Howard J Jacob

Howard J Jacob

UNVERIFIED PROFILE

Are you Howard J Jacob?   Register this Author

Register author
Howard J Jacob

Howard J Jacob

Publications by authors named "Howard J Jacob"

Are you Howard J Jacob?   Register this Author

100Publications

2428Reads

20Profile Views

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.

N Engl J Med 2018 11 10;379(22):2131-2139. Epub 2018 Oct 10.

From Harvard Medical School (K.S., C.E., I.S.K., J.L., A.T.M., D.A.S.), Brigham and Women's Hospital (J.L.), and Massachusetts General Hospital (D.A.S.) - all in Boston; the National Institutes of Health Clinical Center (D.R.A., W.A.G., J.J.M., C.J.T.) and the National Human Genome Research Institute (A.L.W.), Bethesda, and the University of Maryland, College Park (A.M.C.-J., B.K., L.P.) - all in Maryland; Baylor College of Medicine, Houston (C.A.B., H.J.B., C.M.E., B.H.L., X.L., M.F.W., S.Y.); Stanford University, Stanford (J.A.B., C.R., M.T.W., E.A.A.), and the University of California, Los Angeles, Los Angeles (S.F.N., C.G.S.P.) - both in California; Vanderbilt University, Nashville (R.H., J.A.P.); HudsonAlpha Institute for Biotechnology, Huntsville, AL (H.J.J., E.A.W.); Oregon Health and Science University, Portland (D.M.K.); the Pacific Northwest National Laboratory, Richland, WA (T.O.M.); the University of Oregon, Eugene (J.H.P., M.W.); and Duke University, Durham, NC (V.S., N.M.W.).

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1714458
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1714458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481166PMC
November 2018

Molecular modeling in the age of clinical genomics, the enterprise of the next generation.

J Mol Model 2017 Mar 15;23(3):75. Epub 2017 Feb 15.

HudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00894-017-3258-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529140PMC
March 2017

Rat Blastocysts from Nuclear Injection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells.

Cell Reprogram 2016 Apr 18;18(2):108-15. Epub 2016 Mar 18.

1 Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences , Okazaki, Aichi, 444-8787, Japan .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/cell.2015.0084DOI Listing
April 2016

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

Authors:
Alexander Teumer Adrienne Tin Rossella Sorice Mathias Gorski Nan Cher Yeo Audrey Y Chu Man Li Yong Li Vladan Mijatovic Yi-An Ko Daniel Taliun Alessandro Luciani Ming-Huei Chen Qiong Yang Meredith C Foster Matthias Olden Linda T Hiraki Bamidele O Tayo Christian Fuchsberger Aida Karina Dieffenbach Alan R Shuldiner Albert V Smith Allison M Zappa Antonio Lupo Barbara Kollerits Belen Ponte Bénédicte Stengel Bernhard K Krämer Bernhard Paulweber Braxton D Mitchell Caroline Hayward Catherine Helmer Christa Meisinger Christian Gieger Christian M Shaffer Christian Müller Claudia Langenberg Daniel Ackermann David Siscovick Eric Boerwinkle Florian Kronenberg Georg B Ehret Georg Homuth Gerard Waeber Gerjan Navis Giovanni Gambaro Giovanni Malerba Gudny Eiriksdottir Guo Li H Erich Wichmann Harald Grallert Henri Wallaschofski Henry Völzke Herrmann Brenner Holly Kramer I Mateo Leach Igor Rudan Hans L Hillege Jacques S Beckmann Jean Charles Lambert Jian'an Luan Jing Hua Zhao John Chalmers Josef Coresh Joshua C Denny Katja Butterbach Lenore J Launer Luigi Ferrucci Lyudmyla Kedenko Margot Haun Marie Metzger Mark Woodward Matthew J Hoffman Matthias Nauck Melanie Waldenberger Menno Pruijm Murielle Bochud Myriam Rheinberger Niek Verweij Nicholas J Wareham Nicole Endlich Nicole Soranzo Ozren Polasek Pim van der Harst Peter Paul Pramstaller Peter Vollenweider Philipp S Wild Ron T Gansevoort Rainer Rettig Reiner Biffar Robert J Carroll Ronit Katz Ruth J F Loos Shih-Jen Hwang Stefan Coassin Sven Bergmann Sylvia E Rosas Sylvia Stracke Tamara B Harris Tanguy Corre Tanja Zeller Thomas Illig Thor Aspelund Toshiko Tanaka Uwe Lendeckel Uwe Völker Vilmundur Gudnason Vincent Chouraki Wolfgang Koenig Zoltan Kutalik Jeffrey R O'Connell Afshin Parsa Iris M Heid Andrew D Paterson Ian H de Boer Olivier Devuyst Jozef Lazar Karlhans Endlich Katalin Susztak Johanne Tremblay Pavel Hamet Howard J Jacob Carsten A Böger Caroline S Fox Cristian Pattaro Anna Köttgen

Diabetes 2016 Mar 2;65(3):803-17. Epub 2015 Dec 2.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Renal Division, Medical Center, University of Freiburg, Freiburg, Germany

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/content/early/2015/11/2
Web Search
http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
Publisher Site
http://dx.doi.org/10.2337/db15-1313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764151PMC
March 2016

The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains.

Biol Sex Differ 2016 3;7:10. Epub 2016 Feb 3.

HudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL 35806 USA ; Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226 USA ; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13293-016-0064-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740989PMC
February 2016

Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury.

Kidney Int 2015 Oct 24;88(4):796-803. Epub 2015 Jun 24.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ki.2015.176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589441PMC
October 2015

B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension.

Hypertension 2015 Jul 11;66(1):199-210. Epub 2015 May 11.

From the Department of Molecular Medicine (S.J.H., C.A.S., R.N., J.M.T., K.-W.P., Y.I.) and Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Departments of Medicine and Physiology (J.C.B., A.C.), Mayo Clinic, College of Medicine, Rochester, MN; Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee (A.G., H.J.J.); and Institute for Experimental Medical Research, Oslo University Hospital, University of Oslo, Oslo, Norway (A.C.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.115.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467451PMC
July 2015

Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.

Hypertension 2015 May 16;65(5):1111-7. Epub 2015 Mar 16.

From the Department of Physiology (N.P.R., H.L., J.R.C.P., B.T.E., J.W.P., H.J.J., A.M.G., D.L.M.), and Human and Molecular Genetics Center (B.T.E., J.W.P., H.J.J., A.M.G.), Medical College of Wisconsin, Milwaukee; and Department of Medicine, Medical College of Wisconsin, Zablocki Veterans Affairs Medical Center, Milwaukee (E.P.C.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412596PMC
May 2015

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

Circ Cardiovasc Genet 2015 Apr 27;8(2):294-304. Epub 2015 Jan 27.

From the Human and Molecular Genetics Center (M.J.F., M.J.H., A.L., S.Z.P., S.-W.T., A.M.G., J.L., H.J.J.), Departments of Physiology (M.J.F., M.J.H., A.L., S.Z.P., N.R., A.M.G., H.J.J.), Dermatology (J.L.), and Pediatrics (H.J.J.), Medical College of Wisconsin, Milwaukee; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (C.C.O'M.); Department of Cardiovascular and Metabolic Disease at MedImmune, Cambridge, United Kingdom (C.M.); and Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (N.A., J.L.H.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.114.000527DOI Listing
April 2015

Improved rat genome gene prediction by integration of ESTs with RNA-Seq information.

Bioinformatics 2015 Jan 12;31(1):25-32. Epub 2014 Sep 12.

Department of Gynecologic Oncology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, Institute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang 310058, China, Division of Respiratory Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China, Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA and Human Molecular and Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Gynecologic Oncology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, Institute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang 310058, China, Division of Respiratory Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China, Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA and Human Molecular and Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/bioinformatics/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btu608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296142PMC
January 2015

Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity.

Genome Res 2015 Jan 1;25(1):57-65. Epub 2014 Oct 1.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.182881.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317173PMC
January 2015

CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

Cancer Res 2014 Nov 29;74(22):6419-29. Epub 2014 Aug 29.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin. Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-3212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247541PMC
November 2014

Refined mapping of a hypertension susceptibility locus on rat chromosome 12.

Hypertension 2014 Oct 7;64(4):883-90. Epub 2014 Jul 7.

From the Human and Molecular Genetics Center (S.Z.P., J.W.P., A.B.S., N.C.Y., M.J.H., C.C.H., H.J.J., M.J.F., J.L.) and Departments of Physiology (S.Z.P., J.W.P., A.B.S., N.C.Y., M.J.H., H.J.J., M.J.F., J.L.), Pediatrics (H.J.J.), and Dermatology (J.L.), Medical College of Wisconsin, Milwaukee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162822PMC
October 2014

Vascular dysfunction precedes hypertension associated with a blood pressure locus on rat chromosome 12.

Am J Physiol Heart Circ Physiol 2014 Oct 22;307(8):H1103-10. Epub 2014 Aug 22.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00464.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200336PMC
October 2014

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.

Hypertension 2014 Sep 16;64(3):541-50. Epub 2014 Jun 16.

From the Department of Physiology (C.J, J.S., C.A.S., H.O., B.B., S.D., A.G., R.P., P.M.O.) and Department of Pharmacology and Toxicology (N.A.L.), Georgia Regents University, Augusta; Department of Physiology, Medical College of Wisconsin, Milwaukee (A.M.G., H.J.J.); and Department of Biology & Physics, Kennesaw State University, Atlanta, GA (S.M.E.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324599PMC
September 2014

Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.

Proc Natl Acad Sci U S A 2014 Sep 18;111(35):12817-22. Epub 2014 Aug 18.

Departments of Physiology and Human and Molecular Genetics Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1410745111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156702PMC
September 2014

CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.

Hypertension 2014 Mar 16;63(3):559-64. Epub 2013 Dec 16.

Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945169PMC
March 2014

Genetic diagnosis through whole-exome sequencing.

Authors:
Howard J Jacob

N Engl J Med 2014 03;370(11):1069

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMc1315908
Publisher Site
http://dx.doi.org/10.1056/NEJMc1315908DOI Listing
March 2014

Identifying multiple causative genes at a single GWAS locus.

Genome Res 2013 Dec 4;23(12):1996-2002. Epub 2013 Sep 4.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.160283.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847770PMC
December 2013

Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD.

J Biomed Semantics 2013 Nov 22;4(1):36. Epub 2013 Nov 22.

Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee 53226-3548, WI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2041-1480-4-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177145PMC
November 2013

Analysis of disease-associated objects at the Rat Genome Database.

Database (Oxford) 2013 21;2013:bat046. Epub 2013 Jun 21.

Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/database/article/doi/10.1093/databa
Publisher Site
http://dx.doi.org/10.1093/database/bat046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689439PMC
October 2013

Next-generation sequencing for clinical diagnostics.

Authors:
Howard J Jacob

N Engl J Med 2013 Oct 2;369(16):1557-8. Epub 2013 Oct 2.

From the Departments of Physiology and Pediatrics, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee.

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMe1310846
Publisher Site
http://dx.doi.org/10.1056/NEJMe1310846DOI Listing
October 2013

Female-specific hypertension loci on rat chromosome 13.

Hypertension 2013 Sep 1;62(3):557-63. Epub 2013 Jul 1.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870583PMC
September 2013

The Rat Genome Database 2013--data, tools and users.

Brief Bioinform 2013 Jul 22;14(4):520-6. Epub 2013 Feb 22.

Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226-3548, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bib/bbt007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713714PMC
July 2013

Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains.

Stem Cells Dev 2013 May 1. Epub 2013 May 1.

University of Michigan, Cardiac Surgery, Ann Arbor, Michigan, United States, Medical College of Wisconsin, Human and Molecular Genetics Center, Milwaukee, Wisconsin, United States ;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2012.0416DOI Listing
May 2013

Congenic mapping and sequence analysis of the Renin locus.

Hypertension 2013 Apr 4;61(4):850-6. Epub 2013 Mar 4.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.01008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770301PMC
April 2013

Genetic basis of the impaired renal myogenic response in FHH rats.

Am J Physiol Renal Physiol 2013 Mar 5;304(5):F565-77. Epub 2012 Dec 5.

Dept. of Pharmacology and Toxicology, Univ. of Mississippi Medical Center, 2500 North State St. Jackson, MS 39216, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajprenal.00404.2012
Publisher Site
http://dx.doi.org/10.1152/ajprenal.00404.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602705PMC
March 2013

Rat chromosome 8 confers protection against dyslipidemia caused by a high-fat/low-carbohydrate diet.

J Nutrigenet Nutrigenomics 2012 19;5(2):81-93. Epub 2012 Jun 19.

Medical College of Wisconsin, Department of Pediatrics, Human and Molecular Genetics Center, Milwaukee, WI 53226.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000338848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167734PMC
February 2013

Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury.

Physiol Genomics 2013 Feb 18;45(3):110-8. Epub 2012 Dec 18.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00119.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568879PMC
February 2013

Rab38 modulates proteinuria in model of hypertension-associated renal disease.

J Am Soc Nephrol 2013 Feb 4;24(2):283-92. Epub 2013 Jan 4.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2012090927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559491PMC
February 2013

Exploring genetic, genomic, and phenotypic data at the rat genome database.

Curr Protoc Bioinformatics 2012 Dec;Chapter 1:Unit1.14

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/0471250953.bi0114s40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555435PMC
December 2012

Identification of hypertension susceptibility loci on rat chromosome 12.

Hypertension 2012 Oct 6;60(4):942-8. Epub 2012 Aug 6.

Human and Molecular Genetics Center, Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.112.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.198200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873777PMC
October 2012

Role of genetic modifiers in an orthologous rat model of ARPKD.

Physiol Genomics 2012 Aug 5;44(15):741-53. Epub 2012 Jun 5.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00187.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774585PMC
August 2012

Ontology searching and browsing at the Rat Genome Database.

Database (Oxford) 2012 20;2012:bas016. Epub 2012 Mar 20.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226-3548, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/database/bas016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308169PMC
June 2012

Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling.

J Biol Chem 2012 Jun 27;287(26):22174-82. Epub 2012 Apr 27.

Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.327866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381178PMC
June 2012

Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats.

Am J Physiol Regul Integr Comp Physiol 2012 May 21;302(10):R1209-18. Epub 2012 Mar 21.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpregu.00604.2011
Publisher Site
http://dx.doi.org/10.1152/ajpregu.00604.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362151PMC
May 2012

The Rat Genome Database pathway portal.

Database (Oxford) 2011 8;2011:bar010. Epub 2011 Apr 8.

Human and Molecular Genetics Center, Medical College of Wisconsin, WI, 53226-3548, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/database/bar010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072770PMC
September 2011

Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains.

Am J Physiol Heart Circ Physiol 2011 Apr 21;300(4):H1530-5. Epub 2011 Jan 21.

Department of Physiology, Medical College of Wisconsin, Milwaukee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.01026.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075031PMC
April 2011

Refined mapping of the renal failure RF-3 quantitative trait locus.

J Am Soc Nephrol 2011 Mar 2;22(3):518-25. Epub 2010 Dec 2.

Human and Molecular Genetics Center, Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2010060661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060445PMC
March 2011

A timely arrival for genomic medicine.

Genet Med 2011 Mar;13(3):195-6

Department of Pediatrics, Section of Gastroenterology, Division of Pediatric Surgery, The Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GIM.0b013e3182095089DOI Listing
March 2011

Creation and characterization of a renin knockout rat.

Hypertension 2011 Mar 17;57(3):614-9. Epub 2011 Jan 17.

Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.163840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513323PMC
March 2011

Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains.

Am J Physiol Renal Physiol 2011 Feb 3;300(2):F330-8. Epub 2010 Nov 3.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajprenal.00261.2010
Publisher Site
http://dx.doi.org/10.1152/ajprenal.00261.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043997PMC
February 2011

Gene targeting in the rat: advances and opportunities.

Trends Genet 2010 Dec 1;26(12):510-8. Epub 2010 Oct 1.

Department of Dermatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tig.2010.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991520PMC
December 2010

Analyzing complex traits with congenic strains.

Mamm Genome 2010 Jun 4;21(5-6):276-86. Epub 2010 Jun 4.

Department of Genetics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00335-010-9267-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805105PMC
June 2010

The rat: a model used in biomedical research.

Authors:
Howard J Jacob

Methods Mol Biol 2010 ;597:1-11

Human & Molecular Genetics Center, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-60327-389-3_1
Publisher Site
http://dx.doi.org/10.1007/978-1-60327-389-3_1DOI Listing
February 2010

Sequencing of the rat genome and databases.

Methods Mol Biol 2010 ;597:33-53

Human & Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60327-389-3_3DOI Listing
February 2010

Generation of gene-specific mutated rats using zinc-finger nucleases.

Methods Mol Biol 2010 ;597:211-25

Human and Molecular Genetics Center, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60327-389-3_15DOI Listing
February 2010

The rat genome database curators: who, what, where, why.

PLoS Comput Biol 2009 Nov 26;5(11):e1000582. Epub 2009 Nov 26.

Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1000582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775909PMC
November 2009

Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat.

Physiol Genomics 2009 Sep 7;39(1):38-46. Epub 2009 Jul 7.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53266, USA.

View Article

Download full-text PDF

Source
http://physiolgenomics.physiology.org/content/physiolgenomic
Web Search
http://physiolgenomics.physiology.org/cgi/doi/10.1152/physio
Publisher Site
http://dx.doi.org/10.1152/physiolgenomics.90389.2008DOI Listing
September 2009

Rats!

Dis Model Mech 2009 May-Jun;2(5-6):206-10

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.002733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675817PMC
July 2009

Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR.

Physiol Genomics 2009 Mar 6;37(1):52-7. Epub 2009 Jan 6.

Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.90299.2008DOI Listing
March 2009

The Rat Genome Database 2009: variation, ontologies and pathways.

Nucleic Acids Res 2009 Jan 7;37(Database issue):D744-9. Epub 2008 Nov 7.

Department of Physiology and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkn842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686558PMC
January 2009

Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats.

Cancer Genet Cytogenet 2008 Oct;186(1):41-8

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226-0509, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cancergencyto.2008.05.014DOI Listing
October 2008

Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.

Am J Physiol Renal Physiol 2008 Sep 23;295(3):F837-42. Epub 2008 Jul 23.

Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajprenal.90341.2008
Publisher Site
http://dx.doi.org/10.1152/ajprenal.90341.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536867PMC
September 2008

Engineered heart tissue: high throughput platform for dissection of complex diseases.

J Cardiovasc Transl Res 2008 Sep 10;1(3):232-5. Epub 2008 May 10.

Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-008-9026-0
Publisher Site
http://dx.doi.org/10.1007/s12265-008-9026-0DOI Listing
September 2008

Comparative genomics for detecting human disease genes.

Adv Genet 2008 ;60:655-97

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0065-2660(07)00423-3DOI Listing
June 2008

Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats.

Physiol Genomics 2008 Jun 22;34(1):54-64. Epub 2008 Apr 22.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00031.2008DOI Listing
June 2008

Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats.

Am J Physiol Renal Physiol 2007 Dec 26;293(6):F1905-14. Epub 2007 Sep 26.

Dept. of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00012.2007DOI Listing
December 2007

Tissue engineering: a new frontier in physiological genomics.

Physiol Genomics 2007 Dec 23;32(1):28-32. Epub 2007 Oct 23.

Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/physiolgenomics.00165.
Publisher Site
http://dx.doi.org/10.1152/physiolgenomics.00165.2007DOI Listing
December 2007

Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat.

Physiol Genomics 2007 Oct 12;31(2):228-35. Epub 2007 Jun 12.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53266, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/physiolgenomics.00280.
Publisher Site
http://dx.doi.org/10.1152/physiolgenomics.00280.2006DOI Listing
October 2007

Efficient transgenic rat production by a lentiviral vector.

Am J Physiol Heart Circ Physiol 2007 Jul 23;293(1):H881-94. Epub 2007 Feb 23.

Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00060.2007DOI Listing
July 2007

The Rat Genome Database, update 2007--easing the path from disease to data and back again.

Nucleic Acids Res 2007 Jan 6;35(Database issue):D658-62. Epub 2006 Dec 6.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

View Article

Download full-text PDF

Source
https://nar.oxfordjournals.org/content/35/suppl_1/D658.full-
Web Search
http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkl988
Publisher Site
http://dx.doi.org/10.1093/nar/gkl988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761441PMC
January 2007