and Data Management Center, Duke University, Durham, NC) (KO); GlaxoSmithKline, Research Triangle Park, NC (DW); Independent contractor, Williamsville, NY (KD); Department of Medicine and Center for Personalized Therapeutics, University of Chicago, Chicago, IL (PNF, MJR); DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, Tampa, FL (HLM).

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http://jnci.oxfordjournals.org/content/107/10/djv188.full.pd
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv18
Publisher Site
http://dx.doi.org/10.1093/jnci/djv188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758036PMC
October 2015

Single-Nucleotide Polymorphisms in Cytochrome P450 2E1 (CYP2E1) 3'-Untranslated Region Affect the Regulation of CYP2E1 by miR-570.

Drug Metab Dispos 2015 Oct 21;43(10):1450-7. Epub 2015 Jul 21.

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (Ma.N., T.M., T.F., Mi.N.); Department of Legal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan (M.T., Y.A.); Department of Medicine, School of Medicine, Washington University, St. Louis, Missouri (H.L.M.)

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http://dx.doi.org/10.1124/dmd.115.065664DOI Listing
October 2015

Clinical Implications of Opioid Pharmacogenomics in Patients With Cancer.

Cancer Control 2015 Oct;22(4):426-32

Mission Health, Fullerton Genetics Center, Asheville, NC.

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https://moffitt.org/media/4656/426.pdf
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http://www.thblack.com/links/RSD/ClinJPain2010_26_S16_Opioid
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http://dx.doi.org/10.1177/107327481502200408DOI Listing
October 2015

Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups.

Pharmacogenomics 2015 Jul 17;16(8):817-24. Epub 2015 Jun 17.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, PR China.

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http://dx.doi.org/10.2217/pgs.15.41DOI Listing
July 2015

Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.

PLoS One 2014 11;9(4):e94727. Epub 2014 Apr 11.

DeBartolo Family Personalized Medicine Institute, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094727PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984266PMC
May 2015

Heritage-specific mechanisms for cancer adverse reactions: one gene does not explain the world.

J Clin Oncol 2015 Apr 9;33(11):1230-1. Epub 2015 Mar 9.

DeBartolo Personalized Medicine Institute, Moffitt Comprehensive Cancer Center, Tampa, FL; and XiangYa Hospital, Central South University, Changsha, Hunan, China

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http://dx.doi.org/10.1200/JCO.2014.60.1740DOI Listing
April 2015

Fast and frugal trees: translating population-based pharmacogenomics to medication prioritization.

Per Med 2015 Mar;12(2):117-128

Faculty of Pharmacy & Pharmaceutical Sciences, Katz Group Centre for Pharmacy & Health Research, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

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http://dx.doi.org/10.2217/pme.14.66DOI Listing
March 2015

Precision medicine to improve the risk and benefit of cancer care: genetic factors in vincristine-related neuropathy.

Authors:
Howard L McLeod

JAMA 2015 Feb;313(8):803-4

DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, Tampa, Florida2Xiangya Hospital, Institute of Clinical Pharmacology, Central South University, Changsha, China.

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http://dx.doi.org/10.1001/jama.2015.1086DOI Listing
February 2015

The prognostic value of altered eIF3a and its association with p27 in non-small cell lung cancers.

PLoS One 2014 30;9(4):e96008. Epub 2014 Apr 30.

Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan 8, P. R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096008PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005749PMC
January 2015

A community-based multicenter trial of pharmacokinetically guided 5-fluorouracil dosing for personalized colorectal cancer therapy.

Oncologist 2014 Sep 12;19(9):959-65. Epub 2014 Aug 12.

Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina, USA; Eshelman School of Pharmacy, Institute for Pharmacogenomics and Individualized Therapy, and Biostatistics Core, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA; Indiana University Simon Cancer Center, Indianapolis, Indiana, USA; Cone Health Cancer Center, Greensboro, North Carolina, USA; Rex Healthcare, Raleigh, North Carolina, USA; Leo W. Jenkins Cancer Center, Greenville, North Carolina, USA; Marion L. Shepard Cancer Center, Washington, North Carolina, USA; Cancer Care of Western North Carolina, Asheville, North Carolina, USA; Moffitt Cancer Center, Tampa, Florida, USA.

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http://dx.doi.org/10.1634/theoncologist.2014-0132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153454PMC
September 2014

Personalizing medicine in geriatric oncology.

J Clin Oncol 2014 Aug;32(24):2581-6

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http://dx.doi.org/10.1200/JCO.2014.55.9047DOI Listing
August 2014

Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics.

BMC Res Notes 2014 Jun 12;7:360. Epub 2014 Jun 12.

Bioinformatics Research Center, North Carolina State University, 307 Ricks Hall, 1 Lampe Dr, Raleigh, NC 27695 CB7566, USA.

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http://dx.doi.org/10.1186/1756-0500-7-360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068968PMC
June 2014

Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy.

Breast Cancer Res Treat 2014 May 6;145(1):245-54. Epub 2014 Apr 6.

Department of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, 428 Church St, Ann Arbor, MI, 48109, USA,

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http://link.springer.com/10.1007/s10549-014-2910-1
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http://dx.doi.org/10.1007/s10549-014-2910-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256153PMC
May 2014

Using pharmacogene polymorphism panels to detect germline pharmacodynamic markers in oncology.

Clin Cancer Res 2014 May;20(10):2530-40

Authors' Affiliations: Department of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan; Moffitt Cancer Center; and DeBartolo Family Personalized Medicine Institute, Tampa, FloridaAuthors' Affiliations: Department of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan; Moffitt Cancer Center; and DeBartolo Family Personalized Medicine Institute, Tampa, Florida

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2780DOI Listing
May 2014

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.

J Clin Oncol 2014 Apr 3;32(10):1031-9. Epub 2014 Mar 3.

Dan Rosmarin, Claire Palles, David Church, Enric Domingo, Angela Jones, Ian Tomlinson, Wellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, University of Oxford; Dan Rosmarin, David Church, Elaine Johnstone, Haitao Wang, Sharon Love, Patrick Julier, Claire Scudder, George Nicholson, Rachel Midgley, David Kerr, and George Nicholson, University of Oxford, Oxford; Michael Braun, The Christie NHS Foundation Trust, Manchester; Matthew Seymour, St James's University Hospital, Leeds; Lindsay Thompson, Medical Research Council Clinical Trials Unit; Rohini Sharma, Imperial College Healthcare NHS Trust, Hammersmith and Charing Cross Hospitals, London, United Kingdom; Anna Gonzalez-Neira, Spanish National Cancer Research Centre; Miguel Martin, Instituto de Investigacion Sanitaria Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid; Nuria Ribelles, Hospital Universitario Virgen de la Victoria, Málaga; Eva Martinez-Balibrea, Institut Català d'Oncologia, Institut de Recerca Sanitària Germans Trias i Pujol, Barcelona; Jesus Garcia-Foncillas, University Clinic of Navarra, University of Navarra, Pamplona, Spain; Daniel Sargent, Erin Green, Mayo Clinic, Rochester, MN; Howard McLeod, University of North Carolina, Chapel Hill, NC; Ulrich M. Zanger, Matthias Schwab, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Ulrich M. Zanger, Matthias Schwab, University Hospital Tuebingenl, Tuebingen, Germany; Benjamin Lacas, Valérie Boige, Jean-Pierre Pignon, Institut Gustave Roussy, Villejuif; Marie-Christine Etienne-Grimaldi, Gérard Milano, Centre Antoine Lacassagne, Nice; Thierry Lecomte, Pierre Laurent-Puig, Assistance Publique Hopitaux de Paris, Hopital Européen Georges Pompidou, Paris; Alain Morel, Institut National de la Sante et de la Recherche Medicale U564, Centre Paul Papin, Angers, France; Shoaib Afzal, Henrik Enghusen, Laboratory of Clinical Pharmacology, Rigshospitalet, Copenhagen; Sør

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http://dx.doi.org/10.1200/JCO.2013.51.1857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879695PMC
April 2014

Epigenetic perspectives on cancer chemotherapy response.

Pharmacogenomics 2014 Apr;15(5):699-715

Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China.

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http://dx.doi.org/10.2217/pgs.14.41DOI Listing
April 2014

Cancer pharmacogenomics, adoption by oncologists and patient benefit.

Per Med 2014 Mar;11(2):143-153

Moffit Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.

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http://dx.doi.org/10.2217/pme.14.1DOI Listing
March 2014

Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.

Pharmacogenomics 2014 Feb;15(2):137-46

Bioinformatics Research Center, Department of Statistics, North Carolina State University, Raleigh, NC 27607, USA.

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http://dx.doi.org/10.2217/pgs.13.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055088PMC
February 2014

Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity.

Clin Cancer Res 2013 Oct 20;19(20):5769-76. Epub 2013 Aug 20.

Authors' Affiliations: Schools of Pharmacy and Medicine; Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill; Bioinformatics Research Center and Department of Statistics, North Carolina State University; The Beatson Oncology Centre, University of Glasgow, Glasgow; and Department of Oncology, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798385PMC
October 2013

Impact of genotype-guided dosing on anticoagulation visits for adults starting warfarin: a randomized controlled trial.

Pharmacogenomics 2013 Oct;14(13):1593-603

Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, 5034 Old Clinic Building, CB #7110, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2217/pgs.13.145DOI Listing
October 2013

Implications of genome-wide association studies in cancer therapeutics.

Br J Clin Pharmacol 2013 Sep;76(3):370-80

UNC Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, NC, 27599-7361, USA.

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http://dx.doi.org/10.1111/bcp.12166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769665PMC
September 2013

Exome resequencing identifies potential tumor-suppressor genes that predispose to colorectal cancer.

Hum Mutat 2013 Jul 20;34(7):1026-34. Epub 2013 May 20.

Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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http://dx.doi.org/10.1002/humu.22333DOI Listing
July 2013

Analysis of innate and acquired resistance to anti-CD20 antibodies in malignant and nonmalignant B cells.

PeerJ 2013 12;1:e31. Epub 2013 Feb 12.

Lineberger Comprehensive Cancer Center , University of North Carolina at Chapel Hill , NC , USA ; Division of Hematology/Oncology , University of North Carolina at Chapel Hill , NC , USA ; UNC Institute for Pharmacogenomics and Individualized Therapy , University of North Carolina at Chapel Hill , NC , USA.

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http://dx.doi.org/10.7717/peerj.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628892PMC
July 2013

Gastric cancer pharmacogenetics: progress or old tripe?

Pharmacogenomics 2013 Jul;14(9):1053-64

UNC Institute for Pharmacogenomics & Individualized Therapy, University of North Carolina, Chapel Hill, NC 27599-7361, USA.

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http://dx.doi.org/10.2217/pgs.13.88DOI Listing
July 2013

VKORC1 Asp36Tyr geographic distribution and its impact on warfarin dose requirements in Egyptians.

Thromb Haemost 2013 Jun 21;109(6):1045-50. Epub 2013 Mar 21.

Center for Pharmacogenomics, University of Florida, Health Science Center, PO Box 100486, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1160/TH12-10-0789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712827PMC
June 2013

Use of pharmacogenetics for predicting cancer prognosis and treatment exposure, response and toxicity.

J Hum Genet 2013 Jun 16;58(6):346-52. Epub 2013 May 16.

UNC Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/jhg.2013.42DOI Listing
June 2013

Genomic medicine: a decade of successes, challenges, and opportunities.

Sci Transl Med 2013 Jun;5(189):189sr4

Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1126/scitranslmed.3005785DOI Listing
June 2013

Current pharmacogenomic studies on hERG potassium channels.

Trends Mol Med 2013 Apr 29;19(4):227-38. Epub 2013 Jan 29.

Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan 410078, PR China.

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http://dx.doi.org/10.1016/j.molmed.2012.12.006DOI Listing
April 2013

Pharmacogenetics, enzyme probes and therapeutic drug monitoring as potential tools for individualizing taxane therapy.

Pharmacogenomics 2013 Apr;14(5):555-74

UNC Institute for Pharmacogenomics & Individualized Therapy, University of North Carolina at Chapel Hill, 120 Mason Farm Road, CB 7361, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2217/pgs.13.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975654PMC
April 2013

Genome-wide studies in pharmacogenomics: harnessing the power of extreme phenotypes.

Pharmacogenomics 2013 Mar;14(4):337-9

Department of Human Molecular Genetics & Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.

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http://dx.doi.org/10.2217/pgs.13.35DOI Listing
March 2013

Cancer pharmacogenomics: early promise, but concerted effort needed.

Authors:
Howard L McLeod

Science 2013 Mar;339(6127):1563-6

Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/science.1234139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900028PMC
March 2013